Development Level

Tbio 122 | 11,651
Tclin 5 | 612
Tchem 3 | 1,388
Tdark 2 | 6,593

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

decreased mean corpuscular vol... 3 | 79
abnormal embryo size 2 | 220
abnormal neural tube closure 2 | 46
decreased bone mineral content 2 | 151
embryonic lethality prior to t... 2 | 278
increased lean body mass 2 | 172
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal placenta size 1 | 20
abnormal sleep behavior 1 | 70
absent seminal vesicle 1 | 4
cataract 1 | 92
decreased body length 1 | 101
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
female infertility 1 | 60
impaired righting response 1 | 26
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small uterus 1 | 3
thrombocytopenia 1 | 56

Disease

Cancer 101 | 2,499
psoriasis 81 | 6,694
Carcinoma 71 | 11,493
Ankylosing spondylitis 70 | 140
Behcet's disease 70 | 89
Hypersensitivity reaction type II disease 63 | 253
diabetes mellitus 62 | 1,728
dermatomyositis 61 | 966
Arthritis 60 | 290
Acquired immunodeficiency syndrome 57 | 197
Herpes zoster 57 | 68
Juvenile rheumatoid arthritis 57 | 111
Uveitis 56 | 103
Human immunodeficiency virus infectious disease 53 | 138
Stevens-Johnson syndrome 51 | 92
Psoriatic arthritis 49 | 86
Multiple Sclerosis 47 | 540
Rheumatoid arthritis 45 | 1,191
ovarian cancer 40 | 8,520
lung cancer 39 | 4,740
juvenile dermatomyositis 37 | 1,187
Dermatitis 36 | 157
tuberculosis 36 | 2,010
Behcet's syndrome 35 | 50
Congenital adrenal hyperplasia 35 | 73
Nephritis 35 | 51
Retinal vasculitis 35 | 36
Spondyloarthropathy, Susceptibility To, 1 35 | 35
Synovitis 35 | 78
Takayasu's arteritis 35 | 53
drug-induced hepatitis 35 | 44
cutaneous lupus erythematosus 33 | 1,057
glioblastoma 29 | 5,792
pancreatic cancer 29 | 2,398
Hepatitis B 27 | 108
Anemia 26 | 365
lung carcinoma 26 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
medulloblastoma, large-cell 25 | 6,241
osteosarcoma 25 | 7,950
Influenza 24 | 142
Kidney disease 23 | 430
Skin disease 23 | 66
malignant mesothelioma 23 | 3,232
subependymal giant cell astrocytoma 23 | 2,287
Astrocytoma, Pilocytic 22 | 3,081
Hemochromatosis 22 | 54
Primary immunodeficiency disease 22 | 54
Birdshot chorioretinopathy 21 | 23
Breast cancer 21 | 3,578
Leprosy 21 | 73
Liver disease 21 | 237
Multiple myeloma 21 | 1,332
Systemic lupus erythematosus 21 | 194
cystic fibrosis 21 | 1,696
Microphthalmia with limb anomalies 20 | 40
interstitial cystitis 20 | 2,312
active Crohn's disease 19 | 922
invasive ductal carcinoma 19 | 2,951
primary Sjogren syndrome 19 | 735
Influenza, Human 18 | 51
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
astrocytoma 16 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
Pre-Eclampsia 15 | 68
active ulcerative colitis 15 | 764
pituitary cancer 15 | 1,972
Human immunodeficiency virus type 1, susceptibility to 14 | 26
Psoriasis susceptibility 1 14 | 14
breast carcinoma 14 | 1,638
ependymoma 14 | 4,679
esophageal adenocarcinoma 13 | 737
group 4 medulloblastoma 13 | 1,855
adult high grade glioma 12 | 3,801
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Atopic dermatitis 11 | 952
Hepatitis C 11 | 94
Duchenne muscular dystrophy 10 | 601
non-small cell lung cancer 10 | 2,890
ulcerative colitis 10 | 1,819
Autosomal recessive predisposition 9 | 1,442
atypical teratoid / rhabdoid tumor 9 | 5,112
lung adenocarcinoma 9 | 2,716
Hepatitis 8 | 67
Liver Cirrhosis, Experimental 8 | 769
group 3 medulloblastoma 8 | 4,104
posterior fossa group A ependymoma 8 | 468
acute quadriplegic myopathy 7 | 1,158
nasopharyngeal carcinoma 7 | 1,058
pediatric high grade glioma 7 | 1,064
primary pancreatic ductal adenocarcinoma 7 | 1,109
Down syndrome 6 | 499
limb girdle muscular dystrophy 2I 6 | 32
Arthritis, Rheumatoid 5 | 174
Asthma 5 | 385
Kidney cancer 5 | 2,613
Schizophrenia 5 | 1,160
acute myeloid leukemia 5 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
hepatocellular carcinoma 5 | 547

Tissue

Blood and immune system 52 | 16,909
Male tissues 51 | 17,142
Digestive Tract 50 | 17,369
Endocrine System 50 | 18,159
Female tissues 50 | 17,400
Liver and Pancreas 50 | 16,750
Nervous System 50 | 16,725
Respiratory system 50 | 16,393
Urinary Tract 50 | 16,678
Cardiovascular System 49 | 15,192
Skin and soft tissues 49 | 17,230

Target Family

Non-IDG 107 | 12,091
Transcription Factor 12 | 1,400
Enzyme 7 | 4,145
Kinase 5 | 634
TF/Epigenetic 1 | 38

GO Process

type I interferon signaling pa... 132 | 132
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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