Development Level

Tbio 5 | 10,625

IMPC Phenotype

abnormal kidney morphology 1 | 30
abnormal seminal vesicle morph... 1 | 47
decreased total body fat amoun... 1 | 186
increased grip strength 1 | 83
increased lean body mass 1 | 107
preweaning lethality, complete... 1 | 633

Disease

ovarian cancer 4 | 8,491
Methylmalonic acidemia 3 | 39
astrocytic glioma 3 | 2,241
medulloblastoma 3 | 1,524
medulloblastoma, large-cell 3 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
ulcerative colitis 3 | 2,087
Lactic acidosis 2 | 43
Leigh disease 2 | 81
Mitochondrial myopathy 2 | 24
Multiple myeloma 2 | 1,327
Obesity 2 | 616
atypical teratoid / rhabdoid tumor 2 | 4,369
ependymoma 2 | 2,514
glioblastoma 2 | 5,572
malignant mesothelioma 2 | 3,163
oligodendroglioma 2 | 2,849
psoriasis 2 | 6,685
ALPHA-KETOGLUTARATE DEHYDROGENASE DEFICIENCY 1 | 1
Bilateral retinoblastoma 1 | 3
Breast cancer 1 | 3,098
Cellulitis 1 | 13
Cholera 1 | 33
Deafness dystonia syndrome 1 | 20
Disease Progression 1 | 125
Down syndrome 1 | 548
Dystonia 1 | 77
Endometriosis 1 | 535
Heart conduction disease 1 | 65
MITOCHONDRIAL DNA DEPLETION SYNDROME 2 (MYOPATHIC TYPE) 1 | 2
MITOCHONDRIAL DNA DEPLETION SYNDROME 3 (HEPATOCEREBRAL TYPE) 1 | 5
MITOCHONDRIAL DNA DEPLETION SYNDROME 5 (ENCEPHALOMYOPATHIC WITH OR WITHOUT METHYLMALONIC ACIDURIA) 1 | 1
MITOCHONDRIAL DNA DEPLETION SYNDROME 9 (ENCEPHALOMYOPATHIC TYPE WITH METHYLMALONIC ACIDURIA) 1 | 1
Mitochondrial DNA depletion syndrome 2 1 | 2
Mitochondrial DNA depletion syndrome 5 1 | 1
Mitochondrial DNA depletion syndrome 9 1 | 1
Orotic aciduria 1 | 16
Pearson syndrome 1 | 17
Pharyngitis 1 | 17
Pick disease 1 | 1,893
Primary biliary cirrhosis 1 | 45
Sideroblastic anemia 1 | 18
Stomach Neoplasms 1 | 282
Vasomotor rhinitis 1 | 15
Waldenstrons macroglobulinemia 1 | 764
adult high grade glioma 1 | 2,148
astrocytoma 1 | 1,493
colon cancer 1 | 1,475
dermatomyositis 1 | 966
glioblastoma multiforme 1 | 347
group 4 medulloblastoma 1 | 1,875
hereditary spastic paraplegia 1 | 313
invasive ductal carcinoma 1 | 2,950
lung adenocarcinoma 1 | 2,714
lung cancer 1 | 4,473
mucosa-associated lymphoid tissue lymphoma 1 | 480
osteosarcoma 1 | 7,933
pilocytic astrocytoma 1 | 3,086
primitive neuroectodermal tumor 1 | 3,031
subependymal giant cell astrocytoma 1 | 2,287
tuberculosis 1 | 1,563

Tissue

Blood and immune system 5 | 17,994
Cardiovascular System 5 | 17,957
Digestive Tract 5 | 18,472
Endocrine System 5 | 18,511
Female tissues 5 | 18,646
Liver and Pancreas 5 | 18,135
Male tissues 5 | 17,968
Nervous System 5 | 18,560
Respiratory system 5 | 17,483
Skin and soft tissues 5 | 18,114
Urinary Tract 5 | 18,443

Target Family

Enzyme 5 | 4,146

GO Process

succinyl-CoA metabolic process 5 | 5
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 367 | 367
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
chemical synaptic transmission 238 | 238
MAPK cascade 237 | 237
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 199 | 199
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 180 | 180
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 175 | 175
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
protein folding 162 | 162
negative regulation of canonic... 161 | 161
response to lipopolysaccharide 161 | 161
T cell receptor signaling path... 160 | 160
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2-M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
type I interferon signaling pa... 130 | 130
endocytosis 129 | 129

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