Development Level

Tbio 50 | 11,445
Tdark 6 | 6,588
Tchem 4 | 1,598

IMPC Phenotype

preweaning lethality, complete... 6 | 979
preweaning lethality, incomple... 3 | 499
decreased bone mineral content 2 | 151
decreased circulating total pr... 2 | 49
decreased lean body mass 2 | 135
increased total body fat amoun... 2 | 134
vertebral fusion 2 | 23
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal hair growth 1 | 10
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased lymphocyte cell numb... 1 | 83
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating total pr... 1 | 28
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
male infertility 1 | 123
short tibia 1 | 97

Disease

ovarian cancer 45 | 8,520
Carcinoma 36 | 11,493
osteosarcoma 34 | 7,950
medulloblastoma, large-cell 23 | 6,241
psoriasis 22 | 6,694
glioblastoma 21 | 5,792
atypical teratoid / rhabdoid tumor 17 | 5,112
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
Multiple myeloma 16 | 1,332
ependymoma 13 | 4,679
lung cancer 12 | 4,740
group 3 medulloblastoma 11 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
primitive neuroectodermal tumor 11 | 3,035
Pick disease 10 | 1,894
astrocytoma 10 | 1,146
malignant mesothelioma 10 | 3,232
pancreatic cancer 10 | 2,398
Breast cancer 9 | 3,578
adult high grade glioma 9 | 3,801
lung adenocarcinoma 9 | 2,716
dermatomyositis 8 | 966
Astrocytoma, Pilocytic 7 | 3,081
Cancer 7 | 2,499
acute quadriplegic myopathy 7 | 1,158
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
Alzheimer's disease 6 | 658
Kidney cancer 6 | 2,613
Neurodegenerative disease 6 | 414
Rheumatoid arthritis 6 | 1,191
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
juvenile dermatomyositis 6 | 1,187
non primary Sjogren syndrome sicca 6 | 891
tuberculosis 6 | 2,010
Amyotrophic lateral sclerosis 5 | 451
Familial encephalopathy with neuroserpin inclusion bodies 5 | 10
active Crohn's disease 5 | 922
astrocytic glioma 5 | 2,597
diabetes mellitus 5 | 1,728
non-small cell lung cancer 5 | 2,890
oligodendroglioma 5 | 2,850
progressive supranuclear palsy 5 | 676
subependymal giant cell astrocytoma 5 | 2,287
Autosomal recessive predisposition 4 | 1,442
Down syndrome 4 | 499
Intellectual disability 4 | 1,016
Prostatic Neoplasms 4 | 495
Stevens-Johnson syndrome 4 | 92
Waldenstrons macroglobulinemia 4 | 765
breast carcinoma 4 | 1,638
group 4 medulloblastoma 4 | 1,855
hepatocellular carcinoma 4 | 547
invasive ductal carcinoma 4 | 2,951
medulloblastoma 4 | 720
periodontitis 4 | 293
ulcerative colitis 4 | 1,819
Anxiety 3 | 136
Anxiety disease 3 | 113
Bipolar Disorder 3 | 666
Chemical and Drug Induced Liver Injury 3 | 195
Deglutition Disorders 3 | 132
Dementia 3 | 175
Depressive disorder 3 | 409
Dysarthria 3 | 192
Frontotemporal dementia 3 | 51
Gait abnormality 3 | 135
Neurogenic Muscular Atrophy 3 | 139
Neurogenic muscle atrophy, especially in the lower limbs 3 | 139
Skeletal muscle atrophy 3 | 139
hereditary spastic paraplegia 3 | 318
lung carcinoma 3 | 2,843
muscle degeneration 3 | 139
pancreatic carcinoma 3 | 562
pediatric high grade glioma 3 | 1,064
spina bifida 3 | 1,074
Aggressive behavior 2 | 75
Aggressive reaction 2 | 75
Cholestasis 2 | 155
Dystonia 2 | 164
Dystonic disease 2 | 106
Epilepsy 2 | 792
Machado-Joseph disease 2 | 18
Multiple Sclerosis 2 | 540
Muscle Spasticity 2 | 195
Myopathy 2 | 185
Parkinson's disease 2 | 392
Physical aggression 2 | 76
Progressive disorder 2 | 142
Seizures 2 | 596
Vascular disease 2 | 319
active ulcerative colitis 2 | 764
aldosterone-producing adenoma 2 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
chronic rhinosinusitis 2 | 512
cystic fibrosis 2 | 1,696
esophageal adenocarcinoma 2 | 737
primary pancreatic ductal adenocarcinoma 2 | 1,109
severe Alzheimer's disease 2 | 47
tuberculosis and treatment for 6 months 2 | 409

Tissue

Blood and immune system 60 | 16,909
Cardiovascular System 60 | 15,192
Digestive Tract 60 | 17,369
Endocrine System 60 | 18,159
Female tissues 60 | 17,400
Liver and Pancreas 60 | 16,750
Male tissues 60 | 17,142
Nervous System 60 | 16,725
Respiratory system 60 | 16,393
Skin and soft tissues 60 | 17,230
Urinary Tract 60 | 16,678

Target Family

Non-IDG 40 | 12,091
Enzyme 20 | 4,145

GO Process

ubiquitin-dependent ERAD pathw... 60 | 60
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 Tchem Enzyme -1.80418 63.8 91
E3 ubiquitin-protein ligase AMFR AMFR Tbio Enzyme -2.46909 292.8 203
Derlin-3 DERL3 Tbio Non-IDG -1.46252 25.1 60
F-box only protein 2 FBXO2 Tbio Non-IDG -1.36281 26.8 157
Derlin-1 DERL1 Tbio Non-IDG -1.88253 69.7 178
Transmembrane and ubiquitin-like domain-containing protein 1 TMUB1 Tdark Non-IDG -0.56820 4.39 88
Wolframin WFS1 Tbio Non-IDG -2.40006 260.2 118
Small glutamine-rich tetratricopeptide repeat-containing protein alpha SGTA Tbio Non-IDG -2.39136 244.6 191
Endoplasmin HSP90B1 Tchem Non-IDG -2.76074 629.2 850
E3 ubiquitin-protein ligase TM129 TMEM129 Tbio Enzyme -0.34077 2.86 1