Development Level

Tbio 11,122 | 11,651
Tdark 4,822 | 6,593
Tchem 1,361 | 1,388
Tclin 591 | 612

Collection

RFA-RM-18-021 306 | 328
Kinase: IDG Consortium (Target... 120 | 125
GPCR: IDG Consortium (Targets) 111 | 126
Ion Channel: IDG Consortium (T... 94 | 99
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 965 | 979
preweaning lethality, incomple... 493 | 499
abnormal behavior 292 | 298
embryonic lethality prior to t... 275 | 278
embryonic lethality prior to o... 238 | 239
abnormal embryo size 215 | 220
enlarged heart 204 | 210
decreased total body fat amoun... 202 | 207
decreased vertical activity 198 | 208
abnormal bone structure 182 | 187
increased lean body mass 165 | 172
abnormal heart morphology 158 | 162
decreased body weight 156 | 161
decreased bone mineral content 148 | 151
hyperactivity 146 | 148
decreased lean body mass 133 | 135
hypoactivity 131 | 132
increased total body fat amoun... 129 | 134
decreased bone mineral density 125 | 126
decreased circulating glucose ... 125 | 126
male infertility 122 | 123
increased circulating alkaline... 120 | 122
decreased grip strength 113 | 116
abnormal seminal vesicle morph... 111 | 114
embryonic growth retardation 105 | 106
increased bone mineral content 105 | 108
increased startle reflex 105 | 112
decreased body length 99 | 101
increased or absent threshold ... 99 | 101
short tibia 96 | 97
increased mean corpuscular hem... 94 | 96
increased mean corpuscular vol... 92 | 92
decreased circulating choleste... 91 | 93
cataract 89 | 92
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 82 | 83
decreased prepulse inhibition 81 | 82
decreased circulating serum al... 80 | 82
abnormal lens morphology 79 | 81
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 78 | 79
increased circulating HDL chol... 78 | 80
improved glucose tolerance 77 | 79
decreased startle reflex 75 | 75
decreased circulating insulin ... 74 | 76
increased fasted circulating g... 74 | 76
decreased leukocyte cell numbe... 73 | 73
impaired glucose tolerance 72 | 75
small superior vagus ganglion 72 | 74
increased bone mineral density 71 | 72
increased circulating sodium l... 71 | 71
abnormal retina morphology 69 | 71
abnormal sleep behavior 69 | 70
abnormal eye morphology 68 | 68
abnormal gait 67 | 69
decreased circulating HDL chol... 67 | 68
decreased hemoglobin content 66 | 68
increased circulating choleste... 66 | 66
abnormal behavioral response t... 65 | 66
abnormal kidney morphology 64 | 65
abnormal coat-hair pigmentatio... 63 | 64
decreased fasted circulating g... 63 | 65
increased monocyte cell number 62 | 63
decreased erythrocyte cell num... 61 | 62
female infertility 59 | 60
edema 57 | 59
increased heart weight 57 | 62
small testis 56 | 58
abnormal spleen morphology 53 | 55
thrombocytopenia 53 | 56
decreased caudal vertebrae num... 52 | 53
hydrometra 50 | 53
abnormal skin morphology 49 | 50
decreased blood urea nitrogen ... 49 | 51
decreased mean corpuscular hem... 49 | 50
decreased circulating total pr... 48 | 49
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alanine ... 46 | 47
increased blood urea nitrogen ... 46 | 48
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
decreased circulating alkaline... 44 | 46
decreased hematocrit 44 | 46
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
increased hemoglobin content 42 | 45
increased mean platelet volume 42 | 45
abnormal testis morphology 41 | 43
enlarged spleen 41 | 41
limb grasping 40 | 41
decreased red blood cell distr... 39 | 41
increased circulating chloride... 39 | 41
increased erythrocyte cell num... 39 | 39
abnormal epididymis morphology 38 | 42
decreased circulating LDL chol... 38 | 38
increased circulating creatini... 38 | 38
increased grip strength 38 | 41
abnormal bone mineralization 37 | 38
decreased circulating creatini... 37 | 39

Disease

Carcinoma 10,844 | 11,493
ovarian cancer 8,330 | 8,520
osteosarcoma 7,733 | 7,950
psoriasis 6,341 | 6,694
medulloblastoma, large-cell 6,085 | 6,241
glioblastoma 5,687 | 5,792
atypical teratoid / rhabdoid tumor 5,013 | 5,112
lung cancer 4,611 | 4,740
ependymoma 4,598 | 4,679
group 3 medulloblastoma 4,018 | 4,104
adult high grade glioma 3,714 | 3,801
Breast cancer 3,499 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,229 | 3,291
malignant mesothelioma 3,163 | 3,232
Astrocytoma, Pilocytic 3,029 | 3,081
primitive neuroectodermal tumor 2,984 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,933 | 2,989
invasive ductal carcinoma 2,908 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,903 | 2,955
non-small cell lung cancer 2,842 | 2,890
oligodendroglioma 2,800 | 2,850
lung carcinoma 2,780 | 2,843
lung adenocarcinoma 2,662 | 2,716
astrocytic glioma 2,549 | 2,597
Kidney cancer 2,538 | 2,613
pancreatic cancer 2,356 | 2,398
Cancer 2,327 | 2,499
interstitial cystitis 2,270 | 2,312
subependymal giant cell astrocytoma 2,246 | 2,287
tuberculosis 1,948 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,935 | 1,962
pituitary cancer 1,930 | 1,972
Pick disease 1,871 | 1,894
group 4 medulloblastoma 1,827 | 1,855
ulcerative colitis 1,784 | 1,819
ductal carcinoma in situ 1,722 | 1,745
cystic fibrosis 1,663 | 1,696
breast carcinoma 1,611 | 1,638
diabetes mellitus 1,500 | 1,728
colon cancer 1,447 | 1,478
Autosomal recessive predisposition 1,413 | 1,442
adrenocortical carcinoma 1,410 | 1,428
Multiple myeloma 1,321 | 1,332
juvenile dermatomyositis 1,168 | 1,187
acute quadriplegic myopathy 1,142 | 1,158
astrocytoma 1,126 | 1,146
Rheumatoid arthritis 1,120 | 1,191
Schizophrenia 1,105 | 1,160
primary pancreatic ductal adenocarcinoma 1,103 | 1,109
spina bifida 1,051 | 1,074
pediatric high grade glioma 1,047 | 1,064
nasopharyngeal carcinoma 1,041 | 1,058
cutaneous lupus erythematosus 1,039 | 1,057
Intellectual disability 991 | 1,016
Atopic dermatitis 927 | 952
dermatomyositis 920 | 966
active Crohn's disease 897 | 922
non primary Sjogren syndrome sicca 865 | 891
gastric carcinoma 793 | 807
acute myeloid leukemia 775 | 783
Epilepsy 772 | 792
Liver Cirrhosis, Experimental 759 | 769
Waldenstrons macroglobulinemia 758 | 765
active ulcerative colitis 743 | 764
esophageal adenocarcinoma 731 | 737
primary Sjogren syndrome 721 | 735
medulloblastoma 702 | 720
Melanoma 681 | 711
progressive supranuclear palsy 664 | 676
aldosterone-producing adenoma 656 | 665
Obesity 650 | 678
Alzheimer's disease 640 | 658
Bipolar Disorder 635 | 666
Dull intelligence 634 | 645
Low intelligence 634 | 645
Mental Retardation 634 | 645
Mental deficiency 634 | 645
Poor school performance 634 | 645
Cognitive delay 603 | 608
Global developmental delay 603 | 608
Mental and motor retardation 603 | 608
Duchenne muscular dystrophy 588 | 601
Seizures 584 | 596
Liver cancer 575 | 604
Muscle hypotonia 563 | 571
pancreatic carcinoma 555 | 562
fibroadenoma 552 | 559
hepatocellular carcinoma 537 | 547
Endometriosis 531 | 540
Short stature 517 | 531
chronic rhinosinusitis 504 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 501 | 510
Multiple Sclerosis 493 | 540
Down syndrome 484 | 499
Prostatic Neoplasms 482 | 495
mucosa-associated lymphoid tissue lymphoma 473 | 484
posterior fossa group A ependymoma 462 | 468
sonic hedgehog group medulloblastoma 458 | 467
gastric cancer 449 | 459
Skin cancer 448 | 469

Tissue

Endocrine System 17,440 | 18,159
Female tissues 16,949 | 17,400
Digestive Tract 16,919 | 17,369
Skin and soft tissues 16,820 | 17,230
Male tissues 16,690 | 17,142
Blood and immune system 16,532 | 16,909
Liver and Pancreas 16,423 | 16,750
Nervous System 16,401 | 16,725
Urinary Tract 16,350 | 16,678
Respiratory system 16,101 | 16,393
Cardiovascular System 14,995 | 15,192

Target Family

Non-IDG 10,435 | 12,091
Enzyme 3,922 | 4,145
Transcription Factor 1,340 | 1,400
Kinase 620 | 634
Transporter 455 | 473
GPCR 362 | 408
Ion Channel 327 | 344
Epigenetic 235 | 242
oGPCR 116 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38

GTEx Tissue

Artery - Aorta 17,896 | 17,896
Testis 18,518 | 18,518
Prostate 18,213 | 18,213
Cells - EBV-transformed lympho... 18,186 | 18,186
Brain - Hypothalamus 18,169 | 18,169
Pituitary 18,147 | 18,147
Pancreas 18,123 | 18,123
Adipose - Subcutaneous 18,110 | 18,110
Breast - Mammary Tissue 18,103 | 18,103
Colon - Sigmoid 18,089 | 18,089
Skin - Not Sun Exposed (Suprap... 18,081 | 18,081
Esophagus - Mucosa 18,076 | 18,076
Adrenal Gland 18,071 | 18,071
Liver 18,071 | 18,071
Brain - Frontal Cortex (BA9) 18,069 | 18,069
Lung 18,057 | 18,057
Brain - Cortex 18,039 | 18,039
Brain - Nucleus accumbens (bas... 18,024 | 18,024
Thyroid 18,024 | 18,024
Esophagus - Muscularis 18,017 | 18,017
Brain - Cerebellar Hemisphere 18,015 | 18,015
Brain - Hippocampus 18,011 | 18,011
Nerve - Tibial 18,007 | 18,007
Brain - Amygdala 18,006 | 18,006
Heart - Left Ventricle 18,006 | 18,006
Minor Salivary Gland 18,005 | 18,005
Brain - Caudate (basal ganglia... 18,001 | 18,001
Esophagus - Gastroesophageal J... 18,000 | 18,000
Brain - Anterior cingulate cor... 17,989 | 17,989
Brain - Cerebellum 17,983 | 17,983
Brain - Substantia nigra 17,981 | 17,981
Brain - Spinal cord (cervical ... 17,973 | 17,973
Ovary 17,971 | 17,971
Skin - Sun Exposed (Lower leg) 17,968 | 17,968
Small Intestine - Terminal Ile... 17,954 | 17,954
Artery - Coronary 17,949 | 17,949
Adipose - Visceral (Omentum) 17,937 | 17,937
Heart - Atrial Appendage 17,896 | 17,896
Stomach 17,879 | 17,879
Brain - Putamen (basal ganglia... 17,863 | 17,863
Vagina 17,834 | 17,834
Colon - Transverse 17,825 | 17,825
Muscle - Skeletal 17,778 | 17,778
Artery - Tibial 17,631 | 17,631
Uterus 17,618 | 17,618
Spleen 17,614 | 17,614
Cells - Transformed fibroblast... 17,577 | 17,577
Whole Blood 17,439 | 17,439
Kidney - Cortex 17,329 | 17,329

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Interleukin-9 IL9 Tbio Non-IDG -2.50811 334.4 459
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115