Development Level

Tchem 5 | 1,598
Tbio 3 | 11,445
Tclin 2 | 613

IMPC Phenotype

abnormal heart morphology 2 | 162
decreased circulating HDL chol... 2 | 68
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal fibula morphology 1 | 2
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal rib morphology 1 | 10
abnormal scapula morphology 1 | 3
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
absent mammary gland 1 | 1
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating calcium ... 1 | 36
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased skeletal muscle mass 1 | 1
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
hypoactivity 1 | 132
increased anti-nuclear antigen... 1 | 19
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
preweaning lethality, complete... 1 | 979
small heart 1 | 10
small kidney 1 | 16
small ovary 1 | 1
small spleen 1 | 19
small uterus 1 | 3
thin skin 1 | 2

Disease

Carcinoma 10 | 11,493
Cancer 7 | 2,499
psoriasis 6 | 6,694
Kidney disease 5 | 430
Autosomal recessive predisposition 4 | 1,442
Rickets 4 | 49
nephrosclerosis 4 | 333
osteosarcoma 4 | 7,950
Bone Diseases, Metabolic 3 | 14
Breast Neoplasms 3 | 445
Failure to gain weight 3 | 365
Hyperparathyroidism 3 | 48
Hypertension 3 | 396
Mammary Neoplasms 3 | 425
Metabolic Bone Disorder 3 | 11
Multiple Sclerosis 3 | 540
Osteomalacia 3 | 35
Osteoporosis 3 | 363
Pediatric failure to thrive 3 | 365
Prostatic Neoplasms 3 | 495
Schizophrenia 3 | 1,160
diabetes mellitus 3 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
ovarian cancer 3 | 8,520
tuberculosis 3 | 2,010
Abortion, Spontaneous 2 | 109
Addison's disease 2 | 31
Breast cancer 2 | 3,578
Chemical and Drug Induced Liver Injury 2 | 195
Cushing's syndrome 2 | 48
Cystinosis 2 | 14
Dehydration 2 | 40
Depressive Symptoms 2 | 28
Dull intelligence 2 | 645
Endometrial cancer 2 | 311
Fanconi-like syndrome 2 | 3
Hypercalcemia 2 | 59
Hypocalcemic vitamin D-dependent rickets 2 | 2
Hypophosphatemia 2 | 40
Intellectual disability 2 | 1,016
Kidney cancer 2 | 2,613
Liver Cirrhosis 2 | 181
Liver Cirrhosis, Experimental 2 | 769
Liver cancer 2 | 604
Liver disease 2 | 237
Low intelligence 2 | 645
Lung Neoplasms 2 | 232
Male infertility 2 | 206
Melanoma 2 | 711
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Muscle hypotonia 2 | 571
Pick disease 2 | 1,894
Poor school performance 2 | 645
Proteinuria 2 | 144
Skin cancer 2 | 469
Spontaneous abortion 2 | 113
Vitamin D-dependent rickets, type 1 2 | 2
Vomiting 2 | 116
cutaneous lupus erythematosus 2 | 1,057
glioblastoma 2 | 5,792
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung adenocarcinoma 2 | 2,716
lung cancer 2 | 4,740
medulloblastoma, large-cell 2 | 6,241
nutritional deficiency disease 2 | 9
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
Acute cystitis 1 | 35
Adrenocorticotropic hormone excess 1 | 5
Aortic valve stenosis 1 | 28
Arteritis 1 | 3
Autoimmune polyendocrine syndrome 1 | 6
Birth Weight 1 | 13
Diaphragmatic Hernia 1 | 40
Elevated follicle stimulating hormone 1 | 15
Elevated luteinizing hormone 1 | 14
Exanthem 1 | 37
Female external genitalia in males 1 | 13
Femoral bowing 1 | 20
Fibular bowing 1 | 5
Graves Disease 1 | 11
Hernia, Diaphragmatic 1 | 40
Increased serum parathyroid hormone 1 | 14
Irritation - emotion 1 | 68
Low maternal serum estriol 1 | 2
Lung Injury 1 | 20
Metaphyseal irregularity 1 | 23
Micronuclei, Chromosome-Defective 1 | 25
Occupational Diseases 1 | 12
Plaque psoriasis 1 | 17
Schistosomiasis 1 | 35
Secondary malignant neoplasm of female breast 1 | 3
Septic Shock 1 | 5
Sex reversal 1 | 10
Shock, Septic 1 | 6
Tibial bowing 1 | 19
Urogenital sinus anomaly 1 | 15

Tissue

Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678
Blood and immune system 9 | 16,909
Nervous System 9 | 16,725
Respiratory system 9 | 16,393
Cardiovascular System 5 | 15,192

Target Family

Enzyme 6 | 4,145
Non-IDG 4 | 12,091

GO Process

vitamin D metabolic process 10 | 10
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Vitamin D 25-hydroxylase CYP2R1 Tbio Enzyme -1.96830 95.4 152
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial CYP24A1 Tchem Enzyme -2.91460 825.9 228
Cytochrome P450 3A4 CYP3A4 Tclin Enzyme -3.65839 4688.0 397
Cytochrome P450 1A1 CYP1A1 Tchem Non-IDG -3.54987 3641.5 384
Vitamin D-binding protein GC Tchem Non-IDG -3.07485 1140.6 428
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 Tchem Enzyme -2.70628 492.9 68
Low-density lipoprotein receptor-related protein 2 LRP2 Tbio Non-IDG -2.69021 515.4 164
Legumain LGMN Tchem Enzyme -2.36019 233.2 207
Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 Tclin Enzyme -2.93656 785.3 296
Cubilin CUBN Tbio Non-IDG -2.18842 161.0 78