Development Level

Tbio 120 | 10,625
Tclin 5 | 602
Tdark 3 | 7,003
Tchem 2 | 1,890

IMPC Term

abnormal embryo size 2 | 112
abnormal neural tube closure 2 | 37
decreased CD4-positive, CD25-p... 2 | 24
decreased Ly6C low monocyte nu... 2 | 23
decreased body length 2 | 108
decreased bone mineral content 2 | 157
embryonic lethality prior to t... 2 | 187
increased lean body mass 2 | 107
preweaning lethality, incomple... 2 | 260
abnormal bone structure 1 | 131
abnormal coping response 1 | 12
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal optic disc morphology 1 | 10
abnormal placenta size 1 | 10
abnormal sleep behavior 1 | 63
abnormal spinal cord morpholog... 1 | 8
absent seminal vesicle 1 | 2
decreased B cell number 1 | 30
decreased CD5-positive Ly6C-po... 1 | 4
decreased KLRG1+ CD8 alpha bet... 1 | 8
decreased NK T cell number 1 | 28
decreased effector memory CD4-... 1 | 6
decreased effector memory CD8-... 1 | 24
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased monocyte cell number 1 | 28
decreased neutrophil cell numb... 1 | 37
embryonic lethality prior to o... 1 | 148
enlarged lymph nodes 1 | 27
female infertility 1 | 34
increased B cell number 1 | 23
increased NK cell number 1 | 19
increased circulating HDL chol... 1 | 63
increased circulating sodium l... 1 | 71
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased prepulse inhibition 1 | 21
male infertility 1 | 62
pale yolk sac 1 | 12
pallor 1 | 13
preweaning lethality, complete... 1 | 633
short tibia 1 | 82
thrombocytopenia 1 | 46

Disease

Cancer 99 | 2,346
psoriasis 79 | 6,685
Ankylosing spondylitis 70 | 138
Hypersensitivity reaction type II disease 61 | 235
diabetes mellitus 61 | 1,663
Arthritis 58 | 248
Acquired immunodeficiency syndrome 57 | 164
Behcet's disease 56 | 74
Juvenile rheumatoid arthritis 56 | 104
Uveitis 56 | 103
Multiple Sclerosis 49 | 498
Psoriatic arthritis 49 | 83
Rheumatoid Arthritis 44 | 1,160
Stevens-Johnson syndrome 38 | 78
ovarian cancer 38 | 8,484
lung cancer 37 | 4,466
juvenile dermatomyositis 36 | 1,189
Congenital adrenal hyperplasia 35 | 74
Retinal vasculitis 35 | 36
Takayasu's arteritis 35 | 52
cutaneous lupus erythematosus 32 | 1,056
pancreatic cancer 29 | 2,300
Hepatitis B 28 | 103
dermatomyositis 27 | 933
glioblastoma 26 | 5,572
Anemia 25 | 252
lung carcinoma 25 | 2,844
osteosarcoma 25 | 7,933
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,289
medulloblastoma, large-cell 24 | 6,234
Influenza 23 | 142
Kidney disease 23 | 396
Skin disease 23 | 65
Hemochromatosis 22 | 55
Liver disease 22 | 219
malignant mesothelioma 22 | 3,162
pilocytic astrocytoma 22 | 3,086
primary Sjogren syndrome 22 | 789
subependymal giant cell astrocytoma 22 | 2,287
Leprosy 21 | 77
Multiple myeloma 21 | 1,327
Primary immunodeficiency disease 21 | 52
cystic fibrosis 21 | 1,665
interstitial cystitis 20 | 2,299
systemic lupus erythematosus 20 | 156
active Crohn's disease 19 | 918
invasive ductal carcinoma 19 | 2,950
ulcerative colitis 18 | 2,087
Human immunodeficiency virus infectious disease 17 | 92
astrocytoma 17 | 1,493
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
posterior fossa group A ependymoma 17 | 1,511
group 4 medulloblastoma 16 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,988
pituitary cancer 15 | 1,972
pre-eclampsia 15 | 67
breast carcinoma 14 | 1,614
tuberculosis 14 | 1,557
Breast cancer 13 | 3,094
esophageal adenocarcinoma 13 | 737
Hepatitis C 12 | 90
pediatric high grade glioma 12 | 2,712
Atopic dermatitis 11 | 944
Duchenne muscular dystrophy 10 | 602
non-small cell lung cancer 10 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
inflammatory breast cancer 9 | 404
lung adenocarcinoma 9 | 2,713
primary pancreatic ductal adenocarcinoma 9 | 1,271
Down syndrome 8 | 548
atypical teratoid / rhabdoid tumor 8 | 4,369
Hepatitis 7 | 61
active ulcerative colitis 7 | 477
nasopharyngeal carcinoma 7 | 1,056
acute quadriplegic myopathy 6 | 1,157
limb girdle muscular dystrophy 2I 6 | 56
Severe acute respiratory syndrome 5 | 26
West Nile encephalitis 5 | 8
acute myeloid leukemia 5 | 780
adult high grade glioma 5 | 2,148
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
hepatocellular carcinoma 5 | 532
pancreatic carcinoma 5 | 567
Asthma 4 | 349
Barrett's esophagus 4 | 183
Carcinoma 4 | 2,147
Encephalitis 4 | 54
Melanoma 4 | 261
Muscle Weakness 4 | 92
Myocardial Ischemia 4 | 169
Pick disease 4 | 1,893
Polycythemia Vera 4 | 24
Thrombocytopenia 4 | 105
adrenocortical carcinoma 4 | 1,427
ductal carcinoma in situ 4 | 1,745
gastric carcinoma 4 | 832
glioblastoma multiforme 4 | 347
group 3 medulloblastoma 4 | 2,254
oligodendroglioma 4 | 2,849
progressive supranuclear palsy 4 | 674

Tissue

Nervous System 67 | 18,561
Digestive Tract 65 | 18,473
Female tissues 65 | 18,647
Urinary Tract 65 | 18,444
Blood and immune system 61 | 17,995
Endocrine System 61 | 18,512
Cardiovascular System 59 | 17,958
Liver and Pancreas 59 | 18,136
Respiratory system 58 | 17,484
Skin and soft tissues 58 | 18,115
Male tissues 55 | 17,969

Target Family

Non-IDG 106 | 11,971
Transcription Factor 12 | 1,400
Enzyme 7 | 4,146
Kinase 4 | 634
TF/Epigenetic 1 | 38

GO Process

type I interferon signaling pa... 130 | 130
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130

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