Development Level

Tbio 44 | 11,445
Tdark 25 | 6,588
Tchem 8 | 1,598
Tclin 4 | 613

Collection

Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
decreased blood urea nitrogen ... 2 | 51
decreased circulating insulin ... 2 | 76
abnormal brain morphology 1 | 13
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal midbrain development 1 | 20
abnormal nail morphology 1 | 8
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
abnormal urinary bladder morph... 1 | 11
cataract 1 | 92
cystolithiasis 1 | 3
decreased NK cell number 1 | 2
decreased basophil cell number 1 | 16
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased cardiac muscle contr... 1 | 11
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
dilated heart left ventricle 1 | 11
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
female infertility 1 | 60
hydroencephaly 1 | 14
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased circulating aspartat... 1 | 15
increased circulating creatine... 1 | 5
increased circulating iron lev... 1 | 30
increased lean body mass 1 | 172
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
limb grasping 1 | 41
male infertility 1 | 123
polycystic kidney 1 | 15
prolonged QRS complex duration 1 | 8
short tibia 1 | 97
thick skin 1 | 4

Disease

Carcinoma 51 | 11,493
psoriasis 36 | 6,694
ovarian cancer 34 | 8,520
medulloblastoma, large-cell 33 | 6,241
osteosarcoma 33 | 7,950
atypical teratoid / rhabdoid tumor 24 | 5,112
glioblastoma 24 | 5,792
lung cancer 22 | 4,740
malignant mesothelioma 19 | 3,232
ependymoma 17 | 4,679
group 3 medulloblastoma 17 | 4,104
adult high grade glioma 15 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
primitive neuroectodermal tumor 14 | 3,035
Breast cancer 13 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
non-small cell lung cancer 13 | 2,890
oligodendroglioma 13 | 2,850
Astrocytoma, Pilocytic 12 | 3,081
Kidney cancer 12 | 2,613
interstitial cystitis 12 | 2,312
lung carcinoma 12 | 2,843
Cancer 11 | 2,499
lung adenocarcinoma 11 | 2,716
ulcerative colitis 11 | 1,819
Autosomal recessive predisposition 10 | 1,442
Pick disease 10 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
astrocytic glioma 9 | 2,597
colon cancer 9 | 1,478
subependymal giant cell astrocytoma 9 | 2,287
group 4 medulloblastoma 8 | 1,855
invasive ductal carcinoma 8 | 2,951
pituitary cancer 8 | 1,972
Liver cancer 7 | 604
cystic fibrosis 7 | 1,696
ductal carcinoma in situ 7 | 1,745
pancreatic cancer 7 | 2,398
Melanoma 6 | 711
Muscle hypotonia 6 | 571
Status Epilepticus 6 | 98
diabetes mellitus 6 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Cataract 5 | 297
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
Multiple myeloma 5 | 1,332
Schizophrenia 5 | 1,160
nasopharyngeal carcinoma 5 | 1,058
pediatric high grade glioma 5 | 1,064
spina bifida 5 | 1,074
tuberculosis 5 | 2,010
Celiac disease 4 | 116
Chromosome 17q12 deletion syndrome 4 | 16
Crohn's disease 4 | 321
Dull intelligence 4 | 645
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Multiple Sclerosis 4 | 540
Obesity 4 | 678
Poor school performance 4 | 645
Skin cancer 4 | 469
Waldenstrons macroglobulinemia 4 | 765
astrocytoma 4 | 1,146
posterior fossa group A ependymoma 4 | 468
Atopic dermatitis 3 | 952
Big calvaria 3 | 147
Bipolar Disorder 3 | 666
Breast Neoplasms 3 | 445
Dilated ventricles (finding) 3 | 121
Endometrial cancer 3 | 311
Epilepsy 3 | 792
Increased head circumference 3 | 147
Increased size of cranium 3 | 147
Increased size of skull 3 | 147
Lens Opacities 3 | 231
Mammary Neoplasms 3 | 425
Osteoporosis 3 | 363
Prostatic Neoplasms 3 | 495
Pulmonary Fibrosis 3 | 106
Rheumatoid arthritis 3 | 1,191
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
breast carcinoma 3 | 1,638
chronic rhinosinusitis 3 | 512
dermatomyositis 3 | 966
esophageal adenocarcinoma 3 | 737
fibroadenoma 3 | 559
gastric carcinoma 3 | 807
juvenile dermatomyositis 3 | 1,187
primary Sjogren syndrome 3 | 735
primary pancreatic ductal adenocarcinoma 3 | 1,109
sarcoidosis 3 | 370
tuberculosis and treatment for 3 months 3 | 179
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
hepatocellular carcinoma 2 | 547
sonic hedgehog group medulloblastoma 2 | 467

Tissue

Endocrine System 76 | 18,159
Blood and immune system 74 | 16,909
Digestive Tract 74 | 17,369
Female tissues 74 | 17,400
Male tissues 74 | 17,142
Skin and soft tissues 74 | 17,230
Liver and Pancreas 73 | 16,750
Nervous System 72 | 16,725
Urinary Tract 72 | 16,678
Respiratory system 70 | 16,393
Cardiovascular System 66 | 15,192

Target Family

Non-IDG 45 | 12,091
Enzyme 19 | 4,145
GPCR 5 | 408
Transcription Factor 4 | 1,400
Ion Channel 3 | 344
Kinase 3 | 634
Epigenetic 1 | 242
Transporter 1 | 473

GWAS Trait

Macrophage inflammatory protei... 81 | 81
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA topoisomerase 3-beta-1 TOP3B Tbio Enzyme -1.06981 9.54 153
Uncharacterized protein C17orf50 C17orf50 Tdark Non-IDG 0.00000 4
Testis- and ovary-specific PAZ domain-containing protein 1 TOPAZ1 Tdark Non-IDG -0.53601 3.90 16
Anoctamin-10 ANO10 Tbio Non-IDG -1.22069 14.6 54
Probable ATP-dependent RNA helicase DDX52 DDX52 Tbio Enzyme -1.26645 18.0 73
39S ribosomal protein L45, mitochondrial MRPL45 Tdark Non-IDG 0.51 0.23 0
Protein unc-45 homolog B UNC45B Tbio Non-IDG -1.54873 42.8 123
ERC protein 2 ERC2 Tbio Non-IDG -1.60862 40.7 36
Sterol regulatory element-binding protein cleavage-activating protein SCAP Tbio Non-IDG -1.85010 73.9 172
Leucine-rich repeat-containing protein 2 LRRC2 Tdark Non-IDG -0.14932 1.61 111