Development Level

Tbio 28 | 11,651
Tchem 7 | 1,388
Tclin 3 | 612

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to o... 4 | 239
abnormal coat- hair morphology 1 | 19
abnormal retinal inner nuclear... 1 | 8
decreased circulating glucose ... 1 | 126
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased total retina thickne... 1 | 17
embryonic lethality prior to t... 1 | 278
increased aggression 1 | 4
increased grip strength 1 | 41
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 25 | 11,493
ovarian cancer 24 | 8,520
lung cancer 18 | 4,740
Breast cancer 17 | 3,578
medulloblastoma, large-cell 15 | 6,241
osteosarcoma 15 | 7,950
psoriasis 15 | 6,694
Cancer 14 | 2,499
group 3 medulloblastoma 14 | 4,104
glioblastoma 11 | 5,792
Short stature 10 | 531
malignant mesothelioma 10 | 3,232
Autosomal recessive predisposition 9 | 1,442
atypical teratoid / rhabdoid tumor 9 | 5,112
Intellectual disability 8 | 1,016
Waldenstrons macroglobulinemia 8 | 765
lung adenocarcinoma 8 | 2,716
Dull intelligence 7 | 645
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Xeroderma pigmentosum 7 | 43
non-small cell lung cancer 7 | 2,890
Dyskeratosis congenita 6 | 24
Fanconi anemia 6 | 56
Kidney cancer 6 | 2,613
Melanoma 6 | 711
Multiple myeloma 6 | 1,332
Small head 6 | 374
diabetes mellitus 6 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
primitive neuroectodermal tumor 6 | 3,035
Ataxia telangiectasia 5 | 34
Atrophic condition of skin 5 | 25
Cerebellar Ataxia 5 | 304
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
Pick disease 5 | 1,894
Premature canities 5 | 24
Prostatic Neoplasms 5 | 495
Telangiectasia of the skin 5 | 39
Werner syndrome 5 | 29
ependymoma 5 | 4,679
oligodendroglioma 5 | 2,850
subependymal giant cell astrocytoma 5 | 2,287
ulcerative colitis 5 | 1,819
Bladder Neoplasm 4 | 112
Bone marrow hypocellularity 4 | 20
Breast Neoplasms 4 | 445
Carcinoma, Hepatocellular 4 | 228
Cataract 4 | 297
Convex nasal ridge 4 | 37
Decreased platelet count 4 | 111
Fetal Growth Retardation 4 | 189
Hair shaft abnormalities 4 | 30
Hypogonadism 4 | 173
Hypoplastic mandible condyle 4 | 275
Infant, Small for Gestational Age 4 | 176
Intrauterine retardation 4 | 176
Liver carcinoma 4 | 240
Lung Neoplasms 4 | 232
Mammary Neoplasms 4 | 425
Mandibular hypoplasia 4 | 275
Micrognathism 4 | 275
Neurodegenerative disease 4 | 414
Nijmegen breakage syndrome 4 | 24
Osteoporosis 4 | 363
Thrombocytopenia 4 | 197
Urinary Bladder Neoplasms 4 | 114
breast carcinoma 4 | 1,638
dermatomyositis 4 | 966
gastric carcinoma 4 | 807
hair abnormalities (non-specific) 4 | 30
invasive ductal carcinoma 4 | 2,951
nasopharyngeal carcinoma 4 | 1,058
non primary Sjogren syndrome sicca 4 | 891
Acquired scoliosis 3 | 281
Anemia 3 | 365
Curvature of spine 3 | 282
Disease Progression 3 | 136
Failure to gain weight 3 | 365
Heart disease 3 | 306
Hepatic enzyme increased 3 | 81
Liver Dysfunction 3 | 99
Liver enzymes abnormal 3 | 81
Liver function tests abnormal finding 3 | 81
Muscle Spasticity 3 | 195
Pediatric failure to thrive 3 | 365
Polycystic ovary syndrome 3 | 360
Prostate cancer 3 | 175
Seizures 3 | 596
Strabismus 3 | 270
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
astrocytoma 3 | 1,146
pancreatic cancer 3 | 2,398
pituitary cancer 3 | 1,972
progressive supranuclear palsy 3 | 676

Tissue

Blood and immune system 36 | 16,909
Digestive Tract 36 | 17,369
Endocrine System 36 | 18,159
Cardiovascular System 35 | 15,192
Female tissues 35 | 17,400
Liver and Pancreas 35 | 16,750
Male tissues 35 | 17,142
Nervous System 35 | 16,725
Respiratory system 35 | 16,393
Skin and soft tissues 35 | 17,230
Urinary Tract 35 | 16,678

Target Family

Non-IDG 18 | 12,091
Enzyme 16 | 4,145
Transcription Factor 2 | 1,400
Kinase 1 | 634
TF/Epigenetic 1 | 38

GO Process

telomere maintenance 38 | 38
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Poly [ADP-ribose] polymerase 3 PARP3 Tclin Enzyme -1.66230 41.9 193
F-box only protein 4 FBXO4 Tbio Non-IDG -1.07080 11.1 225
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.06760 110.4 225
X-ray repair cross-complementing protein 5 XRCC5 Tbio Non-IDG -2.68622 470.8 874
DNA polymerase delta subunit 2 POLD2 Tbio Enzyme -0.95222 8.52 115
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.48277 297.9 350
DNA-(apurinic or apyrimidinic site) lyase APEX1 Tchem Enzyme -3.47746 2989.0 646
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.13711 11.3 1721
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.79461 61.4 510
DNA replication ATP-dependent helicase/nuclease DNA2 DNA2 Tbio Enzyme -2.42159 256.1 101