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Target Filters...

Development Level

Tbio 44 | 11,445
Tchem 6 | 1,598
Tclin 5 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased body weight 3 | 161
hyperactivity 3 | 148
abnormal behavior 2 | 298
abnormal whole-body plethysmog... 2 | 4
decreased body temperature 2 | 2
abnormal eating behavior 1 | 1
abnormal eye morphology 1 | 68
abnormal forced expiratory flo... 1 | 1
abnormal heart morphology 1 | 162
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal rib morphology 1 | 10
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
altered righting response 1 | 1
cataract 1 | 92
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased lean body mass 1 | 135
decreased lumbar vertebrae num... 1 | 2
decreased prepulse inhibition 1 | 82
decreased tidal volume 1 | 1
enlarged heart 1 | 210
enlarged uterus 1 | 11
hydrometra 1 | 53
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased cellular hemoglobin ... 1 | 1
increased circulating alkaline... 1 | 122
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased heart weight 1 | 62
increased kidney weight 1 | 6
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
macrophthalmia 1 | 2
male infertility 1 | 123
mydriasis 1 | 6
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Carcinoma 43 | 11,493
ependymoma 26 | 4,679
group 3 medulloblastoma 25 | 4,104
medulloblastoma, large-cell 25 | 6,241
osteosarcoma 23 | 7,950
psoriasis 23 | 6,694
Autosomal recessive predisposition 22 | 1,442
ovarian cancer 21 | 8,520
glioblastoma 19 | 5,792
Intellectual disability 17 | 1,016
Dull intelligence 16 | 645
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Poor school performance 16 | 645
Retinitis Pigmentosa 16 | 226
atypical teratoid / rhabdoid tumor 16 | 5,112
Nystagmus 15 | 317
Breast cancer 13 | 3,578
Glaucoma 13 | 239
Hypogonadism 13 | 173
Kidney cancer 13 | 2,613
lung cancer 13 | 4,740
oligodendroglioma 13 | 2,850
Abnormality of retinal pigmentation 12 | 111
Astrocytoma, Pilocytic 12 | 3,081
Congenital hypoplasia of penis 12 | 176
Obesity 12 | 678
Optic Atrophy 12 | 242
Retinal pigment epithelial abnormality 12 | 111
astrocytic glioma 12 | 2,597
Broad flat nasal bridge 11 | 236
Nasal bridge wide 11 | 236
Night Blindness 11 | 101
primitive neuroectodermal tumor 11 | 3,035
Anteverted nostril 10 | 191
Blind Vision 10 | 111
Blindness, Legal 10 | 110
Cataract 10 | 297
Conductive hearing loss 10 | 123
Difficulties with night vision 10 | 87
Electroretinogram abnormal 10 | 95
Fundus dystrophy 10 | 83
Lens Opacities 10 | 231
Ophthalmoplegia 10 | 106
Photodysphoria 10 | 121
Photophobia 10 | 121
Pick disease 10 | 1,894
Retinal Degeneration 10 | 106
Sensorineural Hearing Loss (disorder) 10 | 284
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
malignant mesothelioma 10 | 3,232
Abnormality of the retinal vasculature 9 | 59
Atypical scarring of skin 9 | 62
Cancer 9 | 2,499
Congenital anomaly of testis 9 | 52
Hyperinsulinism 9 | 133
Keratoconus 9 | 113
Muscle hypotonia 9 | 571
Night blindness, progressive 9 | 51
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
invasive ductal carcinoma 9 | 2,951
pancreatic cancer 9 | 2,398
Leber congenital amaurosis 8 | 69
Reduced visual acuity 8 | 63
adult high grade glioma 8 | 3,801
pituitary cancer 8 | 1,972
Cone dystrophy 7 | 71
Epilepsy 7 | 792
Myopia 7 | 176
astrocytoma 7 | 1,146
diabetes mellitus 7 | 1,728
subependymal giant cell astrocytoma 7 | 2,287
tuberculosis 7 | 2,010
Alzheimer's disease 6 | 658
Low Vision 6 | 174
Schizophrenia 6 | 1,160
Strabismus 6 | 270
Visual Impairment 6 | 174
adrenocortical carcinoma 6 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
pediatric high grade glioma 6 | 1,064
Abnormality of macular pigmentation 5 | 16
Autistic Disorder 5 | 364
Blindness 5 | 88
Macular pigmentary changes 5 | 16
Prostatic Neoplasms 5 | 495
Seizures 5 | 596
Short stature 5 | 531
breast carcinoma 5 | 1,638
cone-rod dystrophy 5 | 59
cystic fibrosis 5 | 1,696
juvenile dermatomyositis 5 | 1,187
lung adenocarcinoma 5 | 2,716
lung carcinoma 5 | 2,843
non-small cell lung cancer 5 | 2,890
Rheumatoid arthritis 4 | 1,191
gastric carcinoma 4 | 807
ulcerative colitis 4 | 1,819

Tissue

Endocrine System 54 | 18,159
Skin and soft tissues 51 | 17,230
Digestive Tract 50 | 17,369
Female tissues 50 | 17,400
Nervous System 49 | 16,725
Blood and immune system 48 | 16,909
Liver and Pancreas 48 | 16,750
Male tissues 48 | 17,142
Urinary Tract 48 | 16,678
Respiratory system 45 | 16,393
Cardiovascular System 40 | 15,192

Target Family

Non-IDG 23 | 12,091
Transcription Factor 12 | 1,400
Enzyme 9 | 4,145
Kinase 4 | 634
Nuclear Receptor 3 | 48
GPCR 2 | 408
Epigenetic 1 | 242
Ion Channel 1 | 344
Transporter 1 | 473

GO Process

retina development in camera-t... 56 | 56
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Photoreceptor-specific nuclear receptor NR2E3 Tbio Nuclear Receptor 0.00000 261
Tubulin polyglutamylase TTLL5 TTLL5 Tbio Enzyme -0.67048 4.78 28
POU domain, class 4, transcription factor 2 POU4F2 Tbio Transcription Factor -1.94397 90.2 145
Tyrosine-protein kinase Mer MERTK Tchem Kinase -2.27276 199.1 609
Paired box protein Pax-6 PAX6 Tbio Transcription Factor -3.16650 1458.6 570
Electrogenic sodium bicarbonate cotransporter 4 SLC4A5 Tbio Transporter -1.31656 21.0 30
Membrane frizzled-related protein MFRP Tbio Non-IDG -2.04418 60.6 209
Intraflagellar transport protein 140 homolog IFT140 Tbio Non-IDG -1.42568 23.3 45
Chloride channel protein 2 CLCN2 Tclin Ion Channel -2.04014 106.6 218
Retinitis pigmentosa 1-like 1 protein RP1L1 Tbio Non-IDG -1.29040 21.3 0