Development Level

Tbio 128 | 11,445
Tdark 26 | 6,588
Tchem 10 | 1,598

IMPC Phenotype

preweaning lethality, complete... 25 | 979
abnormal behavior 8 | 298
decreased body weight 5 | 161
decreased bone mineral content 5 | 151
decreased circulating glucose ... 5 | 126
decreased lean body mass 5 | 135
hypoactivity 5 | 132
male infertility 5 | 123
preweaning lethality, incomple... 5 | 499
thrombocytopenia 5 | 56
abnormal bone structure 4 | 187
decreased circulating alkaline... 4 | 46
decreased circulating fructosa... 4 | 30
decreased neutrophil cell numb... 4 | 42
increased mean corpuscular hem... 4 | 96
increased mean corpuscular vol... 4 | 92
abnormal embryo size 3 | 220
decreased circulating choleste... 3 | 93
decreased circulating total pr... 3 | 49
decreased erythrocyte cell num... 3 | 62
decreased grip strength 3 | 116
decreased hemoglobin content 3 | 68
decreased leukocyte cell numbe... 3 | 73
decreased mean corpuscular vol... 3 | 79
decreased mean platelet volume 3 | 25
decreased total body fat amoun... 3 | 207
increased circulating HDL chol... 3 | 80
increased circulating triglyce... 3 | 42
increased heart weight 3 | 62
increased total body fat amoun... 3 | 134
short tibia 3 | 97
abnormal bone mineralization 2 | 38
abnormal gait 2 | 69
abnormal vocalization 2 | 21
cardiovascular system phenotyp... 2 | 36
decreased basophil cell number 2 | 16
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating alanine ... 2 | 47
decreased circulating creatini... 2 | 39
decreased circulating iron lev... 2 | 32
decreased circulating triglyce... 2 | 79
decreased hematocrit 2 | 46
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased prepulse inhibition 2 | 82
decreased red blood cell distr... 2 | 41
decreased startle reflex 2 | 75
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
female infertility 2 | 60
hyperactivity 2 | 148
increased circulating alkaline... 2 | 122
increased circulating bilirubi... 2 | 16
increased circulating choleste... 2 | 66
increased circulating glucose ... 2 | 24
increased circulating phosphat... 2 | 26
increased eosinophil cell numb... 2 | 11
increased lean body mass 2 | 172
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular hem... 2 | 36
increased mean platelet volume 2 | 45
increased or absent threshold ... 2 | 101
increased red blood cell distr... 2 | 34
increased startle reflex 2 | 112
irregularly shaped pupil 2 | 7
long tibia 2 | 25
prenatal lethality prior to he... 2 | 87
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
thin ventricular wall 2 | 24
thrombocytosis 2 | 27
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal esophagus morphology 1 | 5
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal tooth morphology 1 | 24
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating serum al... 1 | 82
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating total pr... 1 | 28
increased hematocrit 1 | 46
increased large unstained cell... 1 | 5
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
persistence of hyaloid vascula... 1 | 33
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 103 | 11,493
ovarian cancer 101 | 8,520
osteosarcoma 74 | 7,950
medulloblastoma, large-cell 54 | 6,241
glioblastoma 51 | 5,792
atypical teratoid / rhabdoid tumor 49 | 5,112
psoriasis 41 | 6,694
lung cancer 39 | 4,740
Cancer 32 | 2,499
adult high grade glioma 32 | 3,801
ependymoma 32 | 4,679
group 3 medulloblastoma 29 | 4,104
Breast cancer 28 | 3,578
astrocytic glioma 27 | 2,597
Kidney cancer 26 | 2,613
Multiple myeloma 26 | 1,332
malignant mesothelioma 24 | 3,232
primitive neuroectodermal tumor 23 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
subependymal giant cell astrocytoma 20 | 2,287
Pick disease 19 | 1,894
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
non-small cell lung cancer 19 | 2,890
juvenile dermatomyositis 18 | 1,187
oligodendroglioma 18 | 2,850
spina bifida 18 | 1,074
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
group 4 medulloblastoma 15 | 1,855
lung adenocarcinoma 15 | 2,716
tuberculosis 15 | 2,010
adrenocortical carcinoma 14 | 1,428
invasive ductal carcinoma 14 | 2,951
Astrocytoma, Pilocytic 13 | 3,081
dermatomyositis 13 | 966
pituitary cancer 13 | 1,972
Parkinson's disease 12 | 392
acute quadriplegic myopathy 12 | 1,158
lung carcinoma 12 | 2,843
diabetes mellitus 11 | 1,728
Waldenstrons macroglobulinemia 9 | 765
astrocytoma 9 | 1,146
esophageal adenocarcinoma 9 | 737
Intellectual disability 8 | 1,016
Rheumatoid arthritis 8 | 1,191
breast carcinoma 8 | 1,638
hereditary spastic paraplegia 8 | 318
medulloblastoma 8 | 720
non primary Sjogren syndrome sicca 8 | 891
tuberculosis and treatment for 6 months 8 | 409
ulcerative colitis 8 | 1,819
Atopic dermatitis 7 | 952
Neurodegenerative disease 7 | 414
pancreatic cancer 7 | 2,398
progressive supranuclear palsy 7 | 676
Amyotrophic lateral sclerosis 6 | 451
Dull intelligence 6 | 645
Liver cancer 6 | 604
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Muscle hypotonia 6 | 571
Poor school performance 6 | 645
Schizophrenia 6 | 1,160
acute myeloid leukemia 6 | 783
interstitial cystitis 6 | 2,312
pediatric high grade glioma 6 | 1,064
primary Sjogren syndrome 6 | 735
Large intestine cancer 5 | 126
active Crohn's disease 5 | 922
aldosterone-producing adenoma 5 | 665
colon cancer 5 | 1,478
hepatocellular carcinoma 5 | 547
nasopharyngeal carcinoma 5 | 1,058
sonic hedgehog group medulloblastoma 5 | 467
Autistic Disorder 4 | 364
Autosomal recessive predisposition 4 | 1,442
Cardiovascular system disease 4 | 246
Cerebral atrophy 4 | 178
Cognitive delay 4 | 608
Epilepsy 4 | 792
Gaucher disease type 1 4 | 180
Global developmental delay 4 | 608
Infertility 4 | 188
Male infertility 4 | 206
Mental and motor retardation 4 | 608
Obesity 4 | 678
Polycystic ovary syndrome 4 | 360
Seizures 4 | 596
Short neck 4 | 140
ductal carcinoma in situ 4 | 1,745
primary pancreatic ductal adenocarcinoma 4 | 1,109
Acquired scoliosis 3 | 281
Alzheimer's disease 3 | 658
Attention deficit hyperactivity disorder 3 | 278
Broad flat nasal bridge 3 | 236
Curvature of spine 3 | 282
Down syndrome 3 | 499
Prostatic Neoplasms 3 | 495
cystic fibrosis 3 | 1,696

Tissue

Endocrine System 147 | 18,159
Blood and immune system 144 | 16,909
Female tissues 144 | 17,400
Nervous System 144 | 16,725
Digestive Tract 143 | 17,369
Male tissues 143 | 17,142
Respiratory system 143 | 16,393
Skin and soft tissues 143 | 17,230
Liver and Pancreas 142 | 16,750
Urinary Tract 142 | 16,678
Cardiovascular System 139 | 15,192

Target Family

Enzyme 102 | 4,145
Non-IDG 60 | 12,091
Kinase 1 | 634
Transcription Factor 1 | 1,400

GO Process

ubiquitin-dependent protein ca... 164 | 164
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Uncharacterized protein ZSWIM9 ZSWIM9 Tdark Non-IDG 0.00000 12
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
F-box only protein 11 FBXO11 Tbio Non-IDG -1.53905 34.1 258
E3 ubiquitin-protein ligase AMFR AMFR Tbio Enzyme -2.46909 292.8 203
Ubiquitin carboxyl-terminal hydrolase 17-like protein 3 USP17L3 Tdark Enzyme -0.71476 13.1 15
F-box/LRR-repeat protein 12 FBXL12 Tdark Non-IDG -0.43169 3.45 132
Ubiquitin carboxyl-terminal hydrolase 40 USP40 Tbio Enzyme -0.38917 2.14 68
Ubiquitin carboxyl-terminal hydrolase 29 USP29 Tbio Enzyme -1.22772 15.2 111
Ubiquitin carboxyl-terminal hydrolase 15 USP15 Tbio Enzyme -1.64742 41.6 242
E3 ubiquitin-protein ligase RNF8 RNF8 Tbio Enzyme -1.80196 70.0 250