Development Level

Tbio 10,726 | 11,178
Tdark 4,863 | 6,569
Tchem 1,835 | 1,885
Tclin 600 | 612

Collection

Kinase: IDG Consortium (Target... 121 | 125
GPCR: IDG Consortium (Targets) 114 | 126
Ion Channel: IDG Consortium (T... 95 | 99
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 965 | 979
preweaning lethality, incomple... 492 | 499
abnormal behavior 288 | 298
embryonic lethality prior to t... 276 | 278
embryonic lethality prior to o... 238 | 239
abnormal embryo size 215 | 220
enlarged heart 205 | 210
decreased total body fat amoun... 201 | 207
decreased vertical activity 199 | 208
abnormal bone structure 182 | 187
increased lean body mass 165 | 172
abnormal heart morphology 161 | 162
decreased body weight 157 | 161
decreased bone mineral content 147 | 151
hyperactivity 144 | 148
decreased lean body mass 133 | 135
increased total body fat amoun... 129 | 134
hypoactivity 128 | 132
decreased circulating glucose ... 125 | 126
decreased bone mineral density 124 | 126
increased circulating alkaline... 120 | 122
male infertility 120 | 123
abnormal seminal vesicle morph... 113 | 114
decreased grip strength 110 | 116
increased startle reflex 106 | 112
embryonic growth retardation 105 | 106
increased bone mineral content 103 | 108
increased or absent threshold ... 100 | 101
decreased body length 99 | 101
short tibia 96 | 97
increased mean corpuscular hem... 94 | 96
increased mean corpuscular vol... 92 | 92
cataract 90 | 92
decreased circulating choleste... 90 | 93
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 82 | 83
decreased circulating serum al... 81 | 82
decreased prepulse inhibition 80 | 82
abnormal lens morphology 79 | 81
decreased circulating triglyce... 78 | 79
decreased mean corpuscular vol... 78 | 79
improved glucose tolerance 77 | 79
increased circulating HDL chol... 76 | 80
decreased startle reflex 75 | 75
increased fasted circulating g... 74 | 76
decreased leukocyte cell numbe... 73 | 73
decreased circulating insulin ... 72 | 76
small superior vagus ganglion 72 | 74
impaired glucose tolerance 71 | 75
increased bone mineral density 71 | 72
increased circulating sodium l... 71 | 71
abnormal sleep behavior 69 | 70
abnormal eye morphology 68 | 68
abnormal gait 68 | 69
abnormal retina morphology 68 | 71
decreased hemoglobin content 67 | 68
decreased circulating HDL chol... 66 | 68
abnormal behavioral response t... 65 | 66
increased circulating choleste... 65 | 66
abnormal kidney morphology 64 | 65
abnormal coat-hair pigmentatio... 63 | 64
decreased fasted circulating g... 63 | 65
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 61 | 62
increased heart weight 58 | 62
edema 57 | 59
female infertility 57 | 60
small testis 56 | 58
abnormal spleen morphology 54 | 55
thrombocytopenia 53 | 56
decreased caudal vertebrae num... 52 | 53
hydrometra 50 | 53
abnormal skin morphology 49 | 50
decreased blood urea nitrogen ... 49 | 51
decreased mean corpuscular hem... 49 | 50
decreased circulating total pr... 48 | 49
increased blood urea nitrogen ... 47 | 48
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alanine ... 46 | 47
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
decreased hematocrit 45 | 46
decreased circulating alkaline... 44 | 46
increased mean platelet volume 44 | 45
increased hemoglobin content 43 | 45
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
abnormal testis morphology 41 | 43
enlarged spleen 41 | 41
abnormal epididymis morphology 40 | 42
decreased red blood cell distr... 40 | 41
limb grasping 40 | 41
increased circulating chloride... 39 | 41
increased erythrocyte cell num... 39 | 39
decreased circulating LDL chol... 38 | 38
decreased circulating creatini... 38 | 39
increased circulating creatini... 38 | 38
increased grip strength 38 | 41
prolonged QT interval 37 | 38

Disease

Carcinoma 10,603 | 11,192
ovarian cancer 8,127 | 8,297
osteosarcoma 7,560 | 7,766
psoriasis 6,201 | 6,514
medulloblastoma, large-cell 5,947 | 6,086
glioblastoma 5,540 | 5,635
atypical teratoid / rhabdoid tumor 4,889 | 4,971
ependymoma 4,493 | 4,559
lung cancer 4,493 | 4,607
group 3 medulloblastoma 3,934 | 4,002
adult high grade glioma 3,625 | 3,701
Breast cancer 3,403 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,148 | 3,204
malignant mesothelioma 3,070 | 3,135
Astrocytoma, Pilocytic 2,963 | 3,006
primitive neuroectodermal tumor 2,915 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,853 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,828 | 2,872
invasive ductal carcinoma 2,827 | 2,867
non-small cell lung cancer 2,755 | 2,799
oligodendroglioma 2,726 | 2,768
lung carcinoma 2,699 | 2,755
lung adenocarcinoma 2,575 | 2,627
astrocytic glioma 2,489 | 2,530
Kidney cancer 2,474 | 2,548
pancreatic cancer 2,288 | 2,322
Cancer 2,223 | 2,388
interstitial cystitis 2,200 | 2,237
subependymal giant cell astrocytoma 2,195 | 2,230
tuberculosis 1,905 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 1,884 | 1,911
pituitary cancer 1,879 | 1,915
Pick disease 1,833 | 1,856
group 4 medulloblastoma 1,778 | 1,806
ulcerative colitis 1,738 | 1,765
ductal carcinoma in situ 1,666 | 1,686
cystic fibrosis 1,605 | 1,629
breast carcinoma 1,566 | 1,589
diabetes mellitus 1,483 | 1,683
colon cancer 1,404 | 1,428
Autosomal recessive predisposition 1,385 | 1,407
adrenocortical carcinoma 1,368 | 1,385
Multiple myeloma 1,285 | 1,296
juvenile dermatomyositis 1,128 | 1,147
acute quadriplegic myopathy 1,117 | 1,133
astrocytoma 1,095 | 1,113
Rheumatoid arthritis 1,091 | 1,156
Schizophrenia 1,088 | 1,136
primary pancreatic ductal adenocarcinoma 1,067 | 1,071
spina bifida 1,034 | 1,053
pediatric high grade glioma 1,018 | 1,035
nasopharyngeal carcinoma 1,013 | 1,024
cutaneous lupus erythematosus 1,003 | 1,016
Intellectual disability 976 | 998
dermatomyositis 895 | 941
Atopic dermatitis 893 | 915
active Crohn's disease 860 | 882
non primary Sjogren syndrome sicca 836 | 861
gastric carcinoma 768 | 781
Epilepsy 761 | 775
acute myeloid leukemia 752 | 760
Waldenstrons macroglobulinemia 736 | 742
Liver Cirrhosis, Experimental 724 | 733
active ulcerative colitis 721 | 736
primary Sjogren syndrome 698 | 710
esophageal adenocarcinoma 692 | 696
medulloblastoma 685 | 702
Melanoma 666 | 689
progressive supranuclear palsy 646 | 656
aldosterone-producing adenoma 640 | 646
Obesity 631 | 655
Dull intelligence 625 | 634
Low intelligence 625 | 634
Mental Retardation 625 | 634
Mental deficiency 625 | 634
Poor school performance 625 | 634
Bipolar Disorder 622 | 646
Alzheimer's disease 618 | 640
Cognitive delay 592 | 596
Global developmental delay 592 | 596
Mental and motor retardation 592 | 596
Seizures 577 | 584
Duchenne muscular dystrophy 574 | 587
Liver cancer 566 | 589
Muscle hypotonia 557 | 562
pancreatic carcinoma 548 | 555
fibroadenoma 532 | 538
hepatocellular carcinoma 526 | 536
Endometriosis 515 | 521
Short stature 503 | 514
chronic rhinosinusitis 498 | 505
Multiple Sclerosis 486 | 527
autosomal dominant Emery-Dreifuss muscular dystrophy 483 | 492
Down syndrome 465 | 480
mucosa-associated lymphoid tissue lymphoma 462 | 473
Prostatic Neoplasms 459 | 472
sonic hedgehog group medulloblastoma 451 | 459
posterior fossa group A ependymoma 450 | 456
Skin cancer 438 | 451
gastric cancer 435 | 445

Tissue

Endocrine System 17,553 | 18,159
Female tissues 17,035 | 17,400
Digestive Tract 17,003 | 17,369
Skin and soft tissues 16,886 | 17,230
Male tissues 16,771 | 17,142
Blood and immune system 16,594 | 16,909
Liver and Pancreas 16,478 | 16,750
Nervous System 16,448 | 16,725
Urinary Tract 16,416 | 16,678
Respiratory system 16,138 | 16,393
Cardiovascular System 15,008 | 15,192

Target Family

Non-IDG 10,493 | 12,091
Enzyme 3,944 | 4,145
Transcription Factor 1,352 | 1,400
Kinase 620 | 634
Transporter 455 | 473
GPCR 370 | 408
Ion Channel 331 | 344
Epigenetic 235 | 242
oGPCR 141 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 36 | 38

GTEx Tissue

Thyroid 18,024 | 18,024
Testis 18,518 | 18,518
Prostate 18,213 | 18,213
Cells - EBV-transformed lympho... 18,186 | 18,186
Brain - Hypothalamus 18,169 | 18,169
Pituitary 18,147 | 18,147
Pancreas 18,123 | 18,123
Adipose - Subcutaneous 18,110 | 18,110
Breast - Mammary Tissue 18,103 | 18,103
Colon - Sigmoid 18,089 | 18,089
Skin - Not Sun Exposed (Suprap... 18,081 | 18,081
Esophagus - Mucosa 18,076 | 18,076
Adrenal Gland 18,071 | 18,071
Liver 18,071 | 18,071
Brain - Frontal Cortex (BA9) 18,069 | 18,069
Lung 18,057 | 18,057
Brain - Cortex 18,039 | 18,039
Brain - Nucleus accumbens (bas... 18,024 | 18,024
Esophagus - Muscularis 18,017 | 18,017
Brain - Cerebellar Hemisphere 18,015 | 18,015
Brain - Hippocampus 18,011 | 18,011
Nerve - Tibial 18,007 | 18,007
Brain - Amygdala 18,006 | 18,006
Heart - Left Ventricle 18,006 | 18,006
Minor Salivary Gland 18,005 | 18,005
Brain - Caudate (basal ganglia... 18,001 | 18,001
Esophagus - Gastroesophageal J... 18,000 | 18,000
Brain - Anterior cingulate cor... 17,989 | 17,989
Brain - Cerebellum 17,983 | 17,983
Brain - Substantia nigra 17,981 | 17,981
Brain - Spinal cord (cervical ... 17,973 | 17,973
Ovary 17,971 | 17,971
Skin - Sun Exposed (Lower leg) 17,968 | 17,968
Small Intestine - Terminal Ile... 17,954 | 17,954
Artery - Coronary 17,949 | 17,949
Adipose - Visceral (Omentum) 17,937 | 17,937
Artery - Aorta 17,896 | 17,896
Heart - Atrial Appendage 17,896 | 17,896
Stomach 17,879 | 17,879
Brain - Putamen (basal ganglia... 17,863 | 17,863
Vagina 17,834 | 17,834
Colon - Transverse 17,825 | 17,825
Muscle - Skeletal 17,778 | 17,778
Artery - Tibial 17,631 | 17,631
Uterus 17,618 | 17,618
Spleen 17,614 | 17,614
Cells - Transformed fibroblast... 17,577 | 17,577
Whole Blood 17,439 | 17,439
Kidney - Cortex 17,329 | 17,329

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 12 MAGEA12 Tbio Non-IDG -1.35716 21.7 116
Melanoma-associated antigen B1 MAGEB1 Tbio Non-IDG -0.95979 9.05 218
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153