Development Level

Tbio 38 | 10,625
Tchem 37 | 1,890
Tclin 13 | 602

Collection

Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

increased total body fat amoun... 4 | 57
preweaning lethality, complete... 4 | 633
decreased bone mineral content 3 | 157
decreased lean body mass 3 | 195
increased circulating triglyce... 3 | 24
preweaning lethality, incomple... 3 | 260
decreased circulating alanine ... 2 | 53
decreased fasted circulating g... 2 | 49
decreased heart weight 2 | 44
decreased total body fat amoun... 2 | 186
increased circulating HDL chol... 2 | 63
increased mean corpuscular vol... 2 | 91
abnormal behavioral response t... 1 | 52
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal coat/hair pigmentatio... 1 | 54
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal esophagus morphology 1 | 4
abnormal head morphology 1 | 10
abnormal pancreas morphology 1 | 6
abnormal retina morphology 1 | 100
abnormal seminal vesicle morph... 1 | 47
abnormal skin coloration 1 | 18
abnormal skin morphology 1 | 23
abnormal sleep behavior 1 | 63
abnormal snout morphology 1 | 18
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
absent lymph nodes 1 | 3
absent testes 1 | 2
anophthalmia 1 | 20
athymia 1 | 1
corneal opacity 1 | 25
decreased Ly6C low monocyte nu... 1 | 23
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased effector memory CD8-... 1 | 24
decreased erythrocyte cell num... 1 | 43
decreased grip strength 1 | 123
decreased kidney weight 1 | 7
decreased spleen weight 1 | 13
edema 1 | 11
enlarged heart 1 | 111
enlarged spleen 1 | 26
female infertility 1 | 34
hemorrhage 1 | 12
impaired glucose tolerance 1 | 52
impaired pupillary reflex 1 | 14
impaired righting response 1 | 19
increased Ly6C high monocyte n... 1 | 12
increased NK T cell number 1 | 11
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased effector memory CD4-... 1 | 15
increased gamma-delta T cell n... 1 | 16
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased monocyte cell number 1 | 27
increased sacral vertebrae num... 1 | 62
male infertility 1 | 62
narrow eye opening 1 | 15
short tibia 1 | 82
small testis 1 | 37
thrombocytopenia 1 | 46

Disease

ovarian cancer 59 | 8,484
Cancer 52 | 2,346
psoriasis 49 | 6,685
lung cancer 43 | 4,466
glioblastoma 40 | 5,572
medulloblastoma, large-cell 40 | 6,234
osteosarcoma 38 | 7,933
Breast cancer 33 | 3,094
atypical teratoid / rhabdoid tumor 33 | 4,369
malignant mesothelioma 33 | 3,162
invasive ductal carcinoma 31 | 2,950
breast carcinoma 29 | 1,614
lung adenocarcinoma 28 | 2,713
Prostatic Neoplasms 27 | 471
non-small cell lung cancer 25 | 2,798
pancreatic cancer 25 | 2,300
oligodendroglioma 24 | 2,849
primitive neuroectodermal tumor 24 | 3,031
Mammary Neoplasms 23 | 410
lung carcinoma 23 | 2,844
ulcerative colitis 23 | 2,087
interstitial cystitis 22 | 2,299
pilocytic astrocytoma 22 | 3,086
diabetes mellitus 21 | 1,663
ductal carcinoma in situ 21 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
pediatric high grade glioma 21 | 2,712
pituitary cancer 21 | 1,972
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
Endometriosis 18 | 535
astrocytoma 18 | 1,493
cystic fibrosis 18 | 1,665
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,956
nasopharyngeal carcinoma 17 | 1,056
Lung Neoplasms 16 | 171
tuberculosis 16 | 1,557
adrenocortical carcinoma 15 | 1,427
adult high grade glioma 15 | 2,148
ependymoma 15 | 2,514
subependymal giant cell astrocytoma 15 | 2,287
juvenile dermatomyositis 14 | 1,189
Asthma 13 | 349
Atopic dermatitis 13 | 944
Carcinoma 13 | 2,147
Obesity 13 | 616
acute quadriplegic myopathy 13 | 1,157
colon cancer 13 | 1,475
fibroadenoma 13 | 557
group 4 medulloblastoma 13 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
Adenocarcinoma 12 | 115
Autistic Disorder 12 | 320
Hypertension 12 | 287
Schizophrenia 12 | 501
group 3 medulloblastoma 12 | 2,254
posterior fossa group A ependymoma 12 | 1,511
primary pancreatic ductal adenocarcinoma 12 | 1,271
sonic hedgehog group medulloblastoma 12 | 1,482
Alzheimer's disease 11 | 644
Atherosclerosis 11 | 275
Duchenne muscular dystrophy 11 | 602
Kidney disease 11 | 396
Liver carcinoma 11 | 217
Liver disease 11 | 219
Vascular disease 11 | 281
medulloblastoma 11 | 1,524
non-small cell lung carcinoma 11 | 413
posterior fossa group B ependymoma 11 | 1,530
Adenoma 10 | 165
Hypertensive disease 10 | 193
Stomach Neoplasms 10 | 282
astrocytic glioma 10 | 2,241
esophageal adenocarcinoma 10 | 737
gastric carcinoma 10 | 832
Colorectal Neoplasms 9 | 217
Diabetes Mellitus, Non-Insulin-Dependent 9 | 157
Liver Cirrhosis, Experimental 9 | 108
Multiple myeloma 9 | 1,327
Neoplasm Metastasis 9 | 138
Rheumatoid Arthritis 9 | 1,160
atypical teratoid/rhabdoid tumor 9 | 1,095
primary Sjogren syndrome 9 | 789
Colonic Neoplasms 8 | 126
Heart disease 8 | 279
Hyperglycemia 8 | 120
Mammary Neoplasms, Experimental 8 | 150
Osteoporosis 8 | 257
Parkinson's disease 8 | 364
Toxic encephalopathy 8 | 131
active Crohn's disease 8 | 918
aldosterone-producing adenoma 8 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
Arthritis 7 | 248
Myocardial Ischemia 7 | 169
Reperfusion Injury 7 | 84
Waldenstrons macroglobulinemia 7 | 765
cutaneous lupus erythematosus 7 | 1,056
pancreatic carcinoma 7 | 567
spina bifida 7 | 1,064
urothelial carcinoma 7 | 318

Tissue

Digestive Tract 88 | 18,473
Female tissues 88 | 18,647
Liver and Pancreas 88 | 18,136
Nervous System 88 | 18,561
Urinary Tract 88 | 18,444
Endocrine System 87 | 18,512
Male tissues 87 | 17,969
Respiratory system 87 | 17,484
Skin and soft tissues 87 | 18,115
Blood and immune system 86 | 17,995
Cardiovascular System 86 | 17,958

Target Family

Non-IDG 39 | 11,971
Enzyme 21 | 4,146
Transcription Factor 9 | 1,400
GPCR 6 | 406
Epigenetic 4 | 242
Nuclear Receptor 4 | 48
Transporter 3 | 473
Ion Channel 1 | 341
Kinase 1 | 634

GO Process

response to estradiol 88 | 88
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
N-glycosylase/DNA lyase OGG1 Tbio Enzyme -3.23405 1747.3 234
Fibroblast growth factor 10 FGF10 Tbio Non-IDG -2.51373 345.1 271
Prostaglandin G/H synthase 2 PTGS2 Tclin Enzyme -4.03668 12041.6 648
G1/S-specific cyclin-D1 CCND1 Tchem Non-IDG -3.77851 5447.1 1111
Elongation factor 2 EEF2 Tchem Non-IDG -2.93803 911.5 347
Amphiregulin AREG Tchem Non-IDG -2.56925 21.0 236
NAD(P)H dehydrogenase [quinone] 1 NQO1 Tchem Enzyme -3.06431 1230.1 502
Estrogen receptor ESR1 Tclin Nuclear Receptor -3.97123 8119.2 2214
DNA (cytosine-5)-methyltransferase 3A DNMT3A Tclin Epigenetic -2.80919 625.6 631