Development Level

Tbio 243 | 11,445
Tdark 90 | 6,588
Tchem 44 | 1,598
Tclin 12 | 613

Collection

RFA-RM-18-021 8 | 328
Kinase: IDG Consortium (Target... 6 | 125
GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, incomple... 18 | 499
preweaning lethality, complete... 14 | 979
male infertility 13 | 123
enlarged heart 9 | 210
abnormal embryo size 8 | 220
embryonic lethality prior to t... 8 | 278
abnormal behavior 7 | 298
abnormal heart morphology 6 | 162
abnormal seminal vesicle morph... 6 | 114
decreased vertical activity 6 | 208
small testis 6 | 58
female infertility 5 | 60
hyperactivity 5 | 148
impaired glucose tolerance 5 | 75
increased bone mineral content 5 | 108
abnormal bone structure 4 | 187
embryonic growth retardation 4 | 106
embryonic lethality prior to o... 4 | 239
increased circulating HDL chol... 4 | 80
increased circulating alkaline... 4 | 122
thrombocytopenia 4 | 56
decreased body length 3 | 101
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
increased grip strength 3 | 41
prenatal lethality prior to he... 3 | 87
abnormal craniofacial morpholo... 2 | 33
abnormal embryo turning 2 | 31
abnormal liver morphology 2 | 17
abnormal pericardium morpholog... 2 | 26
abnormal spleen morphology 2 | 55
abnormal testis morphology 2 | 43
anophthalmia 2 | 33
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral density 2 | 126
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating phosphat... 2 | 27
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
edema 2 | 59
hypoactivity 2 | 132
increased circulating triglyce... 2 | 42
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 36
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased total body fat amoun... 2 | 134
prolonged ST segment 2 | 36
shortened RR interval 2 | 17
small superior vagus ganglion 2 | 74
abnormal behavioral response t... 1 | 66
abnormal epididymis morphology 1 | 42
abnormal esophagus morphology 1 | 5
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal heart looping 1 | 5
abnormal locomotor activation 1 | 16
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal tail movements 1 | 12
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased caudal vertebrae num... 1 | 53
decreased circulating serum al... 1 | 82
decreased eosinophil cell numb... 1 | 24
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased pulmonary respirator... 1 | 5
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
limb grasping 1 | 41
long tibia 1 | 25
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
small kidney 1 | 16
small spleen 1 | 19
urinary bladder obstruction 1 | 4

Disease

Carcinoma 238 | 11,493
ovarian cancer 169 | 8,520
osteosarcoma 162 | 7,950
psoriasis 148 | 6,694
medulloblastoma, large-cell 134 | 6,241
glioblastoma 112 | 5,792
group 3 medulloblastoma 100 | 4,104
atypical teratoid / rhabdoid tumor 99 | 5,112
lung cancer 97 | 4,740
ependymoma 86 | 4,679
Cancer 80 | 2,499
Breast cancer 75 | 3,578
Kidney cancer 72 | 2,613
malignant mesothelioma 68 | 3,232
adult high grade glioma 64 | 3,801
primitive neuroectodermal tumor 64 | 3,035
non-small cell lung cancer 61 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 60 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 55 | 2,955
lung adenocarcinoma 55 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 54 | 2,989
Male infertility 53 | 206
oligodendroglioma 47 | 2,850
invasive ductal carcinoma 46 | 2,951
Infertility 45 | 188
Astrocytoma, Pilocytic 44 | 3,081
astrocytic glioma 42 | 2,597
pancreatic cancer 40 | 2,398
pituitary cancer 36 | 1,972
lung carcinoma 35 | 2,843
subependymal giant cell astrocytoma 35 | 2,287
breast carcinoma 33 | 1,638
colon cancer 33 | 1,478
diabetes mellitus 33 | 1,728
tuberculosis 33 | 2,010
Autosomal recessive predisposition 32 | 1,442
ductal carcinoma in situ 31 | 1,745
ulcerative colitis 31 | 1,819
Schizophrenia 30 | 1,160
interstitial cystitis 30 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,962
Azoospermia 29 | 110
group 4 medulloblastoma 29 | 1,855
adrenocortical carcinoma 27 | 1,428
Pick disease 26 | 1,894
cutaneous lupus erythematosus 25 | 1,057
nasopharyngeal carcinoma 24 | 1,058
acute quadriplegic myopathy 23 | 1,158
juvenile dermatomyositis 23 | 1,187
Endometriosis 21 | 540
Melanoma 21 | 711
Cryptorchidism 20 | 296
Multiple myeloma 20 | 1,332
cystic fibrosis 20 | 1,696
Bipolar Disorder 19 | 666
Obesity 19 | 678
Rheumatoid arthritis 19 | 1,191
Skin cancer 19 | 469
astrocytoma 19 | 1,146
Intellectual disability 18 | 1,016
dermatomyositis 18 | 966
non primary Sjogren syndrome sicca 18 | 891
pediatric high grade glioma 18 | 1,064
primary pancreatic ductal adenocarcinoma 18 | 1,109
spina bifida 18 | 1,074
Atopic dermatitis 17 | 952
Alzheimer's disease 16 | 658
Liver cancer 15 | 604
acute myeloid leukemia 15 | 783
Breast Neoplasms 14 | 445
Mammary Neoplasms 14 | 425
Prostatic Neoplasms 14 | 495
Hypogonadism 13 | 173
Short stature 13 | 531
medulloblastoma 13 | 720
primary Sjogren syndrome 13 | 735
Depressive disorder 12 | 409
Dull intelligence 12 | 645
Liver Cirrhosis, Experimental 12 | 769
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Pancreatic Neoplasms 12 | 85
Polycystic ovary syndrome 12 | 360
Poor school performance 12 | 645
aldosterone-producing adenoma 12 | 665
pancreatic carcinoma 12 | 562
Cognitive delay 11 | 608
Global developmental delay 11 | 608
Mental and motor retardation 11 | 608
Oligospermia 11 | 36
Pancreatic Neoplasm 11 | 85
Sertoli cell-only syndrome 11 | 37
Small head 11 | 374
Waldenstrons macroglobulinemia 11 | 765
fibroadenoma 11 | 559
gastric carcinoma 11 | 807
hepatocellular carcinoma 11 | 547
posterior fossa group B ependymoma 11 | 416
Congenital hypoplasia of penis 10 | 176

Tissue

Endocrine System 379 | 18,159
Male tissues 326 | 17,142
Digestive Tract 325 | 17,369
Female tissues 325 | 17,400
Skin and soft tissues 318 | 17,230
Blood and immune system 312 | 16,909
Nervous System 305 | 16,725
Liver and Pancreas 303 | 16,750
Urinary Tract 303 | 16,678
Respiratory system 298 | 16,393
Cardiovascular System 262 | 15,192

Target Family

Non-IDG 230 | 12,091
Enzyme 56 | 4,145
Transcription Factor 37 | 1,400
Kinase 19 | 634
Epigenetic 18 | 242
GPCR 10 | 408
Transporter 7 | 473
Nuclear Receptor 5 | 48
TF/Epigenetic 4 | 38
Ion Channel 2 | 344
oGPCR 1 | 421

GO Process

spermatogenesis 389 | 389
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protocadherin gamma-A9 PCDHGA9 Tdark Non-IDG 0.51 0.72 31
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 ASZ1 Tbio Non-IDG -2.81661 644.9 107
T-complex protein 11 homolog TCP11 Tbio Non-IDG -1.26152 18.0 80
Meiotic recombination protein SPO11 SPO11 Tbio Non-IDG -2.33263 208.9 148
Sperm-associated antigen 8 SPAG8 Tbio Non-IDG -0.96272 9.29 158
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 SOHLH2 Tbio Transcription Factor -1.26578 21.4 126
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
HORMA domain-containing protein 1 HORMAD1 Tbio Non-IDG -1.44656 27.9 135
Disintegrin and metalloproteinase domain-containing protein 29 ADAM29 Tbio Enzyme -1.11051 12.4 58
Choline-phosphate cytidylyltransferase B PCYT1B Tbio Enzyme -1.46937 28.8 40