Development Level

Tbio 9,889 | 10,625
Tdark 4,850 | 7,003
Tchem 1,792 | 1,890
Tclin 571 | 602

Collection

Kinase: IDG Consortium (Targets) 121 | 125
GPCR: IDG Consortium (Targets) 96 | 127
Ion Channel: IDG Consortium (Targets) 94 | 102
Kinase: IDG Consortium (Complete/Control) 35 | 37
GPCR: IDG Consortium (Complete/Control) 23 | 26

IMPC Phenotype

preweaning lethality, complete... 619 | 633
preweaning lethality, incomple... 252 | 260
abnormal behavior 221 | 226
decreased lean body mass 189 | 195
embryonic lethality prior to t... 184 | 187
decreased total body fat amoun... 183 | 186
decreased body weight 168 | 174
decreased bone mineral content 154 | 157
embryonic lethality prior to o... 147 | 148
abnormal bone structure 126 | 131
increased or absent threshold ... 123 | 128
decreased bone mineral density 122 | 126
decreased circulating glucose ... 119 | 121
decreased grip strength 115 | 123
increased circulating alkaline... 112 | 119
abnormal embryo size 107 | 112
decreased body length 107 | 108
enlarged heart 106 | 111
hyperactivity 104 | 108
increased lean body mass 103 | 107
abnormal retina morphology 97 | 100
increased mean corpuscular vol... 91 | 91
increased bone mineral content 90 | 92
increased mean corpuscular hem... 90 | 93
hypoactivity 85 | 89
decreased circulating choleste... 82 | 85
decreased circulating triglyce... 82 | 83
increased grip strength 80 | 83
short tibia 80 | 82
decreased circulating serum al... 76 | 79
decreased circulating HDL chol... 75 | 77
abnormal lens morphology 70 | 73
decreased circulating insulin ... 70 | 75
increased circulating sodium l... 69 | 71
increased fasted circulating g... 65 | 68
abnormal sleep behavior 61 | 63
prenatal lethality prior to he... 61 | 64
decreased lumbar vertebrae num... 60 | 62
increased sacral vertebrae num... 60 | 62
abnormal retinal pigmentation 59 | 61
increased circulating HDL chol... 58 | 63
male infertility 58 | 62
decreased rib number 56 | 59
increased exploration in new e... 55 | 56
abnormal coat-hair pigmentatio... 53 | 54
decreased leukocyte cell numbe... 53 | 54
improved glucose tolerance 53 | 56
increased total body fat amoun... 53 | 57
abnormal behavioral response t... 51 | 52
decreased circulating alanine ... 51 | 53
decreased hemoglobin content 51 | 53
abnormal bone mineralization 50 | 55
abnormal gait 50 | 51
decreased mean corpuscular vol... 50 | 50
decreased prepulse inhibition 50 | 52
increased bone mineral density 50 | 52
abnormal heart morphology 49 | 51
impaired glucose tolerance 49 | 52
increased circulating choleste... 49 | 53
decreased caudal vertebrae num... 48 | 49
decreased fasted circulating g... 48 | 49
decreased startle reflex 45 | 48
thrombocytopenia 44 | 46
decreased heart weight 43 | 44
increased blood urea nitrogen ... 43 | 44
increased hemoglobin content 43 | 45
abnormal seminal vesicle morph... 42 | 47
decreased erythrocyte cell num... 42 | 43
increased body weight 42 | 42
decreased eosinophil cell numb... 41 | 41
increased circulating chloride... 41 | 43
decreased circulating total pr... 40 | 41
increased rib number 40 | 41
decreased circulating free fat... 39 | 39
decreased circulating LDL chol... 37 | 37
decreased circulating alkaline... 37 | 41
increased startle reflex 37 | 38
abnormal eye morphology 36 | 38
abnormal neural tube closure 35 | 37
decreased neutrophil cell numb... 35 | 37
increased leukocyte cell numbe... 35 | 37
abnormal spleen morphology 34 | 36
increased hematocrit 34 | 36
small testis 34 | 37
cardiovascular system phenotyp... 33 | 35
decreased mean corpuscular hem... 33 | 34
limb grasping 33 | 35
abnormal cranium morphology 32 | 32
female infertility 32 | 34
tremors 32 | 34
decreased circulating calcium ... 31 | 33
decreased circulating chloride... 31 | 32
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31
increased heart weight 31 | 37
decreased T cell number 30 | 31
decreased circulating creatini... 30 | 31
increased circulating calcium ... 30 | 32
decreased B cell number 29 | 30
decreased blood urea nitrogen ... 29 | 31

Disease

ovarian cancer 8,209 | 8,491
osteosarcoma 7,597 | 7,933
psoriasis 6,162 | 6,685
medulloblastoma, large-cell 5,997 | 6,234
glioblastoma 5,424 | 5,572
lung cancer 4,344 | 4,473
atypical teratoid / rhabdoid tumor 4,247 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,217 | 3,289
malignant mesothelioma 3,066 | 3,163
Breast cancer 3,016 | 3,098
pilocytic astrocytoma 3,003 | 3,086
primitive neuroectodermal tumor 2,957 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,911 | 2,988
invasive ductal carcinoma 2,887 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,882 | 2,956
oligodendroglioma 2,780 | 2,849
lung carcinoma 2,753 | 2,844
non-small cell lung cancer 2,733 | 2,798
pediatric high grade glioma 2,651 | 2,712
lung adenocarcinoma 2,627 | 2,714
ependymoma 2,451 | 2,514
pancreatic cancer 2,242 | 2,300
interstitial cystitis 2,236 | 2,299
subependymal giant cell astrocytoma 2,228 | 2,287
astrocytic glioma 2,185 | 2,241
group 3 medulloblastoma 2,179 | 2,254
Cancer 2,124 | 2,346
adult high grade glioma 2,049 | 2,148
ulcerative colitis 2,029 | 2,087
Carcinoma 2,028 | 2,147
pituitary cancer 1,911 | 1,972
Pick disease 1,856 | 1,893
group 4 medulloblastoma 1,815 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,749 | 1,795
ductal carcinoma in situ 1,712 | 1,745
cystic fibrosis 1,624 | 1,670
breast carcinoma 1,579 | 1,614
tuberculosis 1,517 | 1,563
medulloblastoma 1,482 | 1,524
posterior fossa group B ependymoma 1,481 | 1,530
posterior fossa group A ependymoma 1,473 | 1,511
astrocytoma 1,452 | 1,493
sonic hedgehog group medulloblastoma 1,445 | 1,482
colon cancer 1,427 | 1,475
adrenocortical carcinoma 1,404 | 1,427
diabetes mellitus 1,380 | 1,663
Multiple myeloma 1,306 | 1,327
primary pancreatic ductal adenocarcinoma 1,255 | 1,271
juvenile dermatomyositis 1,159 | 1,189
acute quadriplegic myopathy 1,138 | 1,157
Rheumatoid Arthritis 1,078 | 1,170
atypical teratoid/rhabdoid tumor 1,062 | 1,095
spina bifida 1,037 | 1,064
nasopharyngeal carcinoma 1,027 | 1,056
cutaneous lupus erythematosus 1,024 | 1,056
dermatomyositis 914 | 966
Atopic dermatitis 895 | 944
active Crohn's disease 885 | 918
gastric carcinoma 817 | 832
non primary Sjogren syndrome sicca 796 | 840
acute myeloid leukemia 768 | 785
primary Sjogren syndrome 766 | 788
Waldenstrons macroglobulinemia 752 | 764
esophageal adenocarcinoma 724 | 737
tuberculosis and treatment for 6 months 669 | 686
progressive supranuclear palsy 660 | 674
aldosterone-producing adenoma 653 | 664
Alzheimer's disease 613 | 644
Obesity 586 | 616
Duchenne muscular dystrophy 584 | 602
Intellectual disability 556 | 573
pancreatic carcinoma 555 | 567
fibroadenoma 546 | 557
Down syndrome 533 | 548
hepatocellular carcinoma 533 | 550
Endometriosis 521 | 535
chronic rhinosinusitis 500 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 487 | 499
Schizophrenia 469 | 503
mucosa-associated lymphoid tissue lymphoma 465 | 480
active ulcerative colitis 461 | 477
Prostatic Neoplasms 453 | 471
IGA Glomerulonephritis 443 | 454
Multiple Sclerosis 438 | 498
Amyotrophic Lateral Sclerosis 427 | 432
gastric cancer 420 | 436
Mammary Neoplasms 395 | 410
non-small cell lung carcinoma 393 | 413
inflammatory breast cancer 387 | 404
Neurodegenerative disease 373 | 383
Kidney disease 354 | 397
Parkinson's disease 349 | 364
sarcoidosis 343 | 368
glioblastoma multiforme 338 | 347
Epilepsy 326 | 346
tuberculosis and treatment for 3 months 322 | 327
Asthma 321 | 349
Polycystic Ovary Syndrome 320 | 334
nephrosclerosis 316 | 329
hereditary spastic paraplegia 312 | 313

Tissue

Cardiovascular System 17,102 | 17,957
Female tissues 17,090 | 18,646
Endocrine System 17,083 | 18,511
Nervous System 17,078 | 18,560
Digestive Tract 17,074 | 18,472
Urinary Tract 17,071 | 18,443
Skin and soft tissues 17,058 | 18,114
Liver and Pancreas 16,969 | 18,135
Male tissues 16,912 | 17,968
Blood and immune system 16,904 | 17,994
Respiratory system 16,806 | 17,483

Target Family

Non-IDG 9,920 | 11,969
Enzyme 3,829 | 4,146
Transcription Factor 1,270 | 1,400
Kinase 613 | 634
Transporter 447 | 473
GPCR 333 | 408
Ion Channel 315 | 341
Epigenetic 232 | 242
oGPCR 61 | 421
Nuclear Receptor 46 | 48
TF/Epigenetic 36 | 38

GTEx Tissue

Heart - Atrial Appendage 17,102 | 17,102
Testis 18,072 | 18,072
Cervix - Ectocervix 17,912 | 17,912
Bladder 17,869 | 17,869
Minor Salivary Gland 17,628 | 17,628
Fallopian Tube 17,587 | 17,587
Kidney - Cortex 17,582 | 17,582
Brain - Substantia nigra 17,564 | 17,564
Brain - Putamen (basal ganglia... 17,523 | 17,523
Cervix - Endocervix 17,504 | 17,504
Pituitary 17,481 | 17,481
Brain - Cortex 17,477 | 17,477
Brain - Cerebellum 17,467 | 17,467
Brain - Amygdala 17,450 | 17,450
Brain - Hypothalamus 17,432 | 17,432
Small Intestine - Terminal Ile... 17,426 | 17,426
Cells - EBV-transformed lympho... 17,414 | 17,414
Brain - Frontal Cortex (BA9) 17,402 | 17,402
Brain - Anterior cingulate cor... 17,374 | 17,374
Brain - Nucleus accumbens (bas... 17,316 | 17,316
Brain - Caudate (basal ganglia... 17,303 | 17,303
Brain - Spinal cord (cervical ... 17,275 | 17,275
Colon - Sigmoid 17,275 | 17,275
Brain - Hippocampus 17,259 | 17,259
Colon - Transverse 17,245 | 17,245
Esophagus - Mucosa 17,240 | 17,240
Brain - Cerebellar Hemisphere 17,238 | 17,238
Breast - Mammary Tissue 17,183 | 17,183
Prostate 17,182 | 17,182
Skin - Sun Exposed (Lower leg) 17,176 | 17,176
Pancreas 17,144 | 17,144
Stomach 17,141 | 17,141
Skin - Not Sun Exposed (Suprap... 17,121 | 17,121
Nerve - Tibial 17,120 | 17,120
Liver 17,114 | 17,114
Spleen 17,059 | 17,059
Adipose - Subcutaneous 17,040 | 17,040
Lung 17,031 | 17,031
Vagina 16,991 | 16,991
Thyroid 16,984 | 16,984
Artery - Coronary 16,968 | 16,968
Adipose - Visceral (Omentum) 16,958 | 16,958
Adrenal Gland 16,955 | 16,955
Esophagus - Gastroesophageal J... 16,943 | 16,943
Ovary 16,865 | 16,865
Esophagus - Muscularis 16,862 | 16,862
Uterus 16,748 | 16,748
Heart - Left Ventricle 16,745 | 16,745
Artery - Aorta 16,699 | 16,699
Cells - Transformed fibroblast... 16,616 | 16,616
Artery - Tibial 16,609 | 16,609
Muscle - Skeletal 16,593 | 16,593
Whole Blood 16,359 | 16,359

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
5-hydroxytryptamine receptor 1E HTR1E Tchem GPCR -1.54352 34.9 99