Development Level

Tbio 171 | 11,651
Tchem 64 | 1,388
Tclin 60 | 612
Tdark 8 | 6,593

Collection

GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 21 | 979
preweaning lethality, incomple... 14 | 499
abnormal behavior 12 | 298
enlarged heart 10 | 210
abnormal heart morphology 9 | 162
hyperactivity 8 | 148
decreased total body fat amoun... 7 | 207
embryonic lethality prior to t... 7 | 278
embryonic lethality prior to o... 6 | 239
increased startle reflex 6 | 112
increased total body fat amoun... 6 | 134
decreased bone mineral content 5 | 151
decreased circulating insulin ... 5 | 76
decreased lean body mass 5 | 135
hypoactivity 5 | 132
impaired glucose tolerance 5 | 75
increased circulating alkaline... 5 | 122
prolonged ST segment 5 | 36
abnormal embryo size 4 | 220
decreased body weight 4 | 161
decreased lymphocyte cell numb... 4 | 83
increased bone mineral content 4 | 108
increased circulating HDL chol... 4 | 80
increased neutrophil cell numb... 4 | 46
prolonged QT interval 4 | 38
thrombocytopenia 4 | 56
abnormal bone structure 3 | 187
abnormal gait 3 | 69
abnormal lung morphology 3 | 26
abnormal seminal vesicle morph... 3 | 114
abnormal skin morphology 3 | 50
cataract 3 | 92
decreased bone mineral density 3 | 126
decreased circulating amylase ... 3 | 28
decreased circulating triglyce... 3 | 79
decreased fasted circulating g... 3 | 65
decreased grip strength 3 | 116
decreased neutrophil cell numb... 3 | 42
decreased startle reflex 3 | 75
female infertility 3 | 60
increased body weight 3 | 25
increased circulating triglyce... 3 | 42
increased monocyte cell number 3 | 63
abnormal bone mineralization 2 | 38
abnormal epididymis morphology 2 | 42
abnormal lens morphology 2 | 81
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
decreased circulating HDL chol... 2 | 68
decreased circulating alkaline... 2 | 46
decreased circulating glycerol... 2 | 16
decreased circulating serum al... 2 | 82
decreased erythrocyte cell num... 2 | 62
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
decreased vertical activity 2 | 208
enlarged epididymis 2 | 31
impaired righting response 2 | 26
improved glucose tolerance 2 | 79
increased bone mineral density 2 | 72
increased circulating choleste... 2 | 66
increased circulating glucose ... 2 | 24
increased circulating sodium l... 2 | 71
increased circulating total pr... 2 | 28
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular hem... 2 | 96
increased spleen weight 2 | 10
increased vertical activity 2 | 24
male infertility 2 | 123
mammalian phenotype 2 | 17
prenatal lethality prior to he... 2 | 87
small superior vagus ganglion 2 | 74
tremors 2 | 39
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal liver morphology 1 | 17
abnormal retinal vasculature m... 1 | 27
abnormal spleen morphology 1 | 55
abnormal vibrissa morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
cardiovascular system phenotyp... 1 | 36
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased eosinophil cell numb... 1 | 24
decreased pulmonary respirator... 1 | 5
enlarged spleen 1 | 41
increased cardiac muscle contr... 1 | 8
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating iron lev... 1 | 30
increased circulating serum al... 1 | 22
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
microphthalmia 1 | 26
small testis 1 | 58
urinary bladder obstruction 1 | 4

Disease

Carcinoma 201 | 11,493
ovarian cancer 178 | 8,519
Cancer 153 | 2,499
psoriasis 149 | 6,694
lung cancer 137 | 4,740
glioblastoma 134 | 5,792
osteosarcoma 129 | 7,950
medulloblastoma, large-cell 120 | 6,241
ependymoma 114 | 4,679
malignant mesothelioma 105 | 3,232
atypical teratoid / rhabdoid tumor 104 | 5,112
group 3 medulloblastoma 90 | 4,104
non-small cell lung cancer 85 | 2,890
lung carcinoma 84 | 2,843
Astrocytoma, Pilocytic 83 | 3,081
adult high grade glioma 82 | 3,801
Schizophrenia 81 | 1,160
diabetes mellitus 80 | 1,728
Breast cancer 77 | 3,577
invasive ductal carcinoma 77 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 74 | 3,290
pancreatic cancer 73 | 2,398
primitive neuroectodermal tumor 73 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 70 | 2,954
ulcerative colitis 70 | 1,819
intraductal papillary-mucinous carcinoma (IPMC) 69 | 2,988
oligodendroglioma 66 | 2,850
Autosomal recessive predisposition 63 | 1,442
tuberculosis 63 | 2,010
interstitial cystitis 62 | 2,312
lung adenocarcinoma 62 | 2,716
pituitary cancer 59 | 1,972
Kidney cancer 57 | 2,613
Obesity 54 | 678
subependymal giant cell astrocytoma 53 | 2,287
astrocytic glioma 51 | 2,597
Bipolar Disorder 49 | 666
Hypertension 49 | 396
colon cancer 49 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 49 | 1,962
Liver Cirrhosis, Experimental 46 | 769
breast carcinoma 46 | 1,637
ductal carcinoma in situ 46 | 1,744
Hypertensive disease 44 | 292
Pick disease 44 | 1,894
Seizures 44 | 596
Alzheimer's disease 43 | 658
cystic fibrosis 43 | 1,695
Depressive disorder 42 | 409
Kidney disease 42 | 430
astrocytoma 42 | 1,146
group 4 medulloblastoma 42 | 1,855
Epilepsy 41 | 792
adrenocortical carcinoma 41 | 1,428
Prostatic Neoplasms 40 | 495
Breast Neoplasms 38 | 445
Mammary Neoplasms 37 | 425
Atherosclerosis 35 | 291
Mental Depression 35 | 333
Parkinson's disease 35 | 392
Rheumatoid arthritis 35 | 1,191
nasopharyngeal carcinoma 35 | 1,058
Alcoholic Intoxication, Chronic 34 | 289
Endometriosis 34 | 540
Major Depressive Disorder 34 | 301
Multiple myeloma 34 | 1,332
Vascular disease 34 | 319
Atopic dermatitis 33 | 952
Mood Disorders 32 | 184
Asthma 31 | 385
acute quadriplegic myopathy 31 | 1,158
cutaneous lupus erythematosus 31 | 1,057
gastric carcinoma 31 | 807
primary pancreatic ductal adenocarcinoma 31 | 1,108
Coronary artery disease 30 | 268
Intellectual disability 30 | 1,016
Lung Neoplasms 29 | 232
Unipolar Depression 29 | 250
active Crohn's disease 29 | 922
pediatric high grade glioma 29 | 1,064
Colorectal Neoplasms 28 | 243
Waldenstrons macroglobulinemia 28 | 765
Cognitive delay 27 | 608
Global developmental delay 27 | 608
Heart disease 27 | 306
Mental and motor retardation 27 | 608
juvenile dermatomyositis 27 | 1,187
Autistic Disorder 26 | 364
Diabetes Mellitus, Experimental 26 | 108
Dull intelligence 26 | 645
Low intelligence 26 | 645
Mental Retardation 26 | 645
Mental deficiency 26 | 645
Poor school performance 26 | 645
fibroadenoma 26 | 559
Adenoma 25 | 167
Hyperglycemia 25 | 137
Liver Cirrhosis 25 | 181
Liver disease 25 | 237
active ulcerative colitis 24 | 764

Tissue

Endocrine System 293 | 18,159
Digestive Tract 288 | 17,369
Female tissues 284 | 17,400
Male tissues 281 | 17,142
Skin and soft tissues 280 | 17,230
Nervous System 279 | 16,725
Liver and Pancreas 277 | 16,750
Urinary Tract 276 | 16,678
Blood and immune system 274 | 16,909
Respiratory system 269 | 16,393
Cardiovascular System 248 | 15,192

Target Family

Non-IDG 113 | 12,091
Enzyme 83 | 4,145
Transcription Factor 30 | 1,400
Transporter 26 | 473
GPCR 16 | 408
Kinase 16 | 634
Ion Channel 8 | 344
Epigenetic 5 | 242
oGPCR 5 | 421
Nuclear Receptor 1 | 48

GO Process

response to drug 303 | 303
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388