Development Level

Tbio 11,170 | 11,651
Tdark 4,899 | 6,593
Tchem 1,368 | 1,388
Tclin 602 | 612

Collection

RFA-RM-18-021 311 | 328
Kinase: IDG Consortium (Target... 122 | 125
GPCR: IDG Consortium (Targets) 114 | 126
Ion Channel: IDG Consortium (T... 95 | 99
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 24 | 25

IMPC Phenotype

preweaning lethality, complete... 967 | 979
preweaning lethality, incomple... 493 | 499
abnormal behavior 293 | 298
embryonic lethality prior to t... 276 | 278
embryonic lethality prior to o... 238 | 239
abnormal embryo size 217 | 220
enlarged heart 205 | 210
decreased total body fat amoun... 201 | 207
decreased vertical activity 200 | 208
abnormal bone structure 182 | 187
increased lean body mass 165 | 172
abnormal heart morphology 160 | 162
decreased body weight 158 | 161
decreased bone mineral content 148 | 151
hyperactivity 145 | 148
decreased lean body mass 132 | 135
hypoactivity 129 | 132
increased total body fat amoun... 128 | 134
decreased circulating glucose ... 125 | 126
decreased bone mineral density 124 | 126
male infertility 121 | 123
increased circulating alkaline... 119 | 122
abnormal seminal vesicle morph... 114 | 114
decreased grip strength 113 | 116
embryonic growth retardation 106 | 106
increased startle reflex 106 | 112
increased bone mineral content 105 | 108
decreased body length 100 | 101
increased or absent threshold ... 99 | 101
short tibia 95 | 97
increased mean corpuscular hem... 94 | 96
increased mean corpuscular vol... 92 | 92
cataract 90 | 92
decreased circulating choleste... 90 | 93
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 82 | 83
decreased circulating serum al... 81 | 82
decreased prepulse inhibition 80 | 82
abnormal lens morphology 79 | 81
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 78 | 79
increased circulating HDL chol... 78 | 80
improved glucose tolerance 77 | 79
decreased startle reflex 75 | 75
increased fasted circulating g... 75 | 76
decreased circulating insulin ... 73 | 76
decreased leukocyte cell numbe... 73 | 73
small superior vagus ganglion 72 | 74
impaired glucose tolerance 71 | 75
increased bone mineral density 71 | 72
increased circulating sodium l... 71 | 71
abnormal retina morphology 69 | 71
abnormal sleep behavior 69 | 70
abnormal eye morphology 68 | 68
decreased hemoglobin content 67 | 68
abnormal gait 66 | 69
decreased circulating HDL chol... 66 | 68
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
abnormal behavioral response t... 64 | 66
abnormal coat-hair pigmentatio... 64 | 64
decreased fasted circulating g... 63 | 65
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 61 | 62
female infertility 58 | 60
increased heart weight 58 | 62
edema 57 | 59
small testis 56 | 58
abnormal spleen morphology 53 | 55
thrombocytopenia 53 | 56
decreased caudal vertebrae num... 52 | 53
hydrometra 50 | 53
abnormal skin morphology 49 | 50
decreased blood urea nitrogen ... 49 | 51
decreased mean corpuscular hem... 49 | 50
decreased circulating total pr... 48 | 49
increased blood urea nitrogen ... 47 | 48
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alanine ... 46 | 47
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
decreased hematocrit 45 | 46
decreased circulating alkaline... 44 | 46
increased mean platelet volume 44 | 45
increased hemoglobin content 43 | 45
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
abnormal epididymis morphology 41 | 42
abnormal testis morphology 41 | 43
enlarged spleen 41 | 41
decreased red blood cell distr... 40 | 41
limb grasping 40 | 41
increased circulating chloride... 39 | 41
increased erythrocyte cell num... 39 | 39
decreased circulating LDL chol... 38 | 38
increased circulating creatini... 38 | 38
increased grip strength 38 | 41
abnormal bone mineralization 37 | 38
prolonged QT interval 37 | 38

Disease

Carcinoma 10,930 | 11,493
ovarian cancer 8,341 | 8,520
osteosarcoma 7,741 | 7,950
psoriasis 6,363 | 6,694
medulloblastoma, large-cell 6,106 | 6,241
glioblastoma 5,701 | 5,792
atypical teratoid / rhabdoid tumor 5,032 | 5,112
lung cancer 4,620 | 4,740
ependymoma 4,614 | 4,679
group 3 medulloblastoma 4,034 | 4,104
adult high grade glioma 3,724 | 3,801
Breast cancer 3,505 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,227 | 3,291
malignant mesothelioma 3,166 | 3,232
Astrocytoma, Pilocytic 3,039 | 3,081
primitive neuroectodermal tumor 2,993 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,932 | 2,989
invasive ductal carcinoma 2,905 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,901 | 2,955
non-small cell lung cancer 2,844 | 2,890
oligodendroglioma 2,812 | 2,850
lung carcinoma 2,787 | 2,843
lung adenocarcinoma 2,657 | 2,716
astrocytic glioma 2,558 | 2,597
Kidney cancer 2,548 | 2,613
pancreatic cancer 2,354 | 2,398
Cancer 2,331 | 2,499
interstitial cystitis 2,265 | 2,312
subependymal giant cell astrocytoma 2,250 | 2,287
tuberculosis 1,945 | 2,010
pituitary cancer 1,939 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,935 | 1,962
Pick disease 1,874 | 1,894
group 4 medulloblastoma 1,830 | 1,855
ulcerative colitis 1,783 | 1,819
ductal carcinoma in situ 1,719 | 1,745
cystic fibrosis 1,668 | 1,696
breast carcinoma 1,612 | 1,638
diabetes mellitus 1,525 | 1,728
colon cancer 1,448 | 1,478
Autosomal recessive predisposition 1,418 | 1,442
adrenocortical carcinoma 1,410 | 1,428
Multiple myeloma 1,319 | 1,332
juvenile dermatomyositis 1,169 | 1,187
acute quadriplegic myopathy 1,142 | 1,158
astrocytoma 1,127 | 1,146
Rheumatoid arthritis 1,120 | 1,191
Schizophrenia 1,120 | 1,160
primary pancreatic ductal adenocarcinoma 1,102 | 1,109
spina bifida 1,050 | 1,074
pediatric high grade glioma 1,048 | 1,064
nasopharyngeal carcinoma 1,046 | 1,058
cutaneous lupus erythematosus 1,040 | 1,057
Intellectual disability 993 | 1,016
Atopic dermatitis 923 | 952
dermatomyositis 920 | 966
active Crohn's disease 896 | 922
non primary Sjogren syndrome sicca 865 | 891
gastric carcinoma 795 | 807
Epilepsy 781 | 792
acute myeloid leukemia 775 | 783
Liver Cirrhosis, Experimental 759 | 769
Waldenstrons macroglobulinemia 758 | 765
active ulcerative colitis 743 | 764
esophageal adenocarcinoma 730 | 737
primary Sjogren syndrome 721 | 735
medulloblastoma 704 | 720
Melanoma 687 | 711
progressive supranuclear palsy 665 | 676
aldosterone-producing adenoma 657 | 665
Obesity 655 | 678
Bipolar Disorder 647 | 666
Alzheimer's disease 641 | 658
Dull intelligence 635 | 645
Low intelligence 635 | 645
Mental Retardation 635 | 645
Mental deficiency 635 | 645
Poor school performance 635 | 645
Cognitive delay 605 | 608
Global developmental delay 605 | 608
Mental and motor retardation 605 | 608
Seizures 590 | 596
Duchenne muscular dystrophy 588 | 601
Liver cancer 578 | 604
Muscle hypotonia 565 | 571
pancreatic carcinoma 555 | 562
fibroadenoma 552 | 559
hepatocellular carcinoma 537 | 547
Endometriosis 532 | 540
Short stature 521 | 531
chronic rhinosinusitis 507 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 501 | 510
Multiple Sclerosis 495 | 540
Down syndrome 487 | 499
Prostatic Neoplasms 481 | 495
mucosa-associated lymphoid tissue lymphoma 473 | 484
posterior fossa group A ependymoma 462 | 468
sonic hedgehog group medulloblastoma 458 | 467
Skin cancer 457 | 469
gastric cancer 449 | 459

Tissue

Endocrine System 17,582 | 18,159
Female tissues 17,020 | 17,400
Digestive Tract 16,986 | 17,369
Skin and soft tissues 16,876 | 17,230
Male tissues 16,772 | 17,142
Blood and immune system 16,578 | 16,909
Nervous System 16,472 | 16,725
Liver and Pancreas 16,451 | 16,750
Urinary Tract 16,394 | 16,678
Respiratory system 16,125 | 16,393
Cardiovascular System 15,003 | 15,192

Target Family

Non-IDG 10,488 | 12,091
Enzyme 3,946 | 4,145
Transcription Factor 1,353 | 1,400
Kinase 623 | 634
Transporter 457 | 473
GPCR 373 | 408
Ion Channel 334 | 344
Epigenetic 235 | 242
oGPCR 146 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38

GTEx Tissue

Brain - Cortex 18,039 | 18,039
Testis 18,518 | 18,518
Prostate 18,213 | 18,213
Cells - EBV-transformed lympho... 18,186 | 18,186
Brain - Hypothalamus 18,169 | 18,169
Pituitary 18,147 | 18,147
Pancreas 18,123 | 18,123
Adipose - Subcutaneous 18,110 | 18,110
Breast - Mammary Tissue 18,103 | 18,103
Colon - Sigmoid 18,089 | 18,089
Skin - Not Sun Exposed (Suprap... 18,081 | 18,081
Esophagus - Mucosa 18,076 | 18,076
Adrenal Gland 18,071 | 18,071
Liver 18,071 | 18,071
Brain - Frontal Cortex (BA9) 18,069 | 18,069
Lung 18,057 | 18,057
Brain - Nucleus accumbens (bas... 18,024 | 18,024
Thyroid 18,024 | 18,024
Esophagus - Muscularis 18,017 | 18,017
Brain - Cerebellar Hemisphere 18,015 | 18,015
Brain - Hippocampus 18,011 | 18,011
Nerve - Tibial 18,007 | 18,007
Brain - Amygdala 18,006 | 18,006
Heart - Left Ventricle 18,006 | 18,006
Minor Salivary Gland 18,005 | 18,005
Brain - Caudate (basal ganglia... 18,001 | 18,001
Esophagus - Gastroesophageal J... 18,000 | 18,000
Brain - Anterior cingulate cor... 17,989 | 17,989
Brain - Cerebellum 17,983 | 17,983
Brain - Substantia nigra 17,981 | 17,981
Brain - Spinal cord (cervical ... 17,973 | 17,973
Ovary 17,971 | 17,971
Skin - Sun Exposed (Lower leg) 17,968 | 17,968
Small Intestine - Terminal Ile... 17,954 | 17,954
Artery - Coronary 17,949 | 17,949
Adipose - Visceral (Omentum) 17,937 | 17,937
Artery - Aorta 17,896 | 17,896
Heart - Atrial Appendage 17,896 | 17,896
Stomach 17,879 | 17,879
Brain - Putamen (basal ganglia... 17,863 | 17,863
Vagina 17,834 | 17,834
Colon - Transverse 17,825 | 17,825
Muscle - Skeletal 17,778 | 17,778
Artery - Tibial 17,631 | 17,631
Uterus 17,618 | 17,618
Spleen 17,614 | 17,614
Cells - Transformed fibroblast... 17,577 | 17,577
Whole Blood 17,439 | 17,439
Kidney - Cortex 17,329 | 17,329

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Interleukin-9 IL9 Tbio Non-IDG -2.50811 334.4 459
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115