Development Level

Tbio 92 | 11,445
Tchem 8 | 1,598
Tdark 7 | 6,588
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 22 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 5 | 278
decreased circulating choleste... 4 | 93
decreased total body fat amoun... 3 | 207
embryonic growth retardation 3 | 106
increased fasted circulating g... 3 | 76
preweaning lethality, incomple... 3 | 499
abnormal coat-hair pigmentatio... 2 | 64
abnormal embryo size 2 | 220
abnormal tail morphology 2 | 25
cataract 2 | 92
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating serum al... 2 | 82
increased circulating HDL chol... 2 | 80
increased circulating chloride... 2 | 41
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal motor learning 1 | 3
abnormal placenta morphology 1 | 5
abnormal placenta size 1 | 20
abnormal placenta vasculature 1 | 2
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal testis morphology 1 | 43
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating chloride... 1 | 30
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating glucose ... 1 | 24
increased heart weight 1 | 62
increased thermal nociceptive ... 1 | 9
long tibia 1 | 25
male infertility 1 | 123
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
shortened RR interval 1 | 17
small testis 1 | 58
syndactyly 1 | 23
tremors 1 | 39

Disease

Carcinoma 72 | 11,493
ovarian cancer 70 | 8,520
medulloblastoma, large-cell 68 | 6,241
group 3 medulloblastoma 67 | 4,104
glioblastoma 60 | 5,792
atypical teratoid / rhabdoid tumor 59 | 5,112
lung cancer 57 | 4,740
primitive neuroectodermal tumor 54 | 3,035
osteosarcoma 52 | 7,950
psoriasis 51 | 6,694
Breast cancer 48 | 3,578
ependymoma 40 | 4,679
malignant mesothelioma 40 | 3,232
non-small cell lung cancer 40 | 2,890
adult high grade glioma 38 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 38 | 3,291
adrenocortical carcinoma 37 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
invasive ductal carcinoma 33 | 2,951
lung adenocarcinoma 28 | 2,716
Kidney cancer 27 | 2,613
colon cancer 23 | 1,478
ductal carcinoma in situ 22 | 1,745
oligodendroglioma 22 | 2,850
Cancer 21 | 2,499
breast carcinoma 21 | 1,638
nasopharyngeal carcinoma 20 | 1,058
pancreatic cancer 20 | 2,398
Atopic dermatitis 19 | 952
Endometriosis 19 | 540
Multiple myeloma 16 | 1,332
Astrocytoma, Pilocytic 15 | 3,081
Intellectual disability 15 | 1,016
astrocytic glioma 15 | 2,597
Waldenstrons macroglobulinemia 14 | 765
Pick disease 13 | 1,894
Small head 13 | 374
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Cognitive delay 12 | 608
Global developmental delay 12 | 608
Mental and motor retardation 12 | 608
acute quadriplegic myopathy 12 | 1,158
dermatomyositis 12 | 966
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
pediatric high grade glioma 12 | 1,064
Rheumatoid arthritis 11 | 1,191
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
Short stature 10 | 531
subependymal giant cell astrocytoma 10 | 2,287
Microcephaly 9 | 166
juvenile dermatomyositis 9 | 1,187
pituitary cancer 9 | 1,972
ulcerative colitis 9 | 1,819
Hypoplastic mandible condyle 8 | 275
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Roberts syndrome 8 | 15
tuberculosis 8 | 2,010
Autosomal recessive predisposition 7 | 1,442
active Crohn's disease 7 | 922
acute myeloid leukemia 7 | 783
astrocytoma 7 | 1,146
interstitial cystitis 7 | 2,312
primary Sjogren syndrome 7 | 735
Anteverted nostril 6 | 191
Cornelia de Lange syndrome 6 | 21
Fetal Growth Retardation 6 | 189
Infant, Small for Gestational Age 6 | 176
Intrauterine retardation 6 | 176
Lissencephaly 6 | 69
Short nose 6 | 132
Small nose 6 | 132
group 4 medulloblastoma 6 | 1,855
Cerebellar Hypoplasia 5 | 61
Concave bridge of nose 5 | 195
Congenital Epicanthus 5 | 177
Cryptorchidism 5 | 296
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Down syndrome 5 | 499
Epilepsy 5 | 792
Lymphoid leukemia 5 | 160
Schizophrenia 5 | 1,160
Seizures 5 | 596
Short neck 5 | 140
gastric carcinoma 5 | 807
hereditary spastic paraplegia 5 | 318
non primary Sjogren syndrome sicca 5 | 891
posterior fossa group A ependymoma 5 | 468
Alzheimer's disease 4 | 658
Attention deficit hyperactivity disorder 4 | 278
Byzanthine arch palate 4 | 194
Glaucoma 4 | 239
Micromelia 4 | 58
aldosterone-producing adenoma 4 | 665
lung carcinoma 4 | 2,843

Tissue

Endocrine System 108 | 18,159
Blood and immune system 107 | 16,909
Male tissues 107 | 17,142
Digestive Tract 106 | 17,369
Female tissues 106 | 17,400
Liver and Pancreas 106 | 16,750
Skin and soft tissues 106 | 17,230
Nervous System 105 | 16,725
Respiratory system 105 | 16,393
Urinary Tract 105 | 16,678
Cardiovascular System 102 | 15,192

Target Family

Non-IDG 94 | 12,091
Enzyme 8 | 4,145
Kinase 5 | 634
Epigenetic 1 | 242

GO Process

sister chromatid cohesion 108 | 108
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nuclear distribution protein nudE homolog 1 NDE1 Tbio Non-IDG -2.01711 96.0 192
Mitotic spindle assembly checkpoint protein MAD1 MAD1L1 Tbio Non-IDG -1.17500 13.6 283
N-acetyltransferase ESCO1 ESCO1 Tbio Enzyme -1.65145 44.6 49
Mini-chromosome maintenance complex-binding protein MCMBP Tbio Non-IDG -0.65233 5.60 92
Cohesin subunit SA-1 STAG1 Tbio Non-IDG -2.47449 292.2 200
Centromere protein K CENPK Tbio Non-IDG -1.21832 16.6 130
Kinesin-like protein KIF2C KIF2C Tbio Non-IDG -2.12404 136.3 256
Spindle and kinetochore-associated protein 2 SKA2 Tbio Non-IDG -1.23206 10.2 108
Nuclear pore complex protein Nup160 NUP160 Tbio Non-IDG -1.13177 13.6 169
Centromere protein F CENPF Tbio Non-IDG -2.02939 109.1 186