Development Level

Tbio 10,964 | 11,651
Tdark 4,712 | 6,593
Tchem 1,346 | 1,388
Tclin 592 | 612

Collection

RFA-RM-18-021 297 | 328
Kinase: IDG Consortium (Target... 119 | 125
GPCR: IDG Consortium (Targets) 101 | 126
Ion Channel: IDG Consortium (T... 92 | 99
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 961 | 979
preweaning lethality, incomple... 488 | 499
abnormal behavior 291 | 298
embryonic lethality prior to t... 276 | 278
embryonic lethality prior to o... 238 | 239
abnormal embryo size 215 | 220
decreased total body fat amoun... 200 | 207
enlarged heart 200 | 210
decreased vertical activity 193 | 208
abnormal bone structure 177 | 187
increased lean body mass 164 | 172
decreased body weight 157 | 161
abnormal heart morphology 156 | 162
decreased bone mineral content 144 | 151
hyperactivity 142 | 148
decreased lean body mass 130 | 135
hypoactivity 127 | 132
increased total body fat amoun... 126 | 134
decreased circulating glucose ... 123 | 126
decreased bone mineral density 121 | 126
male infertility 119 | 123
increased circulating alkaline... 116 | 122
decreased grip strength 110 | 116
abnormal seminal vesicle morph... 108 | 114
increased startle reflex 106 | 112
embryonic growth retardation 105 | 106
increased bone mineral content 101 | 108
increased or absent threshold ... 98 | 101
decreased body length 97 | 101
short tibia 95 | 97
increased mean corpuscular hem... 92 | 96
increased mean corpuscular vol... 92 | 92
cataract 90 | 92
decreased circulating choleste... 90 | 93
prenatal lethality prior to he... 84 | 87
decreased lymphocyte cell numb... 81 | 83
decreased prepulse inhibition 81 | 82
decreased circulating serum al... 80 | 82
abnormal lens morphology 79 | 81
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 76 | 79
increased circulating HDL chol... 76 | 80
improved glucose tolerance 75 | 79
decreased circulating insulin ... 73 | 76
decreased startle reflex 73 | 75
increased fasted circulating g... 73 | 76
decreased leukocyte cell numbe... 72 | 73
small superior vagus ganglion 72 | 74
increased bone mineral density 71 | 72
increased circulating sodium l... 70 | 71
abnormal sleep behavior 69 | 70
abnormal eye morphology 68 | 68
abnormal gait 68 | 69
impaired glucose tolerance 68 | 75
abnormal retina morphology 67 | 71
decreased circulating HDL chol... 67 | 68
decreased hemoglobin content 65 | 68
increased circulating choleste... 65 | 66
abnormal coat-hair pigmentatio... 64 | 64
abnormal behavioral response t... 63 | 66
abnormal kidney morphology 62 | 65
increased monocyte cell number 62 | 63
decreased fasted circulating g... 61 | 65
decreased erythrocyte cell num... 60 | 62
increased heart weight 58 | 62
edema 57 | 59
female infertility 57 | 60
small testis 55 | 58
abnormal spleen morphology 52 | 55
thrombocytopenia 52 | 56
decreased caudal vertebrae num... 51 | 53
hydrometra 50 | 53
abnormal skin morphology 49 | 50
decreased blood urea nitrogen ... 49 | 51
decreased circulating total pr... 48 | 49
decreased mean corpuscular hem... 48 | 50
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
increased blood urea nitrogen ... 46 | 48
increased hematocrit 46 | 46
decreased circulating alanine ... 45 | 47
increased neutrophil cell numb... 45 | 46
decreased circulating alkaline... 44 | 46
decreased hematocrit 44 | 46
increased mean platelet volume 43 | 45
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
increased hemoglobin content 42 | 45
enlarged spleen 41 | 41
abnormal testis morphology 40 | 43
increased circulating chloride... 39 | 41
increased erythrocyte cell num... 39 | 39
limb grasping 39 | 41
decreased red blood cell distr... 38 | 41
abnormal bone mineralization 37 | 38
abnormal epididymis morphology 37 | 42
decreased circulating LDL chol... 37 | 38
decreased circulating creatini... 37 | 39
increased grip strength 37 | 41
tremors 37 | 39

Disease

Carcinoma 10,657 | 11,493
ovarian cancer 8,289 | 8,520
osteosarcoma 7,699 | 7,950
psoriasis 6,258 | 6,694
medulloblastoma, large-cell 6,032 | 6,241
glioblastoma 5,645 | 5,792
atypical teratoid / rhabdoid tumor 4,977 | 5,112
lung cancer 4,573 | 4,740
ependymoma 4,562 | 4,679
group 3 medulloblastoma 3,996 | 4,104
adult high grade glioma 3,683 | 3,801
Breast cancer 3,475 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,219 | 3,291
malignant mesothelioma 3,147 | 3,232
Astrocytoma, Pilocytic 2,998 | 3,081
primitive neuroectodermal tumor 2,963 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,929 | 2,989
invasive ductal carcinoma 2,902 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,899 | 2,955
non-small cell lung cancer 2,830 | 2,890
oligodendroglioma 2,775 | 2,850
lung carcinoma 2,760 | 2,843
lung adenocarcinoma 2,647 | 2,716
astrocytic glioma 2,522 | 2,597
Kidney cancer 2,487 | 2,613
pancreatic cancer 2,346 | 2,398
Cancer 2,301 | 2,499
interstitial cystitis 2,255 | 2,312
subependymal giant cell astrocytoma 2,239 | 2,287
tuberculosis 1,948 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,925 | 1,962
pituitary cancer 1,916 | 1,972
Pick disease 1,859 | 1,894
group 4 medulloblastoma 1,812 | 1,855
ulcerative colitis 1,781 | 1,819
ductal carcinoma in situ 1,715 | 1,745
cystic fibrosis 1,658 | 1,696
breast carcinoma 1,609 | 1,638
diabetes mellitus 1,480 | 1,728
colon cancer 1,441 | 1,478
adrenocortical carcinoma 1,406 | 1,428
Autosomal recessive predisposition 1,402 | 1,442
Multiple myeloma 1,320 | 1,332
juvenile dermatomyositis 1,167 | 1,187
acute quadriplegic myopathy 1,142 | 1,158
astrocytoma 1,122 | 1,146
Rheumatoid arthritis 1,117 | 1,191
primary pancreatic ductal adenocarcinoma 1,101 | 1,109
Schizophrenia 1,085 | 1,160
spina bifida 1,047 | 1,074
pediatric high grade glioma 1,041 | 1,064
cutaneous lupus erythematosus 1,035 | 1,057
nasopharyngeal carcinoma 1,029 | 1,058
Intellectual disability 985 | 1,016
dermatomyositis 919 | 966
Atopic dermatitis 912 | 952
active Crohn's disease 889 | 922
non primary Sjogren syndrome sicca 852 | 891
gastric carcinoma 789 | 807
acute myeloid leukemia 774 | 783
Epilepsy 766 | 792
Waldenstrons macroglobulinemia 757 | 765
Liver Cirrhosis, Experimental 755 | 769
active ulcerative colitis 737 | 764
esophageal adenocarcinoma 731 | 737
primary Sjogren syndrome 721 | 735
medulloblastoma 697 | 720
progressive supranuclear palsy 665 | 676
Melanoma 660 | 711
aldosterone-producing adenoma 655 | 665
Obesity 641 | 678
Alzheimer's disease 631 | 658
Dull intelligence 631 | 645
Low intelligence 631 | 645
Mental Retardation 631 | 645
Mental deficiency 631 | 645
Poor school performance 631 | 645
Bipolar Disorder 625 | 666
Cognitive delay 601 | 608
Global developmental delay 601 | 608
Mental and motor retardation 601 | 608
Duchenne muscular dystrophy 588 | 601
Seizures 580 | 596
Liver cancer 564 | 604
Muscle hypotonia 564 | 571
pancreatic carcinoma 555 | 562
fibroadenoma 551 | 559
hepatocellular carcinoma 537 | 547
Endometriosis 525 | 540
Short stature 516 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 501 | 510
Multiple Sclerosis 494 | 540
chronic rhinosinusitis 494 | 512
Down syndrome 479 | 499
Prostatic Neoplasms 476 | 495
mucosa-associated lymphoid tissue lymphoma 472 | 484
posterior fossa group A ependymoma 459 | 468
sonic hedgehog group medulloblastoma 455 | 467
gastric cancer 449 | 459
Amyotrophic lateral sclerosis 442 | 451

Tissue

Endocrine System 17,189 | 18,159
Female tissues 16,765 | 17,400
Digestive Tract 16,763 | 17,369
Skin and soft tissues 16,663 | 17,230
Male tissues 16,540 | 17,142
Blood and immune system 16,440 | 16,909
Liver and Pancreas 16,274 | 16,750
Nervous System 16,242 | 16,725
Urinary Tract 16,237 | 16,678
Respiratory system 15,993 | 16,393
Cardiovascular System 14,937 | 15,192

Target Family

Non-IDG 10,265 | 12,091
Enzyme 3,888 | 4,145
Transcription Factor 1,297 | 1,400
Kinase 616 | 634
Transporter 447 | 473
GPCR 341 | 408
Ion Channel 324 | 344
Epigenetic 234 | 242
oGPCR 120 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 35 | 38

GTEx Tissue

Spleen 17,614 | 17,614
Testis 18,518 | 18,518
Prostate 18,213 | 18,213
Cells - EBV-transformed lympho... 18,186 | 18,186
Brain - Hypothalamus 18,169 | 18,169
Pituitary 18,147 | 18,147
Pancreas 18,123 | 18,123
Adipose - Subcutaneous 18,110 | 18,110
Breast - Mammary Tissue 18,103 | 18,103
Colon - Sigmoid 18,089 | 18,089
Skin - Not Sun Exposed (Suprap... 18,081 | 18,081
Esophagus - Mucosa 18,076 | 18,076
Adrenal Gland 18,071 | 18,071
Liver 18,071 | 18,071
Brain - Frontal Cortex (BA9) 18,069 | 18,069
Lung 18,057 | 18,057
Brain - Cortex 18,039 | 18,039
Brain - Nucleus accumbens (bas... 18,024 | 18,024
Thyroid 18,024 | 18,024
Esophagus - Muscularis 18,017 | 18,017
Brain - Cerebellar Hemisphere 18,015 | 18,015
Brain - Hippocampus 18,011 | 18,011
Nerve - Tibial 18,007 | 18,007
Brain - Amygdala 18,006 | 18,006
Heart - Left Ventricle 18,006 | 18,006
Minor Salivary Gland 18,005 | 18,005
Brain - Caudate (basal ganglia... 18,001 | 18,001
Esophagus - Gastroesophageal J... 18,000 | 18,000
Brain - Anterior cingulate cor... 17,989 | 17,989
Brain - Cerebellum 17,983 | 17,983
Brain - Substantia nigra 17,981 | 17,981
Brain - Spinal cord (cervical ... 17,973 | 17,973
Ovary 17,971 | 17,971
Skin - Sun Exposed (Lower leg) 17,968 | 17,968
Small Intestine - Terminal Ile... 17,954 | 17,954
Artery - Coronary 17,949 | 17,949
Adipose - Visceral (Omentum) 17,937 | 17,937
Artery - Aorta 17,896 | 17,896
Heart - Atrial Appendage 17,896 | 17,896
Stomach 17,879 | 17,879
Brain - Putamen (basal ganglia... 17,863 | 17,863
Vagina 17,834 | 17,834
Colon - Transverse 17,825 | 17,825
Muscle - Skeletal 17,778 | 17,778
Artery - Tibial 17,631 | 17,631
Uterus 17,618 | 17,618
Cells - Transformed fibroblast... 17,577 | 17,577
Whole Blood 17,439 | 17,439
Kidney - Cortex 17,329 | 17,329

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50