Development Level

Tbio 8 | 11,651
Tchem 1 | 1,388

IMPC Phenotype

preweaning lethality, complete... 1 | 979

Disease

Carcinoma 5 | 11,493
malignant mesothelioma 5 | 3,232
medulloblastoma, large-cell 5 | 6,241
osteosarcoma 5 | 7,950
ovarian cancer 5 | 8,520
ductal carcinoma in situ 4 | 1,745
ependymoma 4 | 4,679
glioblastoma 4 | 5,792
group 3 medulloblastoma 4 | 4,104
lung cancer 4 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
psoriasis 4 | 6,694
active Crohn's disease 3 | 922
adult high grade glioma 3 | 3,801
astrocytoma 3 | 1,146
atypical teratoid / rhabdoid tumor 3 | 5,112
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
pancreatic cancer 3 | 2,398
primitive neuroectodermal tumor 3 | 3,035
Astrocytoma, Pilocytic 2 | 3,081
Atopic dermatitis 2 | 952
Autosomal recessive predisposition 2 | 1,442
Breast cancer 2 | 3,578
Cardiomegaly 2 | 116
Chronic Lymphocytic Leukemia 2 | 262
Congestive heart failure 2 | 113
Methemoglobinemia 2 | 17
Multiple myeloma 2 | 1,332
Pelger-Huet anomaly 2 | 8
Pick disease 2 | 1,894
Pruritus 2 | 58
Waldenstrons macroglobulinemia 2 | 765
active ulcerative colitis 2 | 764
adrenocortical carcinoma 2 | 1,428
chronic rhinosinusitis 2 | 512
esophageal adenocarcinoma 2 | 737
gastric carcinoma 2 | 807
invasive ductal carcinoma 2 | 2,951
lung carcinoma 2 | 2,843
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
Abnormal lung lobation 1 | 10
Abnormal maturation of the pelvis bone 1 | 3
Abnormal ossification involving the femoral head and neck 1 | 2
Abnormal pelvis bone ossification 1 | 3
Absent or minimally ossified vertebral bodies 1 | 3
Absent toenails (anonychia) 1 | 7
Anterior rib punctate calcifications 1 | 1
Atrioventricular nodal disease 1 | 10
Barrel chest 1 | 12
CREST Syndrome 1 | 16
Calcification of trachea 1 | 3
Calvarial defect 1 | 10
Cranial defect 1 | 10
Defect of skull ossification 1 | 10
Diaphyseal thickening 1 | 11
Dry Eye Syndromes 1 | 8
Extramedullary Hematopoiesis (disorder) 1 | 5
Extramedullary erythropoiesis 1 | 5
Gastrointestinal Hemorrhage 1 | 52
Hepatic calcification 1 | 2
Horizontal sacrum 1 | 3
Hydrops Fetalis, Non-Immune 1 | 8
Hypervitaminosis A 1 | 13
Hypoplastic vertebral bodies 1 | 7
Islets of Langerhans hyperplasia 1 | 11
Keratitis sicca 1 | 6
Laryngeal calcification 1 | 2
Lethal skeletal dysplasia 1 | 6
Long clavicle 1 | 7
Mesomelia 1 | 8
Metaphyseal cupping 1 | 10
Misalignment of teeth 1 | 8
Mucosal telangiectasiae 1 | 14
Multiple fractures present at birth 1 | 5
Myalgia 1 | 54
Neonatal Death 1 | 14
Pleural effusion disorder 1 | 6
Progeria 1 | 25
Reynolds syndrome 1 | 1
Schizotypal personality disorder 1 | 7
Sclerodactyly 1 | 1
Scleroderma 1 | 7
Scleroderma-like secondary cutaneous sclerosis 1 | 7
Sclerosis of skull base 1 | 5
Severe hydrops fetalis 1 | 1
Severe short-limb dwarfism 1 | 4
Short phalanx of finger 1 | 32
Skull defect 1 | 10
Spade-like hand 1 | 16
Sternal punctate calcifications 1 | 1
Tinea cruris 1 | 12
White blood cell abnormality 1 | 1
Xerophthalmia 1 | 16
joint abnormality 1 | 5

Tissue

Blood and immune system 9 | 16,909
Cardiovascular System 9 | 15,192
Digestive Tract 9 | 17,369
Endocrine System 9 | 18,159
Female tissues 9 | 17,400
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Nervous System 9 | 16,725
Respiratory system 9 | 16,393
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678

Target Family

Enzyme 8 | 4,145
Epigenetic 1 | 242

GO Process

sterol biosynthetic process 9 | 9
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lamin-B receptor LBR Tbio Epigenetic -3.02961 1057.1 134
Phosphomevalonate kinase PMVK Tbio Enzyme -1.96385 92.3 144
Cholesterol 25-hydroxylase CH25H Tbio Enzyme -1.54426 38.2 54
NADH-cytochrome b5 reductase 1 CYB5R1 Tbio Enzyme -0.95573 7.22 142
NADH-cytochrome b5 reductase 2 CYB5R2 Tbio Enzyme -0.96076 7.49 58
Delta(14)-sterol reductase TM7SF2 Tbio Enzyme -1.10571 12.4 88
Squalene monooxygenase SQLE Tchem Enzyme -1.89887 71.9 109
Methylsterol monooxygenase 1 MSMO1 Tbio Enzyme -1.64987 43.8 106
5'-AMP-activated protein kinase subunit gamma-2 PRKAG2 Tbio Enzyme -1.98404 96.0 120