Development Level

Tbio 245 | 11,445
Tchem 53 | 1,598
Tdark 30 | 6,588
Tclin 23 | 613

Collection

GPCR: IDG Consortium (Complete... 1 | 25
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, incomple... 12 | 499
preweaning lethality, complete... 10 | 979
abnormal seminal vesicle morph... 6 | 114
enlarged heart 6 | 210
decreased bone mineral content 5 | 151
decreased circulating glucose ... 5 | 126
embryonic lethality prior to o... 5 | 239
abnormal retina morphology 4 | 71
decreased mean corpuscular vol... 4 | 79
decreased total body fat amoun... 4 | 207
decreased vertical activity 4 | 208
increased circulating alkaline... 4 | 122
male infertility 4 | 123
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
decreased bone mineral density 3 | 126
decreased lymphocyte cell numb... 3 | 83
embryonic lethality prior to t... 3 | 278
increased circulating triglyce... 3 | 42
increased hematocrit 3 | 46
increased mean corpuscular hem... 3 | 96
increased monocyte cell number 3 | 63
increased neutrophil cell numb... 3 | 46
increased total body fat amoun... 3 | 134
thrombocytopenia 3 | 56
tremors 3 | 39
abnormal behavioral response t... 2 | 66
abnormal coat-hair pigmentatio... 2 | 64
abnormal gait 2 | 69
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal sleep behavior 2 | 70
absent vibrissae 2 | 12
cataract 2 | 92
convulsive seizures 2 | 13
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased heart weight 2 | 27
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased startle reflex 2 | 75
hypoactivity 2 | 132
increased bone mineral content 2 | 108
increased circulating bilirubi... 2 | 16
increased circulating choleste... 2 | 66
increased circulating glucose ... 2 | 24
increased circulating iron lev... 2 | 30
increased circulating phosphat... 2 | 26
increased fasted circulating g... 2 | 76
increased grip strength 2 | 41
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular vol... 2 | 92
increased mean platelet volume 2 | 45
increased or absent threshold ... 2 | 101
limb grasping 2 | 41
persistence of hyaloid vascula... 2 | 33
short tibia 2 | 97
small superior vagus ganglion 2 | 74
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal pancreas morphology 1 | 13
abnormal retinal vasculature m... 1 | 27
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 25
anophthalmia 1 | 33
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
impaired glucose tolerance 1 | 75
increased anti-nuclear antigen... 1 | 19
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating fructosa... 1 | 13
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11

Disease

Carcinoma 224 | 11,493
psoriasis 185 | 6,694
ovarian cancer 157 | 8,520
osteosarcoma 149 | 7,950
lung cancer 134 | 4,740
glioblastoma 111 | 5,792
medulloblastoma, large-cell 108 | 6,241
lung carcinoma 99 | 2,843
non-small cell lung cancer 88 | 2,890
atypical teratoid / rhabdoid tumor 87 | 5,112
malignant mesothelioma 86 | 3,232
invasive ductal carcinoma 82 | 2,951
Cancer 81 | 2,499
adult high grade glioma 79 | 3,801
ependymoma 78 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 76 | 3,291
ulcerative colitis 76 | 1,819
intraductal papillary-mucinous adenoma (IPMA) 75 | 2,955
Breast cancer 73 | 3,578
interstitial cystitis 73 | 2,312
lung adenocarcinoma 72 | 2,716
tuberculosis 71 | 2,010
Astrocytoma, Pilocytic 70 | 3,081
pancreatic cancer 69 | 2,398
cystic fibrosis 65 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 65 | 2,989
group 3 medulloblastoma 64 | 4,104
pancreatic ductal adenocarcinoma liver metastasis 63 | 1,962
Kidney cancer 62 | 2,613
oligodendroglioma 50 | 2,850
diabetes mellitus 48 | 1,728
colon cancer 47 | 1,478
astrocytic glioma 46 | 2,597
Rheumatoid arthritis 45 | 1,191
subependymal giant cell astrocytoma 45 | 2,287
pituitary cancer 44 | 1,972
primitive neuroectodermal tumor 44 | 3,035
Autosomal recessive predisposition 43 | 1,442
breast carcinoma 43 | 1,638
ductal carcinoma in situ 43 | 1,745
active Crohn's disease 40 | 922
Atopic dermatitis 37 | 952
adrenocortical carcinoma 37 | 1,428
cutaneous lupus erythematosus 37 | 1,057
Kidney disease 35 | 430
Schizophrenia 35 | 1,160
Liver Cirrhosis, Experimental 34 | 769
esophageal adenocarcinoma 32 | 737
Atherosclerosis 30 | 291
Coronary artery disease 30 | 268
gastric carcinoma 30 | 807
Asthma 29 | 385
Hypertension 29 | 396
mucosa-associated lymphoid tissue lymphoma 29 | 484
Arthritis 28 | 290
Pick disease 28 | 1,894
group 4 medulloblastoma 28 | 1,855
juvenile dermatomyositis 28 | 1,187
primary pancreatic ductal adenocarcinoma 28 | 1,109
Multiple Sclerosis 27 | 540
active ulcerative colitis 27 | 764
non primary Sjogren syndrome sicca 27 | 891
primary Sjogren syndrome 27 | 735
Alzheimer's disease 26 | 658
Melanoma 26 | 711
Obesity 26 | 678
Duchenne muscular dystrophy 25 | 601
Vascular disease 25 | 319
Multiple myeloma 24 | 1,332
dermatomyositis 24 | 966
nasopharyngeal carcinoma 24 | 1,058
acute quadriplegic myopathy 23 | 1,158
Cerebrovascular disease 22 | 238
Skin cancer 22 | 469
Hypertensive disease 21 | 292
astrocytoma 21 | 1,146
fibroadenoma 21 | 559
periodontitis 21 | 293
Endometriosis 20 | 540
pediatric high grade glioma 20 | 1,064
autosomal dominant Emery-Dreifuss muscular dystrophy 19 | 510
pancreatic carcinoma 18 | 562
Heart disease 17 | 306
Prostatic Neoplasms 17 | 495
head and neck cancer and chronic obstructive pulmonary disease 17 | 239
Thrombocytopenia 16 | 197
Age related macular degeneration 15 | 72
Bipolar Disorder 15 | 666
Waldenstrons macroglobulinemia 15 | 765
aldosterone-producing adenoma 15 | 665
limb girdle muscular dystrophy 2A 15 | 213
sarcoidosis 15 | 370
urothelial carcinoma 15 | 318
Breast Neoplasms 14 | 445
Cardiovascular system disease 14 | 246
Chemical and Drug Induced Liver Injury 14 | 195
Crohn's disease 14 | 321
Hypersensitivity reaction type II disease 14 | 253
nephrosclerosis 14 | 333
spina bifida 14 | 1,074

Tissue

Digestive Tract 331 | 17,369
Endocrine System 331 | 18,159
Female tissues 328 | 17,400
Liver and Pancreas 326 | 16,750
Urinary Tract 326 | 16,678
Skin and soft tissues 324 | 17,230
Male tissues 317 | 17,142
Blood and immune system 316 | 16,909
Respiratory system 307 | 16,393
Nervous System 293 | 16,725
Cardiovascular System 274 | 15,192

Target Family

Non-IDG 223 | 12,091
Enzyme 85 | 4,145
Kinase 15 | 634
Transcription Factor 7 | 1,400
Transporter 7 | 473
GPCR 6 | 408
Ion Channel 5 | 344
Epigenetic 1 | 242
Nuclear Receptor 1 | 48
oGPCR 1 | 421

GWAS Trait

Blood protein levels 351 | 351
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pre-mRNA-splicing factor CWC22 homolog CWC22 Tbio Non-IDG -3.08456 1172.8 103
Transmembrane protein 8B TMEM8B Tbio Non-IDG -1.34736 25.6 106
Calcyphosin-like protein CAPSL Tdark Non-IDG -0.31087 1.84 28
HORMA domain-containing protein 1 HORMAD1 Tbio Non-IDG -1.44656 27.9 135
CD109 antigen CD109 Tbio Non-IDG -1.85817 77.8 239
POU domain, class 2, transcription factor 3 POU2F3 Tbio Transcription Factor -2.50813 322.4 96
Kallikrein-12 KLK12 Tbio Enzyme -0.99694 11.0 111
Mitogen-activated protein kinase kinase kinase 4 MAP3K4 Tbio Kinase -1.49704 31.8 244
Transmembrane glycoprotein NMB GPNMB Tbio Non-IDG -2.05817 130.8 293
Adipocyte plasma membrane-associated protein APMAP Tbio Non-IDG -0.99483 11.3 155