Development Level

Tbio 82 | 11,651
Tchem 7 | 1,388
Tdark 6 | 6,593

Collection

Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 18 | 979
embryonic lethality prior to o... 9 | 239
embryonic lethality prior to t... 7 | 278
abnormal retina morphology 3 | 71
abnormal heart morphology 2 | 162
decreased lean body mass 2 | 135
enlarged heart 2 | 210
hypoactivity 2 | 132
increased circulating potassiu... 2 | 29
short tibia 2 | 97
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal lens morphology 1 | 81
abnormal skin morphology 1 | 50
cataract 1 | 92
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased coping response 1 | 8
decreased kidney weight 1 | 1
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
enlarged epididymis 1 | 31
female infertility 1 | 60
increased anti-nuclear antigen... 1 | 19
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating creatine... 1 | 5
increased circulating free fat... 1 | 20
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
prolonged QRS complex duration 1 | 8
shortened RR interval 1 | 17
thrombocytopenia 1 | 56

Disease

ovarian cancer 59 | 8,520
Carcinoma 57 | 11,493
osteosarcoma 44 | 7,950
lung cancer 26 | 4,740
psoriasis 20 | 6,694
Breast cancer 19 | 3,578
Kidney cancer 19 | 2,613
Multiple myeloma 17 | 1,332
Cancer 15 | 2,499
group 3 medulloblastoma 15 | 4,104
malignant mesothelioma 15 | 3,232
medulloblastoma, large-cell 15 | 6,241
Cockayne syndrome 14 | 60
glioblastoma 14 | 5,792
atypical teratoid / rhabdoid tumor 13 | 5,112
ependymoma 13 | 4,679
Intellectual disability 12 | 1,016
Photosensitive trichothiodystrophy 12 | 30
acute myeloid leukemia 12 | 783
Pick disease 11 | 1,894
diabetes mellitus 11 | 1,728
oligodendroglioma 11 | 2,850
Xeroderma pigmentosum group B 10 | 20
acute quadriplegic myopathy 10 | 1,158
adult high grade glioma 9 | 3,801
astrocytic glioma 9 | 2,597
Waldenstrons macroglobulinemia 8 | 765
primitive neuroectodermal tumor 8 | 3,035
Cognitive delay 7 | 608
Dull intelligence 7 | 645
Global developmental delay 7 | 608
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental and motor retardation 7 | 608
Mental deficiency 7 | 645
Poor school performance 7 | 645
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
pituitary cancer 7 | 1,972
Autosomal recessive predisposition 6 | 1,442
Cerebellar Ataxia 6 | 304
Xeroderma pigmentosum group D 6 | 33
astrocytoma 6 | 1,146
dermatomyositis 6 | 966
group 4 medulloblastoma 6 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
lung adenocarcinoma 6 | 2,716
subependymal giant cell astrocytoma 6 | 2,287
tuberculosis 6 | 2,010
Cryptorchidism 5 | 296
Epidermodysplasia verruciformis 5 | 21
Muscle hypotonia 5 | 571
Rheumatoid arthritis 5 | 1,191
Small head 5 | 374
Xeroderma pigmentosum 5 | 43
breast carcinoma 5 | 1,638
juvenile dermatomyositis 5 | 1,187
non-small cell lung cancer 5 | 2,890
pancreatic cancer 5 | 2,398
pediatric high grade glioma 5 | 1,064
Astrocytoma, Pilocytic 4 | 3,081
Cataract 4 | 297
Congenital deafness 4 | 185
Deafness 4 | 198
Epilepsy 4 | 792
Hearing Loss, Partial 4 | 185
Hereditary spherocytosis type 5 4 | 12
Lens Opacities 4 | 231
Leukemia 4 | 104
Melanoma 4 | 711
Muscle Spasticity 4 | 195
Seizures 4 | 596
Short stature 4 | 531
Trichothiodystrophy Syndromes 4 | 6
Xeroderma pigmentosum group G 4 | 16
hearing impairment 4 | 199
hepatocellular carcinoma 4 | 547
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
invasive ductal carcinoma 4 | 2,951
lung carcinoma 4 | 2,843
non primary Sjogren syndrome sicca 4 | 891
primary pancreatic ductal adenocarcinoma 4 | 1,109
Abnormally small eyeball 3 | 97
Asthma 3 | 385
Broad flat nasal bridge 3 | 236
Chorea 3 | 29
Choreatic disease 3 | 52
Decreased size of eyeball 3 | 97
Failure to gain weight 3 | 365
Feeding difficulties in infancy 3 | 175
Hypoplastic mandible condyle 3 | 275
Intrauterine retardation 3 | 176
Nasal bridge wide 3 | 236
Neurodegenerative disease 3 | 414
Pediatric failure to thrive 3 | 365
Strabismus 3 | 270
aldosterone-producing adenoma 3 | 665
pancreatic carcinoma 3 | 562
progressive supranuclear palsy 3 | 676
ulcerative colitis 3 | 1,819

Tissue

Endocrine System 92 | 18,159
Blood and immune system 91 | 16,909
Cardiovascular System 91 | 15,192
Digestive Tract 91 | 17,369
Female tissues 91 | 17,400
Liver and Pancreas 91 | 16,750
Male tissues 91 | 17,142
Nervous System 91 | 16,725
Skin and soft tissues 91 | 17,230
Urinary Tract 91 | 16,678
Respiratory system 90 | 16,393

Target Family

Non-IDG 54 | 12,091
Enzyme 28 | 4,145
Kinase 5 | 634
Epigenetic 4 | 242
Transcription Factor 4 | 1,400

GO Process

transcription elongation from ... 95 | 95
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231
Transcription initiation factor IIB GTF2B Tbio Non-IDG -2.63302 410.1 286
Nuclear cap-binding protein subunit 2 NCBP2 Tbio Non-IDG -1.45099 24.2 110
RNA polymerase-associated protein LEO1 LEO1 Tbio Enzyme -2.07251 114.4 293
DNA-directed RNA polymerase II subunit RPB11-a POLR2J Tbio Enzyme -1.43224 29.3 213
Nuclear cap-binding protein subunit 1 NCBP1 Tbio Non-IDG -2.34134 207.7 172
Parafibromin CDC73 Tbio Non-IDG -2.42614 286.3 189
DNA-directed RNA polymerase II subunit RPB7 POLR2G Tbio Enzyme -1.77350 60.4 174
General transcription factor IIH subunit 3 GTF2H3 Tbio Non-IDG -0.87291 7.21 78
Transcription elongation factor SPT4 SUPT4H1 Tbio Non-IDG -1.65513 43.4 92