Development Level

Tbio 9,988 | 10,625
Tdark 5,126 | 7,003
Tchem 1,817 | 1,890
Tclin 573 | 602

Collection

Kinase: IDG Consortium (Targets) 121 | 125
GPCR: IDG Consortium (Targets) 104 | 127
Ion Channel: IDG Consortium (Targets) 95 | 102
Kinase: IDG Consortium (Complete/Control) 35 | 37
GPCR: IDG Consortium (Complete/Control) 26 | 26

IMPC Phenotype

preweaning lethality, complete... 620 | 633
preweaning lethality, incomple... 255 | 260
abnormal behavior 218 | 226
decreased lean body mass 190 | 195
embryonic lethality prior to t... 185 | 187
decreased total body fat amoun... 182 | 186
decreased body weight 167 | 174
decreased bone mineral content 155 | 157
embryonic lethality prior to o... 147 | 148
abnormal bone structure 127 | 131
increased or absent threshold ... 125 | 128
decreased bone mineral density 123 | 126
decreased circulating glucose ... 118 | 121
decreased grip strength 116 | 123
increased circulating alkaline... 112 | 119
abnormal embryo size 108 | 112
enlarged heart 107 | 111
decreased body length 106 | 108
hyperactivity 104 | 108
increased lean body mass 103 | 107
abnormal retina morphology 98 | 100
increased mean corpuscular vol... 91 | 91
increased bone mineral content 90 | 92
increased mean corpuscular hem... 89 | 93
hypoactivity 85 | 89
decreased circulating choleste... 82 | 85
decreased circulating triglyce... 81 | 83
increased grip strength 80 | 83
short tibia 80 | 82
decreased circulating serum al... 77 | 79
decreased circulating HDL chol... 74 | 77
decreased circulating insulin ... 73 | 75
abnormal lens morphology 70 | 73
increased circulating sodium l... 67 | 71
increased fasted circulating g... 65 | 68
prenatal lethality prior to he... 62 | 64
abnormal sleep behavior 60 | 63
decreased lumbar vertebrae num... 60 | 62
increased circulating HDL chol... 60 | 63
increased sacral vertebrae num... 60 | 62
abnormal retinal pigmentation 59 | 61
male infertility 59 | 62
decreased rib number 57 | 59
improved glucose tolerance 55 | 56
increased exploration in new e... 55 | 56
increased total body fat amoun... 54 | 57
abnormal coat-hair pigmentatio... 53 | 54
decreased leukocyte cell numbe... 52 | 54
decreased prepulse inhibition 51 | 52
increased circulating choleste... 51 | 53
abnormal behavioral response t... 50 | 52
abnormal bone mineralization 50 | 55
abnormal heart morphology 50 | 51
decreased hemoglobin content 50 | 53
decreased mean corpuscular vol... 50 | 50
impaired glucose tolerance 50 | 52
increased bone mineral density 50 | 52
decreased circulating alanine ... 49 | 53
abnormal gait 48 | 51
decreased caudal vertebrae num... 48 | 49
decreased fasted circulating g... 47 | 49
decreased startle reflex 47 | 48
abnormal seminal vesicle morph... 44 | 47
thrombocytopenia 44 | 46
decreased heart weight 43 | 44
decreased erythrocyte cell num... 42 | 43
increased blood urea nitrogen ... 42 | 44
increased body weight 42 | 42
increased hemoglobin content 42 | 45
decreased eosinophil cell numb... 41 | 41
decreased circulating total pr... 40 | 41
increased circulating chloride... 40 | 43
increased rib number 40 | 41
decreased circulating free fat... 38 | 39
decreased circulating LDL chol... 37 | 37
decreased circulating alkaline... 37 | 41
increased startle reflex 37 | 38
abnormal eye morphology 36 | 38
abnormal neural tube closure 36 | 37
decreased neutrophil cell numb... 36 | 37
cardiovascular system phenotyp... 35 | 35
small testis 35 | 37
increased hematocrit 34 | 36
increased leukocyte cell numbe... 34 | 37
abnormal spleen morphology 33 | 36
decreased mean corpuscular hem... 33 | 34
female infertility 33 | 34
increased heart weight 33 | 37
limb grasping 33 | 35
abnormal cranium morphology 32 | 32
decreased circulating calcium ... 32 | 33
tremors 32 | 34
decreased circulating chloride... 31 | 32
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31
decreased T cell number 30 | 31
decreased blood urea nitrogen ... 30 | 31
decreased circulating creatini... 30 | 31
increased circulating calcium ... 30 | 32
abnormal testis morphology 29 | 30

Disease

ovarian cancer 8,243 | 8,491
osteosarcoma 7,620 | 7,933
psoriasis 6,251 | 6,685
medulloblastoma, large-cell 6,026 | 6,234
glioblastoma 5,430 | 5,572
lung cancer 4,358 | 4,473
atypical teratoid / rhabdoid tumor 4,254 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,217 | 3,289
malignant mesothelioma 3,072 | 3,163
Breast cancer 3,022 | 3,098
pilocytic astrocytoma 2,999 | 3,086
primitive neuroectodermal tumor 2,959 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,916 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,891 | 2,956
invasive ductal carcinoma 2,890 | 2,950
oligodendroglioma 2,772 | 2,849
lung carcinoma 2,762 | 2,844
non-small cell lung cancer 2,739 | 2,798
pediatric high grade glioma 2,647 | 2,712
lung adenocarcinoma 2,638 | 2,714
ependymoma 2,453 | 2,514
pancreatic cancer 2,249 | 2,300
interstitial cystitis 2,244 | 2,299
subependymal giant cell astrocytoma 2,227 | 2,287
astrocytic glioma 2,184 | 2,241
group 3 medulloblastoma 2,182 | 2,254
Cancer 2,151 | 2,346
adult high grade glioma 2,072 | 2,148
Carcinoma 2,068 | 2,147
ulcerative colitis 2,033 | 2,087
pituitary cancer 1,913 | 1,972
Pick disease 1,850 | 1,893
group 4 medulloblastoma 1,817 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,751 | 1,795
ductal carcinoma in situ 1,711 | 1,745
cystic fibrosis 1,632 | 1,670
breast carcinoma 1,578 | 1,614
tuberculosis 1,519 | 1,563
posterior fossa group B ependymoma 1,485 | 1,530
medulloblastoma 1,484 | 1,524
posterior fossa group A ependymoma 1,471 | 1,511
astrocytoma 1,453 | 1,493
sonic hedgehog group medulloblastoma 1,451 | 1,482
diabetes mellitus 1,440 | 1,663
colon cancer 1,434 | 1,475
adrenocortical carcinoma 1,404 | 1,427
Multiple myeloma 1,306 | 1,327
primary pancreatic ductal adenocarcinoma 1,256 | 1,271
juvenile dermatomyositis 1,162 | 1,189
acute quadriplegic myopathy 1,133 | 1,157
Rheumatoid Arthritis 1,084 | 1,170
atypical teratoid/rhabdoid tumor 1,059 | 1,095
spina bifida 1,039 | 1,064
nasopharyngeal carcinoma 1,033 | 1,056
cutaneous lupus erythematosus 1,032 | 1,056
dermatomyositis 914 | 966
Atopic dermatitis 901 | 944
active Crohn's disease 887 | 918
gastric carcinoma 815 | 832
non primary Sjogren syndrome sicca 802 | 840
acute myeloid leukemia 769 | 785
primary Sjogren syndrome 768 | 788
Waldenstrons macroglobulinemia 751 | 764
esophageal adenocarcinoma 727 | 737
tuberculosis and treatment for 6 months 669 | 686
progressive supranuclear palsy 658 | 674
aldosterone-producing adenoma 655 | 664
Alzheimer's disease 614 | 644
Duchenne muscular dystrophy 583 | 602
Obesity 583 | 616
Intellectual disability 559 | 573
pancreatic carcinoma 555 | 567
fibroadenoma 546 | 557
hepatocellular carcinoma 534 | 550
Down syndrome 530 | 548
Endometriosis 525 | 535
chronic rhinosinusitis 503 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 486 | 499
Schizophrenia 470 | 503
mucosa-associated lymphoid tissue lymphoma 466 | 480
active ulcerative colitis 462 | 477
Prostatic Neoplasms 454 | 471
Multiple Sclerosis 444 | 498
IGA Glomerulonephritis 441 | 454
Amyotrophic Lateral Sclerosis 425 | 432
gastric cancer 420 | 436
Mammary Neoplasms 399 | 410
non-small cell lung carcinoma 396 | 413
inflammatory breast cancer 388 | 404
Neurodegenerative disease 373 | 383
Kidney disease 353 | 397
Parkinson's disease 351 | 364
sarcoidosis 343 | 368
glioblastoma multiforme 339 | 347
Epilepsy 330 | 346
Asthma 329 | 349
Polycystic Ovary Syndrome 321 | 334
tuberculosis and treatment for 3 months 320 | 327
nephrosclerosis 314 | 329
urothelial carcinoma 312 | 318

Tissue

Female tissues 17,504 | 18,646
Urinary Tract 17,437 | 18,443
Endocrine System 17,432 | 18,511
Nervous System 17,425 | 18,560
Digestive Tract 17,409 | 18,472
Skin and soft tissues 17,358 | 18,114
Liver and Pancreas 17,207 | 18,135
Cardiovascular System 17,168 | 17,957
Male tissues 17,119 | 17,968
Blood and immune system 17,089 | 17,994
Respiratory system 16,941 | 17,483

Target Family

Non-IDG 10,100 | 11,969
Enzyme 3,859 | 4,146
Transcription Factor 1,293 | 1,400
Kinase 614 | 634
Transporter 452 | 473
GPCR 354 | 408
Ion Channel 320 | 341
Epigenetic 233 | 242
oGPCR 197 | 421
Nuclear Receptor 46 | 48
TF/Epigenetic 36 | 38

GTEx Tissue

Cervix - Endocervix 17,504 | 17,504
Testis 18,072 | 18,072
Cervix - Ectocervix 17,912 | 17,912
Bladder 17,869 | 17,869
Minor Salivary Gland 17,628 | 17,628
Fallopian Tube 17,587 | 17,587
Kidney - Cortex 17,582 | 17,582
Brain - Substantia nigra 17,564 | 17,564
Brain - Putamen (basal ganglia... 17,523 | 17,523
Pituitary 17,481 | 17,481
Brain - Cortex 17,477 | 17,477
Brain - Cerebellum 17,467 | 17,467
Brain - Amygdala 17,450 | 17,450
Brain - Hypothalamus 17,432 | 17,432
Small Intestine - Terminal Ile... 17,426 | 17,426
Cells - EBV-transformed lympho... 17,414 | 17,414
Brain - Frontal Cortex (BA9) 17,402 | 17,402
Brain - Anterior cingulate cor... 17,374 | 17,374
Brain - Nucleus accumbens (bas... 17,316 | 17,316
Brain - Caudate (basal ganglia... 17,303 | 17,303
Brain - Spinal cord (cervical ... 17,275 | 17,275
Colon - Sigmoid 17,275 | 17,275
Brain - Hippocampus 17,259 | 17,259
Colon - Transverse 17,245 | 17,245
Esophagus - Mucosa 17,240 | 17,240
Brain - Cerebellar Hemisphere 17,238 | 17,238
Breast - Mammary Tissue 17,183 | 17,183
Prostate 17,182 | 17,182
Skin - Sun Exposed (Lower leg) 17,176 | 17,176
Pancreas 17,144 | 17,144
Stomach 17,141 | 17,141
Skin - Not Sun Exposed (Suprap... 17,121 | 17,121
Nerve - Tibial 17,120 | 17,120
Liver 17,114 | 17,114
Heart - Atrial Appendage 17,102 | 17,102
Spleen 17,059 | 17,059
Adipose - Subcutaneous 17,040 | 17,040
Lung 17,031 | 17,031
Vagina 16,991 | 16,991
Thyroid 16,984 | 16,984
Artery - Coronary 16,968 | 16,968
Adipose - Visceral (Omentum) 16,958 | 16,958
Adrenal Gland 16,955 | 16,955
Esophagus - Gastroesophageal J... 16,943 | 16,943
Ovary 16,865 | 16,865
Esophagus - Muscularis 16,862 | 16,862
Uterus 16,748 | 16,748
Heart - Left Ventricle 16,745 | 16,745
Artery - Aorta 16,699 | 16,699
Cells - Transformed fibroblast... 16,616 | 16,616
Artery - Tibial 16,609 | 16,609
Muscle - Skeletal 16,593 | 16,593
Whole Blood 16,359 | 16,359

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
5-hydroxytryptamine receptor 1E HTR1E Tchem GPCR -1.54352 34.9 99