Development Level

Tbio 1,005 | 10,625
Tdark 634 | 7,003
Tchem 119 | 1,890
Tclin 21 | 602

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 73 | 633
preweaning lethality, incomple... 26 | 260
abnormal behavior 24 | 226
decreased lean body mass 24 | 195
decreased body weight 23 | 174
embryonic lethality prior to t... 23 | 187
embryonic lethality prior to o... 20 | 148
abnormal bone structure 16 | 131
decreased bone mineral content 16 | 157
decreased total body fat amoun... 16 | 186
decreased body length 15 | 108
increased bone mineral content 15 | 92
increased or absent threshold ... 14 | 128
hyperactivity 13 | 108
decreased bone mineral density 12 | 126
decreased circulating choleste... 12 | 85
abnormal embryo size 11 | 112
decreased circulating HDL chol... 11 | 77
decreased circulating serum al... 11 | 79
increased circulating alkaline... 11 | 119
increased mean corpuscular vol... 11 | 91
decreased circulating glucose ... 10 | 121
decreased circulating triglyce... 10 | 83
decreased lumbar vertebrae num... 10 | 62
hypoactivity 10 | 89
increased mean corpuscular hem... 10 | 93
increased sacral vertebrae num... 10 | 62
decreased erythrocyte cell num... 9 | 43
decreased grip strength 9 | 123
decreased hemoglobin content 9 | 53
decreased leukocyte cell numbe... 9 | 54
increased lean body mass 9 | 107
decreased rib number 8 | 59
abnormal bone mineralization 7 | 55
decreased caudal vertebrae num... 7 | 49
decreased circulating LDL chol... 7 | 37
decreased circulating insulin ... 7 | 75
increased B cell number 7 | 23
increased bone mineral density 7 | 52
short tibia 7 | 82
abnormal coat/hair pigmentatio... 6 | 54
abnormal gait 6 | 51
decreased circulating alkaline... 6 | 41
decreased circulating fructosa... 6 | 31
decreased fasted circulating g... 6 | 49
decreased hematocrit 6 | 25
increased grip strength 6 | 83
increased total body fat amoun... 6 | 57
prenatal lethality prior to he... 6 | 64
thrombocytopenia 6 | 46
abnormal lens morphology 5 | 73
abnormal tooth morphology 5 | 24
decreased T cell number 5 | 31
decreased circulating free fat... 5 | 39
decreased circulating total pr... 5 | 41
decreased eosinophil cell numb... 5 | 41
decreased prepulse inhibition 5 | 52
hydrops fetalis 5 | 22
increased body length 5 | 20
increased body weight 5 | 42
increased circulating choleste... 5 | 53
increased circulating sodium l... 5 | 71
increased fasted circulating g... 5 | 68
increased mean corpuscular hem... 5 | 25
abnormal coat/ hair morphology 4 | 18
abnormal cornea morphology 4 | 24
abnormal neural tube closure 4 | 37
abnormal retina morphology 4 | 100
corneal opacity 4 | 25
decreased CD4-positive, alpha ... 4 | 19
decreased CD8-positive, alpha-... 4 | 26
decreased circulating alanine ... 4 | 53
decreased circulating calcium ... 4 | 33
decreased effector memory CD8-... 4 | 24
decreased mature B cell number 4 | 25
decreased mean corpuscular hem... 4 | 34
decreased mean corpuscular vol... 4 | 50
decreased threshold for audito... 4 | 32
enlarged heart 4 | 111
hydrometra 4 | 13
impaired glucose tolerance 4 | 52
increased circulating HDL chol... 4 | 63
increased circulating chloride... 4 | 43
increased circulating creatini... 4 | 29
increased circulating triglyce... 4 | 24
increased hemoglobin content 4 | 45
limb grasping 4 | 35
male infertility 4 | 62
straub tail 4 | 26
tremors 4 | 34
vertebral fusion 4 | 23
vertebral transformation 4 | 12
abnormal sleep behavior 3 | 63
abnormal spleen morphology 3 | 36
cardiovascular system phenotyp... 3 | 35
increased circulating serum al... 3 | 25
increased exploration in new e... 3 | 56
increased heart weight 3 | 37
increased respiratory quotient 3 | 12
small testis 3 | 37

Disease

osteosarcoma 836 | 7,933
ovarian cancer 805 | 8,484
medulloblastoma, large-cell 576 | 6,234
psoriasis 557 | 6,685
glioblastoma 498 | 5,572
atypical teratoid / rhabdoid tumor 425 | 4,369
lung cancer 423 | 4,466
primitive neuroectodermal tumor 313 | 3,031
malignant mesothelioma 311 | 3,162
Breast cancer 295 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 263 | 3,289
oligodendroglioma 260 | 2,849
Cancer 255 | 2,346
group 3 medulloblastoma 254 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 246 | 2,988
ependymoma 238 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 234 | 2,956
invasive ductal carcinoma 229 | 2,950
Carcinoma 228 | 2,147
group 4 medulloblastoma 228 | 1,875
pediatric high grade glioma 215 | 2,712
pilocytic astrocytoma 207 | 3,086
astrocytic glioma 193 | 2,241
non-small cell lung cancer 188 | 2,798
Pick disease 174 | 1,893
lung adenocarcinoma 171 | 2,713
adult high grade glioma 167 | 2,148
subependymal giant cell astrocytoma 163 | 2,287
pancreatic cancer 162 | 2,300
lung carcinoma 160 | 2,844
pituitary cancer 153 | 1,972
sonic hedgehog group medulloblastoma 152 | 1,482
astrocytoma 151 | 1,493
interstitial cystitis 151 | 2,299
medulloblastoma 150 | 1,524
adrenocortical carcinoma 141 | 1,427
Rheumatoid Arthritis 138 | 1,160
tuberculosis 137 | 1,557
breast carcinoma 129 | 1,614
juvenile dermatomyositis 126 | 1,189
Multiple myeloma 122 | 1,327
cystic fibrosis 120 | 1,665
ductal carcinoma in situ 120 | 1,745
spina bifida 119 | 1,064
ulcerative colitis 116 | 2,087
acute quadriplegic myopathy 115 | 1,157
pancreatic ductal adenocarcinoma liver metastasis 111 | 1,795
posterior fossa group A ependymoma 111 | 1,511
primary pancreatic ductal adenocarcinoma 103 | 1,271
acute myeloid leukemia 102 | 780
tuberculosis and treatment for 6 months 101 | 686
colon cancer 94 | 1,475
diabetes mellitus 93 | 1,663
posterior fossa group B ependymoma 93 | 1,530
dermatomyositis 90 | 933
atypical teratoid/rhabdoid tumor 89 | 1,095
Waldenstrons macroglobulinemia 77 | 765
Intellectual disability 73 | 573
aldosterone-producing adenoma 73 | 664
non primary Sjogren syndrome sicca 70 | 840
primary Sjogren syndrome 69 | 789
progressive supranuclear palsy 69 | 674
cutaneous lupus erythematosus 65 | 1,056
hepatocellular carcinoma 65 | 532
nasopharyngeal carcinoma 62 | 1,056
Atopic dermatitis 56 | 944
active Crohn's disease 56 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 53 | 499
gastric cancer 53 | 430
Mammary Neoplasms 52 | 410
gastric carcinoma 50 | 832
Prostatic Neoplasms 48 | 471
Alzheimer's disease 47 | 644
pancreatic carcinoma 44 | 567
Obesity 40 | 616
Endometriosis 39 | 535
Schizophrenia 38 | 501
Crohn's disease 37 | 304
inflammatory breast cancer 37 | 404
Amyotrophic Lateral Sclerosis 36 | 431
Down syndrome 36 | 548
esophageal adenocarcinoma 36 | 737
Multiple Sclerosis 34 | 498
active ulcerative colitis 34 | 477
Stomach Neoplasms 33 | 282
chronic rhinosinusitis 33 | 512
Melanoma 32 | 261
Duchenne muscular dystrophy 31 | 602
Polycystic Ovary Syndrome 31 | 332
facioscapulohumeral dystrophy 31 | 286
sarcoidosis 31 | 358
Acquired metabolic disease 30 | 267
fibroadenoma 29 | 557
head and neck cancer 29 | 270
Craniofacial Abnormalities 28 | 147
Prostate cancer 28 | 172
glioblastoma multiforme 27 | 347
IGA Glomerulonephritis 26 | 454
hereditary spastic paraplegia 26 | 313
tuberculosis and treatment for 3 months 26 | 327

Tissue

Female tissues 1,729 | 18,647
Nervous System 1,724 | 18,561
Endocrine System 1,720 | 18,512
Digestive Tract 1,719 | 18,473
Urinary Tract 1,708 | 18,444
Liver and Pancreas 1,706 | 18,136
Blood and immune system 1,701 | 17,995
Male tissues 1,701 | 17,969
Skin and soft tissues 1,691 | 18,115
Cardiovascular System 1,686 | 17,958
Respiratory system 1,643 | 17,484

Target Family

Transcription Factor 920 | 1,400
Non-IDG 566 | 11,971
Epigenetic 133 | 242
Enzyme 89 | 4,146
Kinase 32 | 634
TF/Epigenetic 29 | 38
Nuclear Receptor 6 | 48
Transporter 3 | 473
Ion Channel 1 | 341

GO Process

transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -0.92399 9.25 269
Basic helix-loop-helix transcription factor scleraxis SCX Tbio Transcription Factor -2.80657 344.1 42
Achaete-scute homolog 5 ASCL5 Tdark Non-IDG 0.11 0
Transcription factor 24 TCF24 Tdark Non-IDG 0.30 0.09 0
Putative protein SSX6 SSX6 Tdark Non-IDG 0.60 0.17 0