Development Level

Tchem 21 | 1,598
Tbio 9 | 11,445
Tdark 2 | 6,588
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Target... 8 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

decreased mean corpuscular vol... 2 | 79
abnormal embryo size 1 | 220
abnormal retina morphology 1 | 71
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
embryonic lethality prior to t... 1 | 278
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cardiac stroke volum... 1 | 1
increased caudal vertebrae num... 1 | 7
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased or absent threshold ... 1 | 101
prenatal lethality prior to he... 1 | 87
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
small testis 1 | 58

Disease

Carcinoma 31 | 11,493
ovarian cancer 21 | 8,520
osteosarcoma 18 | 7,950
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
lung cancer 12 | 4,740
malignant mesothelioma 12 | 3,232
medulloblastoma, large-cell 12 | 6,241
psoriasis 12 | 6,694
glioblastoma 10 | 5,792
non-small cell lung cancer 10 | 2,890
ependymoma 9 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
Breast cancer 8 | 3,578
Cancer 8 | 2,499
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
lung carcinoma 8 | 2,843
pancreatic cancer 8 | 2,398
Kidney cancer 7 | 2,613
adult high grade glioma 7 | 3,801
atypical teratoid / rhabdoid tumor 7 | 5,112
Astrocytoma, Pilocytic 6 | 3,081
astrocytic glioma 6 | 2,597
invasive ductal carcinoma 6 | 2,951
primitive neuroectodermal tumor 6 | 3,035
pituitary cancer 5 | 1,972
tuberculosis 5 | 2,010
Blastic phase chronic myeloid leukemia 4 | 58
Chronic Myelocytic Leukemia Accelerated Phase 4 | 59
Gastrointestinal stromal tumor 4 | 62
HER2-positive carcinoma of breast 4 | 21
Pancreatic Neuroendocrine Tumor 4 | 45
Renal Cell Carcinoma 4 | 214
cystic fibrosis 4 | 1,696
diabetes mellitus 4 | 1,728
group 3 medulloblastoma 4 | 4,104
group 4 medulloblastoma 4 | 1,855
interstitial cystitis 4 | 2,312
oligodendroglioma 4 | 2,850
spina bifida 4 | 1,074
subependymal giant cell astrocytoma 4 | 2,287
Adenocarcinoma of pancreas 3 | 14
Atopic dermatitis 3 | 952
Autosomal recessive predisposition 3 | 1,442
Hamman-Rich syndrome 3 | 34
Hemangioma 3 | 69
Hypertension 3 | 396
Kidney disease 3 | 430
Liver Cirrhosis, Experimental 3 | 769
Multiple myeloma 3 | 1,332
Rheumatoid arthritis 3 | 1,191
Waldenstrons macroglobulinemia 3 | 765
acute myeloid leukemia 3 | 783
breast carcinoma 3 | 1,638
dermatomyositis 3 | 966
pancreatic carcinoma 3 | 562
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Acute myeloid leukemia, disease 2 | 30
Aggressive systemic mastocytosis 2 | 20
Alzheimer's disease 2 | 658
Ambiguous Genitalia 2 | 24
Amyotrophic lateral sclerosis 2 | 451
Endometriosis 2 | 540
Epilepsy 2 | 792
Hypertensive disease 2 | 292
Hypokalemia 2 | 52
Mast cell leukemia 2 | 13
Parkinson's disease 2 | 392
Pick disease 2 | 1,894
Polycystic ovary syndrome 2 | 360
Pseudohypoaldosteronism 2 | 23
Psychotic Disorders 2 | 151
Schizophrenia 2 | 1,160
active Crohn's disease 2 | 922
acute quadriplegic myopathy 2 | 1,158
aldosterone-producing adenoma 2 | 665
astrocytoma 2 | 1,146
chronic rhinosinusitis 2 | 512
juvenile dermatomyositis 2 | 1,187
lung adenocarcinoma 2 | 2,716
non diabetic and post-ischemic heart failure 2 | 200
posterior fossa group B ependymoma 2 | 416
primary pancreatic ductal adenocarcinoma 2 | 1,109
progressive supranuclear palsy 2 | 676
ulcerative colitis 2 | 1,819
Acrofacial dysostosis 1 | 8
Asphyxiating thoracic dystrophy 1 | 44
Galactosemia 1 | 19
Gitelman syndrome 1 | 6
Hydrops Fetalis 1 | 21
Hyperglycemia 1 | 137
Hypermobility syndrome 1 | 17
Primary hypogonadism 1 | 37
Pure gonadal dysgenesis 1 | 19
Retinitis pigmentosa 28 1 | 19
Sensenbrenner syndrome 1 | 17
Short ribs 1 | 30
Sotos syndrome 1 | 13
Sparse pubic hair 1 | 31
Testicular Germ Cell Tumor 1 | 14
non-syndromic X-linked intellectual disability 1 | 20

Tissue

Endocrine System 33 | 18,159
Male tissues 33 | 17,142
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Skin and soft tissues 32 | 17,230
Cardiovascular System 31 | 15,192
Digestive Tract 31 | 17,369
Respiratory system 31 | 16,393
Nervous System 30 | 16,725
Urinary Tract 30 | 16,678
Blood and immune system 28 | 16,909

Target Family

Kinase 28 | 634
Non-IDG 3 | 12,091
Enzyme 1 | 4,145
TF/Epigenetic 1 | 38

GO Process

stress-activated protein kinas... 33 | 33
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 3 MAP2K3 Tchem Kinase -2.35301 190.9 1060
Mitogen-activated protein kinase kinase kinase 1 MAP3K1 Tchem Kinase -2.12399 119.4 334
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
Serine/threonine-protein kinase PAK 2 PAK2 Tchem Kinase -1.90512 88.8 647
Dual specificity mitogen-activated protein kinase kinase 6 MAP2K6 Tchem Kinase -2.01763 74.4 636
Dual specificity mitogen-activated protein kinase kinase 5 MAP2K5 Tchem Kinase -1.91294 66.2 415
Serine/threonine-protein kinase 4 STK4 Tchem Kinase -1.53051 32.9 266
Aldose reductase AKR1B1 Tclin Enzyme -3.27314 1915.8 350
Serine/threonine-protein kinase 24 STK24 Tchem Kinase -2.24110 132.9 243
Mitogen-activated protein kinase kinase kinase 8 MAP3K8 Tchem Kinase -2.09230 154.3 433