Development Level

Tbio 117 | 11,445
Tchem 28 | 1,598
Tdark 22 | 6,588
Tclin 13 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 11 | 979
embryonic lethality prior to t... 4 | 278
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
embryonic lethality prior to o... 3 | 239
increased grip strength 3 | 41
preweaning lethality, incomple... 3 | 499
abnormal coat-hair pigmentatio... 2 | 64
abnormal cornea morphology 2 | 31
abnormal eye morphology 2 | 68
abnormal seminal vesicle morph... 2 | 114
decreased circulating amylase ... 2 | 28
decreased circulating creatini... 2 | 39
decreased fasted circulating g... 2 | 65
decreased large unstained cell... 2 | 11
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
hydrometra 2 | 53
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased anti-nuclear antigen... 2 | 19
increased circulating alkaline... 2 | 122
increased fasted circulating g... 2 | 76
increased leukocyte cell numbe... 2 | 47
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
small superior vagus ganglion 2 | 74
abnormal bone structure 1 | 187
abnormal coat- hair morphology 1 | 19
abnormal eye anterior chamber ... 1 | 9
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal maxilla morphology 1 | 17
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal skin condition 1 | 6
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vitelline vasculature... 1 | 6
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
enlarged spleen 1 | 41
head bobbing 1 | 5
hemorrhage 1 | 23
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
increased thermal nociceptive ... 1 | 9
irregularly shaped pupil 1 | 7
long tibia 1 | 25
male infertility 1 | 123
pale yolk sac 1 | 25
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
short tibia 1 | 97
small testis 1 | 58
thrombocytopenia 1 | 56
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 120 | 11,493
osteosarcoma 111 | 7,950
ovarian cancer 100 | 8,520
medulloblastoma, large-cell 73 | 6,241
psoriasis 69 | 6,694
glioblastoma 66 | 5,792
lung cancer 64 | 4,740
atypical teratoid / rhabdoid tumor 48 | 5,112
Cancer 47 | 2,499
ependymoma 44 | 4,679
group 3 medulloblastoma 43 | 4,104
Breast cancer 42 | 3,578
adult high grade glioma 41 | 3,801
tuberculosis 41 | 2,010
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,291
lung carcinoma 39 | 2,843
malignant mesothelioma 39 | 3,232
ulcerative colitis 38 | 1,819
Astrocytoma, Pilocytic 37 | 3,081
interstitial cystitis 37 | 2,312
Kidney cancer 36 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 36 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,989
invasive ductal carcinoma 35 | 2,951
primitive neuroectodermal tumor 35 | 3,035
non-small cell lung cancer 34 | 2,890
lung adenocarcinoma 33 | 2,716
pancreatic cancer 32 | 2,398
subependymal giant cell astrocytoma 28 | 2,287
Asthma 27 | 385
diabetes mellitus 26 | 1,728
Rheumatoid arthritis 25 | 1,191
oligodendroglioma 24 | 2,850
Crohn's disease 22 | 321
Pick disease 22 | 1,894
Schizophrenia 22 | 1,160
cystic fibrosis 22 | 1,696
pituitary cancer 22 | 1,972
astrocytoma 21 | 1,146
group 4 medulloblastoma 21 | 1,855
Atopic dermatitis 20 | 952
Autosomal recessive predisposition 20 | 1,442
Multiple myeloma 20 | 1,332
astrocytic glioma 20 | 2,597
ductal carcinoma in situ 19 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
primary pancreatic ductal adenocarcinoma 19 | 1,109
breast carcinoma 18 | 1,638
juvenile dermatomyositis 18 | 1,187
primary Sjogren syndrome 18 | 735
acute quadriplegic myopathy 17 | 1,158
cutaneous lupus erythematosus 17 | 1,057
spina bifida 16 | 1,074
Alzheimer's disease 15 | 658
Breast Neoplasms 15 | 445
Mammary Neoplasms 15 | 425
adrenocortical carcinoma 15 | 1,428
Intellectual disability 14 | 1,016
Liver cancer 14 | 604
Multiple Sclerosis 14 | 540
Waldenstrons macroglobulinemia 14 | 765
colon cancer 14 | 1,478
gastric carcinoma 13 | 807
non primary Sjogren syndrome sicca 13 | 891
Kidney disease 12 | 430
Leukemia, Myelocytic, Acute 12 | 120
Lymphoid leukemia 12 | 160
Prostatic Neoplasms 12 | 495
active Crohn's disease 12 | 922
dermatomyositis 12 | 966
nasopharyngeal carcinoma 12 | 1,058
pediatric high grade glioma 12 | 1,064
Allergic rhinitis 11 | 94
Celiac disease 11 | 116
Chronic Lymphocytic Leukemia 11 | 262
Hypereosinophilic syndrome 11 | 71
Inflammatory bowel disease 11 | 151
Leukemia, Myeloid, Acute 11 | 105
fibroadenoma 11 | 559
Arthritis, Rheumatoid 10 | 174
Autistic Disorder 10 | 364
Bipolar Disorder 10 | 666
Dull intelligence 10 | 645
Fatigue 10 | 182
Hypersensitivity reaction type II disease 10 | 253
Hypertensive disease 10 | 292
Liver Cirrhosis, Experimental 10 | 769
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Obesity 10 | 678
Polycystic ovary syndrome 10 | 360
Poor school performance 10 | 645
Vascular disease 10 | 319
medulloblastoma 10 | 720
progressive supranuclear palsy 10 | 676
Duchenne muscular dystrophy 9 | 601
Immune system cancer 9 | 140
Muscle hypotonia 9 | 571
Splenomegaly 9 | 190

Tissue

Digestive Tract 172 | 17,369
Female tissues 172 | 17,400
Endocrine System 171 | 18,159
Skin and soft tissues 171 | 17,230
Blood and immune system 170 | 16,909
Liver and Pancreas 170 | 16,750
Urinary Tract 170 | 16,678
Male tissues 167 | 17,142
Respiratory system 167 | 16,393
Nervous System 166 | 16,725
Cardiovascular System 160 | 15,192

Target Family

Non-IDG 93 | 12,091
Transcription Factor 32 | 1,400
Enzyme 25 | 4,145
Kinase 14 | 634
GPCR 7 | 408
Epigenetic 5 | 242
Transporter 2 | 473
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

GWAS Trait

Eosinophil counts 180 | 180
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein Helios IKZF2 Tbio Transcription Factor -1.26324 15.8 221
Krueppel-like factor 2 KLF2 Tbio Transcription Factor -2.30630 216.2 308
T-box transcription factor TBX6 TBX6 Tbio Transcription Factor -1.78720 63.0 315
Transcriptional-regulating factor 1 TRERF1 Tbio Transcription Factor -0.69436 6.18 146
5-hydroxytryptamine receptor 4 HTR4 Tclin GPCR -2.87235 796.4 248
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
Serpin B12 SERPINB12 Tbio Non-IDG -0.56624 4.27 155
Serine/threonine-protein kinase SIK3 SIK3 Tchem Kinase -1.18286 18.2 0
Suppressor of tumorigenicity 20 protein ST20 Tdark Non-IDG -1.66163 0.71 0
Protein transport protein Sec16A SEC16A Tbio Non-IDG -1.49890 33.9 31