Development Level

Tbio 25 | 11,445
Tchem 2 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 2 | 278
abnormal behavior 1 | 298
abnormal posture 1 | 2
abnormal retina morphology 1 | 71
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased circulating sodium l... 1 | 22
increased anti-nuclear antigen... 1 | 19
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29

Disease

ovarian cancer 16 | 8,520
Carcinoma 13 | 11,493
lung cancer 12 | 4,740
osteosarcoma 12 | 7,950
Cockayne syndrome 10 | 60
Photosensitive trichothiodystrophy 10 | 30
Xeroderma pigmentosum group B 6 | 20
glioblastoma 6 | 5,792
group 3 medulloblastoma 6 | 4,104
medulloblastoma, large-cell 6 | 6,241
psoriasis 6 | 6,694
Intellectual disability 5 | 1,016
Multiple myeloma 5 | 1,332
Pick disease 5 | 1,894
Xeroderma pigmentosum 5 | 43
Xeroderma pigmentosum group D 5 | 33
Autosomal recessive predisposition 4 | 1,442
Cancer 4 | 2,499
Cerebellar Ataxia 4 | 304
Dull intelligence 4 | 645
Hypoplastic mandible condyle 4 | 275
Low intelligence 4 | 645
Mandibular hypoplasia 4 | 275
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Micrognathism 4 | 275
Poor school performance 4 | 645
Small head 4 | 374
Strabismus 4 | 270
Xeroderma pigmentosum group G 4 | 16
atypical teratoid / rhabdoid tumor 4 | 5,112
ependymoma 4 | 4,679
malignant mesothelioma 4 | 3,232
pediatric high grade glioma 4 | 1,064
primitive neuroectodermal tumor 4 | 3,035
Abnormally small eyeball 3 | 97
Atrophic condition of skin 3 | 25
Atrophy of cerebellum 3 | 103
Broad flat nasal bridge 3 | 236
Cataract 3 | 297
Cerebellar degeneration 3 | 103
Cryptorchidism 3 | 296
Decreased size of eyeball 3 | 97
Dry skin 3 | 75
Epilepsy 3 | 792
Failure to gain weight 3 | 365
Freckles 3 | 33
Hereditary spherocytosis type 5 3 | 12
Hypogonadism 3 | 173
Infratentorial atrophy 3 | 103
Keratitis 3 | 62
Kidney cancer 3 | 2,613
Lens Opacities 3 | 231
Low Vision 3 | 174
Microphthalmos 3 | 100
Muscle Spasticity 3 | 195
Nasal bridge wide 3 | 236
Optic Atrophy 3 | 242
Pediatric failure to thrive 3 | 365
Photosensitivity of skin 3 | 51
Poikiloderma 3 | 14
Seizures 3 | 596
Sensorineural Hearing Loss (disorder) 3 | 284
Short stature 3 | 531
Trichothiodystrophy 1, photosensitive 3 | 4
Trichothiodystrophy Syndromes 3 | 6
Visual Impairment 3 | 174
Xerosis 3 | 75
acute myeloid leukemia 3 | 783
colon cancer 3 | 1,478
diabetes mellitus 3 | 1,728
group 4 medulloblastoma 3 | 1,855
hearing impairment 3 | 199
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
nasopharyngeal carcinoma 3 | 1,058
non-small cell lung cancer 3 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
tuberculosis 3 | 2,010
Arsenic Poisoning 2 | 62
Arthralgia 2 | 90
Cerebellar hypoplasia and atrophy 2 | 41
Congenital deafness 2 | 185
Conjunctival telangiectasis 2 | 14
Deafness 2 | 198
Death in early childhood 2 | 82
Death in infancy 2 | 82
Decreased nerve conduction velocity 2 | 35
Dermatologic disorders 2 | 93
Downward slant of palpebral fissure 2 | 158
Fatigue 2 | 182
Fever 2 | 138
Hearing Loss, Partial 2 | 185
Joint stiffness 2 | 84
Mental deterioration 2 | 32
Photodysphoria 2 | 121
Photophobia 2 | 121
Severe psychomotor retardation 2 | 47
Skin Diseases 2 | 71
Telangiectasis 2 | 36
Tremor 2 | 113

Tissue

Blood and immune system 29 | 16,909
Cardiovascular System 29 | 15,192
Digestive Tract 29 | 17,369
Endocrine System 29 | 18,159
Female tissues 29 | 17,400
Liver and Pancreas 29 | 16,750
Male tissues 29 | 17,142
Nervous System 29 | 16,725
Respiratory system 29 | 16,393
Skin and soft tissues 29 | 17,230
Urinary Tract 29 | 16,678

Target Family

Enzyme 19 | 4,145
Non-IDG 8 | 12,091
Kinase 1 | 634
Transcription Factor 1 | 1,400

GO Process

transcription elongation from ... 29 | 29
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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