Development Level

Tbio 9,751 | 10,625
Tdark 4,683 | 7,003
Tchem 1,753 | 1,890
Tclin 558 | 602

Collection

Kinase: IDG Consortium (Targets) 120 | 125
Ion Channel: IDG Consortium (Targets) 92 | 102
GPCR: IDG Consortium (Targets) 89 | 127
Kinase: IDG Consortium (Complete/Control) 34 | 37
GPCR: IDG Consortium (Complete/Control) 22 | 26

IMPC Phenotype

preweaning lethality, complete... 621 | 633
preweaning lethality, incomple... 252 | 260
abnormal behavior 219 | 226
decreased lean body mass 189 | 195
embryonic lethality prior to t... 184 | 187
decreased total body fat amoun... 182 | 186
decreased body weight 165 | 174
decreased bone mineral content 153 | 157
embryonic lethality prior to o... 147 | 148
abnormal bone structure 125 | 131
increased or absent threshold ... 122 | 128
decreased bone mineral density 119 | 126
decreased circulating glucose ... 117 | 121
decreased grip strength 113 | 123
increased circulating alkaline... 112 | 119
abnormal embryo size 109 | 112
decreased body length 106 | 108
enlarged heart 105 | 111
hyperactivity 104 | 108
increased lean body mass 103 | 107
abnormal retina morphology 97 | 100
increased mean corpuscular vol... 91 | 91
increased bone mineral content 90 | 92
increased mean corpuscular hem... 88 | 93
hypoactivity 84 | 89
decreased circulating choleste... 82 | 85
decreased circulating triglyce... 81 | 83
increased grip strength 80 | 83
short tibia 79 | 82
decreased circulating serum al... 76 | 79
decreased circulating HDL chol... 74 | 77
abnormal lens morphology 70 | 73
decreased circulating insulin ... 69 | 75
increased circulating sodium l... 68 | 71
increased fasted circulating g... 65 | 68
abnormal sleep behavior 60 | 63
prenatal lethality prior to he... 60 | 64
abnormal retinal pigmentation 59 | 61
decreased lumbar vertebrae num... 59 | 62
increased sacral vertebrae num... 59 | 62
male infertility 59 | 62
increased circulating HDL chol... 57 | 63
decreased rib number 55 | 59
improved glucose tolerance 55 | 56
abnormal coat-hair pigmentatio... 53 | 54
decreased leukocyte cell numbe... 53 | 54
increased exploration in new e... 53 | 56
increased total body fat amoun... 53 | 57
abnormal bone mineralization 50 | 55
abnormal gait 50 | 51
decreased circulating alanine ... 50 | 53
decreased hemoglobin content 50 | 53
decreased prepulse inhibition 50 | 52
impaired glucose tolerance 50 | 52
increased bone mineral density 50 | 52
abnormal heart morphology 49 | 51
decreased mean corpuscular vol... 49 | 50
abnormal behavioral response t... 48 | 52
decreased caudal vertebrae num... 48 | 49
decreased fasted circulating g... 48 | 49
increased circulating choleste... 48 | 53
decreased startle reflex 45 | 48
thrombocytopenia 44 | 46
increased hemoglobin content 43 | 45
decreased erythrocyte cell num... 42 | 43
increased body weight 42 | 42
abnormal seminal vesicle morph... 41 | 47
decreased heart weight 41 | 44
increased blood urea nitrogen ... 41 | 44
increased circulating chloride... 41 | 43
decreased circulating total pr... 40 | 41
decreased eosinophil cell numb... 40 | 41
increased rib number 40 | 41
decreased circulating free fat... 39 | 39
decreased circulating LDL chol... 37 | 37
increased startle reflex 37 | 38
abnormal eye morphology 36 | 38
decreased circulating alkaline... 36 | 41
small testis 36 | 37
abnormal neural tube closure 35 | 37
decreased neutrophil cell numb... 35 | 37
increased hematocrit 35 | 36
cardiovascular system phenotyp... 34 | 35
increased leukocyte cell numbe... 34 | 37
limb grasping 34 | 35
abnormal spleen morphology 33 | 36
decreased mean corpuscular hem... 33 | 34
abnormal cranium morphology 32 | 32
decreased circulating calcium ... 32 | 33
female infertility 32 | 34
tremors 32 | 34
decreased circulating fructosa... 31 | 31
increased circulating calcium ... 31 | 32
increased circulating potassiu... 31 | 31
increased heart weight 31 | 37
decreased T cell number 30 | 31
decreased blood urea nitrogen ... 30 | 31
decreased circulating chloride... 30 | 32
decreased circulating creatini... 30 | 31
decreased B cell number 29 | 30

Disease

ovarian cancer 8,164 | 8,491
osteosarcoma 7,562 | 7,933
psoriasis 6,036 | 6,685
medulloblastoma, large-cell 5,950 | 6,234
glioblastoma 5,396 | 5,572
lung cancer 4,335 | 4,473
atypical teratoid / rhabdoid tumor 4,218 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,204 | 3,289
malignant mesothelioma 3,059 | 3,163
Breast cancer 3,001 | 3,098
pilocytic astrocytoma 2,985 | 3,086
primitive neuroectodermal tumor 2,945 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,899 | 2,988
invasive ductal carcinoma 2,886 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,872 | 2,956
oligodendroglioma 2,760 | 2,849
non-small cell lung cancer 2,730 | 2,798
lung carcinoma 2,729 | 2,844
pediatric high grade glioma 2,640 | 2,712
lung adenocarcinoma 2,618 | 2,714
ependymoma 2,442 | 2,514
pancreatic cancer 2,233 | 2,300
interstitial cystitis 2,228 | 2,299
subependymal giant cell astrocytoma 2,223 | 2,287
astrocytic glioma 2,172 | 2,241
group 3 medulloblastoma 2,171 | 2,254
Cancer 2,105 | 2,346
adult high grade glioma 2,032 | 2,148
ulcerative colitis 2,015 | 2,087
Carcinoma 1,997 | 2,147
pituitary cancer 1,899 | 1,972
Pick disease 1,853 | 1,893
group 4 medulloblastoma 1,813 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,737 | 1,795
ductal carcinoma in situ 1,708 | 1,745
cystic fibrosis 1,616 | 1,670
breast carcinoma 1,578 | 1,614
tuberculosis 1,513 | 1,563
medulloblastoma 1,475 | 1,524
posterior fossa group B ependymoma 1,466 | 1,530
posterior fossa group A ependymoma 1,463 | 1,511
astrocytoma 1,449 | 1,493
sonic hedgehog group medulloblastoma 1,436 | 1,482
colon cancer 1,421 | 1,475
adrenocortical carcinoma 1,401 | 1,427
diabetes mellitus 1,352 | 1,663
Multiple myeloma 1,304 | 1,327
primary pancreatic ductal adenocarcinoma 1,254 | 1,271
juvenile dermatomyositis 1,156 | 1,189
acute quadriplegic myopathy 1,138 | 1,157
Rheumatoid Arthritis 1,068 | 1,170
atypical teratoid/rhabdoid tumor 1,060 | 1,095
spina bifida 1,034 | 1,064
cutaneous lupus erythematosus 1,019 | 1,056
nasopharyngeal carcinoma 1,019 | 1,056
dermatomyositis 914 | 966
Atopic dermatitis 890 | 944
active Crohn's disease 878 | 918
gastric carcinoma 816 | 832
non primary Sjogren syndrome sicca 792 | 840
acute myeloid leukemia 768 | 785
primary Sjogren syndrome 766 | 788
Waldenstrons macroglobulinemia 752 | 764
esophageal adenocarcinoma 720 | 737
tuberculosis and treatment for 6 months 669 | 686
progressive supranuclear palsy 660 | 674
aldosterone-producing adenoma 648 | 664
Alzheimer's disease 608 | 644
Duchenne muscular dystrophy 583 | 602
Obesity 572 | 616
pancreatic carcinoma 555 | 567
Intellectual disability 553 | 573
fibroadenoma 544 | 557
hepatocellular carcinoma 533 | 550
Down syndrome 529 | 548
Endometriosis 511 | 535
chronic rhinosinusitis 489 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 486 | 499
mucosa-associated lymphoid tissue lymphoma 465 | 480
Schizophrenia 457 | 503
active ulcerative colitis 454 | 477
Prostatic Neoplasms 447 | 471
IGA Glomerulonephritis 441 | 454
Multiple Sclerosis 429 | 498
Amyotrophic Lateral Sclerosis 423 | 432
gastric cancer 420 | 436
Mammary Neoplasms 391 | 410
non-small cell lung carcinoma 385 | 413
inflammatory breast cancer 384 | 404
Neurodegenerative disease 372 | 383
Parkinson's disease 345 | 364
Kidney disease 340 | 397
sarcoidosis 339 | 368
glioblastoma multiforme 335 | 347
Epilepsy 324 | 346
tuberculosis and treatment for 3 months 322 | 327
Asthma 316 | 349
Polycystic Ovary Syndrome 314 | 334
hereditary spastic paraplegia 312 | 313
nephrosclerosis 308 | 329

Tissue

Cardiovascular System 16,745 | 17,957
Nervous System 16,738 | 18,560
Endocrine System 16,736 | 18,511
Digestive Tract 16,735 | 18,472
Female tissues 16,735 | 18,646
Skin and soft tissues 16,726 | 18,114
Urinary Tract 16,726 | 18,443
Liver and Pancreas 16,674 | 18,135
Male tissues 16,621 | 17,968
Blood and immune system 16,605 | 17,994
Respiratory system 16,564 | 17,483

Target Family

Non-IDG 9,709 | 11,969
Enzyme 3,778 | 4,146
Transcription Factor 1,247 | 1,400
Kinase 610 | 634
Transporter 430 | 473
GPCR 315 | 408
Ion Channel 307 | 341
Epigenetic 230 | 242
Nuclear Receptor 45 | 48
oGPCR 38 | 421
TF/Epigenetic 36 | 38

GTEx Tissue

Heart - Left Ventricle 16,745 | 16,745
Testis 18,072 | 18,072
Cervix - Ectocervix 17,912 | 17,912
Bladder 17,869 | 17,869
Minor Salivary Gland 17,628 | 17,628
Fallopian Tube 17,587 | 17,587
Kidney - Cortex 17,582 | 17,582
Brain - Substantia nigra 17,564 | 17,564
Brain - Putamen (basal ganglia... 17,523 | 17,523
Cervix - Endocervix 17,504 | 17,504
Pituitary 17,481 | 17,481
Brain - Cortex 17,477 | 17,477
Brain - Cerebellum 17,467 | 17,467
Brain - Amygdala 17,450 | 17,450
Brain - Hypothalamus 17,432 | 17,432
Small Intestine - Terminal Ile... 17,426 | 17,426
Cells - EBV-transformed lympho... 17,414 | 17,414
Brain - Frontal Cortex (BA9) 17,402 | 17,402
Brain - Anterior cingulate cor... 17,374 | 17,374
Brain - Nucleus accumbens (bas... 17,316 | 17,316
Brain - Caudate (basal ganglia... 17,303 | 17,303
Brain - Spinal cord (cervical ... 17,275 | 17,275
Colon - Sigmoid 17,275 | 17,275
Brain - Hippocampus 17,259 | 17,259
Colon - Transverse 17,245 | 17,245
Esophagus - Mucosa 17,240 | 17,240
Brain - Cerebellar Hemisphere 17,238 | 17,238
Breast - Mammary Tissue 17,183 | 17,183
Prostate 17,182 | 17,182
Skin - Sun Exposed (Lower leg) 17,176 | 17,176
Pancreas 17,144 | 17,144
Stomach 17,141 | 17,141
Skin - Not Sun Exposed (Suprap... 17,121 | 17,121
Nerve - Tibial 17,120 | 17,120
Liver 17,114 | 17,114
Heart - Atrial Appendage 17,102 | 17,102
Spleen 17,059 | 17,059
Adipose - Subcutaneous 17,040 | 17,040
Lung 17,031 | 17,031
Vagina 16,991 | 16,991
Thyroid 16,984 | 16,984
Artery - Coronary 16,968 | 16,968
Adipose - Visceral (Omentum) 16,958 | 16,958
Adrenal Gland 16,955 | 16,955
Esophagus - Gastroesophageal J... 16,943 | 16,943
Ovary 16,865 | 16,865
Esophagus - Muscularis 16,862 | 16,862
Uterus 16,748 | 16,748
Artery - Aorta 16,699 | 16,699
Cells - Transformed fibroblast... 16,616 | 16,616
Artery - Tibial 16,609 | 16,609
Muscle - Skeletal 16,593 | 16,593
Whole Blood 16,359 | 16,359

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131