Development Level

Tbio 9,946 | 10,625
Tdark 4,933 | 7,003
Tchem 1,818 | 1,890
Tclin 578 | 602

Collection

Kinase: IDG Consortium (Targets) 120 | 125
GPCR: IDG Consortium (Targets) 99 | 127
Ion Channel: IDG Consortium (Targets) 98 | 102
Kinase: IDG Consortium (Complete/Control) 35 | 37
GPCR: IDG Consortium (Complete/Control) 23 | 26

IMPC Phenotype

preweaning lethality, complete... 620 | 633
preweaning lethality, incomple... 253 | 260
abnormal behavior 222 | 226
decreased lean body mass 189 | 195
embryonic lethality prior to t... 184 | 187
decreased total body fat amoun... 183 | 186
decreased body weight 169 | 174
decreased bone mineral content 154 | 157
embryonic lethality prior to o... 147 | 148
abnormal bone structure 125 | 131
decreased bone mineral density 122 | 126
increased or absent threshold ... 122 | 128
decreased circulating glucose ... 118 | 121
decreased grip strength 117 | 123
increased circulating alkaline... 113 | 119
abnormal embryo size 107 | 112
decreased body length 107 | 108
enlarged heart 107 | 111
hyperactivity 106 | 108
increased lean body mass 104 | 107
abnormal retina morphology 97 | 100
increased mean corpuscular vol... 91 | 91
increased bone mineral content 90 | 92
increased mean corpuscular hem... 90 | 93
hypoactivity 86 | 89
decreased circulating choleste... 83 | 85
decreased circulating triglyce... 81 | 83
increased grip strength 81 | 83
short tibia 80 | 82
decreased circulating serum al... 77 | 79
decreased circulating HDL chol... 75 | 77
abnormal lens morphology 71 | 73
decreased circulating insulin ... 71 | 75
increased circulating sodium l... 70 | 71
increased fasted circulating g... 64 | 68
abnormal sleep behavior 61 | 63
increased circulating HDL chol... 61 | 63
prenatal lethality prior to he... 61 | 64
decreased lumbar vertebrae num... 60 | 62
increased sacral vertebrae num... 60 | 62
male infertility 60 | 62
abnormal retinal pigmentation 59 | 61
decreased rib number 57 | 59
improved glucose tolerance 55 | 56
increased exploration in new e... 54 | 56
increased total body fat amoun... 53 | 57
abnormal coat-hair pigmentatio... 52 | 54
decreased leukocyte cell numbe... 52 | 54
decreased circulating alanine ... 51 | 53
increased bone mineral density 51 | 52
increased circulating choleste... 51 | 53
abnormal behavioral response t... 50 | 52
abnormal bone mineralization 50 | 55
abnormal gait 50 | 51
abnormal heart morphology 50 | 51
decreased hemoglobin content 50 | 53
decreased prepulse inhibition 50 | 52
decreased mean corpuscular vol... 49 | 50
impaired glucose tolerance 49 | 52
decreased caudal vertebrae num... 47 | 49
decreased fasted circulating g... 47 | 49
decreased startle reflex 46 | 48
increased hemoglobin content 44 | 45
thrombocytopenia 44 | 46
decreased heart weight 43 | 44
abnormal seminal vesicle morph... 42 | 47
decreased erythrocyte cell num... 42 | 43
increased blood urea nitrogen ... 42 | 44
increased body weight 42 | 42
increased circulating chloride... 42 | 43
decreased eosinophil cell numb... 41 | 41
decreased circulating total pr... 40 | 41
increased rib number 40 | 41
decreased circulating free fat... 39 | 39
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased startle reflex 37 | 38
abnormal eye morphology 36 | 38
decreased circulating alkaline... 36 | 41
small testis 36 | 37
abnormal neural tube closure 35 | 37
increased hematocrit 35 | 36
increased leukocyte cell numbe... 35 | 37
cardiovascular system phenotyp... 34 | 35
abnormal spleen morphology 33 | 36
decreased mean corpuscular hem... 33 | 34
limb grasping 33 | 35
abnormal cranium morphology 32 | 32
decreased circulating calcium ... 32 | 33
female infertility 32 | 34
tremors 32 | 34
decreased circulating fructosa... 31 | 31
increased circulating calcium ... 31 | 32
increased circulating potassiu... 31 | 31
increased heart weight 31 | 37
decreased B cell number 30 | 30
decreased T cell number 30 | 31
decreased blood urea nitrogen ... 30 | 31
decreased circulating chloride... 30 | 32
decreased circulating creatini... 30 | 31

Disease

ovarian cancer 8,225 | 8,491
osteosarcoma 7,628 | 7,933
psoriasis 6,203 | 6,685
medulloblastoma, large-cell 6,016 | 6,234
glioblastoma 5,438 | 5,572
lung cancer 4,358 | 4,473
atypical teratoid / rhabdoid tumor 4,259 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,222 | 3,289
malignant mesothelioma 3,077 | 3,163
Breast cancer 3,019 | 3,098
pilocytic astrocytoma 3,012 | 3,086
primitive neuroectodermal tumor 2,967 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,922 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,894 | 2,956
invasive ductal carcinoma 2,892 | 2,950
oligodendroglioma 2,788 | 2,849
lung carcinoma 2,770 | 2,844
non-small cell lung cancer 2,741 | 2,798
pediatric high grade glioma 2,655 | 2,712
lung adenocarcinoma 2,637 | 2,714
ependymoma 2,460 | 2,514
pancreatic cancer 2,250 | 2,300
interstitial cystitis 2,245 | 2,299
subependymal giant cell astrocytoma 2,233 | 2,287
astrocytic glioma 2,191 | 2,241
group 3 medulloblastoma 2,185 | 2,254
Cancer 2,145 | 2,346
adult high grade glioma 2,067 | 2,148
Carcinoma 2,044 | 2,147
ulcerative colitis 2,039 | 2,087
pituitary cancer 1,915 | 1,972
Pick disease 1,858 | 1,893
group 4 medulloblastoma 1,821 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,752 | 1,795
ductal carcinoma in situ 1,714 | 1,745
cystic fibrosis 1,631 | 1,670
breast carcinoma 1,582 | 1,614
tuberculosis 1,521 | 1,563
medulloblastoma 1,491 | 1,524
posterior fossa group B ependymoma 1,487 | 1,530
posterior fossa group A ependymoma 1,477 | 1,511
astrocytoma 1,456 | 1,493
sonic hedgehog group medulloblastoma 1,449 | 1,482
colon cancer 1,436 | 1,475
adrenocortical carcinoma 1,406 | 1,427
diabetes mellitus 1,399 | 1,663
Multiple myeloma 1,305 | 1,327
primary pancreatic ductal adenocarcinoma 1,259 | 1,271
juvenile dermatomyositis 1,160 | 1,189
acute quadriplegic myopathy 1,138 | 1,157
Rheumatoid Arthritis 1,083 | 1,170
atypical teratoid/rhabdoid tumor 1,064 | 1,095
spina bifida 1,038 | 1,064
nasopharyngeal carcinoma 1,033 | 1,056
cutaneous lupus erythematosus 1,028 | 1,056
dermatomyositis 914 | 966
Atopic dermatitis 897 | 944
active Crohn's disease 893 | 918
gastric carcinoma 818 | 832
non primary Sjogren syndrome sicca 798 | 840
acute myeloid leukemia 767 | 785
primary Sjogren syndrome 766 | 788
Waldenstrons macroglobulinemia 752 | 764
esophageal adenocarcinoma 728 | 737
tuberculosis and treatment for 6 months 669 | 686
progressive supranuclear palsy 660 | 674
aldosterone-producing adenoma 654 | 664
Alzheimer's disease 613 | 644
Obesity 588 | 616
Duchenne muscular dystrophy 584 | 602
Intellectual disability 557 | 573
pancreatic carcinoma 555 | 567
fibroadenoma 547 | 557
hepatocellular carcinoma 534 | 550
Down syndrome 531 | 548
Endometriosis 523 | 535
chronic rhinosinusitis 499 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 486 | 499
Schizophrenia 469 | 503
mucosa-associated lymphoid tissue lymphoma 467 | 480
active ulcerative colitis 463 | 477
Prostatic Neoplasms 455 | 471
IGA Glomerulonephritis 443 | 454
Multiple Sclerosis 443 | 498
Amyotrophic Lateral Sclerosis 426 | 432
gastric cancer 420 | 436
Mammary Neoplasms 399 | 410
non-small cell lung carcinoma 395 | 413
inflammatory breast cancer 388 | 404
Neurodegenerative disease 373 | 383
Kidney disease 353 | 397
Parkinson's disease 352 | 364
sarcoidosis 345 | 368
glioblastoma multiforme 341 | 347
Epilepsy 332 | 346
Asthma 328 | 349
tuberculosis and treatment for 3 months 321 | 327
nephrosclerosis 318 | 329
Polycystic Ovary Syndrome 316 | 334
urothelial carcinoma 312 | 318

Tissue

Digestive Tract 17,275 | 18,472
Female tissues 17,260 | 18,646
Nervous System 17,255 | 18,560
Endocrine System 17,253 | 18,511
Urinary Tract 17,242 | 18,443
Skin and soft tissues 17,229 | 18,114
Cardiovascular System 17,137 | 17,957
Liver and Pancreas 17,121 | 18,135
Male tissues 17,062 | 17,968
Blood and immune system 17,039 | 17,994
Respiratory system 16,932 | 17,483

Target Family

Non-IDG 9,992 | 11,969
Enzyme 3,858 | 4,146
Transcription Factor 1,297 | 1,400
Kinase 613 | 634
Transporter 443 | 473
GPCR 347 | 408
Ion Channel 323 | 341
Epigenetic 232 | 242
oGPCR 88 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 35 | 38

GTEx Tissue

Colon - Sigmoid 17,275 | 17,275
Testis 18,072 | 18,072
Cervix - Ectocervix 17,912 | 17,912
Bladder 17,869 | 17,869
Minor Salivary Gland 17,628 | 17,628
Fallopian Tube 17,587 | 17,587
Kidney - Cortex 17,582 | 17,582
Brain - Substantia nigra 17,564 | 17,564
Brain - Putamen (basal ganglia... 17,523 | 17,523
Cervix - Endocervix 17,504 | 17,504
Pituitary 17,481 | 17,481
Brain - Cortex 17,477 | 17,477
Brain - Cerebellum 17,467 | 17,467
Brain - Amygdala 17,450 | 17,450
Brain - Hypothalamus 17,432 | 17,432
Small Intestine - Terminal Ile... 17,426 | 17,426
Cells - EBV-transformed lympho... 17,414 | 17,414
Brain - Frontal Cortex (BA9) 17,402 | 17,402
Brain - Anterior cingulate cor... 17,374 | 17,374
Brain - Nucleus accumbens (bas... 17,316 | 17,316
Brain - Caudate (basal ganglia... 17,303 | 17,303
Brain - Spinal cord (cervical ... 17,275 | 17,275
Brain - Hippocampus 17,259 | 17,259
Colon - Transverse 17,245 | 17,245
Esophagus - Mucosa 17,240 | 17,240
Brain - Cerebellar Hemisphere 17,238 | 17,238
Breast - Mammary Tissue 17,183 | 17,183
Prostate 17,182 | 17,182
Skin - Sun Exposed (Lower leg) 17,176 | 17,176
Pancreas 17,144 | 17,144
Stomach 17,141 | 17,141
Skin - Not Sun Exposed (Suprap... 17,121 | 17,121
Nerve - Tibial 17,120 | 17,120
Liver 17,114 | 17,114
Heart - Atrial Appendage 17,102 | 17,102
Spleen 17,059 | 17,059
Adipose - Subcutaneous 17,040 | 17,040
Lung 17,031 | 17,031
Vagina 16,991 | 16,991
Thyroid 16,984 | 16,984
Artery - Coronary 16,968 | 16,968
Adipose - Visceral (Omentum) 16,958 | 16,958
Adrenal Gland 16,955 | 16,955
Esophagus - Gastroesophageal J... 16,943 | 16,943
Ovary 16,865 | 16,865
Esophagus - Muscularis 16,862 | 16,862
Uterus 16,748 | 16,748
Heart - Left Ventricle 16,745 | 16,745
Artery - Aorta 16,699 | 16,699
Cells - Transformed fibroblast... 16,616 | 16,616
Artery - Tibial 16,609 | 16,609
Muscle - Skeletal 16,593 | 16,593
Whole Blood 16,359 | 16,359

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
5-hydroxytryptamine receptor 1E HTR1E Tchem GPCR -1.54352 34.9 99