Targets

Target Filters...

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Name	Gene	Development Level	Target Family	Log Novelty	Pubmed Score	Antibody Count
Leukemia inhibitory factor receptor	LIFR	Tchem	Non-IDG	-2.33661	212.2	213
Oncostatin-M-specific receptor subunit beta	OSMR	Tbio	Non-IDG	-2.24105	170.5	217
Metalloproteinase inhibitor 4	TIMP4	Tbio	Enzyme	-1.99351	100.3	348
Transmembrane protein 102	TMEM102	Tbio	Non-IDG	-1.22014	17.5	61
MAP kinase-activated protein kinase 2	MAPKAPK2	Tchem	Kinase	-2.14428	135.6	649
Proto-oncogene c-Fos	FOS	Tchem	Transcription Factor	-4.12726	13094.7	961
Tumor necrosis factor receptor superfamily member 11A	TNFRSF11A	Tbio	Non-IDG	-3.23151	1549.9	406
Interleukin-6 receptor subunit beta	IL6ST	Tclin	Non-IDG	-1.68650	50.5	476
Geranylgeranyl transferase type-1 subunit beta	PGGT1B	Tchem	Enzyme	-1.51052	29.4	60
Cbp/p300-interacting transactivator 1	CITED1	Tbio	Non-IDG	-1.71994	54.2	197

	decreased bone mineral content	4 \| 157
	preweaning lethality, complete...	3 \| 633
	abnormal humerus morphology	2 \| 11
	decreased lean body mass	2 \| 195
	enlarged lymph nodes	2 \| 27
	abnormal behavior	1 \| 226
	abnormal bone structure	1 \| 131
	abnormal brain morphology	1 \| 6
	abnormal coat/hair pigmentatio...	1 \| 54
	abnormal coping response	1 \| 12
	abnormal eye morphology	1 \| 38
	abnormal femur morphology	1 \| 14
	abnormal incisor color	1 \| 2
	abnormal joint morphology	1 \| 14
	abnormal lens morphology	1 \| 73
	abnormal optic disc morphology	1 \| 10
	abnormal tibia morphology	1 \| 14
	abnormal tooth morphology	1 \| 24
	absent vibrissae	1 \| 14
	cataract	1 \| 26
	decreased body length	1 \| 108
	decreased body weight	1 \| 174
	decreased bone mineral density	1 \| 126
	decreased circulating calcium ...	1 \| 33
	decreased circulating iron lev...	1 \| 25
	decreased fasted circulating g...	1 \| 49
	decreased heart weight	1 \| 44
	decreased mean corpuscular hem...	1 \| 34
	decreased mean corpuscular hem...	1 \| 19
	decreased mean corpuscular vol...	1 \| 50
	decreased respiratory quotient	1 \| 12
	decreased startle reflex	1 \| 48
	embryonic lethality prior to o...	1 \| 148
	embryonic lethality prior to t...	1 \| 187
	hyperactivity	1 \| 108
	impaired righting response	1 \| 19
	increased blood urea nitrogen ...	1 \| 44
	increased circulating creatini...	1 \| 29
	increased circulating glucose ...	1 \| 16
	increased circulating iron lev...	1 \| 25
	increased circulating sodium l...	1 \| 71
	increased lean body mass	1 \| 107
	short tibia	1 \| 82
	shortened QT interval	1 \| 4
	small adrenal glands	1 \| 15
	small spleen	1 \| 11
	tremors	1 \| 34

	glioblastoma	30 \| 5,572
	Cancer	29 \| 2,346
	psoriasis	29 \| 6,685
	osteosarcoma	28 \| 7,933
	ovarian cancer	28 \| 8,492
	lung cancer	25 \| 4,473
	medulloblastoma, large-cell	22 \| 6,234
	pilocytic astrocytoma	21 \| 3,086
	lung carcinoma	20 \| 2,844
	non-small cell lung cancer	20 \| 2,798
	pituitary cancer	17 \| 1,972
	ulcerative colitis	17 \| 2,087
	invasive ductal carcinoma	16 \| 2,950
	atypical teratoid / rhabdoid tumor	15 \| 4,369
	pancreatic cancer	15 \| 2,300
	posterior fossa group A ependymoma	15 \| 1,511
	intraductal papillary-mucinous neoplasm (IPMN)	14 \| 3,289
	pediatric high grade glioma	14 \| 2,712
	subependymal giant cell astrocytoma	14 \| 2,287
	tuberculosis	14 \| 1,563
	Breast cancer	13 \| 3,099
	colon cancer	13 \| 1,475
	intraductal papillary-mucinous adenoma (IPMA)	13 \| 2,956
	oligodendroglioma	13 \| 2,849
	malignant mesothelioma	12 \| 3,163
	primitive neuroectodermal tumor	12 \| 3,031
	astrocytoma	11 \| 1,493
	breast carcinoma	11 \| 1,614
	group 4 medulloblastoma	11 \| 1,875
	Multiple myeloma	10 \| 1,328
	diabetes mellitus	10 \| 1,663
	ependymoma	10 \| 2,514
	group 3 medulloblastoma	10 \| 2,254
	lung adenocarcinoma	10 \| 2,714
	Arthritis	9 \| 248
	Atopic dermatitis	9 \| 944
	ductal carcinoma in situ	9 \| 1,745
	interstitial cystitis	9 \| 2,299
	intraductal papillary-mucinous carcinoma (IPMC)	9 \| 2,988
	primary pancreatic ductal adenocarcinoma	9 \| 1,271
	Rheumatoid Arthritis	8 \| 1,171
	acute quadriplegic myopathy	8 \| 1,157
	gastric carcinoma	8 \| 832
	juvenile dermatomyositis	8 \| 1,189
	Liver Cirrhosis	7 \| 101
	Liver carcinoma	7 \| 217
	Pick disease	7 \| 1,893
	Vascular disease	7 \| 281
	active Crohn's disease	7 \| 918
	nasopharyngeal carcinoma	7 \| 1,056
	pancreatic ductal adenocarcinoma liver metastasis	7 \| 1,795
	primary Sjogren syndrome	7 \| 789
	Asthma	6 \| 349
	IGA Glomerulonephritis	6 \| 454
	Kidney disease	6 \| 397
	Lung Neoplasms	6 \| 171
	Lung disease	6 \| 136
	Schizophrenia	6 \| 503
	adrenocortical carcinoma	6 \| 1,427
	adult high grade glioma	6 \| 2,148
	cystic fibrosis	6 \| 1,670
	fibroadenoma	6 \| 557
	gastric cancer	6 \| 436
	head and neck cancer	6 \| 270
	inflammatory breast cancer	6 \| 404
	medulloblastoma	6 \| 1,524
	sarcoidosis	6 \| 368
	COPD	5 \| 116
	Carcinoma	5 \| 2,147
	Diabetes Mellitus, Experimental	5 \| 106
	Down syndrome	5 \| 548
	Duchenne muscular dystrophy	5 \| 602
	Heart disease	5 \| 279
	Heat Stroke	5 \| 12
	Mammary Neoplasms	5 \| 410
	Multiple Sclerosis	5 \| 498
	Osteoporosis	5 \| 259
	Polycystic Ovary Syndrome	5 \| 335
	Prostatic Neoplasms	5 \| 471
	acute myeloid leukemia	5 \| 785
	aldosterone-producing adenoma	5 \| 664
	atypical teratoid/rhabdoid tumor	5 \| 1,095
	mucosa-associated lymphoid tissue lymphoma	5 \| 480
	non primary Sjogren syndrome sicca	5 \| 840
	pancreatic carcinoma	5 \| 567
	progressive supranuclear palsy	5 \| 674
	pterygium	5 \| 74
	sonic hedgehog group medulloblastoma	5 \| 1,482
	spina bifida	5 \| 1,064
	urothelial carcinoma	5 \| 318
	Becker muscular dystrophy	4 \| 187
	Waldenstrons macroglobulinemia	4 \| 765
	chronic lymphosyte leukemia	4 \| 232
	chronic rhinosinusitis	4 \| 512
	cutaneous lupus erythematosus	4 \| 1,056
	dermatomyositis	4 \| 967
	esophageal adenocarcinoma	4 \| 737
	nephrosclerosis	4 \| 329
	non diabetic and post-ischemic heart failure	4 \| 200
	periodontitis	4 \| 269

	Blood and immune system	49 \| 17,995
	Digestive Tract	49 \| 18,473
	Endocrine System	49 \| 18,512
	Female tissues	49 \| 18,647
	Liver and Pancreas	49 \| 18,136
	Male tissues	49 \| 17,969
	Nervous System	49 \| 18,561
	Skin and soft tissues	49 \| 18,115
	Cardiovascular System	48 \| 17,958
	Respiratory system	48 \| 17,484
	Urinary Tract	48 \| 18,444

	Non-IDG	20 \| 11,969
	Enzyme	12 \| 4,146
	Transcription Factor	11 \| 1,400
	GPCR	2 \| 408
	Kinase	2 \| 634
	Nuclear Receptor	1 \| 48
	TF/Epigenetic	1 \| 38

	response to cytokine	49 \| 49
	transcription, DNA-templated	1,779 \| 1,779
	regulation of transcription, D...	1,170 \| 1,170
	signal transduction	969 \| 969
	positive regulation of transcr...	845 \| 845
	G-protein coupled receptor sig...	666 \| 666
	negative regulation of transcr...	620 \| 620
	apoptotic process	506 \| 506
	positive regulation of transcr...	504 \| 504
	negative regulation of transcr...	483 \| 483
	multicellular organism develop...	456 \| 456
	positive regulation of cell pr...	451 \| 451
	cell differentiation	442 \| 442
	negative regulation of apoptot...	440 \| 440
	innate immune response	410 \| 410
	cell adhesion	409 \| 409
	immune response	398 \| 398
	negative regulation of cell pr...	379 \| 379
	inflammatory response	371 \| 371
	viral process	368 \| 368
	spermatogenesis	365 \| 365
	cell proliferation	358 \| 358
	protein transport	356 \| 356
	intracellular signal transduct...	355 \| 355
	cell division	330 \| 330
	regulation of transcription fr...	324 \| 324
	protein phosphorylation	320 \| 320
	response to drug	297 \| 297
	positive regulation of apoptot...	292 \| 292
	nervous system development	275 \| 275
	transcription from RNA polymer...	272 \| 272
	cell surface receptor signalin...	267 \| 267
	protein ubiquitination	260 \| 260
	transport	257 \| 257
	cell-cell signaling	249 \| 249
	regulation of immune response	247 \| 247
	positive regulation of gene ex...	242 \| 242
	mitotic nuclear division	241 \| 241
	MAPK cascade	238 \| 238
	chemical synaptic transmission	238 \| 238
	mRNA splicing, via spliceosome	219 \| 219
	angiogenesis	218 \| 218
	small GTPase mediated signal t...	215 \| 215
	translation	215 \| 215
	rRNA processing	209 \| 209
	intracellular protein transpor...	205 \| 205
	cellular response to DNA damag...	201 \| 201
	cell cycle	200 \| 200
	proteasome-mediated ubiquitin-...	200 \| 200
	proteolysis	199 \| 199
	visual perception	198 \| 198
	DNA repair	196 \| 196
	extracellular matrix organizat...	193 \| 193
	regulation of apoptotic proces...	190 \| 190
	brain development	183 \| 183
	positive regulation of cell mi...	181 \| 181
	protein polyubiquitination	181 \| 181
	in utero embryonic development	178 \| 178
	Fc-epsilon receptor signaling ...	176 \| 176
	Wnt signaling pathway	175 \| 175
	ion transmembrane transport	174 \| 174
	protein homooligomerization	173 \| 173
	heart development	170 \| 170
	positive regulation of ERK1 an...	170 \| 170
	blood coagulation	169 \| 169
	cell migration	168 \| 168
	regulation of cell proliferati...	167 \| 167
	protein autophosphorylation	166 \| 166
	response to hypoxia	164 \| 164
	mRNA processing	162 \| 162
	negative regulation of canonic...	162 \| 162
	protein folding	162 \| 162
	T cell receptor signaling path...	161 \| 161
	response to lipopolysaccharide	161 \| 161
	defense response to virus	160 \| 160
	RNA splicing	158 \| 158
	aging	158 \| 158
	positive regulation of I-kappa...	158 \| 158
	axon guidance	157 \| 157
	homophilic cell adhesion via p...	155 \| 155
	sensory perception of smell	155 \| 155
	ER to Golgi vesicle-mediated t...	151 \| 151
	interferon-gamma-mediated sign...	150 \| 150
	protein ubiquitination involve...	150 \| 150
	transcription initiation from ...	150 \| 150
	ubiquitin-dependent protein ca...	149 \| 149
	DNA replication	144 \| 144
	adaptive immune response	139 \| 139
	cell cycle arrest	139 \| 139
	receptor-mediated endocytosis	139 \| 139
	skeletal system development	136 \| 136
	regulation of cell shape	135 \| 135
	regulation of small GTPase med...	134 \| 134
	G2/M transition of mitotic cel...	133 \| 133
	oxidation-reduction process	133 \| 133
	positive regulation of cytosol...	133 \| 133
	protein stabilization	133 \| 133
	sensory perception of sound	132 \| 132
	positive regulation of NF-kapp...	131 \| 131
	antigen processing and present...	130 \| 130
	type I interferon signaling pa...	130 \| 130

Development Level

IMPC Term

Disease

Tissue

Target Family

GO Process

Drug Target Ontology

Target Development Level

Target Family

PANTHER Protein Ontology

Ligand

GTEx Tissue

HPA RNA Tissue

HPA Protein Tissue

HPM Tissue

JAX/MGI Phenotype

OMIM Phenotype

GWAS Trait

GO Component

UniProt Keywords

Grant Funding IC

Grant Activity

Data Source