Development Level

Tbio 78 | 11,445
Tdark 12 | 6,588
Tchem 11 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, incomple... 8 | 499
preweaning lethality, complete... 6 | 979
decreased bone mineral density 3 | 126
decreased total body fat amoun... 3 | 207
embryonic lethality prior to o... 3 | 239
abnormal cranium morphology 2 | 36
abnormal heart morphology 2 | 162
abnormal snout morphology 2 | 23
cataract 2 | 92
decreased body length 2 | 101
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased red blood cell distr... 2 | 41
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased bone mineral density 2 | 72
increased total body fat amoun... 2 | 134
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal eye morphology 1 | 68
abnormal incisor morphology 1 | 4
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal lymph node morphology 1 | 3
abnormal mandible morphology 1 | 2
abnormal maxilla morphology 1 | 17
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal spinal cord morpholog... 1 | 9
abnormal tooth morphology 1 | 24
absent pinna reflex 1 | 23
convulsive seizures 1 | 13
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating potassiu... 1 | 20
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
enlarged adrenal glands 1 | 3
enlarged kidney 1 | 14
enlarged uterus 1 | 11
female infertility 1 | 60
hydrometra 1 | 53
improved glucose tolerance 1 | 79
increased anti-nuclear antigen... 1 | 19
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased startle reflex 1 | 112
irregularly shaped pupil 1 | 7
male infertility 1 | 123
polycystic kidney 1 | 15
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 82 | 11,493
ovarian cancer 61 | 8,520
lung cancer 47 | 4,740
osteosarcoma 46 | 7,950
glioblastoma 44 | 5,792
medulloblastoma, large-cell 44 | 6,241
psoriasis 44 | 6,694
ependymoma 41 | 4,679
Kidney cancer 40 | 2,613
atypical teratoid / rhabdoid tumor 38 | 5,112
lung carcinoma 36 | 2,843
group 3 medulloblastoma 33 | 4,104
Astrocytoma, Pilocytic 31 | 3,081
adult high grade glioma 31 | 3,801
malignant mesothelioma 31 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
primitive neuroectodermal tumor 27 | 3,035
interstitial cystitis 26 | 2,312
invasive ductal carcinoma 26 | 2,951
oligodendroglioma 26 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,955
Breast cancer 24 | 3,578
astrocytic glioma 24 | 2,597
lung adenocarcinoma 24 | 2,716
Cancer 23 | 2,499
cystic fibrosis 23 | 1,696
non-small cell lung cancer 22 | 2,890
subependymal giant cell astrocytoma 21 | 2,287
pancreatic cancer 20 | 2,398
pituitary cancer 20 | 1,972
ulcerative colitis 20 | 1,819
colon cancer 17 | 1,478
tuberculosis 17 | 2,010
ductal carcinoma in situ 16 | 1,745
Liver cancer 15 | 604
breast carcinoma 15 | 1,638
Autosomal recessive predisposition 14 | 1,442
Melanoma 14 | 711
Pick disease 14 | 1,894
Skin cancer 13 | 469
Endometrial cancer 12 | 311
acute quadriplegic myopathy 12 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 12 | 510
nasopharyngeal carcinoma 12 | 1,058
group 4 medulloblastoma 11 | 1,855
juvenile dermatomyositis 11 | 1,187
medulloblastoma 11 | 720
active Crohn's disease 10 | 922
adrenocortical carcinoma 10 | 1,428
Atopic dermatitis 9 | 952
Schizophrenia 9 | 1,160
astrocytoma 9 | 1,146
primary pancreatic ductal adenocarcinoma 9 | 1,109
Duchenne muscular dystrophy 8 | 601
Intellectual disability 8 | 1,016
Neurodegenerative disease 8 | 414
Obesity 8 | 678
Prostatic Neoplasms 8 | 495
diabetes mellitus 8 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
primary Sjogren syndrome 8 | 735
Multiple myeloma 7 | 1,332
Osteoporosis 7 | 363
Type 2 diabetes mellitus 7 | 272
gastric carcinoma 7 | 807
sonic hedgehog group medulloblastoma 7 | 467
Acquired metabolic disease 6 | 336
Alzheimer's disease 6 | 658
Amyotrophic lateral sclerosis 6 | 451
Bipolar Disorder 6 | 666
Cleft Palate 6 | 271
Dementia 6 | 175
Down syndrome 6 | 499
Dull intelligence 6 | 645
Epilepsy 6 | 792
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
Rheumatoid arthritis 6 | 1,191
Stomach Neoplasms 6 | 300
cutaneous lupus erythematosus 6 | 1,057
spina bifida 6 | 1,074
Depressive disorder 5 | 409
Hydrolethalus syndrome 5 | 128
Hyperreflexia 5 | 209
Hypoplastic mandible condyle 5 | 275
Large intestine cancer 5 | 126
Mandibular hypoplasia 5 | 275
Mental Depression 5 | 333
Micrognathism 5 | 275
gastric cancer 5 | 459
sarcoidosis 5 | 370
Attention deficit hyperactivity disorder 4 | 278
Immune system cancer 4 | 140
Uranostaphyloschisis 4 | 167
fibroadenoma 4 | 559
non diabetic and post-ischemic heart failure 4 | 200
progressive supranuclear palsy 4 | 676

Tissue

Endocrine System 100 | 18,159
Female tissues 100 | 17,400
Blood and immune system 97 | 16,909
Digestive Tract 96 | 17,369
Nervous System 96 | 16,725
Respiratory system 96 | 16,393
Male tissues 95 | 17,142
Skin and soft tissues 95 | 17,230
Urinary Tract 95 | 16,678
Liver and Pancreas 94 | 16,750
Cardiovascular System 87 | 15,192

Target Family

Non-IDG 56 | 12,091
Enzyme 21 | 4,145
Transcription Factor 9 | 1,400
Kinase 8 | 634
Epigenetic 3 | 242
Transporter 3 | 473
GPCR 2 | 408
TF/Epigenetic 1 | 38

GWAS Trait

Lobe attachment (rater-scored ... 103 | 103
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
E3 ubiquitin-protein ligase SHPRH SHPRH Tbio Epigenetic -0.99196 10.7 137
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Histone deacetylase 9 HDAC9 Tclin Epigenetic -2.27309 185.2 431
Butyrophilin subfamily 2 member A2 BTN2A2 Tdark Non-IDG -0.21927 2.32 84
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 DDAH1 Tchem Enzyme -2.13636 144.4 205
Myosin-IIIb MYO3B Tbio Kinase -0.73450 5.14 127
A disintegrin and metalloproteinase with thrombospondin motifs 14 ADAMTS14 Tbio Enzyme -0.89572 7.58 29
Collagen alpha-1(XXI) chain COL21A1 Tbio Non-IDG -0.67130 4.90 89
Serine/threonine-protein kinase SIK3 SIK3 Tchem Kinase -1.18286 18.2 0