Development Level

Tbio 130 | 10,625
Tchem 53 | 1,890
Tclin 41 | 602
Tdark 33 | 7,003

Collection

Eligible Ion Channel Proteins 20 | 117

IMPC Term

preweaning lethality, incomple... 6 | 260
increased circulating alkaline... 5 | 119
preweaning lethality, complete... 5 | 633
abnormal behavior 4 | 226
enlarged heart 4 | 111
increased blood urea nitrogen ... 4 | 44
increased mean corpuscular hem... 4 | 93
abnormal epididymis morphology 3 | 31
abnormal heart morphology 3 | 51
decreased body weight 3 | 174
decreased grip strength 3 | 123
enlarged epididymis 3 | 27
increased startle reflex 3 | 38
abnormal coat/hair pigmentatio... 2 | 54
abnormal gait 2 | 51
abnormal lens morphology 2 | 73
abnormal neural tube closure 2 | 37
abnormal retina morphology 2 | 100
abnormal seminal vesicle morph... 2 | 47
absent vibrissae 2 | 14
cardiovascular system phenotyp... 2 | 35
decreased bone mineral content 2 | 157
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 77
decreased circulating LDL chol... 2 | 37
decreased circulating calcium ... 2 | 33
decreased circulating chloride... 2 | 32
decreased circulating choleste... 2 | 85
decreased circulating fructosa... 2 | 31
decreased circulating iron lev... 2 | 25
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased lumbar vertebrae num... 2 | 62
decreased total body fat amoun... 2 | 186
embryonic lethality prior to t... 2 | 187
hyperactivity 2 | 108
impaired glucose tolerance 2 | 52
improved glucose tolerance 2 | 56
increased circulating alanine ... 2 | 11
increased circulating amylase ... 2 | 13
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased circulating creatini... 2 | 29
increased circulating magnesiu... 2 | 10
increased grip strength 2 | 83
increased heart weight 2 | 37
increased lean body mass 2 | 107
abnormal allantois morphology 1 | 3
abnormal embryo size 1 | 112
abnormal head morphology 1 | 10
abnormal iris morphology 1 | 12
abnormal kidney morphology 1 | 30
abnormal limb bud morphology 1 | 15
abnormal lung morphology 1 | 15
abnormal neural tube morpholog... 1 | 8
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
abnormal tail bud morphology 1 | 6
abnormal testis morphology 1 | 30
abnormal vibrissa morphology 1 | 17
absent pinna reflex 1 | 21
cataract 1 | 26
decreased CD4-positive, alpha ... 1 | 19
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating creatini... 1 | 31
decreased circulating glycerol... 1 | 19
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased neutrophil cell numb... 1 | 37
decreased total retina thickne... 1 | 20
hydrometra 1 | 13
hydrops fetalis 1 | 22
hypoactivity 1 | 89
impaired righting response 1 | 19
increased B cell number 1 | 23
increased body weight 1 | 42
increased caudal vertebrae num... 1 | 8
increased circulating HDL chol... 1 | 63
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating fructosa... 1 | 11
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased circulating total pr... 1 | 20
increased fasted circulating g... 1 | 68
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
short tibia 1 | 82
small superior vagus ganglion 1 | 20
small testis 1 | 37
straub tail 1 | 26
trunk curl 1 | 15
vertebral fusion 1 | 23

Disease

psoriasis 114 | 6,685
ovarian cancer 107 | 8,484
medulloblastoma, large-cell 103 | 6,234
osteosarcoma 101 | 7,933
glioblastoma 96 | 5,572
atypical teratoid / rhabdoid tumor 77 | 4,369
lung cancer 64 | 4,466
oligodendroglioma 64 | 2,849
primitive neuroectodermal tumor 62 | 3,031
pilocytic astrocytoma 57 | 3,086
Carcinoma 54 | 2,147
malignant mesothelioma 53 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 52 | 3,289
lung carcinoma 50 | 2,844
Breast cancer 47 | 3,094
ependymoma 46 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 46 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 45 | 2,956
pediatric high grade glioma 45 | 2,712
astrocytic glioma 44 | 2,241
ulcerative colitis 44 | 2,087
lung adenocarcinoma 42 | 2,713
subependymal giant cell astrocytoma 42 | 2,287
pituitary cancer 40 | 1,972
adult high grade glioma 39 | 2,148
non-small cell lung cancer 38 | 2,798
Epilepsy 36 | 346
pancreatic cancer 34 | 2,300
invasive ductal carcinoma 33 | 2,950
pancreatic ductal adenocarcinoma liver metastasis 33 | 1,795
Cancer 32 | 2,346
Pick disease 32 | 1,893
group 4 medulloblastoma 32 | 1,875
medulloblastoma 32 | 1,524
interstitial cystitis 31 | 2,299
astrocytoma 30 | 1,493
cystic fibrosis 24 | 1,665
group 3 medulloblastoma 24 | 2,254
posterior fossa group A ependymoma 24 | 1,511
Rheumatoid Arthritis 23 | 1,160
colon cancer 23 | 1,475
acute quadriplegic myopathy 22 | 1,157
tuberculosis 22 | 1,557
adrenocortical carcinoma 21 | 1,427
General anesthesia 20 | 53
diabetes mellitus 20 | 1,663
ductal carcinoma in situ 20 | 1,745
posterior fossa group B ependymoma 20 | 1,530
sonic hedgehog group medulloblastoma 20 | 1,482
Schizophrenia 19 | 501
active Crohn's disease 18 | 918
cutaneous lupus erythematosus 18 | 1,056
Autistic Disorder 17 | 320
atypical teratoid/rhabdoid tumor 17 | 1,095
breast carcinoma 17 | 1,614
primary pancreatic ductal adenocarcinoma 17 | 1,271
spina bifida 17 | 1,064
Colorectal Neoplasms 16 | 217
Hypertensive disease 16 | 193
Multiple myeloma 16 | 1,327
juvenile dermatomyositis 16 | 1,189
non primary Sjogren syndrome sicca 16 | 840
Bipolar Disorder 15 | 266
Tonic-clonic epilepsy 15 | 47
Peripheral Neuropathy 14 | 303
gastric carcinoma 14 | 832
Duchenne muscular dystrophy 13 | 602
Intellectual disability 13 | 573
dermatomyositis 13 | 933
Cholestasis 12 | 93
Kidney disease 12 | 396
Neuropathy 12 | 210
esophageal adenocarcinoma 12 | 737
primary Sjogren syndrome 12 | 789
progressive supranuclear palsy 12 | 674
Alzheimer's disease 11 | 644
Anxiety 11 | 24
Atopic dermatitis 11 | 944
IGA Glomerulonephritis 11 | 454
Insomnia 11 | 20
Lennox-Gastaut syndrome 11 | 34
Local anesthesia 11 | 40
Simple partial seizure 11 | 26
acute myeloid leukemia 11 | 780
aldosterone-producing adenoma 11 | 664
nasopharyngeal carcinoma 11 | 1,056
Cerebrovascular disease 10 | 231
Down syndrome 10 | 548
Liver disease 10 | 219
Neurodegenerative disease 10 | 383
Panic disorder 10 | 55
Retinitis pigmentosa 10 | 153
Sedation as Adjunct to Anesthesia 10 | 15
Waldenstrons macroglobulinemia 10 | 765
active ulcerative colitis 10 | 477
Epilepsy characterized by intractable complex partial seizures 9 | 28
Obesity 9 | 616
Status Epilepticus 9 | 85
pancreatic carcinoma 9 | 567
tuberculosis and treatment for 6 months 9 | 686

Tissue

Digestive Tract 254 | 18,473
Nervous System 254 | 18,561
Endocrine System 253 | 18,512
Female tissues 253 | 18,647
Liver and Pancreas 252 | 18,136
Urinary Tract 252 | 18,444
Blood and immune system 251 | 17,995
Cardiovascular System 251 | 17,958
Skin and soft tissues 251 | 18,115
Male tissues 250 | 17,969
Respiratory system 242 | 17,484

Target Family

Transporter 89 | 473
Non-IDG 82 | 11,971
Ion Channel 71 | 341
Enzyme 13 | 4,146
Nuclear Receptor 1 | 48
Transcription Factor 1 | 1,400

GO Process

transport 257 | 257
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Monocarboxylate transporter 8 SLC16A2 Tbio Transporter -2.32240 230.6 103
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
ATP-binding cassette sub-family A member 2 ABCA2 Tbio Transporter -1.41708 32.2 125
V-type proton ATPase catalytic subunit A ATP6V1A Tbio Enzyme -1.80191 64.7 120
Ileal sodium/bile acid cotransporter SLC10A2 Tchem Transporter -2.60727 417.5 121
Gamma-aminobutyric acid receptor subunit rho-1 GABRR1 Tchem Ion Channel -1.70715 50.4 134
Glucose-6-phosphate exchanger SLC37A4 SLC37A4 Tchem Transporter 0.00000 0
Acetylcholine receptor subunit delta CHRND Tclin Ion Channel -1.23749 17.4 128
H(+)/Cl(-) exchange transporter 7 CLCN7 Tbio Ion Channel -1.91579 94.4 137