Development Level

Tbio 10,867 | 11,651
Tdark 4,560 | 6,593
Tchem 1,326 | 1,388
Tclin 576 | 612

Collection

RFA-RM-18-021 287 | 328
Kinase: IDG Consortium (Target... 120 | 125
GPCR: IDG Consortium (Targets) 93 | 126
Ion Channel: IDG Consortium (T... 89 | 99
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 961 | 979
preweaning lethality, incomple... 484 | 499
abnormal behavior 287 | 298
embryonic lethality prior to t... 274 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 215 | 220
enlarged heart 200 | 210
decreased total body fat amoun... 198 | 207
decreased vertical activity 193 | 208
abnormal bone structure 177 | 187
increased lean body mass 161 | 172
abnormal heart morphology 157 | 162
decreased body weight 154 | 161
decreased bone mineral content 143 | 151
hyperactivity 143 | 148
decreased lean body mass 131 | 135
increased total body fat amoun... 127 | 134
hypoactivity 124 | 132
decreased bone mineral density 122 | 126
decreased circulating glucose ... 120 | 126
male infertility 118 | 123
increased circulating alkaline... 114 | 122
decreased grip strength 109 | 116
abnormal seminal vesicle morph... 108 | 114
embryonic growth retardation 105 | 106
increased startle reflex 104 | 112
increased bone mineral content 100 | 108
increased or absent threshold ... 98 | 101
decreased body length 97 | 101
short tibia 95 | 97
increased mean corpuscular vol... 92 | 92
increased mean corpuscular hem... 90 | 96
decreased circulating choleste... 89 | 93
cataract 87 | 92
prenatal lethality prior to he... 83 | 87
decreased lymphocyte cell numb... 82 | 83
decreased prepulse inhibition 80 | 82
decreased circulating serum al... 79 | 82
decreased circulating triglyce... 79 | 79
abnormal lens morphology 77 | 81
decreased mean corpuscular vol... 75 | 79
increased circulating HDL chol... 75 | 80
improved glucose tolerance 73 | 79
increased fasted circulating g... 73 | 76
decreased leukocyte cell numbe... 72 | 73
decreased startle reflex 72 | 75
decreased circulating insulin ... 71 | 76
increased bone mineral density 71 | 72
impaired glucose tolerance 70 | 75
small superior vagus ganglion 70 | 74
abnormal retina morphology 69 | 71
abnormal sleep behavior 69 | 70
abnormal eye morphology 68 | 68
increased circulating sodium l... 68 | 71
abnormal gait 66 | 69
decreased circulating HDL chol... 66 | 68
abnormal behavioral response t... 64 | 66
decreased hemoglobin content 64 | 68
increased circulating choleste... 64 | 66
abnormal kidney morphology 63 | 65
increased monocyte cell number 63 | 63
abnormal coat-hair pigmentatio... 62 | 64
decreased erythrocyte cell num... 61 | 62
decreased fasted circulating g... 60 | 65
increased heart weight 58 | 62
edema 57 | 59
female infertility 55 | 60
small testis 53 | 58
abnormal spleen morphology 52 | 55
decreased caudal vertebrae num... 52 | 53
thrombocytopenia 52 | 56
hydrometra 50 | 53
abnormal skin morphology 49 | 50
decreased circulating total pr... 48 | 49
decreased mean corpuscular hem... 48 | 50
decreased blood urea nitrogen ... 47 | 51
abnormal neural tube closure 46 | 46
increased blood urea nitrogen ... 46 | 48
increased neutrophil cell numb... 46 | 46
increased hematocrit 45 | 46
decreased circulating alanine ... 44 | 47
decreased circulating alkaline... 44 | 46
decreased hematocrit 44 | 46
increased leukocyte cell numbe... 43 | 47
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
increased mean platelet volume 42 | 45
enlarged spleen 41 | 41
increased hemoglobin content 41 | 45
abnormal testis morphology 40 | 43
abnormal epididymis morphology 39 | 42
increased grip strength 39 | 41
decreased red blood cell distr... 38 | 41
increased circulating creatini... 38 | 38
abnormal bone mineralization 37 | 38
decreased circulating LDL chol... 37 | 38
increased erythrocyte cell num... 37 | 39
limb grasping 37 | 41
prolonged QT interval 37 | 38
tremors 37 | 39

Disease

Carcinoma 10,548 | 11,493
ovarian cancer 8,278 | 8,519
osteosarcoma 7,657 | 7,950
psoriasis 6,171 | 6,694
medulloblastoma, large-cell 6,007 | 6,241
glioblastoma 5,630 | 5,792
atypical teratoid / rhabdoid tumor 4,959 | 5,112
lung cancer 4,564 | 4,740
ependymoma 4,546 | 4,679
group 3 medulloblastoma 3,992 | 4,104
adult high grade glioma 3,672 | 3,801
Breast cancer 3,474 | 3,577
intraductal papillary-mucinous neoplasm (IPMN) 3,223 | 3,290
malignant mesothelioma 3,145 | 3,232
Astrocytoma, Pilocytic 2,990 | 3,081
primitive neuroectodermal tumor 2,955 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,923 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,894 | 2,954
invasive ductal carcinoma 2,894 | 2,950
non-small cell lung cancer 2,823 | 2,890
oligodendroglioma 2,768 | 2,850
lung carcinoma 2,760 | 2,843
lung adenocarcinoma 2,632 | 2,716
astrocytic glioma 2,517 | 2,597
Kidney cancer 2,487 | 2,613
pancreatic cancer 2,342 | 2,398
Cancer 2,282 | 2,499
interstitial cystitis 2,252 | 2,312
subependymal giant cell astrocytoma 2,236 | 2,287
tuberculosis 1,939 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,924 | 1,962
pituitary cancer 1,916 | 1,972
Pick disease 1,863 | 1,894
group 4 medulloblastoma 1,807 | 1,855
ulcerative colitis 1,772 | 1,819
ductal carcinoma in situ 1,710 | 1,744
cystic fibrosis 1,649 | 1,695
breast carcinoma 1,608 | 1,637
diabetes mellitus 1,443 | 1,728
colon cancer 1,436 | 1,478
adrenocortical carcinoma 1,407 | 1,428
Autosomal recessive predisposition 1,388 | 1,442
Multiple myeloma 1,319 | 1,332
juvenile dermatomyositis 1,166 | 1,187
acute quadriplegic myopathy 1,138 | 1,158
astrocytoma 1,121 | 1,146
Rheumatoid arthritis 1,111 | 1,191
primary pancreatic ductal adenocarcinoma 1,102 | 1,108
Schizophrenia 1,083 | 1,160
spina bifida 1,047 | 1,074
pediatric high grade glioma 1,038 | 1,064
nasopharyngeal carcinoma 1,036 | 1,058
cutaneous lupus erythematosus 1,035 | 1,057
Intellectual disability 978 | 1,016
dermatomyositis 920 | 966
Atopic dermatitis 897 | 952
active Crohn's disease 886 | 922
non primary Sjogren syndrome sicca 846 | 891
gastric carcinoma 791 | 807
acute myeloid leukemia 770 | 783
Epilepsy 759 | 792
Liver Cirrhosis, Experimental 757 | 769
Waldenstrons macroglobulinemia 757 | 765
active ulcerative colitis 732 | 764
esophageal adenocarcinoma 728 | 737
primary Sjogren syndrome 719 | 735
medulloblastoma 692 | 720
progressive supranuclear palsy 661 | 676
Melanoma 657 | 711
aldosterone-producing adenoma 655 | 665
Alzheimer's disease 629 | 658
Obesity 629 | 678
Dull intelligence 627 | 645
Low intelligence 627 | 645
Mental Retardation 627 | 645
Mental deficiency 627 | 645
Poor school performance 627 | 645
Bipolar Disorder 621 | 666
Cognitive delay 596 | 608
Global developmental delay 596 | 608
Mental and motor retardation 596 | 608
Duchenne muscular dystrophy 586 | 601
Seizures 573 | 596
Liver cancer 562 | 604
Muscle hypotonia 557 | 571
pancreatic carcinoma 552 | 562
fibroadenoma 551 | 559
hepatocellular carcinoma 533 | 547
Endometriosis 528 | 540
Short stature 510 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 510
chronic rhinosinusitis 499 | 512
Down syndrome 479 | 499
Multiple Sclerosis 478 | 540
Prostatic Neoplasms 477 | 495
mucosa-associated lymphoid tissue lymphoma 469 | 484
posterior fossa group A ependymoma 463 | 468
sonic hedgehog group medulloblastoma 455 | 467
gastric cancer 446 | 459
Amyotrophic lateral sclerosis 441 | 451

Tissue

Endocrine System 17,008 | 18,159
Female tissues 16,654 | 17,400
Digestive Tract 16,641 | 17,369
Skin and soft tissues 16,549 | 17,230
Male tissues 16,456 | 17,142
Blood and immune system 16,285 | 16,909
Urinary Tract 16,245 | 16,678
Liver and Pancreas 16,232 | 16,750
Nervous System 16,163 | 16,725
Respiratory system 15,944 | 16,393
Cardiovascular System 14,896 | 15,192

Target Family

Non-IDG 10,104 | 12,091
Enzyme 3,874 | 4,145
Transcription Factor 1,276 | 1,400
Kinase 616 | 634
Transporter 446 | 473
GPCR 323 | 408
Ion Channel 304 | 344
Epigenetic 233 | 242
oGPCR 69 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38

GTEx Tissue

Kidney - Cortex 17,329 | 17,329
Testis 18,518 | 18,518
Prostate 18,213 | 18,213
Cells - EBV-transformed lympho... 18,186 | 18,186
Brain - Hypothalamus 18,169 | 18,169
Pituitary 18,147 | 18,147
Pancreas 18,123 | 18,123
Adipose - Subcutaneous 18,110 | 18,110
Breast - Mammary Tissue 18,103 | 18,103
Colon - Sigmoid 18,089 | 18,089
Skin - Not Sun Exposed (Suprap... 18,081 | 18,081
Esophagus - Mucosa 18,076 | 18,076
Adrenal Gland 18,071 | 18,071
Liver 18,071 | 18,071
Brain - Frontal Cortex (BA9) 18,069 | 18,069
Lung 18,057 | 18,057
Brain - Cortex 18,039 | 18,039
Brain - Nucleus accumbens (bas... 18,024 | 18,024
Thyroid 18,024 | 18,024
Esophagus - Muscularis 18,017 | 18,017
Brain - Cerebellar Hemisphere 18,015 | 18,015
Brain - Hippocampus 18,011 | 18,011
Nerve - Tibial 18,007 | 18,007
Brain - Amygdala 18,006 | 18,006
Heart - Left Ventricle 18,006 | 18,006
Minor Salivary Gland 18,005 | 18,005
Brain - Caudate (basal ganglia... 18,001 | 18,001
Esophagus - Gastroesophageal J... 18,000 | 18,000
Brain - Anterior cingulate cor... 17,989 | 17,989
Brain - Cerebellum 17,983 | 17,983
Brain - Substantia nigra 17,981 | 17,981
Brain - Spinal cord (cervical ... 17,973 | 17,973
Ovary 17,971 | 17,971
Skin - Sun Exposed (Lower leg) 17,968 | 17,968
Small Intestine - Terminal Ile... 17,954 | 17,954
Artery - Coronary 17,949 | 17,949
Adipose - Visceral (Omentum) 17,937 | 17,937
Artery - Aorta 17,896 | 17,896
Heart - Atrial Appendage 17,896 | 17,896
Stomach 17,879 | 17,879
Brain - Putamen (basal ganglia... 17,863 | 17,863
Vagina 17,834 | 17,834
Colon - Transverse 17,825 | 17,825
Muscle - Skeletal 17,778 | 17,778
Artery - Tibial 17,631 | 17,631
Uterus 17,618 | 17,618
Spleen 17,614 | 17,614
Cells - Transformed fibroblast... 17,577 | 17,577
Whole Blood 17,439 | 17,439

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83