Development Level

Tbio 81 | 11,651
Tdark 15 | 6,593
Tchem 10 | 1,388
Tclin 6 | 612

Collection

RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to t... 3 | 278
abnormal embryo size 2 | 220
decreased circulating serum al... 2 | 82
decreased heart left ventricle... 2 | 28
embryonic growth retardation 2 | 106
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
thin ventricular wall 2 | 24
abnormal behavior 1 | 298
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal limb bud morphology 1 | 17
abnormal placenta size 1 | 20
abnormal urinary bladder morph... 1 | 11
abnormal vertebrae morphology 1 | 18
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
female infertility 1 | 60
hyperactivity 1 | 148
increased B cell number 1 | 9
increased body weight 1 | 25
increased cardiac muscle contr... 1 | 8
increased circulating alkaline... 1 | 122
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased kidney weight 1 | 6
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97

Disease

Carcinoma 79 | 11,493
ovarian cancer 67 | 8,520
osteosarcoma 59 | 7,950
medulloblastoma, large-cell 45 | 6,241
psoriasis 45 | 6,694
atypical teratoid / rhabdoid tumor 39 | 5,112
lung cancer 39 | 4,740
glioblastoma 38 | 5,792
group 3 medulloblastoma 33 | 4,104
malignant mesothelioma 30 | 3,232
ependymoma 29 | 4,679
pancreatic cancer 28 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
Breast cancer 26 | 3,578
Cancer 25 | 2,499
adult high grade glioma 24 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
invasive ductal carcinoma 23 | 2,951
lung carcinoma 23 | 2,843
non-small cell lung cancer 23 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
astrocytic glioma 21 | 2,597
cystic fibrosis 21 | 1,696
breast carcinoma 20 | 1,638
lung adenocarcinoma 20 | 2,716
primitive neuroectodermal tumor 20 | 3,035
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
tuberculosis 19 | 2,010
Kidney cancer 18 | 2,613
pituitary cancer 17 | 1,972
ulcerative colitis 17 | 1,819
oligodendroglioma 16 | 2,850
Autosomal recessive predisposition 15 | 1,442
Rheumatoid arthritis 15 | 1,191
ductal carcinoma in situ 15 | 1,745
diabetes mellitus 14 | 1,728
interstitial cystitis 14 | 2,312
Astrocytoma, Pilocytic 13 | 3,081
subependymal giant cell astrocytoma 13 | 2,287
Atopic dermatitis 12 | 952
Pick disease 12 | 1,894
colon cancer 12 | 1,478
Obesity 11 | 678
Peripheral vascular disease 11 | 87
Type 2 diabetes mellitus 11 | 272
Anemia 10 | 365
Multiple myeloma 10 | 1,332
primary pancreatic ductal adenocarcinoma 10 | 1,109
spina bifida 10 | 1,074
Alzheimer's disease 9 | 658
Kidney disease 9 | 430
active Crohn's disease 9 | 922
active ulcerative colitis 9 | 764
esophageal adenocarcinoma 9 | 737
fibroadenoma 9 | 559
Osteoporosis 8 | 363
astrocytoma 8 | 1,146
cutaneous lupus erythematosus 8 | 1,057
dermatomyositis 8 | 966
group 4 medulloblastoma 8 | 1,855
Acquired metabolic disease 7 | 336
Bipolar Disorder 7 | 666
Cardiovascular system disease 7 | 246
Melanoma 7 | 711
Multiple Sclerosis 7 | 540
Schizophrenia 7 | 1,160
adrenocortical carcinoma 7 | 1,428
gastric carcinoma 7 | 807
juvenile dermatomyositis 7 | 1,187
mucosa-associated lymphoid tissue lymphoma 7 | 484
pancreatic carcinoma 7 | 562
progressive supranuclear palsy 7 | 676
Coronary artery disease 6 | 268
Diabetes Mellitus, Experimental 6 | 108
Diabetes Mellitus, Non-Insulin-Dependent 6 | 145
Hemolytic anemia 6 | 77
acute quadriplegic myopathy 6 | 1,158
hepatocellular carcinoma 6 | 547
Colorectal Neoplasms 5 | 243
Diabetes Mellitus, Type 2 5 | 142
Endometriosis 5 | 540
Heart failure 5 | 162
Liver Cirrhosis 5 | 181
Liver disease 5 | 237
Myocardial Ischemia 5 | 169
Neurodegenerative disease 5 | 414
Polycythemia 5 | 25
Splenomegaly 5 | 190
chronic rhinosinusitis 5 | 512
interstitial lung disease 5 | 298
medulloblastoma 5 | 720
non primary Sjogren syndrome sicca 5 | 891
primary Sjogren syndrome 5 | 735
Duchenne muscular dystrophy 4 | 601
Mental Depression 4 | 333
Prostatic Neoplasms 4 | 495
acute myeloid leukemia 4 | 783
aldosterone-producing adenoma 4 | 665
sonic hedgehog group medulloblastoma 4 | 467
urothelial carcinoma 4 | 318

Tissue

Endocrine System 108 | 18,159
Female tissues 108 | 17,400
Digestive Tract 107 | 17,369
Male tissues 107 | 17,142
Skin and soft tissues 106 | 17,230
Urinary Tract 106 | 16,678
Blood and immune system 105 | 16,909
Liver and Pancreas 105 | 16,750
Nervous System 104 | 16,725
Respiratory system 102 | 16,393
Cardiovascular System 97 | 15,192

Target Family

Non-IDG 57 | 12,091
Enzyme 26 | 4,145
Transcription Factor 12 | 1,400
Kinase 6 | 634
GPCR 3 | 408
Transporter 3 | 473
Ion Channel 2 | 344
Nuclear Receptor 2 | 48
Epigenetic 1 | 242

GWAS Trait

Hemoglobin concentration 112 | 112
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B Tbio Non-IDG -2.61667 619.4 476
Metaxin-1 MTX1 Tbio Non-IDG -1.93920 85.1 64
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.81793 64.6 227
Interleukin-2 receptor subunit beta IL2RB Tclin Non-IDG -2.17998 125.4 654
R-spondin-3 RSPO3 Tbio Non-IDG -1.33286 23.2 138
E3 ubiquitin-protein ligase ZNRF3 ZNRF3 Tbio Enzyme -1.17415 16.1 57
Erythropoietin EPO Tbio Non-IDG -3.92285 8985.5 837
Vascular endothelial growth factor A VEGFA Tclin Non-IDG -4.27197 19076.6 1809
Transferrin receptor protein 2 TFR2 Tbio Enzyme -2.11882 135.2 149
Dynamin-3 DNM3 Tbio Non-IDG -1.43916 22.6 146