Development Level

Tbio 156 | 11,651
Tchem 30 | 1,388
Tdark 21 | 6,593
Tclin 8 | 612

Collection

GPCR: IDG Consortium (Complete... 2 | 25
GPCR: IDG Consortium (Targets) 1 | 126
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal bone structure 5 | 187
increased mean corpuscular hem... 5 | 96
preweaning lethality, incomple... 5 | 499
abnormal behavior 4 | 298
decreased bone mineral content 4 | 151
increased grip strength 4 | 41
abnormal heart morphology 3 | 162
decreased lean body mass 3 | 135
decreased vertical activity 3 | 208
enlarged heart 3 | 210
hypoactivity 3 | 132
increased bone mineral content 3 | 108
increased neutrophil cell numb... 3 | 46
abnormal embryo size 2 | 220
abnormal eye anterior chamber ... 2 | 9
abnormal locomotor behavior 2 | 24
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
abnormal vertebrae morphology 2 | 18
cataract 2 | 92
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased circulating bilirubi... 2 | 19
decreased circulating glucose ... 2 | 126
decreased circulating phosphat... 2 | 27
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased large unstained cell... 2 | 11
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
decreased red blood cell distr... 2 | 41
increased circulating amylase ... 2 | 25
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased lymphocyte cell numb... 2 | 32
increased total body fat amoun... 2 | 134
male infertility 2 | 123
abnormal coat-hair pigmentatio... 1 | 64
abnormal colon morphology 1 | 3
abnormal cornea morphology 1 | 31
abnormal duodenum morphology 1 | 4
abnormal epididymis morphology 1 | 42
abnormal facial morphology 1 | 17
abnormal head shape 1 | 10
abnormal lens morphology 1 | 81
abnormal outer ear morphology 1 | 3
abnormal pancreas morphology 1 | 13
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal rib morphology 1 | 10
abnormal spleen morphology 1 | 55
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased IgM level 1 | 1
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased heart weight 1 | 27
decreased monocyte cell number 1 | 8
decreased prepulse inhibition 1 | 82
decreased threshold for audito... 1 | 26
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
female infertility 1 | 60
hydrometra 1 | 53
improved glucose tolerance 1 | 79
increased bone mineral density 1 | 72
increased caudal vertebrae num... 1 | 7
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating serum al... 1 | 22
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased red blood cell distr... 1 | 34
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56
vertebral fusion 1 | 23

Disease

Carcinoma 142 | 11,493
Crohn's disease 132 | 321
ovarian cancer 115 | 8,520
osteosarcoma 113 | 7,950
glioblastoma 84 | 5,792
psoriasis 83 | 6,694
lung cancer 80 | 4,740
medulloblastoma, large-cell 79 | 6,241
ulcerative colitis 70 | 1,819
atypical teratoid / rhabdoid tumor 62 | 5,112
Cancer 61 | 2,499
ependymoma 55 | 4,679
malignant mesothelioma 55 | 3,232
Rheumatoid arthritis 53 | 1,191
group 3 medulloblastoma 53 | 4,104
Astrocytoma, Pilocytic 52 | 3,081
adult high grade glioma 52 | 3,801
interstitial cystitis 52 | 2,312
lung carcinoma 49 | 2,843
invasive ductal carcinoma 48 | 2,951
tuberculosis 47 | 2,010
Breast cancer 43 | 3,578
non-small cell lung cancer 40 | 2,890
oligodendroglioma 38 | 2,850
primitive neuroectodermal tumor 36 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,291
lung adenocarcinoma 35 | 2,716
cystic fibrosis 33 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
pituitary cancer 32 | 1,972
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,955
astrocytic glioma 30 | 2,597
Multiple Sclerosis 29 | 540
subependymal giant cell astrocytoma 29 | 2,287
Kidney cancer 28 | 2,613
ductal carcinoma in situ 28 | 1,745
diabetes mellitus 25 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,962
Asthma 24 | 385
Pick disease 24 | 1,894
astrocytoma 24 | 1,146
pancreatic cancer 24 | 2,398
primary Sjogren syndrome 24 | 735
colon cancer 22 | 1,478
group 4 medulloblastoma 22 | 1,855
pediatric high grade glioma 22 | 1,064
Kidney disease 21 | 430
Schizophrenia 21 | 1,160
cutaneous lupus erythematosus 21 | 1,057
Celiac disease 20 | 116
Common variable immunodeficiency 19 | 101
Crohn Disease 19 | 45
acute quadriplegic myopathy 19 | 1,158
adrenocortical carcinoma 19 | 1,428
juvenile dermatomyositis 19 | 1,187
Autosomal recessive predisposition 18 | 1,442
Colitis, Ulcerative 18 | 59
Inflammatory bowel disease 18 | 151
Liver Cirrhosis, Experimental 18 | 769
Type 1 diabetes mellitus 18 | 109
acute myeloid leukemia 18 | 783
Alzheimer's disease 17 | 658
Arthritis, Rheumatoid 17 | 174
Atopic dermatitis 17 | 952
Hypersensitivity reaction type II disease 17 | 253
active ulcerative colitis 17 | 764
breast carcinoma 17 | 1,638
dermatomyositis 17 | 966
Breast Neoplasms 16 | 445
Obesity 16 | 678
Systemic lupus erythematosus 16 | 194
active Crohn's disease 16 | 922
non primary Sjogren syndrome sicca 16 | 891
Mammary Neoplasms 15 | 425
Multiple myeloma 15 | 1,332
mucosa-associated lymphoid tissue lymphoma 15 | 484
Chronic Lymphocytic Leukemia 14 | 262
Inflammatory Bowel Diseases 14 | 35
Skin cancer 14 | 469
gastric carcinoma 14 | 807
Arthritis 13 | 290
Bipolar Disorder 13 | 666
Melanoma 13 | 711
Vascular disease 13 | 319
aldosterone-producing adenoma 13 | 665
esophageal adenocarcinoma 13 | 737
periodontitis 13 | 293
primary pancreatic ductal adenocarcinoma 13 | 1,109
sarcoidosis 13 | 370
spina bifida 13 | 1,074
Acquired metabolic disease 12 | 336
Leprosy 12 | 73
Liver cancer 12 | 604
Lung Neoplasms 12 | 232
Waldenstrons macroglobulinemia 12 | 765
nasopharyngeal carcinoma 12 | 1,058
Anemia 11 | 365
Endometriosis 11 | 540
Major Depressive Disorder 11 | 301
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 510

Tissue

Digestive Tract 207 | 17,369
Endocrine System 207 | 18,159
Female tissues 204 | 17,400
Blood and immune system 203 | 16,909
Male tissues 203 | 17,142
Skin and soft tissues 203 | 17,230
Liver and Pancreas 202 | 16,750
Respiratory system 201 | 16,393
Urinary Tract 200 | 16,678
Nervous System 197 | 16,725
Cardiovascular System 184 | 15,192

Target Family

Non-IDG 114 | 12,091
Enzyme 49 | 4,145
Transcription Factor 24 | 1,400
Kinase 11 | 634
GPCR 5 | 408
Transporter 5 | 473
Epigenetic 4 | 242
TF/Epigenetic 2 | 38
Nuclear Receptor 1 | 48

GWAS Trait

Crohn's disease 215 | 215
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Intelectin-1 ITLN1 Tbio Non-IDG -2.49500 337.0 194
DNA (cytosine-5)-methyltransferase 3A DNMT3A Tclin Epigenetic -2.91291 722.8 693
Runt-related transcription factor 3 RUNX3 Tbio Transcription Factor -2.71721 536.2 438
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.82293 59.0 314
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.52487 33.2 60
AP-4 complex subunit beta-1 AP4B1 Tbio Non-IDG -0.79214 6.23 124
BTB/POZ domain-containing protein 8 BTBD8 Tdark Non-IDG 0.30 0.70 17
Disintegrin and metalloproteinase domain-containing protein 30 ADAM30 Tdark Enzyme -0.39305 2.44 64
Proton myo-inositol cotransporter SLC2A13 Tbio Transporter -1.10021 10.8 71
Ubiquitin carboxyl-terminal hydrolase 1 USP1 Tchem Enzyme -1.88853 73.3 271