Development Level

Tbio 9,685 | 10,625
Tdark 4,653 | 7,003
Tchem 1,745 | 1,890
Tclin 534 | 602

Collection

Eligible Kinase Proteins 125 | 134
Eligible non-olfactory GPCR Proteins 90 | 143
Eligible Ion Channel Proteins 89 | 117

IMPC Term

preweaning lethality, complete... 616 | 633
preweaning lethality, incomple... 252 | 260
abnormal behavior 216 | 226
decreased lean body mass 186 | 195
embryonic lethality prior to t... 184 | 187
decreased total body fat amoun... 178 | 186
decreased body weight 164 | 174
decreased bone mineral content 150 | 157
embryonic lethality prior to o... 147 | 148
abnormal bone structure 123 | 131
increased or absent threshold ... 121 | 128
decreased bone mineral density 117 | 126
increased circulating alkaline... 113 | 119
decreased grip strength 112 | 123
decreased circulating glucose ... 110 | 121
abnormal embryo size 108 | 112
decreased body length 104 | 108
hyperactivity 101 | 108
increased lean body mass 101 | 107
enlarged heart 100 | 111
abnormal retina morphology 96 | 100
increased mean corpuscular vol... 91 | 91
increased mean corpuscular hem... 89 | 93
increased bone mineral content 88 | 92
hypoactivity 82 | 89
decreased circulating choleste... 81 | 85
increased grip strength 81 | 83
decreased circulating triglyce... 79 | 83
short tibia 79 | 82
decreased circulating serum al... 76 | 79
decreased circulating HDL chol... 73 | 77
abnormal lens morphology 70 | 73
decreased circulating insulin ... 69 | 75
increased circulating sodium l... 66 | 71
increased fasted circulating g... 62 | 68
decreased lumbar vertebrae num... 60 | 62
prenatal lethality prior to he... 60 | 64
increased sacral vertebrae num... 59 | 62
male infertility 59 | 62
abnormal retinal pigmentation 58 | 61
abnormal sleep behavior 57 | 63
increased circulating HDL chol... 56 | 63
decreased rib number 55 | 59
improved glucose tolerance 53 | 56
increased exploration in new e... 53 | 56
increased total body fat amoun... 52 | 57
abnormal coat/hair pigmentatio... 51 | 54
abnormal bone mineralization 50 | 55
decreased leukocyte cell numbe... 50 | 54
abnormal behavioral response t... 49 | 52
decreased hemoglobin content 49 | 53
decreased mean corpuscular vol... 49 | 50
decreased prepulse inhibition 49 | 52
increased bone mineral density 49 | 52
increased circulating choleste... 49 | 53
abnormal gait 48 | 51
decreased circulating alanine ... 48 | 53
impaired glucose tolerance 48 | 52
decreased fasted circulating g... 47 | 49
decreased startle reflex 46 | 48
abnormal heart morphology 45 | 51
decreased caudal vertebrae num... 45 | 49
thrombocytopenia 43 | 46
decreased erythrocyte cell num... 42 | 43
increased body weight 42 | 42
increased hemoglobin content 42 | 45
decreased eosinophil cell numb... 41 | 41
increased blood urea nitrogen ... 41 | 44
decreased circulating total pr... 40 | 41
decreased heart weight 40 | 44
abnormal seminal vesicle morph... 39 | 47
increased rib number 39 | 41
increased circulating chloride... 38 | 43
decreased circulating free fat... 37 | 39
increased startle reflex 37 | 38
abnormal eye morphology 36 | 38
decreased circulating LDL chol... 36 | 37
decreased circulating alkaline... 36 | 41
small testis 36 | 37
abnormal neural tube closure 35 | 37
decreased neutrophil cell numb... 35 | 37
increased hematocrit 34 | 36
abnormal spleen morphology 33 | 36
cardiovascular system phenotyp... 33 | 35
decreased mean corpuscular hem... 33 | 34
increased leukocyte cell numbe... 33 | 37
tremors 32 | 34
abnormal cranium morphology 31 | 32
increased circulating calcium ... 31 | 32
increased heart weight 31 | 37
decreased T cell number 30 | 31
decreased circulating calcium ... 30 | 33
decreased circulating chloride... 30 | 32
decreased circulating fructosa... 30 | 31
increased circulating potassiu... 30 | 31
limb grasping 30 | 35
decreased blood urea nitrogen ... 29 | 31
decreased circulating creatini... 29 | 31
female infertility 29 | 34
embryonic growth retardation 28 | 28

Disease

ovarian cancer 8,147 | 8,484
osteosarcoma 7,493 | 7,933
psoriasis 5,983 | 6,685
medulloblastoma, large-cell 5,915 | 6,234
glioblastoma 5,337 | 5,572
lung cancer 4,302 | 4,466
atypical teratoid / rhabdoid tumor 4,173 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,192 | 3,289
malignant mesothelioma 3,071 | 3,162
Breast cancer 2,994 | 3,094
pilocytic astrocytoma 2,919 | 3,086
primitive neuroectodermal tumor 2,909 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,893 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,873 | 2,956
invasive ductal carcinoma 2,869 | 2,950
oligodendroglioma 2,724 | 2,849
non-small cell lung cancer 2,716 | 2,798
lung carcinoma 2,694 | 2,844
pediatric high grade glioma 2,603 | 2,712
lung adenocarcinoma 2,595 | 2,713
ependymoma 2,416 | 2,514
pancreatic cancer 2,218 | 2,300
subependymal giant cell astrocytoma 2,202 | 2,287
interstitial cystitis 2,194 | 2,299
group 3 medulloblastoma 2,151 | 2,254
astrocytic glioma 2,136 | 2,241
Cancer 2,097 | 2,346
adult high grade glioma 2,011 | 2,148
ulcerative colitis 2,003 | 2,087
Carcinoma 1,983 | 2,147
pituitary cancer 1,873 | 1,972
Pick disease 1,832 | 1,893
group 4 medulloblastoma 1,799 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,737 | 1,795
ductal carcinoma in situ 1,696 | 1,745
cystic fibrosis 1,624 | 1,665
breast carcinoma 1,568 | 1,614
tuberculosis 1,484 | 1,557
posterior fossa group B ependymoma 1,449 | 1,530
medulloblastoma 1,446 | 1,524
astrocytoma 1,438 | 1,493
posterior fossa group A ependymoma 1,434 | 1,511
sonic hedgehog group medulloblastoma 1,431 | 1,482
colon cancer 1,415 | 1,475
adrenocortical carcinoma 1,396 | 1,427
diabetes mellitus 1,350 | 1,663
Multiple myeloma 1,299 | 1,327
primary pancreatic ductal adenocarcinoma 1,251 | 1,271
juvenile dermatomyositis 1,154 | 1,189
acute quadriplegic myopathy 1,133 | 1,157
Rheumatoid Arthritis 1,069 | 1,160
atypical teratoid/rhabdoid tumor 1,051 | 1,095
spina bifida 1,034 | 1,064
nasopharyngeal carcinoma 1,013 | 1,056
cutaneous lupus erythematosus 998 | 1,056
dermatomyositis 914 | 933
Atopic dermatitis 896 | 944
active Crohn's disease 872 | 918
gastric carcinoma 807 | 832
non primary Sjogren syndrome sicca 780 | 840
acute myeloid leukemia 756 | 780
primary Sjogren syndrome 753 | 789
Waldenstrons macroglobulinemia 748 | 765
esophageal adenocarcinoma 722 | 737
tuberculosis and treatment for 6 months 663 | 686
progressive supranuclear palsy 657 | 674
aldosterone-producing adenoma 648 | 664
Alzheimer's disease 600 | 644
Duchenne muscular dystrophy 583 | 602
Obesity 565 | 616
Intellectual disability 549 | 573
pancreatic carcinoma 545 | 567
fibroadenoma 541 | 557
Down syndrome 527 | 548
Endometriosis 515 | 535
hepatocellular carcinoma 509 | 532
chronic rhinosinusitis 489 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 483 | 499
mucosa-associated lymphoid tissue lymphoma 456 | 480
active ulcerative colitis 450 | 477
Prostatic Neoplasms 446 | 471
Schizophrenia 441 | 501
IGA Glomerulonephritis 440 | 454
Multiple Sclerosis 421 | 498
Amyotrophic Lateral Sclerosis 418 | 431
gastric cancer 406 | 430
Mammary Neoplasms 393 | 410
inflammatory breast cancer 382 | 404
non-small cell lung carcinoma 375 | 413
Neurodegenerative disease 372 | 383
Parkinson's disease 342 | 364
Kidney disease 336 | 396
glioblastoma multiforme 336 | 347
sarcoidosis 333 | 358
tuberculosis and treatment for 3 months 316 | 327
Polycystic Ovary Syndrome 313 | 332
hereditary spastic paraplegia 312 | 313
Epilepsy 311 | 346
urothelial carcinoma 308 | 318
Asthma 305 | 349

Tissue

Skin and soft tissues 16,617 | 18,115
Female tissues 16,607 | 18,647
Endocrine System 16,601 | 18,512
Nervous System 16,601 | 18,561
Digestive Tract 16,600 | 18,473
Urinary Tract 16,597 | 18,444
Cardiovascular System 16,524 | 17,958
Liver and Pancreas 16,519 | 18,136
Male tissues 16,474 | 17,969
Blood and immune system 16,457 | 17,995
Respiratory system 16,357 | 17,484

Target Family

Non-IDG 9,631 | 11,971
Enzyme 3,784 | 4,146
Transcription Factor 1,240 | 1,400
Kinase 605 | 634
Transporter 422 | 473
GPCR 291 | 406
Ion Channel 287 | 341
Epigenetic 230 | 242
Nuclear Receptor 46 | 48
oGPCR 46 | 421
TF/Epigenetic 35 | 38

GTEx Tissue

Cells - Transformed fibroblast... 16,617 | 16,617
Testis 18,073 | 18,073
Cervix - Ectocervix 17,913 | 17,913
Bladder 17,870 | 17,870
Minor Salivary Gland 17,629 | 17,629
Fallopian Tube 17,588 | 17,588
Kidney - Cortex 17,583 | 17,583
Brain - Substantia nigra 17,565 | 17,565
Brain - Putamen (basal ganglia... 17,524 | 17,524
Cervix - Endocervix 17,505 | 17,505
Pituitary 17,482 | 17,482
Brain - Cortex 17,478 | 17,478
Brain - Cerebellum 17,468 | 17,468
Brain - Amygdala 17,451 | 17,451
Brain - Hypothalamus 17,433 | 17,433
Small Intestine - Terminal Ile... 17,427 | 17,427
Cells - EBV-transformed lympho... 17,415 | 17,415
Brain - Frontal Cortex (BA9) 17,403 | 17,403
Brain - Anterior cingulate cor... 17,375 | 17,375
Brain - Nucleus accumbens (bas... 17,317 | 17,317
Brain - Caudate (basal ganglia... 17,304 | 17,304
Brain - Spinal cord (cervical ... 17,276 | 17,276
Colon - Sigmoid 17,276 | 17,276
Brain - Hippocampus 17,260 | 17,260
Colon - Transverse 17,246 | 17,246
Esophagus - Mucosa 17,241 | 17,241
Brain - Cerebellar Hemisphere 17,239 | 17,239
Breast - Mammary Tissue 17,184 | 17,184
Prostate 17,183 | 17,183
Skin - Sun Exposed (Lower leg) 17,177 | 17,177
Pancreas 17,145 | 17,145
Stomach 17,142 | 17,142
Skin - Not Sun Exposed (Suprap... 17,122 | 17,122
Nerve - Tibial 17,121 | 17,121
Liver 17,115 | 17,115
Heart - Atrial Appendage 17,103 | 17,103
Spleen 17,060 | 17,060
Adipose - Subcutaneous 17,041 | 17,041
Lung 17,032 | 17,032
Vagina 16,992 | 16,992
Thyroid 16,985 | 16,985
Artery - Coronary 16,969 | 16,969
Adipose - Visceral (Omentum) 16,959 | 16,959
Adrenal Gland 16,956 | 16,956
Esophagus - Gastroesophageal J... 16,944 | 16,944
Ovary 16,866 | 16,866
Esophagus - Muscularis 16,863 | 16,863
Uterus 16,749 | 16,749
Heart - Left Ventricle 16,746 | 16,746
Artery - Aorta 16,700 | 16,700
Artery - Tibial 16,610 | 16,610
Muscle - Skeletal 16,594 | 16,594
Whole Blood 16,360 | 16,360

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
F-box only protein 47 FBXO47 Tdark Non-IDG 0.08 0.95 47
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102