Development Level

Tbio 63 | 11,445
Tchem 7 | 1,598
Tdark 2 | 6,588
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 9 | 979
embryonic lethality prior to o... 7 | 239
embryonic lethality prior to t... 4 | 278
abnormal embryo size 2 | 220
abnormal behavior 1 | 298
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal liver size 1 | 5
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
abnormal urinary bladder morph... 1 | 11
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased bone mineral density 1 | 126
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
hydrometra 1 | 53
improved glucose tolerance 1 | 79
increased anti-nuclear antigen... 1 | 19
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
prenatal lethality prior to he... 1 | 87
small seminal vesicle 1 | 10
small spleen 1 | 19
small superior vagus ganglion 1 | 74
small thymus 1 | 16

Disease

ovarian cancer 44 | 8,520
Carcinoma 39 | 11,493
osteosarcoma 32 | 7,950
Cockayne syndrome 27 | 60
lung cancer 26 | 4,740
malignant mesothelioma 19 | 3,232
Cancer 18 | 2,499
psoriasis 18 | 6,694
group 3 medulloblastoma 17 | 4,104
Xeroderma pigmentosum 15 | 43
Photosensitive trichothiodystrophy 13 | 30
medulloblastoma, large-cell 13 | 6,241
primitive neuroectodermal tumor 13 | 3,035
atypical teratoid / rhabdoid tumor 12 | 5,112
glioblastoma 12 | 5,792
Multiple myeloma 11 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
Cryptorchidism 10 | 296
Dull intelligence 10 | 645
Hypogonadism 10 | 173
Intellectual disability 10 | 1,016
Kidney cancer 10 | 2,613
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
Sensorineural Hearing Loss (disorder) 10 | 284
Short stature 10 | 531
Small head 10 | 374
diabetes mellitus 10 | 1,728
Autosomal recessive predisposition 9 | 1,442
Cataract 9 | 297
Lens Opacities 9 | 231
Photosensitivity of skin 9 | 51
Strabismus 9 | 270
Waldenstrons macroglobulinemia 9 | 765
Xeroderma pigmentosum group B 9 | 20
ependymoma 9 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
Breast cancer 8 | 3,578
Cerebellar Ataxia 8 | 304
Epilepsy 8 | 792
Hypoplastic mandible condyle 8 | 275
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Seizures 8 | 596
Xeroderma pigmentosum group D 8 | 33
acute myeloid leukemia 8 | 783
non-small cell lung cancer 8 | 2,890
Atrophic condition of skin 7 | 25
Dry skin 7 | 75
Electroencephalogram abnormal 7 | 101
Failure to gain weight 7 | 365
Freckles 7 | 33
Melanoma 7 | 711
Muscle Spasticity 7 | 195
Muscle hypotonia 7 | 571
Optic Atrophy 7 | 242
Pediatric failure to thrive 7 | 365
Stomach Neoplasms 7 | 300
Xeroderma pigmentosum group G 7 | 16
Xerosis 7 | 75
adult high grade glioma 7 | 3,801
oligodendroglioma 7 | 2,850
Arthralgia 6 | 90
Broad flat nasal bridge 6 | 236
Cognitive delay 6 | 608
Conjunctival telangiectasis 6 | 14
Deafness 6 | 198
Erythema 6 | 58
Global developmental delay 6 | 608
Keratitis 6 | 62
Low Vision 6 | 174
Mental and motor retardation 6 | 608
Nasal bridge wide 6 | 236
Pick disease 6 | 1,894
Poikiloderma 6 | 14
UV-sensitive syndrome 6 | 10
Visual Impairment 6 | 174
astrocytoma 6 | 1,146
hearing impairment 6 | 199
nasopharyngeal carcinoma 6 | 1,058
pituitary cancer 6 | 1,972
Abnormally small eyeball 5 | 97
Bladder Neoplasm 5 | 112
Cerebral atrophy 5 | 178
Decreased size of eyeball 5 | 97
Developmental regression 5 | 95
Loss of developmental milestones 5 | 95
Mental deterioration in childhood 5 | 95
Neurodevelopmental regression 5 | 95
Psychomotor regression 5 | 95
Psychomotor regression beginning in infancy 5 | 95
Psychomotor regression in infants 5 | 95
Psychomotor regression, progressive 5 | 95
Rheumatoid arthritis 5 | 1,191
Urinary Bladder Neoplasms 5 | 114
astrocytic glioma 5 | 2,597
hepatocellular carcinoma 5 | 547
pancreatic cancer 5 | 2,398

Tissue

Blood and immune system 73 | 16,909
Cardiovascular System 73 | 15,192
Digestive Tract 73 | 17,369
Endocrine System 73 | 18,159
Female tissues 73 | 17,400
Liver and Pancreas 73 | 16,750
Male tissues 73 | 17,142
Nervous System 73 | 16,725
Respiratory system 73 | 16,393
Skin and soft tissues 73 | 17,230
Urinary Tract 73 | 16,678

Target Family

Non-IDG 44 | 12,091
Enzyme 27 | 4,145
Epigenetic 1 | 242
Kinase 1 | 634

GO Process

transcription-coupled nucleoti... 73 | 73
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
Pre-mRNA-splicing factor SYF1 XAB2 Tbio Non-IDG -1.02890 12.5 247
DNA-directed RNA polymerases I, II, and III subunit RPABC2 POLR2F Tbio Enzyme -1.13403 13.9 68
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -1.32757 20.2 148
DNA-directed RNA polymerases I, II, and III subunit RPABC4 POLR2K Tbio Enzyme -0.90716 7.36 65
Pre-mRNA-splicing factor ISY1 homolog ISY1 Tdark Non-IDG 0.70 0.00000 26
COP9 signalosome complex subunit 4 COPS4 Tbio Non-IDG -0.91181 7.39 88