Development Level

Tbio 10,025 | 10,625
Tdark 5,053 | 7,003
Tchem 1,823 | 1,890
Tclin 580 | 602

Collection

Kinase: IDG Consortium (Targets) 120 | 125
GPCR: IDG Consortium (Targets) 105 | 127
Ion Channel: IDG Consortium (Targets) 99 | 102
Kinase: IDG Consortium (Complete/Control) 35 | 37
GPCR: IDG Consortium (Complete/Control) 24 | 26

IMPC Phenotype

preweaning lethality, complete... 621 | 633
preweaning lethality, incomple... 255 | 260
abnormal behavior 223 | 226
decreased lean body mass 191 | 195
embryonic lethality prior to t... 185 | 187
decreased total body fat amoun... 183 | 186
decreased body weight 169 | 174
decreased bone mineral content 155 | 157
embryonic lethality prior to o... 147 | 148
abnormal bone structure 127 | 131
increased or absent threshold ... 124 | 128
decreased bone mineral density 123 | 126
decreased circulating glucose ... 119 | 121
decreased grip strength 116 | 123
increased circulating alkaline... 114 | 119
abnormal embryo size 108 | 112
enlarged heart 108 | 111
decreased body length 107 | 108
hyperactivity 106 | 108
increased lean body mass 104 | 107
abnormal retina morphology 97 | 100
increased mean corpuscular vol... 91 | 91
increased bone mineral content 90 | 92
increased mean corpuscular hem... 90 | 93
hypoactivity 87 | 89
decreased circulating choleste... 83 | 85
decreased circulating triglyce... 82 | 83
increased grip strength 81 | 83
short tibia 80 | 82
decreased circulating serum al... 77 | 79
decreased circulating HDL chol... 75 | 77
abnormal lens morphology 71 | 73
decreased circulating insulin ... 71 | 75
increased circulating sodium l... 70 | 71
increased fasted circulating g... 66 | 68
prenatal lethality prior to he... 62 | 64
abnormal sleep behavior 61 | 63
male infertility 61 | 62
decreased lumbar vertebrae num... 60 | 62
increased circulating HDL chol... 60 | 63
increased sacral vertebrae num... 60 | 62
abnormal retinal pigmentation 59 | 61
decreased rib number 57 | 59
improved glucose tolerance 55 | 56
increased exploration in new e... 55 | 56
increased total body fat amoun... 55 | 57
abnormal coat-hair pigmentatio... 53 | 54
decreased leukocyte cell numbe... 53 | 54
decreased hemoglobin content 52 | 53
abnormal behavioral response t... 51 | 52
abnormal heart morphology 51 | 51
decreased prepulse inhibition 51 | 52
abnormal bone mineralization 50 | 55
decreased mean corpuscular vol... 50 | 50
increased bone mineral density 50 | 52
increased circulating choleste... 50 | 53
abnormal gait 49 | 51
decreased circulating alanine ... 49 | 53
impaired glucose tolerance 49 | 52
decreased caudal vertebrae num... 48 | 49
decreased fasted circulating g... 48 | 49
decreased startle reflex 47 | 48
increased hemoglobin content 44 | 45
thrombocytopenia 44 | 46
abnormal seminal vesicle morph... 43 | 47
decreased heart weight 43 | 44
increased blood urea nitrogen ... 43 | 44
decreased erythrocyte cell num... 42 | 43
increased body weight 42 | 42
increased circulating chloride... 42 | 43
decreased eosinophil cell numb... 41 | 41
decreased circulating total pr... 40 | 41
increased rib number 40 | 41
decreased circulating free fat... 39 | 39
increased startle reflex 37 | 38
abnormal eye morphology 36 | 38
decreased circulating LDL chol... 36 | 37
decreased circulating alkaline... 36 | 41
small testis 36 | 37
abnormal neural tube closure 35 | 37
decreased neutrophil cell numb... 35 | 37
increased hematocrit 35 | 36
increased leukocyte cell numbe... 35 | 37
abnormal spleen morphology 34 | 36
cardiovascular system phenotyp... 34 | 35
limb grasping 34 | 35
decreased mean corpuscular hem... 33 | 34
female infertility 33 | 34
increased heart weight 33 | 37
abnormal cranium morphology 32 | 32
decreased circulating calcium ... 32 | 33
tremors 32 | 34
decreased circulating chloride... 31 | 32
decreased circulating fructosa... 31 | 31
increased circulating calcium ... 31 | 32
increased circulating potassiu... 31 | 31
decreased B cell number 30 | 30
decreased T cell number 30 | 31
decreased blood urea nitrogen ... 30 | 31
decreased circulating creatini... 30 | 31

Disease

ovarian cancer 8,247 | 8,491
osteosarcoma 7,636 | 7,933
psoriasis 6,256 | 6,685
medulloblastoma, large-cell 6,041 | 6,234
glioblastoma 5,441 | 5,572
lung cancer 4,360 | 4,473
atypical teratoid / rhabdoid tumor 4,265 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,221 | 3,289
malignant mesothelioma 3,077 | 3,163
Breast cancer 3,023 | 3,098
pilocytic astrocytoma 3,018 | 3,086
primitive neuroectodermal tumor 2,969 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,921 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,895 | 2,956
invasive ductal carcinoma 2,888 | 2,950
oligodendroglioma 2,797 | 2,849
lung carcinoma 2,769 | 2,844
non-small cell lung cancer 2,743 | 2,798
pediatric high grade glioma 2,658 | 2,712
lung adenocarcinoma 2,637 | 2,714
ependymoma 2,466 | 2,514
pancreatic cancer 2,250 | 2,300
interstitial cystitis 2,246 | 2,299
subependymal giant cell astrocytoma 2,237 | 2,287
astrocytic glioma 2,199 | 2,241
group 3 medulloblastoma 2,186 | 2,254
Cancer 2,156 | 2,346
adult high grade glioma 2,069 | 2,148
Carcinoma 2,051 | 2,147
ulcerative colitis 2,035 | 2,087
pituitary cancer 1,926 | 1,972
Pick disease 1,859 | 1,893
group 4 medulloblastoma 1,828 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,754 | 1,795
ductal carcinoma in situ 1,713 | 1,745
cystic fibrosis 1,631 | 1,670
breast carcinoma 1,582 | 1,614
tuberculosis 1,514 | 1,563
medulloblastoma 1,493 | 1,524
posterior fossa group B ependymoma 1,493 | 1,530
posterior fossa group A ependymoma 1,476 | 1,511
astrocytoma 1,456 | 1,493
sonic hedgehog group medulloblastoma 1,453 | 1,482
colon cancer 1,433 | 1,475
diabetes mellitus 1,418 | 1,663
adrenocortical carcinoma 1,408 | 1,427
Multiple myeloma 1,306 | 1,327
primary pancreatic ductal adenocarcinoma 1,259 | 1,271
juvenile dermatomyositis 1,161 | 1,189
acute quadriplegic myopathy 1,137 | 1,157
Rheumatoid Arthritis 1,081 | 1,170
atypical teratoid/rhabdoid tumor 1,068 | 1,095
spina bifida 1,041 | 1,064
nasopharyngeal carcinoma 1,037 | 1,056
cutaneous lupus erythematosus 1,029 | 1,056
dermatomyositis 913 | 966
Atopic dermatitis 892 | 944
active Crohn's disease 886 | 918
gastric carcinoma 819 | 832
non primary Sjogren syndrome sicca 804 | 840
acute myeloid leukemia 771 | 785
primary Sjogren syndrome 768 | 788
Waldenstrons macroglobulinemia 752 | 764
esophageal adenocarcinoma 727 | 737
tuberculosis and treatment for 6 months 668 | 686
progressive supranuclear palsy 660 | 674
aldosterone-producing adenoma 655 | 664
Alzheimer's disease 618 | 644
Obesity 591 | 616
Duchenne muscular dystrophy 584 | 602
Intellectual disability 559 | 573
pancreatic carcinoma 554 | 567
fibroadenoma 547 | 557
Down syndrome 533 | 548
hepatocellular carcinoma 532 | 550
Endometriosis 525 | 535
chronic rhinosinusitis 504 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 488 | 499
Schizophrenia 473 | 503
mucosa-associated lymphoid tissue lymphoma 466 | 480
active ulcerative colitis 461 | 477
Prostatic Neoplasms 457 | 471
Multiple Sclerosis 446 | 498
IGA Glomerulonephritis 443 | 454
Amyotrophic Lateral Sclerosis 427 | 432
gastric cancer 420 | 436
Mammary Neoplasms 398 | 410
non-small cell lung carcinoma 393 | 413
inflammatory breast cancer 386 | 404
Neurodegenerative disease 374 | 383
Kidney disease 357 | 397
Parkinson's disease 357 | 364
sarcoidosis 345 | 368
glioblastoma multiforme 343 | 347
Epilepsy 336 | 346
Asthma 327 | 349
tuberculosis and treatment for 3 months 323 | 327
nephrosclerosis 319 | 329
Polycystic Ovary Syndrome 318 | 334
hereditary spastic paraplegia 312 | 313

Tissue

Endocrine System 17,481 | 18,511
Nervous System 17,463 | 18,560
Female tissues 17,452 | 18,646
Digestive Tract 17,428 | 18,472
Urinary Tract 17,402 | 18,443
Skin and soft tissues 17,388 | 18,114
Liver and Pancreas 17,259 | 18,135
Cardiovascular System 17,231 | 17,957
Male tissues 17,174 | 17,968
Blood and immune system 17,150 | 17,994
Respiratory system 16,984 | 17,483

Target Family

Non-IDG 10,133 | 11,969
Enzyme 3,879 | 4,146
Transcription Factor 1,320 | 1,400
Kinase 614 | 634
Transporter 451 | 473
GPCR 355 | 408
Ion Channel 331 | 341
Epigenetic 234 | 242
oGPCR 80 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38

GTEx Tissue

Pituitary 17,481 | 17,481
Testis 18,072 | 18,072
Cervix - Ectocervix 17,912 | 17,912
Bladder 17,869 | 17,869
Minor Salivary Gland 17,628 | 17,628
Fallopian Tube 17,587 | 17,587
Kidney - Cortex 17,582 | 17,582
Brain - Substantia nigra 17,564 | 17,564
Brain - Putamen (basal ganglia... 17,523 | 17,523
Cervix - Endocervix 17,504 | 17,504
Brain - Cortex 17,477 | 17,477
Brain - Cerebellum 17,467 | 17,467
Brain - Amygdala 17,450 | 17,450
Brain - Hypothalamus 17,432 | 17,432
Small Intestine - Terminal Ile... 17,426 | 17,426
Cells - EBV-transformed lympho... 17,414 | 17,414
Brain - Frontal Cortex (BA9) 17,402 | 17,402
Brain - Anterior cingulate cor... 17,374 | 17,374
Brain - Nucleus accumbens (bas... 17,316 | 17,316
Brain - Caudate (basal ganglia... 17,303 | 17,303
Brain - Spinal cord (cervical ... 17,275 | 17,275
Colon - Sigmoid 17,275 | 17,275
Brain - Hippocampus 17,259 | 17,259
Colon - Transverse 17,245 | 17,245
Esophagus - Mucosa 17,240 | 17,240
Brain - Cerebellar Hemisphere 17,238 | 17,238
Breast - Mammary Tissue 17,183 | 17,183
Prostate 17,182 | 17,182
Skin - Sun Exposed (Lower leg) 17,176 | 17,176
Pancreas 17,144 | 17,144
Stomach 17,141 | 17,141
Skin - Not Sun Exposed (Suprap... 17,121 | 17,121
Nerve - Tibial 17,120 | 17,120
Liver 17,114 | 17,114
Heart - Atrial Appendage 17,102 | 17,102
Spleen 17,059 | 17,059
Adipose - Subcutaneous 17,040 | 17,040
Lung 17,031 | 17,031
Vagina 16,991 | 16,991
Thyroid 16,984 | 16,984
Artery - Coronary 16,968 | 16,968
Adipose - Visceral (Omentum) 16,958 | 16,958
Adrenal Gland 16,955 | 16,955
Esophagus - Gastroesophageal J... 16,943 | 16,943
Ovary 16,865 | 16,865
Esophagus - Muscularis 16,862 | 16,862
Uterus 16,748 | 16,748
Heart - Left Ventricle 16,745 | 16,745
Artery - Aorta 16,699 | 16,699
Cells - Transformed fibroblast... 16,616 | 16,616
Artery - Tibial 16,609 | 16,609
Muscle - Skeletal 16,593 | 16,593
Whole Blood 16,359 | 16,359

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
5-hydroxytryptamine receptor 1E HTR1E Tchem GPCR -1.54352 34.9 99