Development Level

Tbio 147 | 10,625
Tchem 88 | 1,890
Tclin 59 | 602
Tdark 3 | 7,003

Collection

Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 14 | 633
abnormal behavior 9 | 226
preweaning lethality, incomple... 9 | 260
decreased bone mineral content 7 | 157
increased grip strength 6 | 83
enlarged heart 5 | 111
abnormal bone mineralization 4 | 55
abnormal bone structure 4 | 131
abnormal heart morphology 4 | 51
decreased circulating insulin ... 4 | 75
decreased lean body mass 4 | 195
embryonic lethality prior to t... 4 | 187
hyperactivity 4 | 108
impaired glucose tolerance 4 | 52
increased total body fat amoun... 4 | 57
male infertility 4 | 62
abnormal embryo size 3 | 112
abnormal gait 3 | 51
abnormal lens morphology 3 | 73
abnormal retina morphology 3 | 100
decreased body weight 3 | 174
decreased bone mineral density 3 | 126
decreased circulating alkaline... 3 | 41
decreased circulating triglyce... 3 | 83
decreased fasted circulating g... 3 | 49
decreased grip strength 3 | 123
decreased monocyte cell number 3 | 28
embryonic lethality prior to o... 3 | 148
female infertility 3 | 34
hypoactivity 3 | 89
increased body weight 3 | 42
increased circulating HDL chol... 3 | 63
increased circulating sodium l... 3 | 71
increased circulating triglyce... 3 | 24
abnormal coping response 2 | 12
abnormal epididymis morphology 2 | 31
cataract 2 | 26
decreased blood urea nitrogen ... 2 | 31
decreased body length 2 | 108
decreased circulating HDL chol... 2 | 77
decreased circulating alanine ... 2 | 53
decreased circulating glycerol... 2 | 19
decreased neutrophil cell numb... 2 | 37
decreased startle reflex 2 | 48
decreased total body fat amoun... 2 | 186
enlarged epididymis 2 | 27
immune system phenotype 2 | 17
impaired righting response 2 | 19
increased bone mineral content 2 | 92
increased circulating alkaline... 2 | 119
increased circulating choleste... 2 | 53
increased circulating serum al... 2 | 25
increased circulating total pr... 2 | 20
increased lymphocyte cell numb... 2 | 9
increased or absent threshold ... 2 | 128
increased vertical activity 2 | 18
prenatal lethality prior to he... 2 | 64
straub tail 2 | 26
abnormal coat appearance 1 | 25
abnormal head morphology 1 | 10
abnormal liver morphology 1 | 5
abnormal lung morphology 1 | 15
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 17
decreased NK cell number 1 | 16
decreased caudal vertebrae num... 1 | 49
decreased circulating calcium ... 1 | 33
decreased circulating serum al... 1 | 79
decreased effector memory CD8-... 1 | 24
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased pulmonary respirator... 1 | 4
decreased rib number 1 | 59
enlarged spleen 1 | 26
increased blood urea nitrogen ... 1 | 44
increased bone mineral density 1 | 52
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased eosinophil cell numb... 1 | 9
increased fasted circulating g... 1 | 68
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
limb grasping 1 | 35
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
small testis 1 | 37
stereotypic behavior 1 | 3
thrombocytopenia 1 | 46
tremors 1 | 34
trunk curl 1 | 15
urinary bladder obstruction 1 | 2

Disease

ovarian cancer 173 | 8,484
Cancer 150 | 2,346
psoriasis 150 | 6,685
lung cancer 128 | 4,466
osteosarcoma 127 | 7,933
glioblastoma 126 | 5,572
medulloblastoma, large-cell 118 | 6,234
malignant mesothelioma 100 | 3,162
atypical teratoid / rhabdoid tumor 87 | 4,369
pilocytic astrocytoma 86 | 3,086
non-small cell lung cancer 84 | 2,798
lung carcinoma 80 | 2,844
pediatric high grade glioma 77 | 2,712
ulcerative colitis 77 | 2,087
invasive ductal carcinoma 76 | 2,950
diabetes mellitus 74 | 1,663
intraductal papillary-mucinous neoplasm (IPMN) 74 | 3,289
primitive neuroectodermal tumor 74 | 3,031
pancreatic cancer 73 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 72 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 71 | 2,956
oligodendroglioma 67 | 2,849
Breast cancer 65 | 3,094
lung adenocarcinoma 62 | 2,713
ependymoma 61 | 2,514
interstitial cystitis 61 | 2,299
pituitary cancer 58 | 1,972
tuberculosis 58 | 1,557
subependymal giant cell astrocytoma 54 | 2,287
astrocytoma 52 | 1,493
Obesity 48 | 616
colon cancer 48 | 1,475
group 4 medulloblastoma 48 | 1,875
group 3 medulloblastoma 47 | 2,254
posterior fossa group A ependymoma 47 | 1,511
Alzheimer's disease 46 | 644
ductal carcinoma in situ 46 | 1,745
Carcinoma 45 | 2,147
breast carcinoma 45 | 1,614
sonic hedgehog group medulloblastoma 45 | 1,482
Pick disease 43 | 1,893
Kidney disease 42 | 396
pancreatic ductal adenocarcinoma liver metastasis 42 | 1,795
Prostatic Neoplasms 40 | 471
adrenocortical carcinoma 40 | 1,427
astrocytic glioma 39 | 2,241
cystic fibrosis 39 | 1,665
Mammary Neoplasms 38 | 410
primary pancreatic ductal adenocarcinoma 38 | 1,271
Multiple myeloma 36 | 1,327
Schizophrenia 36 | 501
nasopharyngeal carcinoma 36 | 1,056
Atopic dermatitis 34 | 944
Rheumatoid Arthritis 34 | 1,160
adult high grade glioma 34 | 2,148
Atherosclerosis 33 | 275
Endometriosis 33 | 535
Parkinson's disease 33 | 364
gastric carcinoma 33 | 832
Hypertensive disease 32 | 193
acute quadriplegic myopathy 32 | 1,157
atypical teratoid/rhabdoid tumor 32 | 1,095
cutaneous lupus erythematosus 32 | 1,056
Asthma 31 | 349
Hypertension 31 | 287
Vascular disease 29 | 281
Waldenstrons macroglobulinemia 29 | 765
active Crohn's disease 29 | 918
juvenile dermatomyositis 29 | 1,189
posterior fossa group B ependymoma 28 | 1,530
Adenoma 26 | 165
Autistic Disorder 26 | 320
Colorectal Neoplasms 26 | 217
Coronary artery disease 26 | 240
Diabetes Mellitus, Experimental 26 | 106
Lung Neoplasms 26 | 171
fibroadenoma 26 | 557
Epilepsy 24 | 346
medulloblastoma 24 | 1,524
primary Sjogren syndrome 24 | 789
Arthritis 23 | 248
Down syndrome 23 | 548
Toxic encephalopathy 23 | 131
Colonic Neoplasms 22 | 126
Diabetes Mellitus, Non-Insulin-Dependent 22 | 157
Heart disease 22 | 279
Liver disease 22 | 219
Multiple Sclerosis 22 | 498
Myocardial Infarction 22 | 126
Stomach Neoplasms 22 | 282
Hyperglycemia 21 | 120
Liver carcinoma 21 | 217
esophageal adenocarcinoma 21 | 737
Cerebrovascular disease 20 | 231
Peripheral Neuropathy 20 | 303
aldosterone-producing adenoma 20 | 664
dermatomyositis 20 | 933
non primary Sjogren syndrome sicca 20 | 840
Seizures 19 | 95
nephrosclerosis 19 | 329

Tissue

Digestive Tract 295 | 18,473
Female tissues 295 | 18,647
Liver and Pancreas 293 | 18,136
Endocrine System 292 | 18,512
Male tissues 292 | 17,969
Nervous System 292 | 18,561
Urinary Tract 291 | 18,444
Skin and soft tissues 289 | 18,115
Blood and immune system 288 | 17,995
Cardiovascular System 288 | 17,958
Respiratory system 285 | 17,484

Target Family

Non-IDG 107 | 11,971
Enzyme 85 | 4,146
Transcription Factor 29 | 1,400
Transporter 27 | 473
GPCR 17 | 406
Kinase 17 | 634
Epigenetic 7 | 242
Ion Channel 7 | 341
Nuclear Receptor 1 | 48

GO Process

response to drug 297 | 297
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Muellerian-inhibiting factor AMH Tbio Non-IDG -3.34520 2413.2 212
ATP-binding cassette sub-family A member 2 ABCA2 Tbio Transporter -1.41708 32.2 125
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Trifunctional enzyme subunit alpha, mitochondrial HADHA Tbio Non-IDG -2.96515 948.2 132
Lymphotoxin-alpha LTA Tbio Non-IDG -2.84770 612.8 461
Pancreas/duodenum homeobox protein 1 PDX1 Tbio Transcription Factor -2.33707 243.8 508