Development Level

Tbio 27 | 11,445
Tchem 3 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 2 | 278
abnormal behavior 1 | 298
abnormal posture 1 | 2
abnormal retina morphology 1 | 71
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased circulating sodium l... 1 | 22
increased anti-nuclear antigen... 1 | 19
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29

Disease

ovarian cancer 18 | 8,520
Carcinoma 15 | 11,493
lung cancer 13 | 4,740
osteosarcoma 12 | 7,950
Cockayne syndrome 9 | 60
Photosensitive trichothiodystrophy 9 | 30
psoriasis 8 | 6,694
glioblastoma 7 | 5,792
group 3 medulloblastoma 7 | 4,104
Pick disease 6 | 1,894
Xeroderma pigmentosum group B 6 | 20
medulloblastoma, large-cell 6 | 6,241
Cancer 5 | 2,499
Multiple myeloma 5 | 1,332
Xeroderma pigmentosum 5 | 43
Xeroderma pigmentosum group D 5 | 33
atypical teratoid / rhabdoid tumor 5 | 5,112
diabetes mellitus 5 | 1,728
ependymoma 5 | 4,679
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
pediatric high grade glioma 5 | 1,064
Intellectual disability 4 | 1,016
Xeroderma pigmentosum group G 4 | 16
colon cancer 4 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
malignant mesothelioma 4 | 3,232
non-small cell lung cancer 4 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primitive neuroectodermal tumor 4 | 3,035
Autosomal recessive predisposition 3 | 1,442
Cerebellar Ataxia 3 | 304
Dull intelligence 3 | 645
Hereditary spherocytosis type 5 3 | 12
Hypoplastic mandible condyle 3 | 275
Low intelligence 3 | 645
Mandibular hypoplasia 3 | 275
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Micrognathism 3 | 275
Poor school performance 3 | 645
Small head 3 | 374
Stomach Neoplasms 3 | 300
Strabismus 3 | 270
Trichothiodystrophy 1, photosensitive 3 | 4
Trichothiodystrophy Syndromes 3 | 6
acute myeloid leukemia 3 | 783
acute quadriplegic myopathy 3 | 1,158
breast carcinoma 3 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
lung adenocarcinoma 3 | 2,716
nasopharyngeal carcinoma 3 | 1,058
pancreatic cancer 3 | 2,398
Arsenic Poisoning 2 | 62
Arthralgia 2 | 90
Atrophy of cerebellum 2 | 103
Broad flat nasal bridge 2 | 236
Cerebellar degeneration 2 | 103
Congenital deafness 2 | 185
Congenital small ears 2 | 48
Conjunctival telangiectasis 2 | 14
Deafness 2 | 198
Dermatologic disorders 2 | 93
Developmental regression 2 | 95
Downward slant of palpebral fissure 2 | 158
Electroencephalogram abnormal 2 | 101
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Fatigue 2 | 182
Fever 2 | 138
Gliosis 2 | 56
Hearing Loss, Partial 2 | 185
Impaired cognition 2 | 96
Infratentorial atrophy 2 | 103
Keratitis 2 | 62
Loss of developmental milestones 2 | 95
Low Vision 2 | 174
Melanoma 2 | 711
Mental deterioration in childhood 2 | 95
Mental impairment 2 | 95
Muscle Spasticity 2 | 195
Nasal bridge wide 2 | 236
Neurodegenerative disease 2 | 414
Neurodevelopmental regression 2 | 95
Pediatric failure to thrive 2 | 365
Psychomotor regression 2 | 95
Psychomotor regression beginning in infancy 2 | 95
Psychomotor regression in infants 2 | 95
Psychomotor regression, progressive 2 | 95
Retinal Diseases 2 | 55
Seizures 2 | 596
Sensorineural Hearing Loss (disorder) 2 | 284
Skin Diseases 2 | 71
Squamous cell carcinoma 2 | 129
Thin skin 2 | 47
Visual Impairment 2 | 174
atypical teratoid/rhabdoid tumor 2 | 357
hearing impairment 2 | 199
tuberculosis 2 | 2,010
tuberculosis and treatment for 3 months 2 | 179

Tissue

Blood and immune system 32 | 16,909
Cardiovascular System 32 | 15,192
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Nervous System 32 | 16,725
Respiratory system 32 | 16,393
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678

Target Family

Enzyme 21 | 4,145
Non-IDG 7 | 12,091
Kinase 2 | 634
Transcription Factor 2 | 1,400

GO Process

transcription initiation from ... 32 | 32
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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