Development Level

Tbio 16 | 11,445
Tdark 7 | 6,588
Tchem 2 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased grip strength 2 | 116
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal vibrissa morphology 1 | 25
decreased circulating insulin ... 1 | 76
decreased fasted circulating g... 1 | 65
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172

Disease

ovarian cancer 17 | 8,520
Carcinoma 11 | 11,493
medulloblastoma, large-cell 11 | 6,241
lung cancer 10 | 4,740
glioblastoma 9 | 5,792
osteosarcoma 9 | 7,950
atypical teratoid / rhabdoid tumor 8 | 5,112
group 3 medulloblastoma 7 | 4,104
Multiple myeloma 6 | 1,332
invasive ductal carcinoma 5 | 2,951
psoriasis 5 | 6,694
Waldenstrons macroglobulinemia 4 | 765
ependymoma 4 | 4,679
primitive neuroectodermal tumor 4 | 3,035
progressive supranuclear palsy 4 | 676
Autosomal recessive predisposition 3 | 1,442
Cognitive delay 3 | 608
Epilepsy 3 | 792
Galloway Mowat syndrome 3 | 6
Galloway-Mowat syndrome 3 | 15
Global developmental delay 3 | 608
Mental and motor retardation 3 | 608
Neurodegenerative disease 3 | 414
acute quadriplegic myopathy 3 | 1,158
adult high grade glioma 3 | 3,801
astrocytoma 3 | 1,146
breast carcinoma 3 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
malignant mesothelioma 3 | 3,232
oligodendroglioma 3 | 2,850
pancreatic cancer 3 | 2,398
sonic hedgehog group medulloblastoma 3 | 467
Absent reflex 2 | 92
Absent tendon reflex 2 | 92
Breast cancer 2 | 3,578
Cardiovascular system disease 2 | 246
Cerebral atrophy 2 | 178
Charcot-Marie-Tooth disease 2 | 62
Congenital pes cavus 2 | 88
Degenerative brain disorder 2 | 100
Distal sensory impairment 2 | 52
Foot dorsiflexor weakness 2 | 27
Foot-drop 2 | 27
Muscle hypotonia 2 | 571
Neuropathy 2 | 261
Pick disease 2 | 1,894
Reflex, Deep Tendon, Absent 2 | 92
Shipyard eye 2 | 15
Small head 2 | 374
Supratentorial atrophy 2 | 94
acute myeloid leukemia 2 | 783
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
hereditary spastic paraplegia 2 | 318
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung carcinoma 2 | 2,843
non-small cell lung cancer 2 | 2,890
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010
Adenocarcinoma of lung 1 | 142
Antiphospholipid syndrome 1 | 19
Autoimmune Diseases 1 | 67
Axonal neuropathy 1 | 27
Breast Neoplasms 1 | 445
Congenital deafness 1 | 185
Deafness 1 | 198
Death in early childhood 1 | 82
Death in infancy 1 | 82
Dilated ventricles (finding) 1 | 121
Disease Models, Animal 1 | 155
Disseminated intravascular coagulation 1 | 38
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Hearing Loss, Partial 1 | 185
Highly variable severity 1 | 157
Increased serum lactate 1 | 60
Kidney Diseases 1 | 114
Lupus erythematosus 1 | 57
Mammary Neoplasms 1 | 425
Microcephaly 1 | 166
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
Nonsyndromic deafness 1 | 142
Peripheral axonal neuropathy 1 | 18
Pilocytic astrocytoma 1 | 56
Poor growth 1 | 114
Prenatal onset 1 | 139
Retinitis pigmentosa 11 1 | 59
Rheumatic disease 1 | 8
Sjogren's syndrome 1 | 26
Skeletal muscle atrophy 1 | 139
Variable expressivity 1 | 157
Very poor growth 1 | 114
hearing impairment 1 | 199
muscle degeneration 1 | 139

Tissue

Cardiovascular System 24 | 15,192
Digestive Tract 24 | 17,369
Endocrine System 24 | 18,159
Female tissues 24 | 17,400
Liver and Pancreas 24 | 16,750
Male tissues 24 | 17,142
Nervous System 24 | 16,725
Respiratory system 24 | 16,393
Skin and soft tissues 24 | 17,230
Urinary Tract 24 | 16,678
Blood and immune system 23 | 16,909

Target Family

Enzyme 18 | 4,145
Non-IDG 6 | 12,091
Kinase 1 | 634

GO Process

tRNA processing 25 | 25
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
tRNA-specific adenosine deaminase 1 ADAT1 Tbio Enzyme -1.08814 11.8 136
Probable tRNA(His) guanylyltransferase THG1L Tbio Enzyme -0.60206 3.69 71
Pseudouridylate synthase 7 homolog PUS7 Tbio Enzyme -1.01773 8.78 58
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 Tbio Enzyme -1.13540 12.8 55
EKC/KEOPS complex subunit TPRKB TPRKB Tbio Non-IDG -0.79500 4.88 134
Alanine--tRNA ligase, cytoplasmic AARS Tbio Enzyme -2.49617 295.2 140
G-rich sequence factor 1 GRSF1 Tbio Non-IDG -1.05585 12.0 138
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B Tdark Enzyme 0.00000 0
Pseudouridylate synthase 7 homolog-like protein PUS7L Tdark Enzyme 0.60 0.11 34
Ribonuclease P protein subunit p20 POP7 Tbio Enzyme -0.86962 7.33 47