Development Level

Tbio 275 | 10,625
Tchem 57 | 1,890
Tclin 18 | 602
Tdark 18 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 17 | 633
preweaning lethality, incomple... 6 | 260
increased or absent threshold ... 5 | 128
embryonic lethality prior to o... 4 | 148
abnormal bone structure 3 | 131
abnormal retina morphology 3 | 100
decreased grip strength 3 | 123
embryonic lethality prior to t... 3 | 187
decreased bone mineral content 2 | 157
decreased lean body mass 2 | 195
decreased lumbar vertebrae num... 2 | 62
decreased rib number 2 | 59
decreased total body fat amoun... 2 | 186
increased bone mineral content 2 | 92
increased circulating alkaline... 2 | 119
increased sacral vertebrae num... 2 | 62
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal craniofacial morpholo... 1 | 12
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal hindbrain development 1 | 24
abnormal iris morphology 1 | 12
abnormal maxilla morphology 1 | 16
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pericardium morpholog... 1 | 11
abnormal placement of pupils 1 | 4
abnormal placenta size 1 | 10
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal snout morphology 1 | 18
abnormal spinal cord morpholog... 1 | 8
abnormal thoracic vertebrae mo... 1 | 16
abnormal tooth morphology 1 | 24
abnormal vitreous body morphol... 1 | 7
craniofacial phenotype 1 | 9
decreased Ly6C low monocyte nu... 1 | 23
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating alanine ... 1 | 53
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating iron lev... 1 | 25
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased lymphocyte cell numb... 1 | 9
decreased startle reflex 1 | 48
fusion of vertebral arches 1 | 7
hemorrhage 1 | 12
herniated abdominal wall 1 | 4
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
improved glucose tolerance 1 | 56
increased CD8-positive, naive ... 1 | 3
increased IgG2b level 1 | 1
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 52
increased caudal vertebrae num... 1 | 8
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased effector memory CD4-... 1 | 15
increased granulocyte number 1 | 8
increased grip strength 1 | 83
increased heart weight 1 | 37
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
increased monocyte cell number 1 | 27
increased plasma cell number 1 | 5
increased respiratory quotient 1 | 12
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
male infertility 1 | 62
narrow eye opening 1 | 15
oligodactyly 1 | 14
pale yolk sac 1 | 12
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

ovarian cancer 187 | 8,484
Cancer 179 | 2,346
psoriasis 168 | 6,685
osteosarcoma 152 | 7,933
lung cancer 130 | 4,466
glioblastoma 111 | 5,572
medulloblastoma, large-cell 107 | 6,234
diabetes mellitus 93 | 1,663
Multiple myeloma 79 | 1,327
atypical teratoid / rhabdoid tumor 78 | 4,369
Rheumatoid Arthritis 73 | 1,160
Ankylosing spondylitis 72 | 138
Arthritis 68 | 248
Hypersensitivity reaction type II disease 67 | 235
Acquired immunodeficiency syndrome 64 | 164
intraductal papillary-mucinous neoplasm (IPMN) 63 | 3,289
Breast cancer 62 | 3,094
pediatric high grade glioma 58 | 2,712
Behcet's disease 57 | 74
Juvenile rheumatoid arthritis 57 | 104
group 3 medulloblastoma 57 | 2,254
Uveitis 56 | 103
malignant mesothelioma 56 | 3,162
primitive neuroectodermal tumor 56 | 3,031
invasive ductal carcinoma 55 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 53 | 2,988
Carcinoma 51 | 2,147
oligodendroglioma 50 | 2,849
Psoriatic arthritis 49 | 83
astrocytoma 49 | 1,493
dermatomyositis 49 | 933
non-small cell lung cancer 49 | 2,798
Waldenstrons macroglobulinemia 48 | 765
ependymoma 48 | 2,514
subependymal giant cell astrocytoma 46 | 2,287
lung adenocarcinoma 45 | 2,713
pilocytic astrocytoma 43 | 3,086
Stevens-Johnson syndrome 42 | 78
lung carcinoma 40 | 2,844
Pick disease 37 | 1,893
pancreatic cancer 37 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,795
ulcerative colitis 37 | 2,087
juvenile dermatomyositis 36 | 1,189
Congenital adrenal hyperplasia 35 | 74
Retinal vasculitis 35 | 36
Takayasu's arteritis 35 | 52
acute quadriplegic myopathy 35 | 1,157
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,956
Kidney disease 34 | 396
Multiple Sclerosis 34 | 498
astrocytic glioma 34 | 2,241
colon cancer 34 | 1,475
adult high grade glioma 32 | 2,148
interstitial cystitis 31 | 2,299
primary Sjogren syndrome 30 | 789
Liver disease 28 | 219
adrenocortical carcinoma 27 | 1,427
tuberculosis 27 | 1,557
cutaneous lupus erythematosus 26 | 1,056
ductal carcinoma in situ 26 | 1,745
posterior fossa group A ependymoma 25 | 1,511
sonic hedgehog group medulloblastoma 25 | 1,482
Anemia 24 | 252
Skin disease 24 | 65
breast carcinoma 24 | 1,614
medulloblastoma 24 | 1,524
primary pancreatic ductal adenocarcinoma 24 | 1,271
pituitary cancer 23 | 1,972
Hepatitis B 22 | 103
Leprosy 22 | 77
Primary immunodeficiency disease 22 | 52
acute myeloid leukemia 22 | 780
Hemochromatosis 21 | 55
group 4 medulloblastoma 20 | 1,875
nasopharyngeal carcinoma 20 | 1,056
HIV Infections 19 | 100
Mammary Neoplasms 19 | 410
cystic fibrosis 19 | 1,665
IGA Glomerulonephritis 18 | 454
tuberculosis and treatment for 6 months 18 | 686
Atopic dermatitis 17 | 944
hepatocellular carcinoma 17 | 532
spina bifida 17 | 1,064
esophageal adenocarcinoma 16 | 737
gastric carcinoma 16 | 832
Alzheimer's disease 15 | 644
Human immunodeficiency virus infectious disease 15 | 92
non primary Sjogren syndrome sicca 15 | 840
Intellectual disability 14 | 573
Prostatic Neoplasms 14 | 471
pre-eclampsia 14 | 67
Amyotrophic Lateral Sclerosis 13 | 431
Asthma 13 | 349
Atherosclerosis 13 | 275
Down syndrome 13 | 548
Duchenne muscular dystrophy 13 | 602
Stomach Neoplasms 13 | 282
active Crohn's disease 13 | 918
atypical teratoid/rhabdoid tumor 13 | 1,095

Tissue

Blood and immune system 295 | 17,995
Female tissues 295 | 18,647
Nervous System 295 | 18,561
Cardiovascular System 294 | 17,958
Digestive Tract 294 | 18,473
Endocrine System 294 | 18,512
Liver and Pancreas 294 | 18,136
Male tissues 294 | 17,969
Respiratory system 293 | 17,484
Urinary Tract 292 | 18,444
Skin and soft tissues 286 | 18,115

Target Family

Non-IDG 261 | 11,971
Enzyme 50 | 4,146
Kinase 19 | 634
Epigenetic 16 | 242
Transcription Factor 13 | 1,400
GPCR 4 | 406
Transporter 3 | 473
TF/Epigenetic 2 | 38

GO Process

viral process 368 | 368
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
HLA class I histocompatibility antigen, Cw-5 alpha chain HLA-C Tbio Non-IDG 777.4 0
HLA class I histocompatibility antigen, B-27 alpha chain HLA-B Tbio Non-IDG 1568.8 0
HLA class I histocompatibility antigen, B-38 alpha chain HLA-B Tbio Non-IDG 1568.8 0
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Nuclear pore complex protein Nup98-Nup96 NUP98 Tbio Enzyme -2.21148 186.3 172