Development Level

Tbio 80 | 11,651
Tdark 25 | 6,593
Tchem 18 | 1,388
Tclin 11 | 612

Collection

RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Target... 2 | 125
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, incomple... 8 | 499
preweaning lethality, complete... 7 | 979
embryonic lethality prior to t... 5 | 278
abnormal behavior 4 | 298
embryonic lethality prior to o... 3 | 239
enlarged heart 3 | 210
decreased erythrocyte cell num... 2 | 62
enlarged spleen 2 | 41
increased circulating phosphat... 2 | 26
small testis 2 | 58
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal duodenum morphology 1 | 4
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal eye anterior chamber ... 1 | 9
abnormal eye morphology 1 | 68
abnormal locomotor behavior 1 | 24
abnormal pancreas morphology 1 | 13
abnormal retina morphology 1 | 71
abnormal spleen morphology 1 | 55
abnormal stomach morphology 1 | 10
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased cardiac muscle contr... 1 | 11
decreased caudal vertebrae num... 1 | 53
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating iron lev... 1 | 32
decreased eosinophil cell numb... 1 | 24
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
dilated heart left ventricle 1 | 11
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart left ventricle... 1 | 4
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased vertical activity 1 | 24
long tibia 1 | 25
microphthalmia 1 | 26
shortened QT interval 1 | 4
small heart 1 | 10
small liver 1 | 8
small superior vagus ganglion 1 | 74
thick ventricular wall 1 | 7
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 99 | 11,493
ovarian cancer 62 | 8,520
osteosarcoma 60 | 7,950
medulloblastoma, large-cell 57 | 6,241
psoriasis 53 | 6,694
glioblastoma 51 | 5,792
lung cancer 45 | 4,740
atypical teratoid / rhabdoid tumor 44 | 5,112
ependymoma 44 | 4,679
adult high grade glioma 40 | 3,801
group 3 medulloblastoma 37 | 4,104
Astrocytoma, Pilocytic 36 | 3,081
Kidney cancer 36 | 2,613
Schizophrenia 36 | 1,160
primitive neuroectodermal tumor 35 | 3,035
oligodendroglioma 31 | 2,850
Breast cancer 30 | 3,578
astrocytic glioma 30 | 2,597
malignant mesothelioma 27 | 3,232
Cancer 26 | 2,499
lung carcinoma 26 | 2,843
subependymal giant cell astrocytoma 24 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
Rheumatoid arthritis 21 | 1,191
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
lung adenocarcinoma 20 | 2,716
non-small cell lung cancer 20 | 2,890
Bipolar Disorder 19 | 666
group 4 medulloblastoma 19 | 1,855
interstitial cystitis 19 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
Intellectual disability 16 | 1,016
Pick disease 16 | 1,894
Epilepsy 15 | 792
pancreatic cancer 15 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
tuberculosis 15 | 2,010
Autistic Disorder 14 | 364
Seizures 14 | 596
astrocytoma 14 | 1,146
ulcerative colitis 14 | 1,819
adrenocortical carcinoma 13 | 1,428
cystic fibrosis 13 | 1,696
Melanoma 12 | 711
active Crohn's disease 12 | 922
colon cancer 12 | 1,478
diabetes mellitus 12 | 1,728
primary Sjogren syndrome 12 | 735
pediatric high grade glioma 11 | 1,064
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Multiple Sclerosis 10 | 540
Multiple myeloma 10 | 1,332
Muscle hypotonia 10 | 571
Poor school performance 10 | 645
Type 1 diabetes mellitus 10 | 109
Vitiligo 10 | 73
acute quadriplegic myopathy 10 | 1,158
invasive ductal carcinoma 10 | 2,951
juvenile dermatomyositis 10 | 1,187
pituitary cancer 10 | 1,972
Alzheimer's disease 9 | 658
Autosomal recessive predisposition 9 | 1,442
Liver cancer 9 | 604
Skin cancer 9 | 469
Small head 9 | 374
acute myeloid leukemia 9 | 783
aldosterone-producing adenoma 9 | 665
cutaneous lupus erythematosus 9 | 1,057
Chronic obstructive pulmonary disease 8 | 184
Cognitive delay 8 | 608
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
Waldenstrons macroglobulinemia 8 | 765
active ulcerative colitis 8 | 764
dermatomyositis 8 | 966
Alcoholic Intoxication, Chronic 7 | 289
Attention deficit hyperactivity disorder 7 | 278
Delayed speech and language development 7 | 112
Endometrial cancer 7 | 311
Language Delay 7 | 112
Lung Neoplasms 7 | 232
Osteoporosis 7 | 363
Speech Delay 7 | 112
Speech impairment 7 | 112
Systemic scleroderma 7 | 60
spina bifida 7 | 1,074
Autism spectrum disorder 6 | 101
Depressive disorder 6 | 409
Liver Cirrhosis, Experimental 6 | 769
Low set ears 6 | 181
Motor delay 6 | 147
No development of motor milestones 6 | 147
Stomach Neoplasms 6 | 300
ductal carcinoma in situ 6 | 1,745
nasopharyngeal carcinoma 6 | 1,058
non-small cell lung carcinoma 6 | 317
progressive supranuclear palsy 6 | 676

Tissue

Endocrine System 124 | 18,159
Digestive Tract 123 | 17,369
Female tissues 122 | 17,400
Skin and soft tissues 122 | 17,230
Male tissues 118 | 17,142
Liver and Pancreas 116 | 16,750
Nervous System 116 | 16,725
Urinary Tract 116 | 16,678
Blood and immune system 115 | 16,909
Respiratory system 115 | 16,393
Cardiovascular System 109 | 15,192

Target Family

Non-IDG 71 | 12,091
Enzyme 23 | 4,145
Transcription Factor 11 | 1,400
Ion Channel 9 | 344
Epigenetic 7 | 242
Kinase 7 | 634
Transporter 3 | 473
oGPCR 2 | 421
GPCR 1 | 408

GWAS Trait

Autism spectrum disorder or sc... 134 | 134
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MutS protein homolog 5 MSH5 Tbio Non-IDG -1.75314 0.00000 142
GRAM domain-containing protein 1B GRAMD1B Tdark Non-IDG -0.37654 2.90 39
FK506-binding protein-like FKBPL Tbio Non-IDG -1.42487 28.9 141
Butyrophilin subfamily 2 member A1 BTN2A1 Tbio Non-IDG -1.39139 24.1 150
cGMP-dependent protein kinase 1 PRKG1 Tchem Kinase -2.70325 459.4 238
Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C Tclin Ion Channel -2.75188 537.5 330
Protein phosphatase 1 regulatory inhibitor subunit 16B PPP1R16B Tbio Enzyme -1.00210 13.8 113
Plasma membrane calcium-transporting ATPase 2 ATP2B2 Tbio Transporter -2.07505 125.1 76
Thioredoxin-related transmembrane protein 2 TMX2 Tdark Non-IDG -0.92875 7.36 50
Putative sodium-coupled neutral amino acid transporter 7 SLC38A7 Tdark Transporter -0.52246 3.33 16