Development Level

Tbio 37 | 11,445
Tchem 15 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, incomple... 5 | 499
decreased circulating glucose ... 3 | 126
preweaning lethality, complete... 3 | 979
decreased bone mineral content 2 | 151
decreased mean corpuscular vol... 2 | 79
embryonic lethality prior to t... 2 | 278
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal hair growth 1 | 10
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
decreased urine creatinine lev... 1 | 3
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased mean platelet volume 1 | 45
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
tremors 1 | 39

Disease

ovarian cancer 33 | 8,520
Carcinoma 28 | 11,493
medulloblastoma, large-cell 28 | 6,241
osteosarcoma 26 | 7,950
glioblastoma 24 | 5,792
psoriasis 23 | 6,694
invasive ductal carcinoma 21 | 2,951
atypical teratoid / rhabdoid tumor 19 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
ependymoma 17 | 4,679
non-small cell lung cancer 17 | 2,890
Astrocytoma, Pilocytic 16 | 3,081
Breast cancer 16 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
tuberculosis 16 | 2,010
adult high grade glioma 14 | 3,801
ductal carcinoma in situ 14 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
lung cancer 14 | 4,740
group 3 medulloblastoma 13 | 4,104
interstitial cystitis 13 | 2,312
lung adenocarcinoma 13 | 2,716
lung carcinoma 13 | 2,843
cystic fibrosis 12 | 1,696
malignant mesothelioma 11 | 3,232
pancreatic cancer 11 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
group 4 medulloblastoma 10 | 1,855
subependymal giant cell astrocytoma 10 | 2,287
Atopic dermatitis 9 | 952
Pick disease 9 | 1,894
astrocytic glioma 9 | 2,597
oligodendroglioma 9 | 2,850
pituitary cancer 9 | 1,972
Multiple myeloma 8 | 1,332
acute quadriplegic myopathy 8 | 1,158
adrenocortical carcinoma 8 | 1,428
breast carcinoma 8 | 1,638
Down syndrome 7 | 499
aldosterone-producing adenoma 7 | 665
primary pancreatic ductal adenocarcinoma 7 | 1,109
primitive neuroectodermal tumor 7 | 3,035
Rheumatoid arthritis 6 | 1,191
active Crohn's disease 6 | 922
colon cancer 6 | 1,478
pediatric high grade glioma 6 | 1,064
progressive supranuclear palsy 6 | 676
spina bifida 6 | 1,074
Cancer 5 | 2,499
Ichthyosis 5 | 56
Neurodegenerative disease 5 | 414
active ulcerative colitis 5 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
cutaneous lupus erythematosus 5 | 1,057
esophageal adenocarcinoma 5 | 737
juvenile dermatomyositis 5 | 1,187
posterior fossa group A ependymoma 5 | 468
Farber lipogranulomatosis 4 | 9
Intellectual disability 4 | 1,016
Neuronal ceroid lipofuscinosis 9 4 | 5
acute myeloid leukemia 4 | 783
astrocytoma 4 | 1,146
dermatomyositis 4 | 966
gastric cancer 4 | 459
nasopharyngeal carcinoma 4 | 1,058
primary Sjogren syndrome 4 | 735
ulcerative colitis 4 | 1,819
Alzheimer's disease 3 | 658
Amyotrophic lateral sclerosis 3 | 451
Chronic Lymphocytic Leukemia 3 | 262
Decreased tendon reflex 3 | 122
Dull intelligence 3 | 645
Dysarthria 3 | 192
Epilepsy 3 | 792
Kidney cancer 3 | 2,613
Lipid storage disease 3 | 8
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Neuropathy 3 | 261
Poor school performance 3 | 645
Posterior amorphous corneal dystrophy 3 | 9
facioscapulohumeral dystrophy 3 | 288
hepatocellular carcinoma 3 | 547
hereditary spastic paraplegia 3 | 318
medulloblastoma 3 | 720
posterior fossa group B ependymoma 3 | 416
urothelial carcinoma 3 | 318
Bipolar Disorder 2 | 666
Duchenne muscular dystrophy 2 | 601
Polycystic ovary syndrome 2 | 360
Schizophrenia 2 | 1,160
Waldenstrons macroglobulinemia 2 | 765
chronic rhinosinusitis 2 | 512
diabetes mellitus 2 | 1,728
gastric carcinoma 2 | 807
mucosa-associated lymphoid tissue lymphoma 2 | 484
non diabetic and post-ischemic heart failure 2 | 200
periodontitis 2 | 293
sonic hedgehog group medulloblastoma 2 | 467

Tissue

Blood and immune system 51 | 16,909
Digestive Tract 51 | 17,369
Endocrine System 51 | 18,159
Female tissues 51 | 17,400
Liver and Pancreas 51 | 16,750
Male tissues 51 | 17,142
Skin and soft tissues 51 | 17,230
Nervous System 50 | 16,725
Respiratory system 50 | 16,393
Urinary Tract 50 | 16,678
Cardiovascular System 47 | 15,192

Target Family

Enzyme 31 | 4,145
Non-IDG 10 | 12,091
Kinase 6 | 634
Transcription Factor 5 | 1,400

GO Process

sphingolipid biosynthetic proc... 52 | 52
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Alkaline ceramidase 3 ACER3 Tbio Enzyme -2.07938 117.1 95
Sphingosine-1-phosphate phosphatase 2 SGPP2 Tbio Enzyme -0.72925 6.15 77
Elongation of very long chain fatty acids protein 1 ELOVL1 Tbio Non-IDG -1.29305 16.7 156
Ceramide synthase 6 CERS6 Tbio Transcription Factor -1.48442 32.4 167
Elongation of very long chain fatty acids protein 5 ELOVL5 Tbio Non-IDG -1.90493 83.7 237
Sphingosine-1-phosphate phosphatase 1 SGPP1 Tbio Enzyme -0.90666 6.54 76
Serine/threonine-protein kinase D3 PRKD3 Tchem Kinase -1.23218 13.2 295
Ceramide synthase 1 CERS1 Tbio Enzyme -1.58899 36.9 179
Phosphatidylcholine:ceramide cholinephosphotransferase 1 SGMS1 Tchem Enzyme -1.61164 41.6 0
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122