Development Level

Tbio 252 | 11,651
Tdark 65 | 6,593
Tchem 37 | 1,388
Tclin 15 | 612

Collection

RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 23 | 979
preweaning lethality, incomple... 16 | 499
embryonic lethality prior to t... 10 | 278
abnormal embryo size 9 | 220
decreased body weight 8 | 161
decreased total body fat amoun... 8 | 207
decreased bone mineral content 7 | 151
increased lean body mass 7 | 172
abnormal bone structure 6 | 187
decreased bone mineral density 6 | 126
increased startle reflex 6 | 112
decreased circulating choleste... 5 | 93
decreased lean body mass 5 | 135
decreased lymphocyte cell numb... 5 | 83
embryonic lethality prior to o... 5 | 239
enlarged heart 5 | 210
abnormal heart morphology 4 | 162
abnormal neural tube closure 4 | 46
decreased body length 4 | 101
decreased circulating HDL chol... 4 | 68
increased total body fat amoun... 4 | 134
abnormal behavior 3 | 298
abnormal lung morphology 3 | 26
abnormal seminal vesicle morph... 3 | 114
abnormal testis morphology 3 | 43
abnormal tooth morphology 3 | 24
decreased circulating serum al... 3 | 82
increased body weight 3 | 25
increased bone mineral content 3 | 108
increased circulating sodium l... 3 | 71
increased leukocyte cell numbe... 3 | 47
increased monocyte cell number 3 | 63
male infertility 3 | 123
small testis 3 | 58
abnormal behavioral response t... 2 | 66
abnormal bone mineralization 2 | 38
abnormal coat-hair pigmentatio... 2 | 64
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal forebrain development 2 | 20
abnormal midbrain development 2 | 20
cardiovascular system phenotyp... 2 | 36
convulsive seizures 2 | 13
decreased blood urea nitrogen ... 2 | 51
decreased circulating alkaline... 2 | 46
decreased circulating aspartat... 2 | 34
decreased circulating iron lev... 2 | 32
decreased erythrocyte cell num... 2 | 62
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
edema 2 | 59
embryonic growth retardation 2 | 106
hemorrhage 2 | 23
hypoactivity 2 | 132
increased blood urea nitrogen ... 2 | 48
increased body length 2 | 32
increased bone mineral density 2 | 72
increased circulating creatini... 2 | 38
increased fasted circulating g... 2 | 76
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
increased neutrophil cell numb... 2 | 46
pale yolk sac 2 | 25
shortened RR interval 2 | 17
small superior vagus ganglion 2 | 74
abnormal body wall morphology 1 | 9
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal heart left ventricle ... 1 | 16
abnormal retinal vasculature m... 1 | 27
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
absent vibrissae 1 | 12
cystolithiasis 1 | 3
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
enlarged uterus 1 | 11
hydrometra 1 | 53
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased red blood cell distr... 1 | 34
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
thin ventricular wall 1 | 24
tremors 1 | 39
urinary bladder obstruction 1 | 4

Disease

Carcinoma 263 | 11,493
ovarian cancer 201 | 8,520
osteosarcoma 186 | 7,950
medulloblastoma, large-cell 161 | 6,241
glioblastoma 149 | 5,792
psoriasis 138 | 6,694
atypical teratoid / rhabdoid tumor 124 | 5,112
ependymoma 118 | 4,679
lung cancer 110 | 4,740
group 3 medulloblastoma 109 | 4,104
adult high grade glioma 102 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 102 | 3,291
malignant mesothelioma 98 | 3,232
Breast cancer 96 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 96 | 2,989
Astrocytoma, Pilocytic 89 | 3,081
Kidney cancer 87 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 85 | 2,955
oligodendroglioma 85 | 2,850
Acquired metabolic disease 84 | 336
primitive neuroectodermal tumor 81 | 3,035
invasive ductal carcinoma 76 | 2,951
lung adenocarcinoma 74 | 2,716
non-small cell lung cancer 71 | 2,890
Cancer 70 | 2,499
lung carcinoma 69 | 2,843
pancreatic cancer 63 | 2,398
subependymal giant cell astrocytoma 62 | 2,287
astrocytic glioma 59 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 57 | 1,962
interstitial cystitis 55 | 2,312
pituitary cancer 54 | 1,972
ductal carcinoma in situ 50 | 1,745
breast carcinoma 46 | 1,638
tuberculosis 45 | 2,010
Pick disease 44 | 1,894
adrenocortical carcinoma 44 | 1,428
diabetes mellitus 42 | 1,728
ulcerative colitis 41 | 1,819
Autosomal recessive predisposition 40 | 1,442
cystic fibrosis 40 | 1,696
group 4 medulloblastoma 38 | 1,855
astrocytoma 37 | 1,146
colon cancer 35 | 1,478
Short stature 34 | 531
Schizophrenia 32 | 1,160
Atopic dermatitis 30 | 952
Intellectual disability 30 | 1,016
primary pancreatic ductal adenocarcinoma 30 | 1,109
Rheumatoid arthritis 29 | 1,191
juvenile dermatomyositis 28 | 1,187
Multiple myeloma 26 | 1,332
cutaneous lupus erythematosus 26 | 1,057
gastric carcinoma 26 | 807
pediatric high grade glioma 26 | 1,064
nasopharyngeal carcinoma 24 | 1,058
spina bifida 24 | 1,074
medulloblastoma 23 | 720
active Crohn's disease 22 | 922
dermatomyositis 22 | 966
progressive supranuclear palsy 22 | 676
Dull intelligence 21 | 645
Low intelligence 21 | 645
Melanoma 21 | 711
Mental Retardation 21 | 645
Mental deficiency 21 | 645
Obesity 21 | 678
Poor school performance 21 | 645
Liver cancer 20 | 604
acute myeloid leukemia 20 | 783
esophageal adenocarcinoma 20 | 737
Amyotrophic lateral sclerosis 19 | 451
Endometriosis 19 | 540
Liver Cirrhosis, Experimental 19 | 769
Prostatic Neoplasms 19 | 495
autosomal dominant Emery-Dreifuss muscular dystrophy 19 | 510
Alzheimer's disease 18 | 658
Bipolar Disorder 18 | 666
Cognitive delay 17 | 608
Global developmental delay 17 | 608
Mental and motor retardation 17 | 608
Epilepsy 16 | 792
Osteoporosis 16 | 363
Small head 16 | 374
active ulcerative colitis 16 | 764
acute quadriplegic myopathy 16 | 1,158
primary Sjogren syndrome 16 | 735
sonic hedgehog group medulloblastoma 16 | 467
Crohn's disease 15 | 321
Duchenne muscular dystrophy 15 | 601
Multiple Sclerosis 15 | 540
Waldenstrons macroglobulinemia 15 | 765
non-small cell lung carcinoma 15 | 317
pancreatic carcinoma 15 | 562
Brachydactyly 14 | 156
Seizures 14 | 596
Down syndrome 13 | 499
Polycystic ovary syndrome 13 | 360
aldosterone-producing adenoma 13 | 665
non primary Sjogren syndrome sicca 13 | 891

Tissue

Endocrine System 355 | 18,159
Digestive Tract 349 | 17,369
Female tissues 348 | 17,400
Skin and soft tissues 348 | 17,230
Blood and immune system 342 | 16,909
Male tissues 342 | 17,142
Urinary Tract 340 | 16,678
Respiratory system 339 | 16,393
Liver and Pancreas 338 | 16,750
Nervous System 336 | 16,725
Cardiovascular System 322 | 15,192

Target Family

Non-IDG 210 | 12,091
Enzyme 70 | 4,145
Transcription Factor 40 | 1,400
Kinase 19 | 634
Epigenetic 8 | 242
Ion Channel 7 | 344
GPCR 5 | 408
Transporter 5 | 473
Nuclear Receptor 2 | 48
oGPCR 2 | 421
TF/Epigenetic 1 | 38

GWAS Trait

Height 369 | 369
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
GDH/6PGL endoplasmic bifunctional protein H6PD Tbio Non-IDG -2.24806 169.7 207
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.16239 142.5 123
A disintegrin and metalloproteinase with thrombospondin motifs 2 ADAMTS2 Tbio Enzyme -2.51717 1472.5 133
Disks large homolog 2 DLG2 Tbio Non-IDG -1.75838 53.6 227
Tubby-related protein 4 TULP4 Tdark Transcription Factor -1.15928 14.0 44
cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A Tclin Enzyme -2.09039 125.7 168
Zinc finger protein 678 ZNF678 Tdark Transcription Factor 0.00000 70
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610