Development Level

Tbio 13 | 11,445
Tchem 1 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal heart morphology 2 | 162
embryonic lethality prior to t... 2 | 278
abnormal allantois morphology 1 | 8
abnormal bone structure 1 | 187
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal kidney morphology 1 | 65
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal pericardium morpholog... 1 | 26
decreased body weight 1 | 161
decreased circulating calcium ... 1 | 36
decreased lean body mass 1 | 135
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
impaired glucose tolerance 1 | 75
increased body weight 1 | 25
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41

Disease

Carcinoma 13 | 11,493
osteosarcoma 9 | 7,950
lung cancer 8 | 4,740
ovarian cancer 8 | 8,520
psoriasis 8 | 6,694
Cleft Palate 7 | 271
Breast cancer 6 | 3,578
Cancer 6 | 2,499
Cleft Lip 6 | 141
ductal carcinoma in situ 5 | 1,745
ependymoma 5 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
medulloblastoma, large-cell 5 | 6,241
spina bifida 5 | 1,074
Acquired scoliosis 4 | 281
Curvature of spine 4 | 282
Dull intelligence 4 | 645
Intellectual disability 4 | 1,016
Kidney cancer 4 | 2,613
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Poor school performance 4 | 645
Short stature 4 | 531
Strabismus 4 | 270
adult high grade glioma 4 | 3,801
atypical teratoid / rhabdoid tumor 4 | 5,112
breast carcinoma 4 | 1,638
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
invasive ductal carcinoma 4 | 2,951
pancreatic cancer 4 | 2,398
Abnormally small eyeball 3 | 97
Ameloblastoma 3 | 24
Brachydactyly 3 | 156
Cognitive delay 3 | 608
Decreased size of eyeball 3 | 97
Epilepsy 3 | 792
Gastrointestinal Stromal Tumors 3 | 48
Global developmental delay 3 | 608
Mental and motor retardation 3 | 608
Microphthalmos 3 | 100
Nevoid basal cell carcinoma syndrome 3 | 16
Pectus excavatum 3 | 100
Polydactyly 3 | 107
Seizures 3 | 596
Short distal phalanges 3 | 50
Short philtrum 3 | 53
Syndactyly of fingers 3 | 48
Syndactyly of the toes 3 | 45
astrocytic glioma 3 | 2,597
colon cancer 3 | 1,478
cutaneous lupus erythematosus 3 | 1,057
dermatomyositis 3 | 966
glioblastoma 3 | 5,792
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
primitive neuroectodermal tumor 3 | 3,035
tuberculosis 3 | 2,010
Alobar Holoprosencephaly 2 | 14
Astrocytoma, Pilocytic 2 | 3,081
Bilateral fifth finger clinodactyly 2 | 110
Broad flat nasal bridge 2 | 236
Coarse facial features 2 | 108
Conductive hearing loss 2 | 123
Congenital deafness 2 | 185
Congenital ocular coloboma (disorder) 2 | 40
Craniosynostosis 2 | 74
Curvature of little finger 2 | 110
Deafness 2 | 198
Dilated ventricles (finding) 2 | 121
Duchenne muscular dystrophy 2 | 601
Endometriosis 2 | 540
Flexion contracture of proximal interphalangeal joint 2 | 75
Hearing Loss, Partial 2 | 185
Highly variable severity 2 | 157
Holoprosencephaly 2 | 56
Hypotrichosis 1 2 | 15
Joint hyperflexibility 2 | 78
Nasal bridge wide 2 | 236
Osteoarthritis 2 | 184
Semilobar Holoprosencephaly 2 | 14
Sensorineural Hearing Loss (disorder) 2 | 284
Short nose 2 | 132
Skin cancer 2 | 469
Small nose 2 | 132
Synostosis 2 | 15
Thickened facial skin with coarse facial features 2 | 108
Variable expressivity 2 | 157
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
atypical teratoid/rhabdoid tumor 2 | 357
cystic fibrosis 2 | 1,696
hearing impairment 2 | 199
medulloblastoma 2 | 720
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primary pancreatic ductal adenocarcinoma 2 | 1,109

Tissue

Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Respiratory system 15 | 16,393
Skin and soft tissues 15 | 17,230
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Urinary Tract 14 | 16,678
Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192

Target Family

Non-IDG 7 | 12,091
Enzyme 4 | 4,145
Transcription Factor 3 | 1,400
GPCR 1 | 408

GO Process

somite development 15 | 15
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Smoothened homolog SMO Tclin GPCR -1.17466 14.5 415
Homeobox protein MOX-2 MEOX2 Tbio Transcription Factor -2.20760 167.0 293
E3 ubiquitin-protein ligase RBBP6 RBBP6 Tbio Enzyme -1.36066 29.2 241
C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 Tbio Enzyme -1.97029 90.6 101
Transcription factor SOX-11 SOX11 Tbio Transcription Factor -2.01545 106.1 219
Secreted frizzled-related protein 3 FRZB Tbio Non-IDG -2.51623 308.4 252
Indian hedgehog protein IHH Tbio Non-IDG -2.61880 417.4 375
Nuclear pore complex protein Nup133 NUP133 Tbio Non-IDG -1.36479 22.8 72
Protein patched homolog 1 PTCH1 Tbio Non-IDG -3.04637 1057.4 452
Homeobox protein MOX-1 MEOX1 Tbio Transcription Factor -1.25405 16.6 286