Development Level

Tbio 9,827 | 10,625
Tdark 4,773 | 7,003
Tchem 1,789 | 1,890
Tclin 566 | 602

Collection

Kinase: IDG Consortium (Targets) 119 | 125
Ion Channel: IDG Consortium (Targets) 94 | 102
GPCR: IDG Consortium (Targets) 93 | 128
Kinase: IDG Consortium (Complete/Control) 35 | 37
GPCR: IDG Consortium (Complete/Control) 20 | 24

IMPC Phenotype

preweaning lethality, complete... 620 | 633
preweaning lethality, incomple... 254 | 260
abnormal behavior 221 | 226
decreased lean body mass 188 | 195
embryonic lethality prior to t... 183 | 187
decreased total body fat amoun... 182 | 186
decreased body weight 166 | 174
decreased bone mineral content 150 | 157
embryonic lethality prior to o... 147 | 148
increased or absent threshold ... 124 | 128
abnormal bone structure 123 | 131
decreased bone mineral density 118 | 126
decreased circulating glucose ... 118 | 121
decreased grip strength 117 | 123
increased circulating alkaline... 112 | 119
abnormal embryo size 108 | 112
decreased body length 106 | 108
enlarged heart 105 | 111
increased lean body mass 103 | 107
hyperactivity 102 | 108
abnormal retina morphology 96 | 100
increased mean corpuscular vol... 91 | 91
increased bone mineral content 90 | 92
increased mean corpuscular hem... 89 | 93
hypoactivity 86 | 89
decreased circulating choleste... 82 | 85
decreased circulating triglyce... 81 | 83
increased grip strength 81 | 83
short tibia 80 | 82
decreased circulating serum al... 77 | 79
decreased circulating HDL chol... 74 | 77
decreased circulating insulin ... 73 | 75
abnormal lens morphology 71 | 73
increased circulating sodium l... 68 | 71
increased fasted circulating g... 65 | 68
prenatal lethality prior to he... 61 | 64
abnormal sleep behavior 60 | 63
abnormal retinal pigmentation 59 | 61
decreased lumbar vertebrae num... 59 | 62
increased circulating HDL chol... 59 | 63
increased sacral vertebrae num... 59 | 62
male infertility 59 | 62
decreased rib number 57 | 59
improved glucose tolerance 54 | 56
increased exploration in new e... 53 | 56
increased total body fat amoun... 53 | 57
abnormal coat-hair pigmentatio... 52 | 54
decreased leukocyte cell numbe... 52 | 54
decreased prepulse inhibition 51 | 52
abnormal bone mineralization 50 | 55
abnormal gait 50 | 51
decreased hemoglobin content 50 | 53
increased bone mineral density 50 | 52
increased circulating choleste... 50 | 53
abnormal behavioral response t... 49 | 52
decreased circulating alanine ... 49 | 53
decreased mean corpuscular vol... 49 | 50
impaired glucose tolerance 49 | 52
abnormal heart morphology 48 | 51
decreased fasted circulating g... 48 | 49
decreased caudal vertebrae num... 47 | 49
decreased startle reflex 46 | 48
increased hemoglobin content 44 | 45
thrombocytopenia 43 | 46
abnormal seminal vesicle morph... 42 | 47
decreased erythrocyte cell num... 42 | 43
increased body weight 42 | 42
decreased eosinophil cell numb... 41 | 41
decreased heart weight 41 | 44
increased blood urea nitrogen ... 41 | 44
increased circulating chloride... 41 | 43
decreased circulating total pr... 40 | 41
increased rib number 40 | 41
decreased circulating free fat... 39 | 39
decreased circulating LDL chol... 37 | 37
increased startle reflex 37 | 38
abnormal eye morphology 36 | 38
decreased circulating alkaline... 36 | 41
decreased neutrophil cell numb... 36 | 37
small testis 36 | 37
abnormal neural tube closure 35 | 37
abnormal spleen morphology 34 | 36
cardiovascular system phenotyp... 34 | 35
increased hematocrit 34 | 36
decreased mean corpuscular hem... 33 | 34
increased leukocyte cell numbe... 33 | 37
abnormal cranium morphology 32 | 32
decreased circulating calcium ... 32 | 33
limb grasping 32 | 35
tremors 32 | 34
decreased circulating chloride... 31 | 32
decreased circulating fructosa... 31 | 31
female infertility 31 | 34
increased circulating calcium ... 31 | 32
increased circulating potassiu... 31 | 31
increased heart weight 31 | 37
decreased T cell number 30 | 31
decreased blood urea nitrogen ... 30 | 31
decreased circulating creatini... 30 | 31
abnormal testis morphology 29 | 30

Disease

ovarian cancer 8,193 | 8,491
osteosarcoma 7,577 | 7,933
psoriasis 6,103 | 6,685
medulloblastoma, large-cell 5,984 | 6,234
glioblastoma 5,417 | 5,572
lung cancer 4,343 | 4,473
atypical teratoid / rhabdoid tumor 4,239 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,213 | 3,289
malignant mesothelioma 3,066 | 3,163
Breast cancer 3,004 | 3,098
pilocytic astrocytoma 2,997 | 3,086
primitive neuroectodermal tumor 2,949 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,912 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,884 | 2,956
invasive ductal carcinoma 2,880 | 2,950
oligodendroglioma 2,776 | 2,849
lung carcinoma 2,748 | 2,844
non-small cell lung cancer 2,735 | 2,798
pediatric high grade glioma 2,640 | 2,712
lung adenocarcinoma 2,622 | 2,714
ependymoma 2,448 | 2,514
pancreatic cancer 2,245 | 2,300
interstitial cystitis 2,234 | 2,299
subependymal giant cell astrocytoma 2,228 | 2,287
astrocytic glioma 2,182 | 2,241
group 3 medulloblastoma 2,179 | 2,254
Cancer 2,122 | 2,346
adult high grade glioma 2,050 | 2,148
ulcerative colitis 2,027 | 2,087
Carcinoma 2,017 | 2,147
pituitary cancer 1,914 | 1,972
Pick disease 1,853 | 1,893
group 4 medulloblastoma 1,816 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,751 | 1,795
ductal carcinoma in situ 1,708 | 1,745
cystic fibrosis 1,625 | 1,670
breast carcinoma 1,577 | 1,614
tuberculosis 1,514 | 1,563
medulloblastoma 1,479 | 1,524
posterior fossa group B ependymoma 1,472 | 1,530
posterior fossa group A ependymoma 1,469 | 1,511
astrocytoma 1,451 | 1,493
sonic hedgehog group medulloblastoma 1,439 | 1,482
colon cancer 1,428 | 1,475
adrenocortical carcinoma 1,405 | 1,427
diabetes mellitus 1,368 | 1,663
Multiple myeloma 1,305 | 1,327
primary pancreatic ductal adenocarcinoma 1,258 | 1,271
juvenile dermatomyositis 1,159 | 1,189
acute quadriplegic myopathy 1,133 | 1,157
Rheumatoid Arthritis 1,072 | 1,170
atypical teratoid/rhabdoid tumor 1,056 | 1,095
spina bifida 1,037 | 1,064
cutaneous lupus erythematosus 1,024 | 1,056
nasopharyngeal carcinoma 1,023 | 1,056
dermatomyositis 914 | 966
Atopic dermatitis 882 | 944
active Crohn's disease 880 | 918
gastric carcinoma 815 | 832
non primary Sjogren syndrome sicca 792 | 840
acute myeloid leukemia 767 | 785
primary Sjogren syndrome 766 | 788
Waldenstrons macroglobulinemia 750 | 764
esophageal adenocarcinoma 726 | 737
tuberculosis and treatment for 6 months 669 | 686
progressive supranuclear palsy 658 | 674
aldosterone-producing adenoma 656 | 664
Alzheimer's disease 609 | 644
Obesity 584 | 616
Duchenne muscular dystrophy 581 | 602
Intellectual disability 556 | 573
pancreatic carcinoma 555 | 567
fibroadenoma 544 | 557
hepatocellular carcinoma 534 | 550
Down syndrome 531 | 548
Endometriosis 517 | 535
chronic rhinosinusitis 501 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 485 | 499
Schizophrenia 465 | 503
mucosa-associated lymphoid tissue lymphoma 463 | 480
active ulcerative colitis 458 | 477
Prostatic Neoplasms 453 | 471
IGA Glomerulonephritis 441 | 454
Multiple Sclerosis 433 | 498
Amyotrophic Lateral Sclerosis 424 | 432
gastric cancer 420 | 436
Mammary Neoplasms 396 | 410
non-small cell lung carcinoma 388 | 413
inflammatory breast cancer 385 | 404
Neurodegenerative disease 372 | 383
Kidney disease 350 | 397
Parkinson's disease 345 | 364
sarcoidosis 341 | 368
glioblastoma multiforme 336 | 347
Epilepsy 330 | 346
Asthma 320 | 349
tuberculosis and treatment for 3 months 320 | 327
nephrosclerosis 317 | 329
Polycystic Ovary Syndrome 316 | 334
hereditary spastic paraplegia 312 | 313

Tissue

Endocrine System 16,955 | 18,511
Nervous System 16,950 | 18,560
Female tissues 16,946 | 18,646
Digestive Tract 16,943 | 18,472
Urinary Tract 16,940 | 18,443
Skin and soft tissues 16,934 | 18,114
Liver and Pancreas 16,888 | 18,135
Cardiovascular System 16,883 | 17,957
Male tissues 16,836 | 17,968
Blood and immune system 16,831 | 17,994
Respiratory system 16,755 | 17,483

Target Family

Non-IDG 9,830 | 11,969
Enzyme 3,835 | 4,146
Transcription Factor 1,255 | 1,400
Kinase 611 | 634
Transporter 433 | 473
GPCR 327 | 408
Ion Channel 314 | 341
Epigenetic 230 | 242
Nuclear Receptor 47 | 48
oGPCR 38 | 421
TF/Epigenetic 35 | 38

GTEx Tissue

Adrenal Gland 16,955 | 16,955
Testis 18,072 | 18,072
Cervix - Ectocervix 17,912 | 17,912
Bladder 17,869 | 17,869
Minor Salivary Gland 17,628 | 17,628
Fallopian Tube 17,587 | 17,587
Kidney - Cortex 17,582 | 17,582
Brain - Substantia nigra 17,564 | 17,564
Brain - Putamen (basal ganglia... 17,523 | 17,523
Cervix - Endocervix 17,504 | 17,504
Pituitary 17,481 | 17,481
Brain - Cortex 17,477 | 17,477
Brain - Cerebellum 17,467 | 17,467
Brain - Amygdala 17,450 | 17,450
Brain - Hypothalamus 17,432 | 17,432
Small Intestine - Terminal Ile... 17,426 | 17,426
Cells - EBV-transformed lympho... 17,414 | 17,414
Brain - Frontal Cortex (BA9) 17,402 | 17,402
Brain - Anterior cingulate cor... 17,374 | 17,374
Brain - Nucleus accumbens (bas... 17,316 | 17,316
Brain - Caudate (basal ganglia... 17,303 | 17,303
Brain - Spinal cord (cervical ... 17,275 | 17,275
Colon - Sigmoid 17,275 | 17,275
Brain - Hippocampus 17,259 | 17,259
Colon - Transverse 17,245 | 17,245
Esophagus - Mucosa 17,240 | 17,240
Brain - Cerebellar Hemisphere 17,238 | 17,238
Breast - Mammary Tissue 17,183 | 17,183
Prostate 17,182 | 17,182
Skin - Sun Exposed (Lower leg) 17,176 | 17,176
Pancreas 17,144 | 17,144
Stomach 17,141 | 17,141
Skin - Not Sun Exposed (Suprap... 17,121 | 17,121
Nerve - Tibial 17,120 | 17,120
Liver 17,114 | 17,114
Heart - Atrial Appendage 17,102 | 17,102
Spleen 17,059 | 17,059
Adipose - Subcutaneous 17,040 | 17,040
Lung 17,031 | 17,031
Vagina 16,991 | 16,991
Thyroid 16,984 | 16,984
Artery - Coronary 16,968 | 16,968
Adipose - Visceral (Omentum) 16,958 | 16,958
Esophagus - Gastroesophageal J... 16,943 | 16,943
Ovary 16,865 | 16,865
Esophagus - Muscularis 16,862 | 16,862
Uterus 16,748 | 16,748
Heart - Left Ventricle 16,745 | 16,745
Artery - Aorta 16,699 | 16,699
Cells - Transformed fibroblast... 16,616 | 16,616
Artery - Tibial 16,609 | 16,609
Muscle - Skeletal 16,593 | 16,593
Whole Blood 16,359 | 16,359

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131