Development Level

Tbio 1,005 | 10,625
Tdark 634 | 7,003
Tchem 119 | 1,890
Tclin 21 | 602

Collection

Kinase: IDG Consortium (Targets) 3 | 125
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 73 | 633
preweaning lethality, incomple... 26 | 260
abnormal behavior 24 | 226
decreased lean body mass 24 | 195
decreased body weight 23 | 174
embryonic lethality prior to t... 23 | 187
embryonic lethality prior to o... 20 | 148
abnormal bone structure 16 | 131
decreased bone mineral content 16 | 157
decreased total body fat amoun... 16 | 186
decreased body length 15 | 108
increased bone mineral content 15 | 92
increased or absent threshold ... 14 | 128
hyperactivity 13 | 108
decreased bone mineral density 12 | 126
decreased circulating choleste... 12 | 85
abnormal embryo size 11 | 112
decreased circulating HDL chol... 11 | 77
decreased circulating serum al... 11 | 79
increased circulating alkaline... 11 | 119
increased mean corpuscular vol... 11 | 91
decreased circulating glucose ... 10 | 121
decreased circulating triglyce... 10 | 83
decreased lumbar vertebrae num... 10 | 62
hypoactivity 10 | 89
increased mean corpuscular hem... 10 | 93
increased sacral vertebrae num... 10 | 62
decreased erythrocyte cell num... 9 | 43
decreased grip strength 9 | 123
decreased hemoglobin content 9 | 53
decreased leukocyte cell numbe... 9 | 54
increased lean body mass 9 | 107
decreased rib number 8 | 59
abnormal bone mineralization 7 | 55
decreased caudal vertebrae num... 7 | 49
decreased circulating LDL chol... 7 | 37
decreased circulating insulin ... 7 | 75
increased B cell number 7 | 23
increased bone mineral density 7 | 52
short tibia 7 | 82
abnormal coat-hair pigmentatio... 6 | 54
abnormal gait 6 | 51
decreased circulating alkaline... 6 | 41
decreased circulating fructosa... 6 | 31
decreased fasted circulating g... 6 | 49
decreased hematocrit 6 | 25
increased grip strength 6 | 83
increased total body fat amoun... 6 | 57
prenatal lethality prior to he... 6 | 64
thrombocytopenia 6 | 46
abnormal lens morphology 5 | 73
abnormal tooth morphology 5 | 24
decreased T cell number 5 | 31
decreased circulating free fat... 5 | 39
decreased circulating total pr... 5 | 41
decreased eosinophil cell numb... 5 | 41
decreased prepulse inhibition 5 | 52
hydrops fetalis 5 | 22
increased body length 5 | 20
increased body weight 5 | 42
increased circulating choleste... 5 | 53
increased circulating sodium l... 5 | 71
increased fasted circulating g... 5 | 68
increased mean corpuscular hem... 5 | 25
abnormal coat- hair morphology 4 | 18
abnormal cornea morphology 4 | 24
abnormal neural tube closure 4 | 37
abnormal retina morphology 4 | 100
corneal opacity 4 | 25
decreased CD4-positive, alpha ... 4 | 19
decreased CD8-positive, alpha-... 4 | 26
decreased circulating alanine ... 4 | 53
decreased circulating calcium ... 4 | 33
decreased effector memory CD8-... 4 | 24
decreased mature B cell number 4 | 25
decreased mean corpuscular hem... 4 | 34
decreased mean corpuscular vol... 4 | 50
decreased threshold for audito... 4 | 32
enlarged heart 4 | 111
hydrometra 4 | 13
impaired glucose tolerance 4 | 52
increased circulating HDL chol... 4 | 63
increased circulating chloride... 4 | 43
increased circulating creatini... 4 | 29
increased circulating triglyce... 4 | 24
increased hemoglobin content 4 | 45
limb grasping 4 | 35
male infertility 4 | 62
straub tail 4 | 26
tremors 4 | 34
vertebral fusion 4 | 23
vertebral transformation 4 | 12
abnormal sleep behavior 3 | 63
abnormal spleen morphology 3 | 36
cardiovascular system phenotyp... 3 | 35
increased circulating serum al... 3 | 25
increased exploration in new e... 3 | 56
increased heart weight 3 | 37
increased respiratory quotient 3 | 12
small testis 3 | 37

Disease

osteosarcoma 836 | 7,933
ovarian cancer 808 | 8,491
medulloblastoma, large-cell 576 | 6,234
psoriasis 557 | 6,685
glioblastoma 498 | 5,572
atypical teratoid / rhabdoid tumor 425 | 4,369
lung cancer 425 | 4,473
primitive neuroectodermal tumor 313 | 3,031
malignant mesothelioma 311 | 3,163
Breast cancer 295 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 263 | 3,289
oligodendroglioma 260 | 2,849
Cancer 255 | 2,346
group 3 medulloblastoma 254 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 246 | 2,988
ependymoma 238 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 234 | 2,956
invasive ductal carcinoma 229 | 2,950
Carcinoma 228 | 2,147
group 4 medulloblastoma 228 | 1,875
pediatric high grade glioma 215 | 2,712
pilocytic astrocytoma 207 | 3,086
astrocytic glioma 193 | 2,241
non-small cell lung cancer 188 | 2,798
Pick disease 174 | 1,893
lung adenocarcinoma 171 | 2,714
adult high grade glioma 167 | 2,148
subependymal giant cell astrocytoma 163 | 2,287
pancreatic cancer 162 | 2,300
lung carcinoma 160 | 2,844
pituitary cancer 153 | 1,972
sonic hedgehog group medulloblastoma 152 | 1,482
astrocytoma 151 | 1,493
interstitial cystitis 151 | 2,299
medulloblastoma 150 | 1,524
adrenocortical carcinoma 141 | 1,427
Rheumatoid Arthritis 138 | 1,170
tuberculosis 137 | 1,563
breast carcinoma 129 | 1,614
juvenile dermatomyositis 126 | 1,189
Multiple myeloma 122 | 1,327
cystic fibrosis 120 | 1,670
ductal carcinoma in situ 120 | 1,745
spina bifida 119 | 1,064
ulcerative colitis 116 | 2,087
acute quadriplegic myopathy 115 | 1,157
pancreatic ductal adenocarcinoma liver metastasis 111 | 1,795
posterior fossa group A ependymoma 111 | 1,511
acute myeloid leukemia 104 | 785
primary pancreatic ductal adenocarcinoma 103 | 1,271
tuberculosis and treatment for 6 months 101 | 686
colon cancer 94 | 1,475
diabetes mellitus 93 | 1,663
posterior fossa group B ependymoma 93 | 1,530
dermatomyositis 90 | 966
atypical teratoid/rhabdoid tumor 89 | 1,095
Waldenstrons macroglobulinemia 77 | 764
Intellectual disability 73 | 573
aldosterone-producing adenoma 73 | 664
non primary Sjogren syndrome sicca 70 | 840
primary Sjogren syndrome 69 | 788
progressive supranuclear palsy 69 | 674
hepatocellular carcinoma 67 | 550
cutaneous lupus erythematosus 65 | 1,056
nasopharyngeal carcinoma 62 | 1,056
Atopic dermatitis 56 | 944
active Crohn's disease 56 | 918
gastric cancer 55 | 436
autosomal dominant Emery-Dreifuss muscular dystrophy 53 | 499
Mammary Neoplasms 52 | 410
gastric carcinoma 50 | 832
Prostatic Neoplasms 48 | 471
Alzheimer's disease 47 | 644
pancreatic carcinoma 44 | 567
Obesity 40 | 616
Endometriosis 39 | 535
Schizophrenia 39 | 503
Crohn's disease 37 | 304
inflammatory breast cancer 37 | 404
Amyotrophic Lateral Sclerosis 36 | 432
Down syndrome 36 | 548
esophageal adenocarcinoma 36 | 737
Multiple Sclerosis 34 | 498
active ulcerative colitis 34 | 477
Stomach Neoplasms 33 | 282
chronic rhinosinusitis 33 | 512
Melanoma 32 | 261
Duchenne muscular dystrophy 31 | 602
Polycystic Ovary Syndrome 31 | 334
facioscapulohumeral dystrophy 31 | 286
sarcoidosis 31 | 368
Acquired metabolic disease 30 | 267
fibroadenoma 29 | 557
head and neck cancer 29 | 270
Craniofacial Abnormalities 28 | 147
Prostate cancer 28 | 172
glioblastoma multiforme 27 | 347
IGA Glomerulonephritis 26 | 454
hereditary spastic paraplegia 26 | 313
tuberculosis and treatment for 3 months 26 | 327

Tissue

Female tissues 1,729 | 18,646
Nervous System 1,724 | 18,560
Endocrine System 1,720 | 18,511
Digestive Tract 1,719 | 18,472
Urinary Tract 1,708 | 18,443
Liver and Pancreas 1,706 | 18,135
Blood and immune system 1,701 | 17,994
Male tissues 1,701 | 17,968
Skin and soft tissues 1,691 | 18,114
Cardiovascular System 1,686 | 17,957
Respiratory system 1,643 | 17,483

Target Family

Transcription Factor 920 | 1,400
Non-IDG 566 | 11,969
Epigenetic 133 | 242
Enzyme 89 | 4,146
Kinase 32 | 634
TF/Epigenetic 29 | 38
Nuclear Receptor 6 | 48
Transporter 3 | 473
Ion Channel 1 | 341

GO Process

transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 367 | 367
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
chemical synaptic transmission 238 | 238
MAPK cascade 237 | 237
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 199 | 199
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 180 | 180
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 175 | 175
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
protein folding 162 | 162
negative regulation of canonic... 161 | 161
response to lipopolysaccharide 161 | 161
T cell receptor signaling path... 160 | 160
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2-M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
type I interferon signaling pa... 130 | 130
endocytosis 129 | 129

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Zinc finger protein 214 ZNF214 Tdark Transcription Factor -0.49369 2.48 88
Isobutyryl-CoA dehydrogenase, mitochondrial ACAD8 Tbio Enzyme -1.14784 13.7 122
Zinc finger protein 606 ZNF606 Tdark Transcription Factor 0.00000 1.48 76
Myelin transcription factor 1-like protein MYT1L Tbio Transcription Factor -1.43180 24.8 41
Zinc finger protein 705F ZNF705F Tdark Non-IDG 0.00000 0
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Forkhead box protein B1 FOXB1 Tbio Transcription Factor -1.13586 14.6 100
E3 ubiquitin-protein ligase RLIM RLIM Tbio Enzyme -1.57212 36.3 141
Zinc finger protein 317 ZNF317 Tdark Transcription Factor 0.30 1.00 68