Development Level

Tbio 9,827 | 10,625
Tdark 4,773 | 7,003
Tchem 1,790 | 1,890
Tclin 566 | 602

Collection

Eligible Kinase Proteins 127 | 134
Eligible Ion Channel Proteins 101 | 117
Eligible non-olfactory GPCR Proteins 96 | 143

IMPC Term

preweaning lethality, complete... 620 | 633
preweaning lethality, incomple... 254 | 260
abnormal behavior 221 | 226
decreased lean body mass 188 | 195
embryonic lethality prior to t... 183 | 187
decreased total body fat amoun... 182 | 186
decreased body weight 166 | 174
decreased bone mineral content 150 | 157
embryonic lethality prior to o... 147 | 148
increased or absent threshold ... 124 | 128
abnormal bone structure 123 | 131
decreased bone mineral density 118 | 126
decreased circulating glucose ... 118 | 121
decreased grip strength 117 | 123
increased circulating alkaline... 112 | 119
abnormal embryo size 108 | 112
decreased body length 106 | 108
enlarged heart 105 | 111
increased lean body mass 103 | 107
hyperactivity 102 | 108
abnormal retina morphology 96 | 100
increased mean corpuscular vol... 91 | 91
increased bone mineral content 90 | 92
increased mean corpuscular hem... 89 | 93
hypoactivity 86 | 89
decreased circulating choleste... 82 | 85
decreased circulating triglyce... 81 | 83
increased grip strength 81 | 83
short tibia 80 | 82
decreased circulating serum al... 77 | 79
decreased circulating HDL chol... 74 | 77
decreased circulating insulin ... 73 | 75
abnormal lens morphology 71 | 73
increased circulating sodium l... 68 | 71
increased fasted circulating g... 65 | 68
prenatal lethality prior to he... 61 | 64
abnormal sleep behavior 60 | 63
abnormal retinal pigmentation 59 | 61
decreased lumbar vertebrae num... 59 | 62
increased circulating HDL chol... 59 | 63
increased sacral vertebrae num... 59 | 62
male infertility 59 | 62
decreased rib number 57 | 59
improved glucose tolerance 54 | 56
increased exploration in new e... 53 | 56
increased total body fat amoun... 53 | 57
abnormal coat/hair pigmentatio... 52 | 54
decreased leukocyte cell numbe... 52 | 54
decreased prepulse inhibition 51 | 52
abnormal bone mineralization 50 | 55
abnormal gait 50 | 51
decreased hemoglobin content 50 | 53
increased bone mineral density 50 | 52
increased circulating choleste... 50 | 53
abnormal behavioral response t... 49 | 52
decreased circulating alanine ... 49 | 53
decreased mean corpuscular vol... 49 | 50
impaired glucose tolerance 49 | 52
abnormal heart morphology 48 | 51
decreased fasted circulating g... 48 | 49
decreased caudal vertebrae num... 47 | 49
decreased startle reflex 46 | 48
increased hemoglobin content 44 | 45
thrombocytopenia 43 | 46
abnormal seminal vesicle morph... 42 | 47
decreased erythrocyte cell num... 42 | 43
increased body weight 42 | 42
decreased eosinophil cell numb... 41 | 41
decreased heart weight 41 | 44
increased blood urea nitrogen ... 41 | 44
increased circulating chloride... 41 | 43
decreased circulating total pr... 40 | 41
increased rib number 40 | 41
decreased circulating free fat... 39 | 39
decreased circulating LDL chol... 37 | 37
increased startle reflex 37 | 38
abnormal eye morphology 36 | 38
decreased circulating alkaline... 36 | 41
decreased neutrophil cell numb... 36 | 37
small testis 36 | 37
abnormal neural tube closure 35 | 37
abnormal spleen morphology 34 | 36
cardiovascular system phenotyp... 34 | 35
increased hematocrit 34 | 36
decreased mean corpuscular hem... 33 | 34
increased leukocyte cell numbe... 33 | 37
abnormal cranium morphology 32 | 32
decreased circulating calcium ... 32 | 33
limb grasping 32 | 35
tremors 32 | 34
decreased circulating chloride... 31 | 32
decreased circulating fructosa... 31 | 31
female infertility 31 | 34
increased circulating calcium ... 31 | 32
increased circulating potassiu... 31 | 31
increased heart weight 31 | 37
decreased T cell number 30 | 31
decreased blood urea nitrogen ... 30 | 31
decreased circulating creatini... 30 | 31
abnormal testis morphology 29 | 30

Disease

ovarian cancer 8,186 | 8,484
osteosarcoma 7,577 | 7,933
psoriasis 6,103 | 6,685
medulloblastoma, large-cell 5,984 | 6,234
glioblastoma 5,417 | 5,572
lung cancer 4,336 | 4,466
atypical teratoid / rhabdoid tumor 4,239 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,213 | 3,289
malignant mesothelioma 3,065 | 3,162
Breast cancer 3,000 | 3,094
pilocytic astrocytoma 2,997 | 3,086
primitive neuroectodermal tumor 2,949 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,912 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,884 | 2,956
invasive ductal carcinoma 2,880 | 2,950
oligodendroglioma 2,776 | 2,849
lung carcinoma 2,748 | 2,844
non-small cell lung cancer 2,735 | 2,798
pediatric high grade glioma 2,640 | 2,712
lung adenocarcinoma 2,621 | 2,713
ependymoma 2,448 | 2,514
pancreatic cancer 2,245 | 2,300
interstitial cystitis 2,234 | 2,299
subependymal giant cell astrocytoma 2,228 | 2,287
astrocytic glioma 2,182 | 2,241
group 3 medulloblastoma 2,179 | 2,254
Cancer 2,122 | 2,346
adult high grade glioma 2,050 | 2,148
ulcerative colitis 2,027 | 2,087
Carcinoma 2,017 | 2,147
pituitary cancer 1,914 | 1,972
Pick disease 1,853 | 1,893
group 4 medulloblastoma 1,816 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,751 | 1,795
ductal carcinoma in situ 1,708 | 1,745
cystic fibrosis 1,620 | 1,665
breast carcinoma 1,577 | 1,614
tuberculosis 1,508 | 1,557
medulloblastoma 1,479 | 1,524
posterior fossa group B ependymoma 1,472 | 1,530
posterior fossa group A ependymoma 1,469 | 1,511
astrocytoma 1,451 | 1,493
sonic hedgehog group medulloblastoma 1,439 | 1,482
colon cancer 1,428 | 1,475
adrenocortical carcinoma 1,405 | 1,427
diabetes mellitus 1,368 | 1,663
Multiple myeloma 1,305 | 1,327
primary pancreatic ductal adenocarcinoma 1,258 | 1,271
juvenile dermatomyositis 1,159 | 1,189
acute quadriplegic myopathy 1,133 | 1,157
Rheumatoid Arthritis 1,072 | 1,160
atypical teratoid/rhabdoid tumor 1,056 | 1,095
spina bifida 1,037 | 1,064
cutaneous lupus erythematosus 1,024 | 1,056
nasopharyngeal carcinoma 1,023 | 1,056
dermatomyositis 914 | 933
Atopic dermatitis 882 | 944
active Crohn's disease 880 | 918
gastric carcinoma 815 | 832
non primary Sjogren syndrome sicca 792 | 840
primary Sjogren syndrome 767 | 789
acute myeloid leukemia 762 | 780
Waldenstrons macroglobulinemia 751 | 765
esophageal adenocarcinoma 726 | 737
tuberculosis and treatment for 6 months 669 | 686
progressive supranuclear palsy 658 | 674
aldosterone-producing adenoma 656 | 664
Alzheimer's disease 609 | 644
Obesity 584 | 616
Duchenne muscular dystrophy 581 | 602
Intellectual disability 556 | 573
pancreatic carcinoma 555 | 567
fibroadenoma 544 | 557
Down syndrome 531 | 548
Endometriosis 517 | 535
hepatocellular carcinoma 516 | 532
chronic rhinosinusitis 501 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 485 | 499
Schizophrenia 463 | 501
mucosa-associated lymphoid tissue lymphoma 463 | 480
active ulcerative colitis 458 | 477
Prostatic Neoplasms 453 | 471
IGA Glomerulonephritis 441 | 454
Multiple Sclerosis 433 | 498
Amyotrophic Lateral Sclerosis 423 | 431
gastric cancer 414 | 430
Mammary Neoplasms 396 | 410
non-small cell lung carcinoma 388 | 413
inflammatory breast cancer 385 | 404
Neurodegenerative disease 372 | 383
Kidney disease 349 | 396
Parkinson's disease 345 | 364
sarcoidosis 341 | 358
glioblastoma multiforme 336 | 347
Epilepsy 330 | 346
Asthma 320 | 349
tuberculosis and treatment for 3 months 320 | 327
Polycystic Ovary Syndrome 317 | 332
nephrosclerosis 317 | 329
hereditary spastic paraplegia 312 | 313

Tissue

Endocrine System 16,956 | 18,512
Nervous System 16,951 | 18,561
Female tissues 16,947 | 18,647
Digestive Tract 16,944 | 18,473
Urinary Tract 16,941 | 18,444
Skin and soft tissues 16,935 | 18,115
Liver and Pancreas 16,889 | 18,136
Cardiovascular System 16,884 | 17,958
Male tissues 16,837 | 17,969
Blood and immune system 16,832 | 17,995
Respiratory system 16,756 | 17,484

Target Family

Non-IDG 9,830 | 11,971
Enzyme 3,836 | 4,146
Transcription Factor 1,255 | 1,400
Kinase 611 | 634
Transporter 433 | 473
GPCR 327 | 406
Ion Channel 314 | 341
Epigenetic 230 | 242
Nuclear Receptor 47 | 48
oGPCR 38 | 421
TF/Epigenetic 35 | 38

GTEx Tissue

Adrenal Gland 16,956 | 16,956
Testis 18,073 | 18,073
Cervix - Ectocervix 17,913 | 17,913
Bladder 17,870 | 17,870
Minor Salivary Gland 17,629 | 17,629
Fallopian Tube 17,588 | 17,588
Kidney - Cortex 17,583 | 17,583
Brain - Substantia nigra 17,565 | 17,565
Brain - Putamen (basal ganglia... 17,524 | 17,524
Cervix - Endocervix 17,505 | 17,505
Pituitary 17,482 | 17,482
Brain - Cortex 17,478 | 17,478
Brain - Cerebellum 17,468 | 17,468
Brain - Amygdala 17,451 | 17,451
Brain - Hypothalamus 17,433 | 17,433
Small Intestine - Terminal Ile... 17,427 | 17,427
Cells - EBV-transformed lympho... 17,415 | 17,415
Brain - Frontal Cortex (BA9) 17,403 | 17,403
Brain - Anterior cingulate cor... 17,375 | 17,375
Brain - Nucleus accumbens (bas... 17,317 | 17,317
Brain - Caudate (basal ganglia... 17,304 | 17,304
Brain - Spinal cord (cervical ... 17,276 | 17,276
Colon - Sigmoid 17,276 | 17,276
Brain - Hippocampus 17,260 | 17,260
Colon - Transverse 17,246 | 17,246
Esophagus - Mucosa 17,241 | 17,241
Brain - Cerebellar Hemisphere 17,239 | 17,239
Breast - Mammary Tissue 17,184 | 17,184
Prostate 17,183 | 17,183
Skin - Sun Exposed (Lower leg) 17,177 | 17,177
Pancreas 17,145 | 17,145
Stomach 17,142 | 17,142
Skin - Not Sun Exposed (Suprap... 17,122 | 17,122
Nerve - Tibial 17,121 | 17,121
Liver 17,115 | 17,115
Heart - Atrial Appendage 17,103 | 17,103
Spleen 17,060 | 17,060
Adipose - Subcutaneous 17,041 | 17,041
Lung 17,032 | 17,032
Vagina 16,992 | 16,992
Thyroid 16,985 | 16,985
Artery - Coronary 16,969 | 16,969
Adipose - Visceral (Omentum) 16,959 | 16,959
Esophagus - Gastroesophageal J... 16,944 | 16,944
Ovary 16,866 | 16,866
Esophagus - Muscularis 16,863 | 16,863
Uterus 16,749 | 16,749
Heart - Left Ventricle 16,746 | 16,746
Artery - Aorta 16,700 | 16,700
Cells - Transformed fibroblast... 16,617 | 16,617
Artery - Tibial 16,610 | 16,610
Muscle - Skeletal 16,594 | 16,594
Whole Blood 16,360 | 16,360

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
F-box only protein 47 FBXO47 Tdark Non-IDG 0.08 0.95 47
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102