Development Level

Tbio 77 | 11,445
Tchem 16 | 1,598
Tdark 16 | 6,588
Tclin 7 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 14 | 979
abnormal embryo size 4 | 220
decreased body weight 3 | 161
decreased circulating glucose ... 3 | 126
decreased erythrocyte cell num... 3 | 62
embryonic lethality prior to t... 3 | 278
hyperactivity 3 | 148
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal retina morphology 2 | 71
abnormal retinal vasculature m... 2 | 27
abnormal seminal vesicle morph... 2 | 114
cataract 2 | 92
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased lean body mass 2 | 135
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
improved glucose tolerance 2 | 79
increased anti-nuclear antigen... 2 | 19
increased circulating choleste... 2 | 66
increased mean corpuscular hem... 2 | 36
abnormal coat-hair pigmentatio... 1 | 64
abnormal colon morphology 1 | 3
abnormal embryo turning 1 | 31
abnormal facial morphology 1 | 17
abnormal head shape 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal humerus morphology 1 | 11
abnormal ileum morphology 1 | 2
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal outer ear morphology 1 | 3
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal retinal blood vessel ... 1 | 26
abnormal spine curvature 1 | 9
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
absent optic nerve 1 | 2
absent startle reflex 1 | 24
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased KLRG1+ CD8 alpha bet... 1 | 2
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating chloride... 1 | 30
decreased circulating free fat... 1 | 31
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased lactate dehydrogenas... 1 | 16
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
embryonic lethality prior to o... 1 | 239
enlarged spleen 1 | 41
hypoactivity 1 | 132
increased NK cell number 1 | 3
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased heart rate 1 | 23
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
microphthalmia 1 | 26
pallor 1 | 34
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
prolonged PQ interval 1 | 5
prolonged QRS complex duration 1 | 8
prolonged QT interval 1 | 38
short tibia 1 | 97
small testis 1 | 58
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 89 | 11,493
osteosarcoma 62 | 7,950
ovarian cancer 62 | 8,520
psoriasis 52 | 6,694
medulloblastoma, large-cell 44 | 6,241
glioblastoma 43 | 5,792
atypical teratoid / rhabdoid tumor 38 | 5,112
lung cancer 38 | 4,740
malignant mesothelioma 32 | 3,232
Breast cancer 30 | 3,578
Cardiovascular system disease 30 | 246
ependymoma 30 | 4,679
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,962
Kidney cancer 29 | 2,613
oligodendroglioma 28 | 2,850
group 3 medulloblastoma 27 | 4,104
invasive ductal carcinoma 27 | 2,951
Lipid metabolism disorder 26 | 114
adult high grade glioma 26 | 3,801
diabetes mellitus 26 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
Obesity 24 | 678
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
Atherosclerosis 23 | 291
Coronary artery disease 22 | 268
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
lung carcinoma 22 | 2,843
non-small cell lung cancer 20 | 2,890
pancreatic cancer 20 | 2,398
ductal carcinoma in situ 19 | 1,745
subependymal giant cell astrocytoma 19 | 2,287
Rheumatoid arthritis 18 | 1,191
astrocytic glioma 18 | 2,597
tuberculosis 18 | 2,010
Autosomal recessive predisposition 17 | 1,442
lung adenocarcinoma 17 | 2,716
primitive neuroectodermal tumor 17 | 3,035
Cancer 16 | 2,499
cystic fibrosis 16 | 1,696
Astrocytoma, Pilocytic 14 | 3,081
Metabolic syndrome X 14 | 52
Pick disease 14 | 1,894
Schizophrenia 14 | 1,160
adrenocortical carcinoma 14 | 1,428
breast carcinoma 14 | 1,638
dermatomyositis 14 | 966
interstitial cystitis 14 | 2,312
ulcerative colitis 14 | 1,819
Acquired metabolic disease 13 | 336
Hypertension 13 | 396
Type 2 diabetes mellitus 13 | 272
juvenile dermatomyositis 13 | 1,187
Intellectual disability 12 | 1,016
astrocytoma 12 | 1,146
Liver Cirrhosis, Experimental 11 | 769
colon cancer 11 | 1,478
Alzheimer's disease 10 | 658
Atopic dermatitis 10 | 952
Hypertensive disease 10 | 292
active ulcerative colitis 10 | 764
acute quadriplegic myopathy 10 | 1,158
Kidney disease 9 | 430
Vascular disease 9 | 319
esophageal adenocarcinoma 9 | 737
group 4 medulloblastoma 9 | 1,855
mucosa-associated lymphoid tissue lymphoma 9 | 484
primary pancreatic ductal adenocarcinoma 9 | 1,109
Duchenne muscular dystrophy 8 | 601
Dull intelligence 8 | 645
Hypercholesterolemia, Familial 8 | 23
Hyperlipoproteinemia Type II 8 | 12
Liver cancer 8 | 604
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
aldosterone-producing adenoma 8 | 665
fibroadenoma 8 | 559
non primary Sjogren syndrome sicca 8 | 891
pituitary cancer 8 | 1,972
progressive supranuclear palsy 8 | 676
Anemia 7 | 365
Bipolar Disorder 7 | 666
Cerebrovascular disease 7 | 238
Cognitive delay 7 | 608
Global developmental delay 7 | 608
Heart disease 7 | 306
Hypercholesterolemia 7 | 44
Hyperlipidemia 7 | 43
Mental and motor retardation 7 | 608
Myocardial Infarction 7 | 151
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
cutaneous lupus erythematosus 7 | 1,057
pediatric high grade glioma 7 | 1,064
spina bifida 7 | 1,074
Down syndrome 6 | 499
Multiple myeloma 6 | 1,332
Short stature 6 | 531
hepatocellular carcinoma 6 | 547
non diabetic and post-ischemic heart failure 6 | 200

Tissue

Endocrine System 113 | 18,159
Skin and soft tissues 113 | 17,230
Female tissues 112 | 17,400
Digestive Tract 111 | 17,369
Liver and Pancreas 111 | 16,750
Male tissues 111 | 17,142
Urinary Tract 109 | 16,678
Respiratory system 107 | 16,393
Blood and immune system 106 | 16,909
Nervous System 105 | 16,725
Cardiovascular System 104 | 15,192

Target Family

Non-IDG 61 | 12,091
Enzyme 33 | 4,145
Transcription Factor 8 | 1,400
Kinase 4 | 634
Transporter 4 | 473
GPCR 2 | 408
Nuclear Receptor 2 | 48
Epigenetic 1 | 242
oGPCR 1 | 421

GWAS Trait

HDL cholesterol 116 | 116
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -3.00390 610.8 955
Vascular endothelial growth factor A VEGFA Tclin Non-IDG -4.27197 19076.6 1809
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Apolipoprotein E APOE Tbio Non-IDG -4.20176 15904.9 976
Oxysterols receptor LXR-alpha NR1H3 Tchem Nuclear Receptor -2.19201 123.0 390
Tropomyosin alpha-1 chain TPM1 Tbio Non-IDG -2.19537 154.3 227
Scavenger receptor class B member 1 SCARB1 Tchem Non-IDG -2.93920 915.7 378