Development Level

Tbio 9,951 | 10,625
Tdark 4,964 | 7,003
Tchem 1,810 | 1,890
Tclin 579 | 602

Collection

Eligible Kinase Proteins 128 | 134
Eligible non-olfactory GPCR Proteins 112 | 143
Eligible Ion Channel Proteins 108 | 117

IMPC Term

preweaning lethality, complete... 621 | 633
preweaning lethality, incomple... 254 | 260
abnormal behavior 222 | 226
decreased lean body mass 189 | 195
embryonic lethality prior to t... 185 | 187
decreased total body fat amoun... 182 | 186
decreased body weight 165 | 174
decreased bone mineral content 152 | 157
embryonic lethality prior to o... 147 | 148
abnormal bone structure 125 | 131
increased or absent threshold ... 124 | 128
decreased bone mineral density 122 | 126
decreased circulating glucose ... 117 | 121
decreased grip strength 117 | 123
increased circulating alkaline... 114 | 119
enlarged heart 108 | 111
abnormal embryo size 107 | 112
decreased body length 107 | 108
hyperactivity 104 | 108
increased lean body mass 103 | 107
abnormal retina morphology 97 | 100
increased mean corpuscular vol... 91 | 91
increased bone mineral content 90 | 92
increased mean corpuscular hem... 90 | 93
hypoactivity 88 | 89
decreased circulating choleste... 83 | 85
increased grip strength 81 | 83
decreased circulating triglyce... 80 | 83
short tibia 80 | 82
decreased circulating serum al... 76 | 79
decreased circulating HDL chol... 75 | 77
decreased circulating insulin ... 72 | 75
abnormal lens morphology 71 | 73
increased circulating sodium l... 70 | 71
increased fasted circulating g... 65 | 68
prenatal lethality prior to he... 62 | 64
abnormal sleep behavior 61 | 63
decreased lumbar vertebrae num... 60 | 62
increased circulating HDL chol... 60 | 63
increased sacral vertebrae num... 60 | 62
male infertility 60 | 62
abnormal retinal pigmentation 59 | 61
decreased rib number 57 | 59
increased exploration in new e... 56 | 56
improved glucose tolerance 55 | 56
increased total body fat amoun... 54 | 57
decreased leukocyte cell numbe... 53 | 54
abnormal coat/hair pigmentatio... 52 | 54
abnormal behavioral response t... 51 | 52
abnormal heart morphology 51 | 51
decreased hemoglobin content 51 | 53
decreased prepulse inhibition 51 | 52
increased bone mineral density 51 | 52
abnormal bone mineralization 50 | 55
increased circulating choleste... 50 | 53
abnormal gait 49 | 51
decreased circulating alanine ... 49 | 53
decreased mean corpuscular vol... 49 | 50
impaired glucose tolerance 49 | 52
decreased caudal vertebrae num... 48 | 49
decreased fasted circulating g... 48 | 49
decreased startle reflex 47 | 48
decreased heart weight 44 | 44
thrombocytopenia 44 | 46
abnormal seminal vesicle morph... 43 | 47
increased hemoglobin content 43 | 45
decreased erythrocyte cell num... 42 | 43
increased blood urea nitrogen ... 42 | 44
increased body weight 42 | 42
decreased eosinophil cell numb... 41 | 41
increased circulating chloride... 41 | 43
decreased circulating total pr... 40 | 41
increased rib number 40 | 41
decreased circulating free fat... 38 | 39
increased startle reflex 37 | 38
abnormal eye morphology 36 | 38
decreased circulating LDL chol... 36 | 37
decreased circulating alkaline... 36 | 41
small testis 36 | 37
abnormal neural tube closure 35 | 37
abnormal spleen morphology 35 | 36
decreased neutrophil cell numb... 35 | 37
increased hematocrit 35 | 36
increased leukocyte cell numbe... 35 | 37
cardiovascular system phenotyp... 34 | 35
limb grasping 34 | 35
decreased mean corpuscular hem... 33 | 34
abnormal cranium morphology 32 | 32
decreased circulating calcium ... 32 | 33
increased heart weight 32 | 37
tremors 32 | 34
female infertility 31 | 34
increased circulating calcium ... 31 | 32
increased circulating potassiu... 31 | 31
decreased T cell number 30 | 31
decreased blood urea nitrogen ... 30 | 31
decreased circulating chloride... 30 | 32
decreased circulating creatini... 30 | 31
abnormal testis morphology 29 | 30
decreased circulating fructosa... 29 | 31

Disease

ovarian cancer 8,214 | 8,484
osteosarcoma 7,608 | 7,933
psoriasis 6,199 | 6,685
medulloblastoma, large-cell 6,029 | 6,234
glioblastoma 5,443 | 5,572
lung cancer 4,343 | 4,466
atypical teratoid / rhabdoid tumor 4,266 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,212 | 3,289
malignant mesothelioma 3,070 | 3,162
pilocytic astrocytoma 3,020 | 3,086
Breast cancer 3,007 | 3,094
primitive neuroectodermal tumor 2,973 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,912 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,888 | 2,956
invasive ductal carcinoma 2,885 | 2,950
oligodendroglioma 2,798 | 2,849
lung carcinoma 2,762 | 2,844
non-small cell lung cancer 2,733 | 2,798
pediatric high grade glioma 2,660 | 2,712
lung adenocarcinoma 2,633 | 2,713
ependymoma 2,469 | 2,514
pancreatic cancer 2,242 | 2,300
subependymal giant cell astrocytoma 2,238 | 2,287
interstitial cystitis 2,235 | 2,299
astrocytic glioma 2,200 | 2,241
group 3 medulloblastoma 2,191 | 2,254
Cancer 2,134 | 2,346
adult high grade glioma 2,066 | 2,148
Carcinoma 2,049 | 2,147
ulcerative colitis 2,025 | 2,087
pituitary cancer 1,918 | 1,972
Pick disease 1,861 | 1,893
group 4 medulloblastoma 1,825 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,738 | 1,795
ductal carcinoma in situ 1,709 | 1,745
cystic fibrosis 1,623 | 1,665
breast carcinoma 1,577 | 1,614
tuberculosis 1,506 | 1,557
medulloblastoma 1,496 | 1,524
posterior fossa group B ependymoma 1,491 | 1,530
posterior fossa group A ependymoma 1,477 | 1,511
astrocytoma 1,457 | 1,493
sonic hedgehog group medulloblastoma 1,452 | 1,482
colon cancer 1,422 | 1,475
adrenocortical carcinoma 1,405 | 1,427
diabetes mellitus 1,405 | 1,663
Multiple myeloma 1,304 | 1,327
primary pancreatic ductal adenocarcinoma 1,254 | 1,271
juvenile dermatomyositis 1,161 | 1,189
acute quadriplegic myopathy 1,138 | 1,157
Rheumatoid Arthritis 1,078 | 1,160
atypical teratoid/rhabdoid tumor 1,068 | 1,095
spina bifida 1,037 | 1,064
nasopharyngeal carcinoma 1,033 | 1,056
cutaneous lupus erythematosus 1,019 | 1,056
dermatomyositis 914 | 933
Atopic dermatitis 895 | 944
active Crohn's disease 883 | 918
gastric carcinoma 817 | 832
non primary Sjogren syndrome sicca 799 | 840
primary Sjogren syndrome 767 | 789
acute myeloid leukemia 764 | 780
Waldenstrons macroglobulinemia 753 | 765
esophageal adenocarcinoma 726 | 737
tuberculosis and treatment for 6 months 669 | 686
progressive supranuclear palsy 660 | 674
aldosterone-producing adenoma 654 | 664
Alzheimer's disease 614 | 644
Obesity 592 | 616
Duchenne muscular dystrophy 584 | 602
Intellectual disability 558 | 573
pancreatic carcinoma 554 | 567
fibroadenoma 545 | 557
Down syndrome 534 | 548
Endometriosis 521 | 535
hepatocellular carcinoma 516 | 532
chronic rhinosinusitis 503 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 488 | 499
Schizophrenia 472 | 501
mucosa-associated lymphoid tissue lymphoma 467 | 480
active ulcerative colitis 456 | 477
Prostatic Neoplasms 454 | 471
Multiple Sclerosis 444 | 498
IGA Glomerulonephritis 443 | 454
Amyotrophic Lateral Sclerosis 424 | 431
gastric cancer 412 | 430
non-small cell lung carcinoma 396 | 413
Mammary Neoplasms 395 | 410
inflammatory breast cancer 386 | 404
Neurodegenerative disease 372 | 383
Parkinson's disease 354 | 364
Kidney disease 351 | 396
sarcoidosis 344 | 358
glioblastoma multiforme 343 | 347
Epilepsy 336 | 346
Asthma 324 | 349
tuberculosis and treatment for 3 months 322 | 327
Polycystic Ovary Syndrome 321 | 332
nephrosclerosis 317 | 329
hereditary spastic paraplegia 312 | 313

Tissue

Nervous System 17,304 | 18,561
Endocrine System 17,293 | 18,512
Female tissues 17,277 | 18,647
Digestive Tract 17,258 | 18,473
Urinary Tract 17,250 | 18,444
Skin and soft tissues 17,224 | 18,115
Liver and Pancreas 17,117 | 18,136
Cardiovascular System 17,098 | 17,958
Male tissues 17,013 | 17,969
Blood and immune system 17,003 | 17,995
Respiratory system 16,862 | 17,484

Target Family

Non-IDG 10,033 | 11,971
Enzyme 3,851 | 4,146
Transcription Factor 1,297 | 1,400
Kinase 612 | 634
Transporter 448 | 473
GPCR 351 | 406
Ion Channel 326 | 341
Epigenetic 232 | 242
oGPCR 72 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 35 | 38

GTEx Tissue

Brain - Caudate (basal ganglia... 17,304 | 17,304
Testis 18,073 | 18,073
Cervix - Ectocervix 17,913 | 17,913
Bladder 17,870 | 17,870
Minor Salivary Gland 17,629 | 17,629
Fallopian Tube 17,588 | 17,588
Kidney - Cortex 17,583 | 17,583
Brain - Substantia nigra 17,565 | 17,565
Brain - Putamen (basal ganglia... 17,524 | 17,524
Cervix - Endocervix 17,505 | 17,505
Pituitary 17,482 | 17,482
Brain - Cortex 17,478 | 17,478
Brain - Cerebellum 17,468 | 17,468
Brain - Amygdala 17,451 | 17,451
Brain - Hypothalamus 17,433 | 17,433
Small Intestine - Terminal Ile... 17,427 | 17,427
Cells - EBV-transformed lympho... 17,415 | 17,415
Brain - Frontal Cortex (BA9) 17,403 | 17,403
Brain - Anterior cingulate cor... 17,375 | 17,375
Brain - Nucleus accumbens (bas... 17,317 | 17,317
Brain - Spinal cord (cervical ... 17,276 | 17,276
Colon - Sigmoid 17,276 | 17,276
Brain - Hippocampus 17,260 | 17,260
Colon - Transverse 17,246 | 17,246
Esophagus - Mucosa 17,241 | 17,241
Brain - Cerebellar Hemisphere 17,239 | 17,239
Breast - Mammary Tissue 17,184 | 17,184
Prostate 17,183 | 17,183
Skin - Sun Exposed (Lower leg) 17,177 | 17,177
Pancreas 17,145 | 17,145
Stomach 17,142 | 17,142
Skin - Not Sun Exposed (Suprap... 17,122 | 17,122
Nerve - Tibial 17,121 | 17,121
Liver 17,115 | 17,115
Heart - Atrial Appendage 17,103 | 17,103
Spleen 17,060 | 17,060
Adipose - Subcutaneous 17,041 | 17,041
Lung 17,032 | 17,032
Vagina 16,992 | 16,992
Thyroid 16,985 | 16,985
Artery - Coronary 16,969 | 16,969
Adipose - Visceral (Omentum) 16,959 | 16,959
Adrenal Gland 16,956 | 16,956
Esophagus - Gastroesophageal J... 16,944 | 16,944
Ovary 16,866 | 16,866
Esophagus - Muscularis 16,863 | 16,863
Uterus 16,749 | 16,749
Heart - Left Ventricle 16,746 | 16,746
Artery - Aorta 16,700 | 16,700
Cells - Transformed fibroblast... 16,617 | 16,617
Artery - Tibial 16,610 | 16,610
Muscle - Skeletal 16,594 | 16,594
Whole Blood 16,360 | 16,360

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
F-box only protein 47 FBXO47 Tdark Non-IDG 0.08 0.95 47
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102