Development Level

Tbio 159 | 11,651
Tclin 41 | 612
Tchem 28 | 1,388
Tdark 27 | 6,593

Collection

Ion Channel: IDG Consortium (T... 15 | 99
RFA-RM-18-021 14 | 328

IMPC Phenotype

preweaning lethality, incomple... 10 | 499
preweaning lethality, complete... 7 | 979
abnormal behavior 5 | 298
decreased body weight 5 | 161
decreased vertical activity 5 | 208
enlarged heart 5 | 210
increased circulating alkaline... 5 | 122
abnormal heart morphology 4 | 162
decreased bone mineral density 4 | 126
increased startle reflex 4 | 112
abnormal embryo size 3 | 220
abnormal epididymis morphology 3 | 42
abnormal retina morphology 3 | 71
abnormal seminal vesicle morph... 3 | 114
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
decreased grip strength 3 | 116
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular vol... 3 | 79
embryonic lethality prior to t... 3 | 278
enlarged epididymis 3 | 31
impaired glucose tolerance 3 | 75
increased blood urea nitrogen ... 3 | 48
increased mean corpuscular hem... 3 | 96
increased total body fat amoun... 3 | 134
small superior vagus ganglion 3 | 74
abnormal coat-hair pigmentatio... 2 | 64
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
abnormal skin morphology 2 | 50
abnormal sleep behavior 2 | 70
abnormal spleen morphology 2 | 55
abnormal vibrissa morphology 2 | 25
cataract 2 | 92
decreased body length 2 | 101
decreased circulating LDL chol... 2 | 38
decreased circulating alkaline... 2 | 46
decreased circulating calcium ... 2 | 36
decreased circulating chloride... 2 | 30
decreased circulating creatini... 2 | 39
decreased circulating fructosa... 2 | 30
decreased circulating iron lev... 2 | 32
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
edema 2 | 59
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
hydrometra 2 | 53
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased anti-nuclear antigen... 2 | 19
increased circulating HDL chol... 2 | 80
increased circulating amylase ... 2 | 25
increased circulating calcium ... 2 | 34
increased circulating creatini... 2 | 38
increased circulating serum al... 2 | 22
increased heart weight 2 | 62
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
limb grasping 2 | 41
small heart 2 | 10
small testis 2 | 58
abnormal embryo turning 1 | 31
abnormal head morphology 1 | 10
abnormal heart looping 1 | 5
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal testis morphology 1 | 43
abnormal vocalization 1 | 21
absent vibrissae 1 | 12
decreased IgE level 1 | 6
decreased circulating amylase ... 1 | 28
decreased circulating creatine... 1 | 4
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased hematocrit 1 | 46
decreased neutrophil cell numb... 1 | 42
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
increased body length 1 | 32
increased body weight 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating fructosa... 1 | 13
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased exploration in new e... 1 | 8
increased lean body mass 1 | 172
prenatal lethality 1 | 28
thin ventricular wall 1 | 24
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 169 | 11,493
psoriasis 114 | 6,694
ovarian cancer 110 | 8,520
medulloblastoma, large-cell 105 | 6,241
glioblastoma 102 | 5,792
osteosarcoma 101 | 7,950
atypical teratoid / rhabdoid tumor 90 | 5,112
ependymoma 77 | 4,679
group 3 medulloblastoma 73 | 4,104
adult high grade glioma 69 | 3,801
lung cancer 69 | 4,740
oligodendroglioma 67 | 2,850
primitive neuroectodermal tumor 62 | 3,035
Astrocytoma, Pilocytic 58 | 3,081
Breast cancer 58 | 3,578
Kidney cancer 55 | 2,613
astrocytic glioma 53 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 52 | 3,291
lung carcinoma 50 | 2,843
malignant mesothelioma 50 | 3,232
Autosomal recessive predisposition 49 | 1,442
Schizophrenia 47 | 1,160
Epilepsy 46 | 792
intraductal papillary-mucinous adenoma (IPMA) 46 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 46 | 2,989
subependymal giant cell astrocytoma 42 | 2,287
pituitary cancer 41 | 1,972
lung adenocarcinoma 39 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 38 | 1,962
non-small cell lung cancer 35 | 2,890
Cancer 34 | 2,499
Pick disease 34 | 1,894
invasive ductal carcinoma 34 | 2,951
pancreatic cancer 34 | 2,398
ulcerative colitis 34 | 1,819
Bipolar Disorder 33 | 666
interstitial cystitis 33 | 2,312
tuberculosis 28 | 2,010
Intellectual disability 27 | 1,016
cystic fibrosis 25 | 1,696
Liver Cirrhosis, Experimental 24 | 769
Rheumatoid arthritis 24 | 1,191
astrocytoma 23 | 1,146
colon cancer 23 | 1,478
acute quadriplegic myopathy 22 | 1,158
Hypertensive disease 21 | 292
Seizures 21 | 596
adrenocortical carcinoma 21 | 1,428
diabetes mellitus 21 | 1,728
ductal carcinoma in situ 21 | 1,745
Autistic Disorder 20 | 364
Dull intelligence 20 | 645
General anesthesia 20 | 53
Low intelligence 20 | 645
Mental Retardation 20 | 645
Mental deficiency 20 | 645
Poor school performance 20 | 645
group 4 medulloblastoma 20 | 1,855
Alcoholic Intoxication, Chronic 19 | 289
Hypertension 19 | 396
active Crohn's disease 19 | 922
active ulcerative colitis 19 | 764
Cerebellar Ataxia 18 | 304
Depressive disorder 18 | 409
Muscle hypotonia 18 | 571
breast carcinoma 18 | 1,638
juvenile dermatomyositis 18 | 1,187
spina bifida 18 | 1,074
Infantile onset 17 | 238
Mental Depression 17 | 333
cutaneous lupus erythematosus 17 | 1,057
non primary Sjogren syndrome sicca 17 | 891
pediatric high grade glioma 17 | 1,064
Melanoma 16 | 711
Multiple myeloma 16 | 1,332
Cognitive delay 15 | 608
Colorectal Neoplasms 15 | 243
Duchenne muscular dystrophy 15 | 601
Global developmental delay 15 | 608
Liver cancer 15 | 604
Mental and motor retardation 15 | 608
Nystagmus 15 | 317
Obesity 15 | 678
Tonic-clonic epilepsy 15 | 47
gastric carcinoma 15 | 807
primary pancreatic ductal adenocarcinoma 15 | 1,109
Cataract 13 | 297
Diarrhea 13 | 253
Dysarthria 13 | 192
Failure to gain weight 13 | 365
Kidney disease 13 | 430
Pediatric failure to thrive 13 | 365
esophageal adenocarcinoma 13 | 737
medulloblastoma 13 | 720
Atopic dermatitis 12 | 952
Cholestasis 12 | 155
Neuropathy 12 | 261
dermatomyositis 12 | 966
progressive supranuclear palsy 12 | 676
Retinitis Pigmentosa 11 | 226

Tissue

Endocrine System 247 | 18,159
Digestive Tract 239 | 17,369
Male tissues 238 | 17,142
Skin and soft tissues 236 | 17,230
Nervous System 234 | 16,725
Female tissues 233 | 17,400
Urinary Tract 228 | 16,678
Blood and immune system 226 | 16,909
Liver and Pancreas 224 | 16,750
Respiratory system 211 | 16,393
Cardiovascular System 190 | 15,192

Target Family

Transporter 87 | 473
Non-IDG 83 | 12,091
Ion Channel 70 | 344
Enzyme 13 | 4,145
Nuclear Receptor 1 | 48
Transcription Factor 1 | 1,400

GO Process

transport 255 | 255
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable E3 ubiquitin-protein ligase HERC1 HERC1 Tbio Enzyme -1.02371 5.75 39
Sodium/hydrogen exchanger 5 SLC9A5 Tbio Transporter -1.15040 17.1 43
High affinity cationic amino acid transporter 1 SLC7A1 Tbio Transporter -2.71485 501.4 143
Voltage-dependent calcium channel gamma-2 subunit CACNG2 Tbio Ion Channel -1.92203 89.6 173
Odorant-binding protein 2a OBP2A Tdark Non-IDG -1.05436 11.3 41
Lymphatic vessel endothelial hyaluronic acid receptor 1 LYVE1 Tbio Non-IDG -2.77184 557.5 586
A-kinase anchor protein 9 AKAP9 Tbio Enzyme -2.22554 169.7 142
Transmembrane protein 184B TMEM184B Tdark Non-IDG -0.33113 1.44 57
cGMP-gated cation channel alpha-1 CNGA1 Tchem Ion Channel -1.86143 69.8 62
Organic solute transporter subunit alpha SLC51A Tbio Transporter -1.94606 84.5 82