Development Level

Tbio 626 | 11,651
Tchem 156 | 1,388
Tdark 139 | 6,593
Tclin 84 | 612

Collection

RFA-RM-18-021 26 | 328
Kinase: IDG Consortium (Target... 14 | 125
GPCR: IDG Consortium (Targets) 9 | 126
Ion Channel: IDG Consortium (T... 7 | 99
GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 38 | 979
preweaning lethality, incomple... 37 | 499
abnormal behavior 19 | 298
enlarged heart 19 | 210
abnormal embryo size 16 | 220
abnormal bone structure 15 | 187
embryonic lethality prior to t... 14 | 278
abnormal heart morphology 11 | 162
decreased vertical activity 11 | 208
decreased body weight 10 | 161
increased startle reflex 10 | 112
abnormal eye morphology 9 | 68
decreased bone mineral content 9 | 151
decreased lean body mass 9 | 135
decreased total body fat amoun... 9 | 207
hypoactivity 9 | 132
increased lean body mass 9 | 172
increased monocyte cell number 9 | 63
increased total body fat amoun... 9 | 134
abnormal seminal vesicle morph... 8 | 114
decreased circulating LDL chol... 8 | 38
embryonic lethality prior to o... 8 | 239
improved glucose tolerance 8 | 79
increased circulating alkaline... 8 | 122
increased mean corpuscular vol... 8 | 92
short tibia 8 | 97
cataract 7 | 92
decreased fasted circulating g... 7 | 65
decreased hematocrit 7 | 46
decreased lymphocyte cell numb... 7 | 83
decreased mean corpuscular vol... 7 | 79
hyperactivity 7 | 148
abnormal gait 6 | 69
decreased circulating choleste... 6 | 93
decreased hemoglobin content 6 | 68
decreased leukocyte cell numbe... 6 | 73
decreased prepulse inhibition 6 | 82
edema 6 | 59
increased mean platelet volume 6 | 45
male infertility 6 | 123
abnormal retina morphology 5 | 71
decreased bone mineral density 5 | 126
decreased caudal vertebrae num... 5 | 53
decreased circulating HDL chol... 5 | 68
decreased circulating creatini... 5 | 39
decreased circulating triglyce... 5 | 79
decreased grip strength 5 | 116
decreased neutrophil cell numb... 5 | 42
embryonic growth retardation 5 | 106
impaired glucose tolerance 5 | 75
increased circulating HDL chol... 5 | 80
increased circulating choleste... 5 | 66
increased neutrophil cell numb... 5 | 46
prenatal lethality prior to he... 5 | 87
abnormal lens morphology 4 | 81
abnormal neural tube closure 4 | 46
abnormal skin morphology 4 | 50
abnormal spleen morphology 4 | 55
decreased circulating insulin ... 4 | 76
decreased circulating serum al... 4 | 82
decreased erythrocyte cell num... 4 | 62
decreased heart left ventricle... 4 | 28
decreased startle reflex 4 | 75
enlarged spleen 4 | 41
impaired pupillary reflex 4 | 26
increased bone mineral content 4 | 108
increased circulating calcium ... 4 | 34
increased circulating total pr... 4 | 28
increased mean corpuscular hem... 4 | 96
increased mean corpuscular hem... 4 | 36
increased prepulse inhibition 4 | 32
pale yolk sac 4 | 25
prolonged QT interval 4 | 38
prolonged ST segment 4 | 36
small superior vagus ganglion 4 | 74
small testis 4 | 58
abnormal behavioral response t... 3 | 66
abnormal bone mineralization 3 | 38
abnormal coat-hair pigmentatio... 3 | 64
abnormal craniofacial morpholo... 3 | 33
abnormal cranium morphology 3 | 36
abnormal retinal vasculature m... 3 | 27
abnormal sleep behavior 3 | 70
abnormal snout morphology 3 | 23
abnormal testis morphology 3 | 43
decreased body length 3 | 101
decreased circulating alkaline... 3 | 46
decreased circulating chloride... 3 | 30
decreased circulating total pr... 3 | 49
decreased mean corpuscular hem... 3 | 31
enlarged lymph nodes 3 | 37
enlarged uterus 3 | 11
increased circulating amylase ... 3 | 25
increased circulating chloride... 3 | 41
increased circulating sodium l... 3 | 71
increased circulating triglyce... 3 | 42
increased fasted circulating g... 3 | 76
microphthalmia 3 | 26
syndactyly 3 | 23
thin ventricular wall 3 | 24

Disease

Carcinoma 688 | 11,493
ovarian cancer 467 | 8,520
osteosarcoma 461 | 7,950
psoriasis 408 | 6,694
glioblastoma 392 | 5,792
medulloblastoma, large-cell 390 | 6,241
lung cancer 341 | 4,740
atypical teratoid / rhabdoid tumor 322 | 5,112
ependymoma 317 | 4,679
Cancer 295 | 2,499
adult high grade glioma 280 | 3,801
Breast cancer 246 | 3,578
group 3 medulloblastoma 245 | 4,104
malignant mesothelioma 241 | 3,232
lung carcinoma 236 | 2,843
Astrocytoma, Pilocytic 224 | 3,081
invasive ductal carcinoma 220 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 216 | 3,291
oligodendroglioma 214 | 2,850
non-small cell lung cancer 207 | 2,890
primitive neuroectodermal tumor 207 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 197 | 2,955
astrocytic glioma 191 | 2,597
interstitial cystitis 191 | 2,312
lung adenocarcinoma 188 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 180 | 2,989
subependymal giant cell astrocytoma 171 | 2,287
pancreatic cancer 166 | 2,398
Kidney cancer 164 | 2,613
tuberculosis 159 | 2,010
ulcerative colitis 156 | 1,819
cystic fibrosis 145 | 1,696
pituitary cancer 143 | 1,972
diabetes mellitus 141 | 1,728
group 4 medulloblastoma 131 | 1,855
Schizophrenia 129 | 1,160
ductal carcinoma in situ 119 | 1,745
Pick disease 117 | 1,894
breast carcinoma 116 | 1,638
colon cancer 113 | 1,478
cutaneous lupus erythematosus 99 | 1,057
juvenile dermatomyositis 99 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 95 | 1,962
Rheumatoid arthritis 92 | 1,191
Bipolar Disorder 90 | 666
Autosomal recessive predisposition 83 | 1,442
Liver Cirrhosis, Experimental 79 | 769
primary pancreatic ductal adenocarcinoma 79 | 1,109
astrocytoma 77 | 1,146
acute quadriplegic myopathy 73 | 1,158
gastric carcinoma 73 | 807
Intellectual disability 72 | 1,016
adrenocortical carcinoma 70 | 1,428
pediatric high grade glioma 67 | 1,064
Obesity 66 | 678
active Crohn's disease 65 | 922
primary Sjogren syndrome 62 | 735
Alzheimer's disease 61 | 658
Asthma 61 | 385
Depressive disorder 60 | 409
Breast Neoplasms 59 | 445
Melanoma 59 | 711
Multiple myeloma 59 | 1,332
active ulcerative colitis 59 | 764
esophageal adenocarcinoma 58 | 737
spina bifida 58 | 1,074
Multiple Sclerosis 57 | 540
acute myeloid leukemia 57 | 783
nasopharyngeal carcinoma 57 | 1,058
Atopic dermatitis 56 | 952
Epilepsy 56 | 792
Mammary Neoplasms 56 | 425
Vascular disease 55 | 319
medulloblastoma 54 | 720
Duchenne muscular dystrophy 53 | 601
Major Depressive Disorder 52 | 301
Endometriosis 50 | 540
Hypertension 49 | 396
Kidney disease 48 | 430
Mental Depression 48 | 333
Prostatic Neoplasms 48 | 495
Unipolar Depression 48 | 250
dermatomyositis 48 | 966
non primary Sjogren syndrome sicca 48 | 891
Arthritis 47 | 290
Short stature 45 | 531
fibroadenoma 45 | 559
Autistic Disorder 44 | 364
Dull intelligence 44 | 645
Low intelligence 44 | 645
Mental Retardation 44 | 645
Mental deficiency 44 | 645
Poor school performance 44 | 645
autosomal dominant Emery-Dreifuss muscular dystrophy 44 | 510
Down syndrome 43 | 499
Seizures 41 | 596
mucosa-associated lymphoid tissue lymphoma 41 | 484
Liver cancer 40 | 604
Alcoholic Intoxication, Chronic 39 | 289
Waldenstrons macroglobulinemia 39 | 765

Tissue

Endocrine System 935 | 18,159
Digestive Tract 907 | 17,369
Female tissues 896 | 17,400
Skin and soft tissues 896 | 17,230
Male tissues 894 | 17,142
Blood and immune system 888 | 16,909
Nervous System 880 | 16,725
Liver and Pancreas 878 | 16,750
Respiratory system 869 | 16,393
Urinary Tract 869 | 16,678
Cardiovascular System 802 | 15,192

Target Family

Non-IDG 511 | 12,091
Enzyme 172 | 4,145
Kinase 124 | 634
oGPCR 65 | 421
Ion Channel 42 | 344
Transcription Factor 34 | 1,400
GPCR 29 | 408
Nuclear Receptor 19 | 48
Epigenetic 5 | 242
TF/Epigenetic 2 | 38
Transporter 2 | 473

GO Process

signal transduction 1,005 | 1,005
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Amelogenin, X isoform AMELX Tbio Non-IDG -2.84702 695.0 136
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667
Long-wave-sensitive opsin 1 OPN1LW Tbio GPCR -2.37983 238.7 47
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
E3 ubiquitin-protein ligase CBL-B CBLB Tbio Enzyme -0.82313 6.58 193
Agouti-signaling protein ASIP Tbio Non-IDG -1.78281 57.2 34
Immunoglobulin superfamily member 1 IGSF1 Tbio Non-IDG -1.62840 43.8 149
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Ran-specific GTPase-activating protein RANBP1 Tbio Enzyme -1.80548 64.8 193