Development Level

Tbio 81 | 11,178
Tchem 8 | 1,885
Tdark 6 | 6,569

Collection

Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 18 | 979
embryonic lethality prior to o... 9 | 239
embryonic lethality prior to t... 7 | 278
abnormal retina morphology 3 | 71
abnormal heart morphology 2 | 162
decreased lean body mass 2 | 135
enlarged heart 2 | 210
hypoactivity 2 | 132
increased circulating potassiu... 2 | 29
short tibia 2 | 97
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal lens morphology 1 | 81
abnormal skin morphology 1 | 50
cataract 1 | 92
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased coping response 1 | 8
decreased kidney weight 1 | 1
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
enlarged epididymis 1 | 31
female infertility 1 | 60
increased anti-nuclear antigen... 1 | 19
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating creatine... 1 | 5
increased circulating free fat... 1 | 20
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
prolonged QRS complex duration 1 | 8
shortened RR interval 1 | 17
thrombocytopenia 1 | 56

Disease

ovarian cancer 59 | 8,297
Carcinoma 57 | 11,192
osteosarcoma 44 | 7,766
lung cancer 26 | 4,607
psoriasis 20 | 6,514
Breast cancer 19 | 3,469
Kidney cancer 19 | 2,548
Multiple myeloma 17 | 1,296
Cancer 15 | 2,388
group 3 medulloblastoma 15 | 4,002
malignant mesothelioma 15 | 3,135
medulloblastoma, large-cell 15 | 6,086
Cockayne syndrome 14 | 59
glioblastoma 14 | 5,635
atypical teratoid / rhabdoid tumor 13 | 4,971
ependymoma 13 | 4,559
Intellectual disability 12 | 998
Photosensitive trichothiodystrophy 12 | 30
acute myeloid leukemia 12 | 760
Pick disease 11 | 1,856
diabetes mellitus 11 | 1,683
oligodendroglioma 11 | 2,768
Xeroderma pigmentosum group B 10 | 20
acute quadriplegic myopathy 10 | 1,133
adult high grade glioma 9 | 3,701
astrocytic glioma 9 | 2,530
Waldenstrons macroglobulinemia 8 | 742
primitive neuroectodermal tumor 8 | 2,957
Cognitive delay 7 | 596
Dull intelligence 7 | 634
Global developmental delay 7 | 596
Low intelligence 7 | 634
Mental Retardation 7 | 634
Mental and motor retardation 7 | 596
Mental deficiency 7 | 634
Poor school performance 7 | 634
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,902
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,911
pituitary cancer 7 | 1,915
Autosomal recessive predisposition 6 | 1,407
Cerebellar Ataxia 6 | 302
Xeroderma pigmentosum group D 6 | 32
astrocytoma 6 | 1,113
dermatomyositis 6 | 941
group 4 medulloblastoma 6 | 1,806
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,204
lung adenocarcinoma 6 | 2,627
subependymal giant cell astrocytoma 6 | 2,230
tuberculosis 6 | 1,963
Cryptorchidism 5 | 287
Epidermodysplasia verruciformis 5 | 21
Muscle hypotonia 5 | 562
Rheumatoid arthritis 5 | 1,156
Small head 5 | 366
Xeroderma pigmentosum 5 | 42
breast carcinoma 5 | 1,589
juvenile dermatomyositis 5 | 1,147
non-small cell lung cancer 5 | 2,799
pancreatic cancer 5 | 2,322
pediatric high grade glioma 5 | 1,035
Astrocytoma, Pilocytic 4 | 3,006
Cataract 4 | 290
Congenital deafness 4 | 180
Deafness 4 | 193
Epilepsy 4 | 775
Hearing Loss, Partial 4 | 180
Hereditary spherocytosis type 5 4 | 12
Lens Opacities 4 | 227
Leukemia 4 | 103
Melanoma 4 | 689
Muscle Spasticity 4 | 192
Seizures 4 | 584
Short stature 4 | 514
Trichothiodystrophy Syndromes 4 | 6
Xeroderma pigmentosum group G 4 | 16
hearing impairment 4 | 194
hepatocellular carcinoma 4 | 536
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,872
invasive ductal carcinoma 4 | 2,867
lung carcinoma 4 | 2,755
non primary Sjogren syndrome sicca 4 | 861
primary pancreatic ductal adenocarcinoma 4 | 1,071
Abnormally small eyeball 3 | 94
Asthma 3 | 370
Broad flat nasal bridge 3 | 232
Chorea 3 | 29
Choreatic disease 3 | 51
Decreased size of eyeball 3 | 94
Failure to gain weight 3 | 359
Feeding difficulties in infancy 3 | 174
Hypoplastic mandible condyle 3 | 273
Intrauterine retardation 3 | 174
Nasal bridge wide 3 | 232
Neurodegenerative disease 3 | 402
Pediatric failure to thrive 3 | 359
Strabismus 3 | 265
aldosterone-producing adenoma 3 | 646
pancreatic carcinoma 3 | 555
progressive supranuclear palsy 3 | 656
ulcerative colitis 3 | 1,765

Tissue

Endocrine System 92 | 18,159
Blood and immune system 91 | 16,909
Cardiovascular System 91 | 15,192
Digestive Tract 91 | 17,369
Female tissues 91 | 17,400
Liver and Pancreas 91 | 16,750
Male tissues 91 | 17,142
Nervous System 91 | 16,725
Skin and soft tissues 91 | 17,230
Urinary Tract 91 | 16,678
Respiratory system 90 | 16,393

Target Family

Non-IDG 54 | 12,091
Enzyme 28 | 4,145
Kinase 5 | 634
Epigenetic 4 | 242
Transcription Factor 4 | 1,400

GO Process

transcription elongation from ... 95 | 95
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
DNA-directed RNA polymerase II subunit RPB3 POLR2C Tbio Enzyme -1.40207 26.1 119
Transcription initiation factor TFIID subunit 1 TAF1 Tbio Kinase -2.64215 426.1 228
TFIIH basal transcription factor complex helicase XPD subunit ERCC2 Tbio Enzyme -2.58326 365.8 191
Transcription initiation factor TFIID subunit 9 TAF9 Tbio Non-IDG -2.18859 223.1 83
Transcription factor SOX-10 SOX10 Tbio Transcription Factor -2.69195 478.2 389
WD repeat-containing protein 61 WDR61 Tbio Non-IDG -1.27258 18.3 189
Elongin-A3 member D ELOA3D Tdark Enzyme 0.00000 0
Transcription initiation factor TFIID subunit 13 TAF13 Tbio Non-IDG -0.88957 7.11 91
Transcription initiation factor TFIID subunit 5 TAF5 Tbio Non-IDG -1.08338 9.03 81