Development Level

Tbio 3 | 11,445

IMPC Phenotype

abnormal cranium morphology 1 | 36
abnormal incisor morphology 1 | 4
abnormal radius morphology 1 | 8
abnormal snout morphology 1 | 23
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased total body fat amoun... 1 | 207
increased blood urea nitrogen ... 1 | 48
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
preweaning lethality, incomple... 1 | 499

Disease

Breast cancer 3 | 3,578
Carcinoma 3 | 11,493
atypical teratoid / rhabdoid tumor 3 | 5,112
ependymoma 3 | 4,679
pancreatic cancer 3 | 2,398
pituitary cancer 3 | 1,972
psoriasis 3 | 6,694
Adducted thumb 2 | 22
Aortic root dilatation 2 | 11
Arachnodactyly 2 | 49
Astrocytoma, Pilocytic 2 | 3,081
Brachycephaly 2 | 88
Broad cranium shape 2 | 88
Byzanthine arch palate 2 | 194
Congenital pectus carinatum 2 | 52
Crumpled ear 2 | 3
Ectopia Lentis 2 | 17
Joint stiffness 2 | 84
Kidney cancer 2 | 2,613
Liver Cirrhosis, Experimental 2 | 769
Long narrow head 2 | 75
Marfan Syndrome 2 | 15
Marfanoid body habitus 2 | 11
Mitral Valve Prolapse Syndrome 2 | 39
Mitral regurgitation, mild 2 | 32
Mitral valve insufficiency 2 | 49
Motor delay 2 | 147
Myopia 2 | 176
Narrow cranium shape 2 | 75
Narrow head shape 2 | 75
Narrow skull shape 2 | 75
No development of motor milestones 2 | 147
Patent ductus arteriosus 2 | 90
Turridolichocephaly 2 | 75
Ventricular Septal Defects 2 | 119
Weill-Marchesani syndrome 2 | 14
Wide skull shape 2 | 88
glioblastoma 2 | 5,792
group 3 medulloblastoma 2 | 4,104
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
invasive ductal carcinoma 2 | 2,951
lung carcinoma 2 | 2,843
malignant mesothelioma 2 | 3,232
osteosarcoma 2 | 7,950
ovarian cancer 2 | 8,520
primary pancreatic ductal adenocarcinoma 2 | 1,109
Abnormality of position of teeth 1 | 8
Abnormality of the iris 1 | 14
Aneurysm of ascending aorta 1 | 5
Aortic Aneurysm, Thoracic 1 | 8
Aortic aneurysm, familial thoracic 3 1 | 13
Aortic valve stenosis 1 | 28
Ascending aortic dissection 1 | 13
Broad ribs 1 | 12
Bullet vertebral body 1 | 17
Bullous keratopathy 1 | 7
Cone-shaped epiphyses 1 | 24
Cutis marmorata 1 | 32
Cystic medial necrosis of aorta 1 | 13
Decreased muscle mass 1 | 28
Decreased subcutaneous adipose tissue 1 | 13
Descending aortic dissection 1 | 13
Diffusely thickened skin 1 | 20
Dissection of aorta 1 | 9
Distal arthrogryposis syndrome 1 | 8
Dyspnea on exertion 1 | 24
Dyspnea, Paroxysmal 1 | 13
Eyebrow abnormalities 1 | 12
Familial thoracic aortic aneurysm and aortic dissection 1 | 13
Hammer Toe 1 | 23
Heart murmur 1 | 5
Hypoplasia of iris 1 | 10
Impaired left ventricular function 1 | 16
Lack of skin elasticity 1 | 10
Left-Sided Heart Failure 1 | 16
Lipoatrophy 1 | 19
Loeys-Dietz Aortic Aneurysm Syndrome 1 | 13
Loeys-Dietz syndrome 1 | 23
Misalignment of teeth 1 | 8
Narrow palate 1 | 20
Ovoid vertebral bodies 1 | 17
Pachyderma 1 | 20
Premature osteoarthritis 1 | 6
Proportionate short stature 1 | 4
Protrusio acetabuli 1 | 7
Severe myopia 1 | 22
Shallow anterior chamber of eye 1 | 4
Short phalanx of finger 1 | 32
Short tubular bones 1 | 22
Slender build 1 | 14
Spade-like hand 1 | 16
Spinal canal stenosis 1 | 12
Spondylolisthesis 1 | 22
Stiff skin 1 | 3
Stretched skin 1 | 10
Talipes Calcaneovarus 1 | 2
Thoracic aortic aneurysm 1 | 15
Tracheal stenosis 1 | 23
Tricuspid valve insufficiency 1 | 14

Tissue

Blood and immune system 3 | 16,909
Cardiovascular System 3 | 15,192
Digestive Tract 3 | 17,369
Endocrine System 3 | 18,159
Female tissues 3 | 17,400
Liver and Pancreas 3 | 16,750
Male tissues 3 | 17,142
Nervous System 3 | 16,725
Respiratory system 3 | 16,393
Skin and soft tissues 3 | 17,230
Urinary Tract 3 | 16,678

Target Family

Non-IDG 3 | 12,091

GO Process

sequestering of TGFbeta in ext... 3 | 3
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Latent-transforming growth factor beta-binding protein 1 LTBP1 Tbio Non-IDG -1.97590 101.5 128
Fibrillin-1 FBN1 Tbio Non-IDG -3.08679 1236.3 325
Fibrillin-2 FBN2 Tbio Non-IDG -2.46578 287.6 123