Development Level

Tbio 23 | 11,651
Tchem 12 | 1,388

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to o... 5 | 239
decreased grip strength 3 | 116
embryonic lethality prior to t... 3 | 278
abnormal embryo size 2 | 220
decreased fasted circulating g... 2 | 65
impaired glucose tolerance 2 | 75
increased total body fat amoun... 2 | 134
abnormal QT variability 1 | 10
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal spinal cord morpholog... 1 | 9
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 30
decreased circulating sodium l... 1 | 22
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
decreased urine magnesium leve... 1 | 3
embryonic growth retardation 1 | 106
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased erythrocyte cell num... 1 | 39
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased red blood cell distr... 1 | 34
increased thermal nociceptive ... 1 | 9

Disease

Carcinoma 33 | 11,493
ovarian cancer 30 | 8,520
Autosomal recessive predisposition 16 | 1,442
lung cancer 16 | 4,740
Multiple myeloma 14 | 1,332
psoriasis 14 | 6,694
medulloblastoma, large-cell 11 | 6,241
osteosarcoma 10 | 7,950
Neurodegenerative disease 9 | 414
diabetes mellitus 9 | 1,728
glioblastoma 8 | 5,792
Cancer 7 | 2,499
Cognitive delay 7 | 608
Distal sensory impairment 7 | 52
Epilepsy 7 | 792
Global developmental delay 7 | 608
Mental and motor retardation 7 | 608
Neuropathy 7 | 261
astrocytoma 7 | 1,146
Breast cancer 6 | 3,578
Charcot-Marie-Tooth disease 6 | 62
Failure to gain weight 6 | 365
Muscle hypotonia 6 | 571
Nystagmus 6 | 317
Pediatric failure to thrive 6 | 365
Small head 6 | 374
colon cancer 6 | 1,478
dermatomyositis 6 | 966
Anemia 5 | 365
Kidney cancer 5 | 2,613
Myositis 5 | 30
Progressive disorder 5 | 142
Waldenstrons macroglobulinemia 5 | 765
group 3 medulloblastoma 5 | 4,104
juvenile dermatomyositis 5 | 1,187
non-small cell lung cancer 5 | 2,890
tuberculosis 5 | 2,010
Autosomal recessive Robinow syndrome 4 | 27
Congenital pes cavus 4 | 88
Decreased tendon reflex 4 | 122
Hemoglobin low 4 | 124
Highly variable severity 4 | 157
Pick disease 4 | 1,894
Variable expressivity 4 | 157
acute quadriplegic myopathy 4 | 1,158
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
non primary Sjogren syndrome sicca 4 | 891
sonic hedgehog group medulloblastoma 4 | 467
Absent reflex 3 | 92
Absent tendon reflex 3 | 92
Acidosis, Lactic 3 | 97
Acquired scoliosis 3 | 281
Axonal neuropathy 3 | 27
CNS hypomyelination 3 | 17
Cerebral atrophy 3 | 178
Curvature of spine 3 | 282
Degenerative brain disorder 3 | 100
Distal limb muscle weakness due to peripheral neuropathy 3 | 62
Distal muscle weakness 3 | 62
Foot dorsiflexor weakness 3 | 27
Foot-drop 3 | 27
Gait, Drop Foot 3 | 24
Hammer Toe 3 | 23
Hyperreflexia 3 | 209
Hypomyelination 3 | 17
Hypoplasia of corpus callosum 3 | 90
Lactic acidemia 3 | 95
Leigh disease 3 | 100
Motor delay 3 | 147
Muscle Spasticity 3 | 195
No development of motor milestones 3 | 147
Peripheral axonal neuropathy 3 | 18
Perrault syndrome 3 | 19
Reflex, Deep Tendon, Absent 3 | 92
Seizures 3 | 596
Sensorineural Hearing Loss (disorder) 3 | 284
Slow progression 3 | 89
Supratentorial atrophy 3 | 94
acute myeloid leukemia 3 | 783
atypical teratoid / rhabdoid tumor 3 | 5,112
ependymoma 3 | 4,679
interstitial lung disease 3 | 298
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
invasive ductal carcinoma 3 | 2,951
lung adenocarcinoma 3 | 2,716
malignant mesothelioma 3 | 3,232
oligodendroglioma 3 | 2,850
pancreatic cancer 3 | 2,398
pediatric high grade glioma 3 | 1,064
primitive neuroectodermal tumor 3 | 3,035
Electroencephalogram abnormal 2 | 101
Hepatic enzyme increased 2 | 81
Lactic acidosis 2 | 51
Liver Dysfunction 2 | 99
Liver enzymes abnormal 2 | 81
Liver function tests abnormal finding 2 | 81
Long philtrum 2 | 137
active Crohn's disease 2 | 922
posterior fossa group B ependymoma 2 | 416

Tissue

Blood and immune system 35 | 16,909
Cardiovascular System 35 | 15,192
Digestive Tract 35 | 17,369
Endocrine System 35 | 18,159
Female tissues 35 | 17,400
Liver and Pancreas 35 | 16,750
Male tissues 35 | 17,142
Nervous System 35 | 16,725
Respiratory system 35 | 16,393
Skin and soft tissues 35 | 17,230
Urinary Tract 35 | 16,678

Target Family

Enzyme 34 | 4,145
Non-IDG 1 | 12,091

GO Process

tRNA aminoacylation for protei... 35 | 35
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 AIMP2 Tbio Enzyme -1.35413 26.1 138
Serine--tRNA ligase, cytoplasmic SARS Tbio Enzyme -2.37540 230.1 178
Probable histidine--tRNA ligase, mitochondrial HARS2 Tbio Enzyme -2.45127 269.2 93
Tyrosine--tRNA ligase, mitochondrial YARS2 Tbio Enzyme -2.13699 138.7 93
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 AIMP1 Tbio Enzyme -2.05952 138.6 386
Lysine--tRNA ligase KARS Tchem Enzyme -2.45716 282.5 150
Inorganic pyrophosphatase 2, mitochondrial PPA2 Tbio Enzyme -1.36800 21.4 56
Probable arginine--tRNA ligase, mitochondrial RARS2 Tbio Enzyme -1.86056 68.8 36
Glutamine--tRNA ligase QARS Tchem Enzyme -1.63877 42.2 77
Leucine--tRNA ligase, cytoplasmic LARS Tchem Enzyme -3.18894 1507.3 68