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Development Level

Tbio 10,942 | 11,445
Tdark 4,845 | 6,588
Tchem 1,567 | 1,598
Tclin 600 | 613

Collection

RFA-RM-18-021 312 | 328
Kinase: IDG Consortium (Target... 121 | 125
GPCR: IDG Consortium (Targets) 115 | 126
Ion Channel: IDG Consortium (T... 95 | 99
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 966 | 979
preweaning lethality, incomple... 491 | 499
abnormal behavior 293 | 298
embryonic lethality prior to t... 275 | 278
embryonic lethality prior to o... 238 | 239
abnormal embryo size 215 | 220
enlarged heart 205 | 210
decreased total body fat amoun... 202 | 207
decreased vertical activity 199 | 208
abnormal bone structure 182 | 187
increased lean body mass 166 | 172
abnormal heart morphology 160 | 162
decreased body weight 158 | 161
decreased bone mineral content 148 | 151
hyperactivity 144 | 148
decreased lean body mass 133 | 135
hypoactivity 129 | 132
increased total body fat amoun... 129 | 134
decreased bone mineral density 124 | 126
decreased circulating glucose ... 123 | 126
male infertility 120 | 123
increased circulating alkaline... 118 | 122
abnormal seminal vesicle morph... 112 | 114
decreased grip strength 112 | 116
increased startle reflex 106 | 112
embryonic growth retardation 105 | 106
increased bone mineral content 104 | 108
decreased body length 99 | 101
increased or absent threshold ... 99 | 101
short tibia 96 | 97
increased mean corpuscular hem... 93 | 96
increased mean corpuscular vol... 92 | 92
decreased circulating choleste... 91 | 93
cataract 90 | 92
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 82 | 83
decreased circulating serum al... 81 | 82
decreased prepulse inhibition 81 | 82
abnormal lens morphology 79 | 81
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 78 | 79
improved glucose tolerance 77 | 79
increased circulating HDL chol... 77 | 80
decreased startle reflex 75 | 75
increased fasted circulating g... 75 | 76
decreased circulating insulin ... 74 | 76
decreased leukocyte cell numbe... 73 | 73
impaired glucose tolerance 72 | 75
small superior vagus ganglion 72 | 74
increased bone mineral density 71 | 72
increased circulating sodium l... 71 | 71
abnormal retina morphology 69 | 71
abnormal sleep behavior 69 | 70
abnormal eye morphology 68 | 68
abnormal gait 67 | 69
decreased circulating HDL chol... 67 | 68
decreased hemoglobin content 66 | 68
abnormal kidney morphology 65 | 65
increased circulating choleste... 65 | 66
abnormal coat-hair pigmentatio... 64 | 64
abnormal behavioral response t... 63 | 66
decreased fasted circulating g... 63 | 65
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 61 | 62
increased heart weight 58 | 62
edema 57 | 59
female infertility 57 | 60
small testis 56 | 58
abnormal spleen morphology 53 | 55
thrombocytopenia 53 | 56
decreased caudal vertebrae num... 52 | 53
abnormal skin morphology 50 | 50
hydrometra 50 | 53
decreased blood urea nitrogen ... 49 | 51
decreased mean corpuscular hem... 49 | 50
decreased circulating total pr... 48 | 49
increased blood urea nitrogen ... 47 | 48
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alanine ... 46 | 47
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
decreased circulating alkaline... 44 | 46
decreased hematocrit 44 | 46
increased hemoglobin content 43 | 45
increased mean platelet volume 43 | 45
increased circulating triglyce... 42 | 42
abnormal testis morphology 41 | 43
decreased neutrophil cell numb... 41 | 42
enlarged spleen 41 | 41
abnormal epididymis morphology 40 | 42
decreased red blood cell distr... 40 | 41
limb grasping 40 | 41
increased circulating chloride... 39 | 41
increased erythrocyte cell num... 39 | 39
decreased circulating LDL chol... 38 | 38
increased circulating creatini... 38 | 38
increased grip strength 38 | 41
abnormal bone mineralization 37 | 38
prolonged QT interval 37 | 38

Disease

Carcinoma 10,871 | 11,493
ovarian cancer 8,340 | 8,520
osteosarcoma 7,739 | 7,950
psoriasis 6,365 | 6,694
medulloblastoma, large-cell 6,099 | 6,241
glioblastoma 5,695 | 5,792
atypical teratoid / rhabdoid tumor 5,026 | 5,112
ependymoma 4,611 | 4,679
lung cancer 4,610 | 4,740
group 3 medulloblastoma 4,028 | 4,104
adult high grade glioma 3,722 | 3,801
Breast cancer 3,504 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,231 | 3,291
malignant mesothelioma 3,166 | 3,232
Astrocytoma, Pilocytic 3,038 | 3,081
primitive neuroectodermal tumor 2,992 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,936 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,906 | 2,955
invasive ductal carcinoma 2,906 | 2,951
non-small cell lung cancer 2,843 | 2,890
oligodendroglioma 2,810 | 2,850
lung carcinoma 2,788 | 2,843
lung adenocarcinoma 2,658 | 2,716
astrocytic glioma 2,558 | 2,597
Kidney cancer 2,533 | 2,613
pancreatic cancer 2,354 | 2,398
Cancer 2,328 | 2,499
interstitial cystitis 2,273 | 2,312
subependymal giant cell astrocytoma 2,248 | 2,287
tuberculosis 1,951 | 2,010
pituitary cancer 1,934 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,931 | 1,962
Pick disease 1,874 | 1,894
group 4 medulloblastoma 1,828 | 1,855
ulcerative colitis 1,791 | 1,819
ductal carcinoma in situ 1,721 | 1,745
cystic fibrosis 1,668 | 1,696
breast carcinoma 1,612 | 1,638
diabetes mellitus 1,519 | 1,728
colon cancer 1,449 | 1,478
Autosomal recessive predisposition 1,411 | 1,442
adrenocortical carcinoma 1,411 | 1,428
Multiple myeloma 1,320 | 1,332
juvenile dermatomyositis 1,167 | 1,187
acute quadriplegic myopathy 1,142 | 1,158
astrocytoma 1,125 | 1,146
Rheumatoid arthritis 1,124 | 1,191
Schizophrenia 1,112 | 1,160
primary pancreatic ductal adenocarcinoma 1,102 | 1,109
spina bifida 1,054 | 1,074
pediatric high grade glioma 1,047 | 1,064
nasopharyngeal carcinoma 1,043 | 1,058
cutaneous lupus erythematosus 1,042 | 1,057
Intellectual disability 989 | 1,016
Atopic dermatitis 930 | 952
dermatomyositis 920 | 966
active Crohn's disease 901 | 922
non primary Sjogren syndrome sicca 865 | 891
gastric carcinoma 794 | 807
Epilepsy 776 | 792
acute myeloid leukemia 775 | 783
Liver Cirrhosis, Experimental 760 | 769
Waldenstrons macroglobulinemia 758 | 765
active ulcerative colitis 747 | 764
esophageal adenocarcinoma 732 | 737
primary Sjogren syndrome 722 | 735
medulloblastoma 704 | 720
Melanoma 684 | 711
progressive supranuclear palsy 665 | 676
aldosterone-producing adenoma 656 | 665
Obesity 655 | 678
Bipolar Disorder 640 | 666
Alzheimer's disease 639 | 658
Dull intelligence 633 | 645
Low intelligence 633 | 645
Mental Retardation 633 | 645
Mental deficiency 633 | 645
Poor school performance 633 | 645
Cognitive delay 604 | 608
Global developmental delay 604 | 608
Mental and motor retardation 604 | 608
Duchenne muscular dystrophy 588 | 601
Seizures 587 | 596
Liver cancer 578 | 604
Muscle hypotonia 564 | 571
pancreatic carcinoma 555 | 562
fibroadenoma 552 | 559
hepatocellular carcinoma 536 | 547
Endometriosis 531 | 540
Short stature 517 | 531
chronic rhinosinusitis 504 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 501 | 510
Multiple Sclerosis 494 | 540
Down syndrome 484 | 499
Prostatic Neoplasms 481 | 495
mucosa-associated lymphoid tissue lymphoma 473 | 484
posterior fossa group A ependymoma 462 | 468
sonic hedgehog group medulloblastoma 458 | 467
Skin cancer 452 | 469
gastric cancer 449 | 459

Tissue

Endocrine System 17,486 | 18,159
Female tissues 16,992 | 17,400
Digestive Tract 16,988 | 17,369
Skin and soft tissues 16,855 | 17,230
Male tissues 16,745 | 17,142
Blood and immune system 16,559 | 16,909
Liver and Pancreas 16,450 | 16,750
Nervous System 16,429 | 16,725
Urinary Tract 16,392 | 16,678
Respiratory system 16,116 | 16,393
Cardiovascular System 14,998 | 15,192

Target Family

Non-IDG 10,456 | 12,091
Enzyme 3,941 | 4,145
Transcription Factor 1,328 | 1,400
Kinase 620 | 634
Transporter 454 | 473
GPCR 374 | 408
Ion Channel 330 | 344
Epigenetic 235 | 242
oGPCR 132 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38

GTEx Tissue

Small Intestine - Terminal Ile... 17,954 | 17,954
Testis 18,518 | 18,518
Prostate 18,213 | 18,213
Cells - EBV-transformed lympho... 18,186 | 18,186
Brain - Hypothalamus 18,169 | 18,169
Pituitary 18,147 | 18,147
Pancreas 18,123 | 18,123
Adipose - Subcutaneous 18,110 | 18,110
Breast - Mammary Tissue 18,103 | 18,103
Colon - Sigmoid 18,089 | 18,089
Skin - Not Sun Exposed (Suprap... 18,081 | 18,081
Esophagus - Mucosa 18,076 | 18,076
Adrenal Gland 18,071 | 18,071
Liver 18,071 | 18,071
Brain - Frontal Cortex (BA9) 18,069 | 18,069
Lung 18,057 | 18,057
Brain - Cortex 18,039 | 18,039
Brain - Nucleus accumbens (bas... 18,024 | 18,024
Thyroid 18,024 | 18,024
Esophagus - Muscularis 18,017 | 18,017
Brain - Cerebellar Hemisphere 18,015 | 18,015
Brain - Hippocampus 18,011 | 18,011
Nerve - Tibial 18,007 | 18,007
Brain - Amygdala 18,006 | 18,006
Heart - Left Ventricle 18,006 | 18,006
Minor Salivary Gland 18,005 | 18,005
Brain - Caudate (basal ganglia... 18,001 | 18,001
Esophagus - Gastroesophageal J... 18,000 | 18,000
Brain - Anterior cingulate cor... 17,989 | 17,989
Brain - Cerebellum 17,983 | 17,983
Brain - Substantia nigra 17,981 | 17,981
Brain - Spinal cord (cervical ... 17,973 | 17,973
Ovary 17,971 | 17,971
Skin - Sun Exposed (Lower leg) 17,968 | 17,968
Artery - Coronary 17,949 | 17,949
Adipose - Visceral (Omentum) 17,937 | 17,937
Artery - Aorta 17,896 | 17,896
Heart - Atrial Appendage 17,896 | 17,896
Stomach 17,879 | 17,879
Brain - Putamen (basal ganglia... 17,863 | 17,863
Vagina 17,834 | 17,834
Colon - Transverse 17,825 | 17,825
Muscle - Skeletal 17,778 | 17,778
Artery - Tibial 17,631 | 17,631
Uterus 17,618 | 17,618
Spleen 17,614 | 17,614
Cells - Transformed fibroblast... 17,577 | 17,577
Whole Blood 17,439 | 17,439
Kidney - Cortex 17,329 | 17,329

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39